H3C6 | ENSG00000274750 | NCBI 8353

Details for: H3C6

Gene ID: 8353

Symbol: H3C6

Ensembl ID: ENSG00000274750

Description: H3 clustered histone 6

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2044
Cell Significance Index: 229.2000
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.0879
Cell Significance Index: 15.5900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7139
Cell Significance Index: 15.2100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6497
Cell Significance Index: 586.6000
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.5436
Cell Significance Index: 4.6200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5426
Cell Significance Index: 8.1300
Cell Name: paneth cell (CL0000510)
Fold Change: 0.5418
Cell Significance Index: 5.6100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4573
Cell Significance Index: 49.7400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4511
Cell Significance Index: 6.4600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4266
Cell Significance Index: 25.6100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3963
Cell Significance Index: 64.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3592
Cell Significance Index: 16.2800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3577
Cell Significance Index: 4.8800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3490
Cell Significance Index: 10.0600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3411
Cell Significance Index: 7.3900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2927
Cell Significance Index: 3.0300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2619
Cell Significance Index: 18.1100
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.2381
Cell Significance Index: 2.5800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2378
Cell Significance Index: 23.5200
Cell Name: keratocyte (CL0002363)
Fold Change: 0.2257
Cell Significance Index: 3.5800
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.2250
Cell Significance Index: 5.6100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2153
Cell Significance Index: 5.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2081
Cell Significance Index: 10.8100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.1682
Cell Significance Index: 2.3600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1334
Cell Significance Index: 2.0100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1255
Cell Significance Index: 4.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0727
Cell Significance Index: 2.3300
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.0660
Cell Significance Index: 0.4800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0607
Cell Significance Index: 4.6600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0521
Cell Significance Index: 1.0800
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0512
Cell Significance Index: 5.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0459
Cell Significance Index: 9.1100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0424
Cell Significance Index: 0.4500
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0399
Cell Significance Index: 0.4000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0350
Cell Significance Index: 2.2600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0349
Cell Significance Index: 1.9600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0345
Cell Significance Index: 18.8400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0247
Cell Significance Index: 0.6900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0210
Cell Significance Index: 3.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0176
Cell Significance Index: 0.8200
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.0172
Cell Significance Index: 0.0900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0142
Cell Significance Index: 6.2700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0140
Cell Significance Index: 1.6000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0136
Cell Significance Index: 0.3700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0068
Cell Significance Index: 0.1000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0051
Cell Significance Index: 0.1300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0037
Cell Significance Index: 1.3300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0014
Cell Significance Index: 0.2400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0013
Cell Significance Index: 0.1800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0006
Cell Significance Index: 0.0700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0003
Cell Significance Index: 0.0400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0002
Cell Significance Index: 0.0000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0003
Cell Significance Index: -0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0004
Cell Significance Index: -0.3300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0007
Cell Significance Index: -0.3900
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0009
Cell Significance Index: -0.0100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0010
Cell Significance Index: -0.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0016
Cell Significance Index: -2.9000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.9700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0031
Cell Significance Index: -2.3500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0033
Cell Significance Index: -2.1200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0034
Cell Significance Index: -0.7200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0045
Cell Significance Index: -2.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0058
Cell Significance Index: -1.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0077
Cell Significance Index: -0.3600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0115
Cell Significance Index: -0.3400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0121
Cell Significance Index: -0.4200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0122
Cell Significance Index: -1.5700
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0148
Cell Significance Index: -0.3600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0150
Cell Significance Index: -0.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0154
Cell Significance Index: -2.2400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0156
Cell Significance Index: -0.3900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0156
Cell Significance Index: -1.8400
Cell Name: kidney cell (CL1000497)
Fold Change: -0.0175
Cell Significance Index: -0.1400
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0203
Cell Significance Index: -0.2100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0205
Cell Significance Index: -1.4500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0225
Cell Significance Index: -1.6800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0278
Cell Significance Index: -1.4600
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0282
Cell Significance Index: -0.3800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0322
Cell Significance Index: -2.5500
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0346
Cell Significance Index: -0.2300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0374
Cell Significance Index: -0.4300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0431
Cell Significance Index: -1.1500
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0434
Cell Significance Index: -0.5500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0457
Cell Significance Index: -0.7700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0487
Cell Significance Index: -1.2800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0497
Cell Significance Index: -1.0400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0506
Cell Significance Index: -2.2400
Cell Name: thymocyte (CL0000893)
Fold Change: -0.0514
Cell Significance Index: -0.6500
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0520
Cell Significance Index: -0.7400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0561
Cell Significance Index: -2.0600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0623
Cell Significance Index: -0.7900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0625
Cell Significance Index: -2.1900
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0625
Cell Significance Index: -0.4200
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.0660
Cell Significance Index: -0.8500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0665
Cell Significance Index: -2.5200
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: -0.0669
Cell Significance Index: -0.5200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0689
Cell Significance Index: -1.1800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0692
Cell Significance Index: -2.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H3C6 is a histone protein that is part of the H3 family, which is one of the five major histone families. Histones are characterized by their ability to bind to DNA and form a nucleosome, which is the basic unit of chromatin. H3C6 is unique in its ability to bind to the H3 histone variant, which is essential for the assembly and disassembly of chromatin. This gene is also involved in various chromatin-related processes, including DNA replication, transcription, and repair. Additionally, H3C6 has been implicated in the regulation of gene expression, particularly in the context of cellular differentiation and development. **Pathways and Functions** H3C6 is involved in various cellular pathways, including: 1. **Chromatin Assembly and Disassembly**: H3C6 plays a crucial role in the assembly and disassembly of chromatin during DNA replication, transcription, and repair. 2. **Gene Expression Regulation**: H3C6 is involved in the regulation of gene expression, particularly in the context of cellular differentiation and development. 3. **DNA Replication and Repair**: H3C6 is involved in the regulation of DNA replication and repair, particularly in the context of the origin of replication. 4. **Transcriptional Regulation**: H3C6 is involved in the regulation of transcriptional processes, particularly in the context of the anterior Hox gene cluster and the assembly of the Orc complex. 5. **Cellular Differentiation and Development**: H3C6 is involved in the regulation of cellular differentiation and development, particularly in the context of the development of the hindbrain and the assembly of the pre-replicative complex. **Clinical Significance** The clinical significance of H3C6 is an area of ongoing research. However, its involvement in various chromatin-related processes suggests that alterations in H3C6 expression or function may contribute to various diseases, including: 1. **Cancer**: H3C6 has been implicated in the regulation of gene expression and cellular differentiation, which may contribute to the development of cancer. 2. **Neurological Disorders**: H3C6 has been implicated in the regulation of gene expression and cellular differentiation, which may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune System Disorders**: H3C6 has been implicated in the regulation of gene expression and cellular differentiation, which may contribute to the development of immune system disorders, such as autoimmune diseases. In conclusion, H3C6 is a critical component of the chromatin machinery that plays a crucial role in various cellular processes, including gene expression regulation, DNA replication, and cellular differentiation. Its involvement in various diseases suggests that alterations in H3C6 expression or function may contribute to the development of various diseases. Further research is needed to fully elucidate the clinical significance of H3C6 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.