Details for: TFAP2D

Gene ID: 83741

Symbol: TFAP2D

Ensembl ID: ENSG00000008197

Description: transcription factor AP-2 delta

Associated with

  • Activation of the tfap2 (ap-2) family of transcription factors
    (R-HSA-8866907)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Negative regulation of activity of tfap2 (ap-2) family transcription factors
    (R-HSA-8866904)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
    (R-HSA-8864260)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Inferior colliculus development
    (GO:0061379)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.9638
    Cell Significance Index: 10.0400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: 0.6910
    Cell Significance Index: 7.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6517
    Cell Significance Index: 15.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5719
    Cell Significance Index: 8.1900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3398
    Cell Significance Index: 2.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2847
    Cell Significance Index: 4.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1748
    Cell Significance Index: 2.1800
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.1637
    Cell Significance Index: 1.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1506
    Cell Significance Index: 8.4500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0064
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0024
    Cell Significance Index: 0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -3.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0067
    Cell Significance Index: -3.0600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0133
    Cell Significance Index: -2.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0147
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0151
    Cell Significance Index: -0.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0157
    Cell Significance Index: -0.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0268
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0283
    Cell Significance Index: -3.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0324
    Cell Significance Index: -3.3700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0364
    Cell Significance Index: -0.3600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0386
    Cell Significance Index: -0.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0401
    Cell Significance Index: -1.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0457
    Cell Significance Index: -2.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0468
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0476
    Cell Significance Index: -3.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0490
    Cell Significance Index: -3.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0582
    Cell Significance Index: -2.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0594
    Cell Significance Index: -1.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0692
    Cell Significance Index: -3.2500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0762
    Cell Significance Index: -1.1400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0770
    Cell Significance Index: -0.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0780
    Cell Significance Index: -3.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0825
    Cell Significance Index: -2.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0828
    Cell Significance Index: -2.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0858
    Cell Significance Index: -2.8100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0863
    Cell Significance Index: -0.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0885
    Cell Significance Index: -2.8200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0898
    Cell Significance Index: -0.8600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0909
    Cell Significance Index: -1.1900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0911
    Cell Significance Index: -0.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0927
    Cell Significance Index: -3.5100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0999
    Cell Significance Index: -0.6500
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1036
    Cell Significance Index: -1.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1111
    Cell Significance Index: -3.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1123
    Cell Significance Index: -3.0100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1129
    Cell Significance Index: -1.3900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1132
    Cell Significance Index: -1.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1143
    Cell Significance Index: -2.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1157
    Cell Significance Index: -1.2600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1162
    Cell Significance Index: -2.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1198
    Cell Significance Index: -3.2000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1233
    Cell Significance Index: -1.2200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1254
    Cell Significance Index: -3.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1319
    Cell Significance Index: -2.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1368
    Cell Significance Index: -3.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1384
    Cell Significance Index: -2.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1384
    Cell Significance Index: -3.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1385
    Cell Significance Index: -2.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1512
    Cell Significance Index: -2.9900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1512
    Cell Significance Index: -1.5800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1522
    Cell Significance Index: -1.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1534
    Cell Significance Index: -3.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1537
    Cell Significance Index: -1.9400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1543
    Cell Significance Index: -3.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1590
    Cell Significance Index: -3.1300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1595
    Cell Significance Index: -1.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1655
    Cell Significance Index: -2.6800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1670
    Cell Significance Index: -2.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1673
    Cell Significance Index: -2.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1683
    Cell Significance Index: -2.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1695
    Cell Significance Index: -1.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1739
    Cell Significance Index: -2.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1749
    Cell Significance Index: -1.8500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1755
    Cell Significance Index: -2.3400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1761
    Cell Significance Index: -0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1834
    Cell Significance Index: -3.0700
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1840
    Cell Significance Index: -0.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1842
    Cell Significance Index: -3.1900
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.1842
    Cell Significance Index: -1.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1844
    Cell Significance Index: -2.4200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1915
    Cell Significance Index: -3.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1972
    Cell Significance Index: -3.3800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1972
    Cell Significance Index: -3.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2005
    Cell Significance Index: -2.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2005
    Cell Significance Index: -2.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: TFAP2D is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **AP-2 Family Member**: TFAP2D belongs to the AP-2 family of transcription factors, which are known to play critical roles in development, cell proliferation, and differentiation. 3. **Developmental Expression**: TFAP2D is significantly expressed in embryonic development, particularly during the formation of the nervous system, cardiovascular system, and other tissues. 4. **Cell Type Specificity**: TFAP2D is expressed in various cell types, including progenitor cells, endothelial cells, and immune cells, highlighting its importance in tissue development and immune homeostasis. **Pathways and Functions:** 1. **Activation of TFAP2 Family**: TFAP2D activates the TFAP2 family of transcription factors, which in turn regulate various developmental and cellular processes. 2. **Anatomical Structure Development**: TFAP2D plays a crucial role in the development of anatomical structures, including the nervous system, cardiovascular system, and other tissues. 3. **Chromatin Regulation**: TFAP2D regulates chromatin structure and function, which is essential for gene expression and cellular differentiation. 4. **Negative Regulation of TFAP2 Family**: TFAP2D negatively regulates the activity of the TFAP2 family of transcription factors, which helps to maintain tissue homeostasis and prevent aberrant gene expression. 5. **Regulation of Cell Proliferation**: TFAP2D regulates cell proliferation, particularly in the context of tissue development and immune homeostasis. 6. **Transcriptional Regulation**: TFAP2D regulates transcription by RNA polymerase II, which is essential for gene expression and cellular differentiation. **Clinical Significance:** 1. **Neurological Disorders**: Dysregulation of TFAP2D has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer**: TFAP2D has been identified as a tumor suppressor gene, and its dysregulation has been linked to various types of cancer, including breast cancer and colon cancer. 3. **Immune System Disorders**: TFAP2D plays a crucial role in regulating immune cell development and function, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Cardiovascular Diseases**: TFAP2D has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. In conclusion, TFAP2D is a critical transcription factor that regulates various developmental, cellular, and immunological processes. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further studies are needed to fully elucidate the role of TFAP2D in human disease and to develop therapeutic strategies to target this gene in the treatment of various disorders.

Genular Protein ID: 3033342159

Symbol: AP2D_HUMAN

Name: Transcription factor AP-2-delta

UniProtKB Accession Codes:

Q7Z6R9 Q8IWX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 11 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11733187

Title: Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1).

PubMed ID: 11733187

DOI: 10.1016/s1357-2725(01)00098-x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 452
  • Mass: 49578
  • Checksum: 6623612B172A59EA
  • Sequence:
    • MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST TGTEFASPYF 
STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ YYQQIHHGEP TDFINLHNAR 
ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG 
SVEAQCGLVL NGQGGVIRRG GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP 
PECLNASLLG GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL 
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD LLSQDRSPLG 
SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT VLSEMLNYLE KHTTHKNGGA 
ADSGQGHANS EKAPLRKTSE AAVKEGKTEK TD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.