Details for: PIP5K1B
Gene ID: 8395
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PIP5K1B
Ensembl ID: ENSG00000107242
Description: phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 56.77rCSI 92.96%PRS 59.29
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CSI 38.53rCSI 55.28%PRS 59.71
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CSI 36.69rCSI 47.3%PRS 52.78
-
CSI 36.48rCSI 61.23%PRS 51.44
-
CSI 28.49rCSI 35.44%PRS 49.52
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CSI 26.31rCSI 42.32%PRS 53.33
-
CSI 21.45rCSI 37.89%PRS 50.54
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CSI 16.21rCSI 20.16%PRS 72.08
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CSI 14.83rCSI 33.66%PRS 72.39
-
CSI 13.92rCSI 16.63%PRS 51.25
-
CSI 12.78rCSI 46%PRS 49.62
-
CSI 12.48rCSI 48.79%PRS 47.43
-
CSI 11.15rCSI 13.57%PRS 77.47
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CSI 9.92rCSI 24.56%PRS 69.04
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CSI 9.7rCSI 24.54%PRS 77.16
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CSI 9.59rCSI 8.34%PRS 80.74
-
CSI 9.29rCSI 7.96%PRS 77.8
-
CSI 9.28rCSI 25.58%PRS 65.21
-
CSI 8.73rCSI 8.42%PRS 61.96
-
CSI 8.34rCSI 22.13%PRS 79.42
-
CSI 8.25rCSI 26.55%PRS 67.89
-
CSI 8.24rCSI 23.1%PRS 79.88
-
CSI 8.19rCSI 7.74%PRS 69.57
-
CSI 8.18rCSI 19.89%PRS 49.84
-
CSI 7.94rCSI 9.16%PRS 62.67
-
CSI 7.47rCSI 8.01%PRS 70.69
-
CSI 7.25rCSI 13.02%PRS 63.3
-
CSI 6.72rCSI 15.35%PRS 61.63
-
CSI 6.61rCSI 9.04%PRS 71.26
-
CSI 6.55rCSI 13%PRS 66.81
-
CSI 6.09rCSI 8.95%PRS 63.33
-
CSI 5.88rCSI 19.14%PRS 69.4
-
CSI 5.81rCSI 12.79%PRS 81.04
-
CSI 5.53rCSI 3.68%PRS 73.05
-
CSI 5.44rCSI 4.57%PRS 85.4
-
CSI 5.4rCSI 7.92%PRS 81.4
-
CSI 5.36rCSI 21.85%PRS 63.23
-
CSI 5.35rCSI 39.34%PRS 56.91
-
CSI 5.25rCSI 10.53%PRS 59.46
-
CSI 5.22rCSI 3.88%PRS 82.75
-
CSI 5.21rCSI 11.68%PRS 52.07
-
CSI 5.1rCSI 28.84%PRS 55.57
-
CSI 5.08rCSI 12.12%PRS 70.63
-
CSI 5.07rCSI 5.3%PRS 68.02
