Details for: CASP5

Gene ID: 838

Symbol: CASP5

Ensembl ID: ENSG00000137757

Description: caspase 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7657
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.68
    Marker Score: 1233
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 417.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1139
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 456
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.54
    Marker Score: 1709
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 940
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.46
    Marker Score: 956
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 222
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.36
    Marker Score: 708
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.34
    Marker Score: 208
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.33
    Marker Score: 324
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.28
    Marker Score: 125
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.27
    Marker Score: 663
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.26
    Marker Score: 3423
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.21
    Marker Score: 529
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3278
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 969
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.18
    Marker Score: 113.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.18
    Marker Score: 271
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.16
    Marker Score: 62
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.16
    Marker Score: 4179
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.16
    Marker Score: 257
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 473
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 132
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.14
    Marker Score: 136
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 167
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.12
    Marker Score: 85
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 142
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.11
    Marker Score: 258
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.11
    Marker Score: 436.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 114
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.1
    Marker Score: 263
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.1
    Marker Score: 1163
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 226
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 163
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.09
    Marker Score: 86.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.08
    Marker Score: 44.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.08
    Marker Score: 75
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.08
    Marker Score: 4213
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.07
    Marker Score: 410
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.07
    Marker Score: 18

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Other Information

**Key characteristics:** - CASP5 is a transmembrane protein with a molecular weight of approximately 115 kDa. - It is a member of the Caspase family of cysteine proteases. - CASP5 is a key regulator of apoptosis through different pathways, including the mitochondrial pathway and the caspases-dependent pathway. **Pathways and functions:** - CASP5 is involved in the apoptotic process of immune cells through the mitochondrial pathway. - It is a key regulator of the NLRP1 inflammasome complex, a central component of the innate immune response. - CASP5 also plays a role in the regulation of neuron apoptotic process through the caspases-dependent pathway. - It is involved in programmed cell death, pyroptosis, and regulated necrosis. **Clinical significance:** - Mutations in CASP5 have been linked to several human diseases, including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and cancer. - Caspase-5 inhibitors are being investigated as potential therapeutics for these diseases. **Additional information:** - CASP5 is also involved in the development of the substantia nigra, a neural structure responsible for motor control and reward pathways. - It is a key regulator of the immune response, and its dysregulation can lead to autoimmune diseases.

Genular Protein ID: 3590721377

Symbol: CASP5_HUMAN

Name: Caspase-5 subunit p20

UniProtKB Accession Codes:

P51878 B4DKP5 Q0QVY7 Q0QVY8 Q0QVZ0 Q0QVZ1 Q0QVZ2 Q14DD6 Q1HBJ3 Q6DJV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16893518

Title: Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants.

PubMed ID: 16893518

DOI: 10.1016/j.bbrc.2006.07.104

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 7797592

Title: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

PubMed ID: 7797592

DOI: 10.1074/jbc.270.26.15870

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617266

Title: Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme.

PubMed ID: 8617266

DOI: 10.1111/j.1432-1033.1996.t01-1-00207.x

PubMed ID: 17431422

Title: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

PubMed ID: 17431422

DOI: 10.1038/sj.cdd.4402142

PubMed ID: 29898893

Title: Mechanism of membrane pore formation by human gasdermin-D.

PubMed ID: 29898893

DOI: 10.15252/embj.201798321

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

Sequence Information:

  • Length: 434
  • Mass: 49736
  • Checksum: C5257C2BF15EB6D5
  • Sequence:
    • MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK 
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR 
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD 
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD 
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC 
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF 
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE 
RATLTRDFYL FPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.