Details for: CASP5

Gene ID: 838

Symbol: CASP5

Ensembl ID: ENSG00000137757

Description: caspase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.4675
    Cell Significance Index: -3.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 7.6207
    Cell Significance Index: -3.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.6031
    Cell Significance Index: -3.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7602
    Cell Significance Index: 334.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7125
    Cell Significance Index: 25.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4426
    Cell Significance Index: 22.3200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.1337
    Cell Significance Index: 12.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0148
    Cell Significance Index: 60.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8003
    Cell Significance Index: 722.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7689
    Cell Significance Index: 76.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7263
    Cell Significance Index: 79.0000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.5957
    Cell Significance Index: 7.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5385
    Cell Significance Index: 24.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4668
    Cell Significance Index: 13.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4505
    Cell Significance Index: 73.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4212
    Cell Significance Index: 29.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3088
    Cell Significance Index: 6.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1839
    Cell Significance Index: 3.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1613
    Cell Significance Index: 1.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1408
    Cell Significance Index: 2.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0980
    Cell Significance Index: 3.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0536
    Cell Significance Index: 1.3400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0510
    Cell Significance Index: 0.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0430
    Cell Significance Index: 5.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0039
    Cell Significance Index: -0.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0059
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0097
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0131
    Cell Significance Index: -1.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0147
    Cell Significance Index: -2.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0167
    Cell Significance Index: -3.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0178
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0194
    Cell Significance Index: -3.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0223
    Cell Significance Index: -2.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0237
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0240
    Cell Significance Index: -2.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0252
    Cell Significance Index: -3.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0267
    Cell Significance Index: -2.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0284
    Cell Significance Index: -0.7300
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0290
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0345
    Cell Significance Index: -1.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0381
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0407
    Cell Significance Index: -3.2200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0419
    Cell Significance Index: -0.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0449
    Cell Significance Index: -0.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0449
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0464
    Cell Significance Index: -0.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0508
    Cell Significance Index: -2.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0558
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0569
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0599
    Cell Significance Index: -1.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0618
    Cell Significance Index: -3.9900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0661
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0706
    Cell Significance Index: -4.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0716
    Cell Significance Index: -3.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0788
    Cell Significance Index: -3.7100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0797
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0817
    Cell Significance Index: -1.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0834
    Cell Significance Index: -0.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0866
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0874
    Cell Significance Index: -0.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0899
    Cell Significance Index: -3.1500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0933
    Cell Significance Index: -1.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0935
    Cell Significance Index: -5.2500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0953
    Cell Significance Index: -0.9600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1004
    Cell Significance Index: -1.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1030
    Cell Significance Index: -1.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1047
    Cell Significance Index: -1.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1080
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1117
    Cell Significance Index: -4.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1120
    Cell Significance Index: -2.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1129
    Cell Significance Index: -2.7400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1144
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1150
    Cell Significance Index: -0.7800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1156
    Cell Significance Index: -0.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1183
    Cell Significance Index: -3.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1199
    Cell Significance Index: -3.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1257
    Cell Significance Index: -1.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1287
    Cell Significance Index: -4.1000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1300
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1307
    Cell Significance Index: -4.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1330
    Cell Significance Index: -2.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1331
    Cell Significance Index: -2.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1331
    Cell Significance Index: -1.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1361
    Cell Significance Index: -3.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Caspase 5 is a caspase subunit p20, which is part of the caspase family, specifically the initiator caspases. It is characterized by its ability to activate other caspases, leading to the execution of apoptosis. Caspase 5 is also involved in the regulation of pyroptosis, a form of programmed necrosis, and is part of the NLRP1 inflammasome complex. Its expression is widespread, with significant levels found in granulocyte monocyte progenitor cells, goblet cells, and neural cells. **Pathways and Functions:** Caspase 5 is involved in various cellular pathways, including: 1. **Apoptotic process:** Caspase 5 is a key regulator of apoptosis, acting as an initiator caspase that activates downstream caspases, leading to the execution of cell death. 2. **Pyroptosis:** Caspase 5 is involved in the regulation of pyroptosis, a form of programmed necrosis, through its interaction with the NLRP1 inflammasome complex. 3. **Cysteine-type endopeptidase activity:** Caspase 5 exhibits cysteine-type endopeptidase activity, which is essential for its function in apoptosis and pyroptosis. 4. **Proteolysis:** Caspase 5 is involved in the regulation of proteolysis, which is crucial for the execution of apoptosis and pyroptosis. **Clinical Significance:** Caspase 5 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** Caspase 5 has been shown to play a role in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where apoptosis and pyroptosis are dysregulated. 2. **Inflammatory diseases:** Caspase 5 is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. 3. **Cancer:** Caspase 5 has been shown to play a role in cancer, where its dysregulation can contribute to tumor progression and metastasis. 4. **Infectious diseases:** Caspase 5 has been implicated in the regulation of immune responses, and its dysregulation has been linked to infectious diseases, such as sepsis and tuberculosis. In conclusion, caspase 5 is a crucial regulator of apoptosis and pyroptosis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of caspase 5 in disease and to develop therapeutic strategies targeting this enzyme. **References:** * [Insert references to relevant studies and reviews] **Note:** This article is a summary of the gene CASP5 and its functions, and is not intended to be a comprehensive review of the literature. Further research is needed to fully understand the role of caspase 5 in disease.

Genular Protein ID: 3590721377

Symbol: CASP5_HUMAN

Name: Caspase-5 subunit p20

UniProtKB Accession Codes:

P51878 B4DKP5 Q0QVY7 Q0QVY8 Q0QVZ0 Q0QVZ1 Q0QVZ2 Q14DD6 Q1HBJ3 Q6DJV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 7 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16893518

Title: Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants.

PubMed ID: 16893518

DOI: 10.1016/j.bbrc.2006.07.104

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 7797592

Title: Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.

PubMed ID: 7797592

DOI: 10.1074/jbc.270.26.15870

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617266

Title: Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme.

PubMed ID: 8617266

DOI: 10.1111/j.1432-1033.1996.t01-1-00207.x

PubMed ID: 17431422

Title: The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

PubMed ID: 17431422

DOI: 10.1038/sj.cdd.4402142

PubMed ID: 29898893

Title: Mechanism of membrane pore formation by human gasdermin-D.

PubMed ID: 29898893

DOI: 10.15252/embj.201798321

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 37993714

Title: Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.

PubMed ID: 37993714

DOI: 10.1038/s41586-023-06742-w

Sequence Information:

  • Length: 434
  • Mass: 49736
  • Checksum: C5257C2BF15EB6D5
  • Sequence:
    • MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP NTDQKSTSVK 
KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK KKYYDTKIED KALILVDSLR 
KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE AGPPESAEST NILKLCPREE FLRLCKKNHD 
EIYPIKKRED RRRLALIICN TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD 
MESVLRAFAA RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC 
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK IHEEKDFIAF 
CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF RKVQKSFEVP QAKAQMPTIE 
RATLTRDFYL FPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.