H2BC10 | ENSG00000278588 | NCBI 8346

Details for: H2BC10

Gene ID: 8346

Symbol: H2BC10

Ensembl ID: ENSG00000278588

Description: H2B clustered histone 10

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1.0275
Cell Significance Index: 7.4700
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.8911
Cell Significance Index: 12.7700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.7664
Cell Significance Index: 10.9100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5977
Cell Significance Index: 17.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5824
Cell Significance Index: 26.4000
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3079
Cell Significance Index: 3.8900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3013
Cell Significance Index: 6.2500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2622
Cell Significance Index: 5.6800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2351
Cell Significance Index: 6.2900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2322
Cell Significance Index: 22.9700
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.2241
Cell Significance Index: 3.1100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2226
Cell Significance Index: 13.3700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2198
Cell Significance Index: 41.8300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2075
Cell Significance Index: 22.5700
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.2030
Cell Significance Index: 1.7800
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.1769
Cell Significance Index: 1.7500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1688
Cell Significance Index: 10.8900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1675
Cell Significance Index: 27.2500
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.1513
Cell Significance Index: 1.6400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1502
Cell Significance Index: 2.2500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1231
Cell Significance Index: 3.0700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1215
Cell Significance Index: 1.7400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1062
Cell Significance Index: 1.4900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1024
Cell Significance Index: 3.2800
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0788
Cell Significance Index: 0.7900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0714
Cell Significance Index: 2.5100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0629
Cell Significance Index: 7.4200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0503
Cell Significance Index: 45.4300
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.0451
Cell Significance Index: 0.5600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0373
Cell Significance Index: 2.5800
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0316
Cell Significance Index: 0.4000
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.0271
Cell Significance Index: 0.2400
Cell Name: keratocyte (CL0002363)
Fold Change: 0.0214
Cell Significance Index: 0.3400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0184
Cell Significance Index: 3.3200
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0184
Cell Significance Index: 0.4700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0181
Cell Significance Index: 0.9400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0179
Cell Significance Index: 0.2700
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.0141
Cell Significance Index: 0.1200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0042
Cell Significance Index: 0.0900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0034
Cell Significance Index: 0.4400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0026
Cell Significance Index: 0.1600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0021
Cell Significance Index: 0.9300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0003
Cell Significance Index: -0.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0011
Cell Significance Index: -0.6000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0015
Cell Significance Index: -0.2900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0023
Cell Significance Index: -0.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0024
Cell Significance Index: -1.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0028
Cell Significance Index: -1.8000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0028
Cell Significance Index: -0.3800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0032
Cell Significance Index: -0.0800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0037
Cell Significance Index: -1.7000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0059
Cell Significance Index: -0.6800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0064
Cell Significance Index: -1.0900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0065
Cell Significance Index: -0.4600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0074
Cell Significance Index: -0.9100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0074
Cell Significance Index: -1.4900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0126
Cell Significance Index: -1.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0129
Cell Significance Index: -1.3200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0170
Cell Significance Index: -0.4700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0176
Cell Significance Index: -0.2300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0189
Cell Significance Index: -0.8900
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0194
Cell Significance Index: -0.1100
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0210
Cell Significance Index: -0.2900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0213
Cell Significance Index: -0.2900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0220
Cell Significance Index: -1.6400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0225
Cell Significance Index: -1.2600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0279
Cell Significance Index: -1.3000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0290
Cell Significance Index: -0.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0327
Cell Significance Index: -0.8600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0345
Cell Significance Index: -0.9200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0358
Cell Significance Index: -0.7500
Cell Name: granulocyte (CL0000094)
Fold Change: -0.0381
Cell Significance Index: -0.4600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0406
Cell Significance Index: -1.3300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0430
Cell Significance Index: -1.5800
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0437
Cell Significance Index: -0.8900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0443
Cell Significance Index: -1.4100
Cell Name: adipocyte (CL0000136)
Fold Change: -0.0443
Cell Significance Index: -0.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0446
Cell Significance Index: -1.5500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0521
Cell Significance Index: -0.4800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0539
Cell Significance Index: -0.6100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0542
Cell Significance Index: -1.3800
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0546
Cell Significance Index: -0.5700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0553
Cell Significance Index: -1.3800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0556
Cell Significance Index: -0.9300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0564
Cell Significance Index: -1.6600
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0570
Cell Significance Index: -0.6200
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.0577
Cell Significance Index: -0.6000
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0588
Cell Significance Index: -0.6100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0590
Cell Significance Index: -1.6900
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: -0.0604
Cell Significance Index: -0.5700
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0607
Cell Significance Index: -1.2100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0618
Cell Significance Index: -0.8000
Cell Name: peg cell (CL4033014)
Fold Change: -0.0619
Cell Significance Index: -1.4300
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0621
Cell Significance Index: -1.5500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0621
Cell Significance Index: -1.6900
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0624
Cell Significance Index: -1.0100
Cell Name: tendon cell (CL0000388)
Fold Change: -0.0673
Cell Significance Index: -0.9200
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0683
Cell Significance Index: -1.3400
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.0696
Cell Significance Index: -0.7900
Cell Name: decidual cell (CL2000002)
Fold Change: -0.0717
Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H2BC10 is a histone protein that belongs to the H2B family, which is one of the five main histone families in eukaryotic cells. Histones are essential components of chromatin, the complex of DNA and proteins that make up chromosomes. H2BC10 is characterized by its ability to interact with other proteins and DNA molecules, regulating chromatin structure and gene expression. The gene is highly conserved across species, suggesting its importance in fundamental cellular processes. **Pathways and Functions** H2BC10 is involved in several key cellular pathways, including: 1. **DNA Repair**: H2BC10 plays a role in the repair of DNA double-strand breaks, a process essential for maintaining genome stability. 2. **Chromatin Assembly**: H2BC10 is involved in the assembly of nucleosomes, the basic units of chromatin. 3. **Transcriptional Regulation**: H2BC10 interacts with transcription factors and RNA polymerase to regulate gene expression. 4. **Cell Cycle Regulation**: H2BC10 is involved in the regulation of cell cycle progression, particularly during mitosis. 5. **Immune Response**: H2BC10 is expressed in immune cells, such as thymocytes and goblet cells, and plays a role in the regulation of immune responses. **Clinical Significance** Dysregulation of H2BC10 has been implicated in various diseases, including: 1. **Cancer**: H2BC10 mutations have been associated with certain types of cancer, such as leukemia and lymphoma. 2. **Neurodegenerative Disorders**: H2BC10 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Conditions**: H2BC10 has been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Developmental Disorders**: H2BC10 mutations have been linked to developmental disorders, such as neural tube defects and congenital heart defects. In conclusion, H2BC10 is an essential gene that plays a critical role in various cellular processes, including DNA repair, chromatin assembly, and transcriptional regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and regulation of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.