H2BC9 | ENSG00000275713 | NCBI 8345

Details for: H2BC9

Gene ID: 8345

Symbol: H2BC9

Ensembl ID: ENSG00000275713

Description: H2B clustered histone 9

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 4.5721
Cell Significance Index: 47.3300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.6629
Cell Significance Index: 47.9100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4898
Cell Significance Index: 283.5300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.4095
Cell Significance Index: 21.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3817
Cell Significance Index: 62.6300
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.3269
Cell Significance Index: 14.3800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.0469
Cell Significance Index: 22.6800
Cell Name: sensory neuron (CL0000101)
Fold Change: 1.0239
Cell Significance Index: 5.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.8123
Cell Significance Index: 52.4100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7824
Cell Significance Index: 706.4400
Cell Name: paneth cell (CL0000510)
Fold Change: 0.7762
Cell Significance Index: 8.0300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.7368
Cell Significance Index: 15.2900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6969
Cell Significance Index: 75.8000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6251
Cell Significance Index: 101.6700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6032
Cell Significance Index: 36.2100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.5138
Cell Significance Index: 18.0600
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.4510
Cell Significance Index: 3.5100
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.4129
Cell Significance Index: 3.6100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3445
Cell Significance Index: 40.6300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3335
Cell Significance Index: 6.9800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3277
Cell Significance Index: 22.6700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3217
Cell Significance Index: 8.6100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2833
Cell Significance Index: 3.0800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2521
Cell Significance Index: 3.4400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.2509
Cell Significance Index: -0.5500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2298
Cell Significance Index: 7.3600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2130
Cell Significance Index: 3.2100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1943
Cell Significance Index: 19.2200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1450
Cell Significance Index: 5.0400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1127
Cell Significance Index: 2.4000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1089
Cell Significance Index: 59.5000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0634
Cell Significance Index: 1.7700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0436
Cell Significance Index: 7.8600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0425
Cell Significance Index: 2.2100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0384
Cell Significance Index: 0.9600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0295
Cell Significance Index: 13.0600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0133
Cell Significance Index: 2.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0002
Cell Significance Index: -0.0400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0004
Cell Significance Index: -0.0100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0010
Cell Significance Index: -0.5500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0024
Cell Significance Index: -0.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0032
Cell Significance Index: -5.9900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0037
Cell Significance Index: -0.3800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0053
Cell Significance Index: -8.1200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0069
Cell Significance Index: -0.8900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0074
Cell Significance Index: -0.1900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0082
Cell Significance Index: -6.2000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0102
Cell Significance Index: -6.4500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0105
Cell Significance Index: -0.5900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0153
Cell Significance Index: -6.9600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0153
Cell Significance Index: -2.1000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0161
Cell Significance Index: -5.7700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0173
Cell Significance Index: -0.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0189
Cell Significance Index: -2.3300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0234
Cell Significance Index: -6.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0302
Cell Significance Index: -1.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0313
Cell Significance Index: -6.2800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0395
Cell Significance Index: -5.1000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0407
Cell Significance Index: -2.8800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0442
Cell Significance Index: -6.4200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0465
Cell Significance Index: -0.7200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0520
Cell Significance Index: -3.1900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0566
Cell Significance Index: -4.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0575
Cell Significance Index: -5.9900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0577
Cell Significance Index: -1.5400
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0608
Cell Significance Index: -0.7700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0613
Cell Significance Index: -2.8600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0642
Cell Significance Index: -7.3600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0799
Cell Significance Index: -2.1000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0908
Cell Significance Index: -1.0300
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0938