-
CSI 5.03rCSI 5.25%PRS 70.19
-
CSI 4.96rCSI 11.46%PRS 58.39
-
CSI 4.93rCSI 10.7%PRS 57.94
-
CSI 4.92rCSI 11.72%PRS 70.65
-
CSI 4.92rCSI 9.21%PRS 57.94
-
CSI 4.87rCSI 7.89%PRS 65.9
-
CSI 4.77rCSI 12.71%PRS 58.71
-
CSI 4.71rCSI 10.74%PRS 65.42
-
CSI 4.42rCSI 7.03%PRS 62.87
-
CSI 4.23rCSI 7.41%PRS 62.69
-
CSI 3.95rCSI 5.59%PRS 66.43
-
CSI 3.89rCSI 3.06%PRS 76.79
-
CSI 3.88rCSI 14.78%PRS 60.7
-
CSI 3.86rCSI 7.83%PRS 48.48
-
CSI 3.67rCSI 2.72%PRS 63.04
-
CSI 3.65rCSI 7.99%PRS 77.06
-
CSI 3.51rCSI 21.94%PRS 61.6
-
CSI 3.49rCSI 3.66%PRS 67.21
-
CSI 3.43rCSI 7.57%PRS 56.12
-
CSI 3.4rCSI 4.64%PRS 75.9
-
CSI 3.35rCSI 9.69%PRS 70.88
-
CSI 3.31rCSI 19.47%PRS 52.53
-
CSI 3.23rCSI 5.21%PRS 71.76
-
CSI 3.18rCSI 8.3%PRS 70.59
-
CSI 3.14rCSI 2.54%PRS 72.1
-
CSI 3.1rCSI 2.75%PRS 68.14
-
CSI 2.99rCSI 3.59%PRS 84.45
-
CSI 2.99rCSI 5.61%PRS 81.73
-
CSI 2.9rCSI 9.06%PRS 55.73
-
CSI 2.72rCSI 4.16%PRS 70.93
-
CSI 2.64rCSI 7.78%PRS 69.4
-
CSI 2.61rCSI 3.99%PRS 74.69
-
CSI 2.52rCSI 12.07%PRS 68.14
-
CSI 2.4rCSI 7.11%PRS 79.98
-
CSI 2.36rCSI 5.99%PRS 59.83
-
CSI 2.32rCSI 2.37%PRS 81.72
-
CSI 2.31rCSI 4%PRS 60.66
-
CSI 2.21rCSI 5.96%PRS 76.62
-
CSI 2.14rCSI 18.8%PRS 58.14
-
CSI 2.13rCSI 4.95%PRS 79.32
-
CSI 2.11rCSI 2.48%PRS 72.44
-
CSI 2.08rCSI 5.09%PRS 63.3
-
CSI 2.06rCSI 2.95%PRS 72.63
-
CSI 2.05rCSI 2.75%PRS 70.05
-
CSI 2.05rCSI 7.74%PRS 52.02
-
CSI 1.98rCSI 6.63%PRS 54.72
-
CSI 1.83rCSI 3.9%PRS 79.28
-
CSI 1.79rCSI 2.38%PRS 76.65
-
CSI 1.79rCSI 2.78%PRS 76.64
-
CSI 1.77rCSI 1.6%PRS 67.57
-
CSI 1.76rCSI 7.6%PRS 80.51
-
CSI 1.68rCSI 4.49%PRS 61.21
-
CSI 1.67rCSI 4.32%PRS 65.11
-
CSI 1.64rCSI 5.13%PRS 53.23
-
CSI 1.58rCSI 1.96%PRS 80.7
-
CSI 1.53rCSI 2.52%PRS 75.49
-
CSI 0.4rCSI 3.1%PRS 83.8%
-
CSI 0.5rCSI 5.0%PRS 67.5%
-
CSI 0.5rCSI 2.9%PRS 77.9%
-
CSI 0.5rCSI 7.3%PRS 61.2%
-
CSI 0.9rCSI 17.3%PRS 60.5%
-
CSI 0.9rCSI 3.8%PRS 82.3%
-
CSI 0.9rCSI 6.7%PRS 62.6%
-
CSI 0.9rCSI 3.3%PRS 77.0%
-
CSI 1.1rCSI 2.7%PRS 78.0%