Cell Significance Index: -2.3400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0966
Cell Significance Index: -7.4100
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1020
Cell Significance Index: -0.6100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1185
Cell Significance Index: -6.2200
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.1210
Cell Significance Index: -1.1000
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1226
Cell Significance Index: -1.7200
Cell Name: kidney cell (CL1000497)
Fold Change: -0.1290
Cell Significance Index: -1.0300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1519
Cell Significance Index: -6.7200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1561
Cell Significance Index: -5.7300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1660
Cell Significance Index: -2.4100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1687
Cell Significance Index: -1.9100
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1692
Cell Significance Index: -1.2300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1780
Cell Significance Index: -6.7400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1796
Cell Significance Index: -2.3000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1799
Cell Significance Index: -5.3000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1833
Cell Significance Index: -6.4200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1836
Cell Significance Index: -2.3200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1854
Cell Significance Index: -6.0700
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.1869
Cell Significance Index: -1.1700
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1968
Cell Significance Index: -2.8200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1986
Cell Significance Index: -4.9600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2030
Cell Significance Index: -6.4700
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.2037
Cell Significance Index: -1.6900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.2049
Cell Significance Index: -2.0600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2117
Cell Significance Index: -2.9700
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.2154
Cell Significance Index: -2.1000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2223
Cell Significance Index: -6.0500
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.2258
Cell Significance Index: -2.8600
Cell Name: tendon cell (CL0000388)
Fold Change: -0.2258
Cell Significance Index: -3.0700
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2315
Cell Significance Index: -4.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** H2BC9 is a member of the histone H2B family, which is essential for the assembly of chromatin and the regulation of gene expression. It is characterized by its unique clustered domain, which allows for the formation of a stable histone octamer. H2BC9 is highly conserved across species, with high sequence identity to its counterparts in other organisms. Its expression is widespread, with notable presence in various cell types, including respiratory basal cells, lymphoid lineage-restricted progenitor cells, and intestinal epithelial cells. **Pathways and Functions:** H2BC9 is intricately involved in various cellular processes, including: 1. **Chromatin Organization:** H2BC9 plays a crucial role in maintaining chromatin structure and function, particularly during the assembly of the pre-replicative complex and the replication of DNA. 2. **DNA Repair:** H2BC9 is involved in the recognition and association of DNA glycosylase with damaged bases, facilitating the repair of DNA damage. 3. **Gene Expression:** H2BC9 regulates gene expression through its interaction with other histone variants and chromatin-modifying enzymes, influencing the transcriptional activity of genes. 4. **Cell Cycle Regulation:** H2BC9 is essential for the proper progression of the cell cycle, particularly during mitosis and the G2/M checkpoint. 5. **Stress Response:** H2BC9 is involved in the cellular response to stress, including oxidative stress and DNA damage. **Clinical Significance:** H2BC9 has been implicated in various diseases, including: 1. **Cancer:** Alterations in H2BC9 expression have been observed in various types of cancer, suggesting its potential role as a tumor suppressor gene. 2. **Neurodegenerative Diseases:** H2BC9 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation may contribute to disease progression. 3. **Immunological Disorders:** H2BC9 has been implicated in immunological disorders, including autoimmune diseases, where its dysregulation may contribute to disease pathogenesis. In conclusion, H2BC9 is a multifaceted protein that plays a critical role in chromatin organization, DNA repair, and gene expression. Its dysregulation has been linked to various diseases, highlighting the importance of H2BC9 in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms by which H2BC9 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-H

Genular Protein ID: 2982561975

Symbol: H2B1H_HUMAN

Name: Histone H2B type 1-H

UniProtKB Accession Codes:

Q93079 B2R541 Q4VB74

Database IDs:

Citations:

PubMed ID: 9119399

Title: Human histone gene organization: nonregular arrangement within a large cluster.

PubMed ID: 9119399

DOI: 10.1006/geno.1996.4592

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 16457587

Title: Gene-specific characterization of human histone H2B by electron capture dissociation.

PubMed ID: 16457587

DOI: 10.1021/pr050268v

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 26479788

Title: PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

PubMed ID: 26479788

DOI: 10.1038/ni.3279

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

Length: 126
Mass: 13892
Checksum: FAE0F79FF4BF703D
Sequence:

MPDPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2BC9

Associated with

Cells (max top 100)

Other Information

Human histone gene organization: nonregular arrangement within a large cluster. PubMed ID: 9119399

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Quantitative proteomic analysis of post-translational modifications of human histones. PubMed ID: 16627869

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Gene-specific characterization of human histone H2B by electron capture dissociation. PubMed ID: 16457587

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. PubMed ID: 26479788

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266