-
CSI 1.1rCSI 3.2%PRS 79.4%
-
CSI 1.2rCSI 1.0%PRS 58.2%
-
CSI 1.2rCSI 24.2%PRS 62.0%
-
CSI 1.3rCSI 3.6%PRS 66.2%
-
CSI 1.3rCSI 2.0%PRS 80.3%
-
CSI 1.4rCSI 1.6%PRS 61.2%
-
CSI 1.4rCSI 6.5%PRS 83.6%
-
CSI 1.4rCSI 8.0%PRS 68.0%
-
CSI 1.4rCSI 3.7%PRS 78.7%
-
CSI 1.5rCSI 12.8%PRS 66.1%
-
CSI 1.5rCSI 2.5%PRS 75.5%
-
CSI 1.6rCSI 2.0%PRS 80.7%
-
CSI 1.6rCSI 5.1%PRS 53.2%
-
CSI 1.7rCSI 4.3%PRS 65.1%
-
CSI 1.7rCSI 4.5%PRS 61.2%
-
CSI 1.8rCSI 7.6%PRS 80.5%
-
CSI 1.8rCSI 1.6%PRS 67.6%
-
CSI 1.8rCSI 2.8%PRS 76.6%
-
CSI 1.8rCSI 2.4%PRS 76.7%
-
CSI 1.8rCSI 3.9%PRS 79.3%
-
CSI 2.0rCSI 6.6%PRS 54.7%
-
CSI 2.1rCSI 7.7%PRS 52.0%
-
CSI 2.1rCSI 2.8%PRS 70.1%
-
CSI 2.1rCSI 3.0%PRS 72.6%
-
CSI 2.1rCSI 5.1%PRS 63.3%
-
CSI 2.1rCSI 2.5%PRS 72.4%
-
CSI 2.1rCSI 5.0%PRS 79.3%
-
CSI 2.1rCSI 18.8%PRS 58.1%
-
CSI 2.2rCSI 6.0%PRS 76.6%
-
CSI 2.3rCSI 4.0%PRS 60.7%
-
CSI 2.3rCSI 2.4%PRS 81.7%
-
CSI 2.4rCSI 6.0%PRS 59.8%
-
CSI 2.4rCSI 7.1%PRS 80.0%
-
CSI 2.5rCSI 12.1%PRS 68.1%
-
CSI 2.6rCSI 4.0%PRS 74.7%
-
CSI 2.6rCSI 7.8%PRS 69.4%
-
CSI 2.7rCSI 4.2%PRS 70.9%
-
CSI 2.9rCSI 9.1%PRS 55.7%
-
CSI 3.0rCSI 5.6%PRS 81.7%
-
CSI 3.0rCSI 3.6%PRS 84.5%
-
CSI 3.1rCSI 2.8%PRS 68.1%
-
CSI 3.1rCSI 2.5%PRS 72.1%
-
CSI 3.2rCSI 8.3%PRS 70.6%
-
CSI 3.2rCSI 5.2%PRS 71.8%
-
CSI 3.3rCSI 19.5%PRS 52.5%
-
CSI 3.4rCSI 9.7%PRS 70.9%
-
CSI 3.4rCSI 4.6%PRS 75.9%
-
CSI 3.4rCSI 7.6%PRS 56.1%
-
CSI 3.5rCSI 3.7%PRS 67.2%
-
CSI 3.5rCSI 21.9%PRS 61.6%
-
CSI 3.7rCSI 8.0%PRS 77.1%
-
CSI 3.7rCSI 2.7%PRS 63.0%
-
CSI 3.9rCSI 7.8%PRS 48.5%
-
CSI 3.9rCSI 14.8%PRS 60.7%
-
CSI 3.9rCSI 3.1%PRS 76.8%
-
CSI 4.0rCSI 5.6%PRS 66.4%
-
CSI 4.2rCSI 7.4%PRS 62.7%
-
CSI 4.4rCSI 7.0%PRS 62.9%
-
CSI 4.7rCSI 10.7%PRS 65.4%
-
CSI 4.8rCSI 12.7%PRS 58.7%
-
CSI 4.9rCSI 7.9%PRS 65.9%
-
CSI 4.9rCSI 9.2%PRS 57.9%
-
CSI 4.9rCSI 11.7%PRS 70.7%
-
CSI 4.9rCSI 10.7%PRS 57.9%
-
CSI 5.0rCSI 11.5%PRS 58.4%
-
CSI 5.0rCSI 5.3%PRS 70.2%
-
CSI 5.1rCSI 5.3%PRS 68.0%
-
CSI 5.1rCSI 12.1%PRS 70.6%
-
CSI 5.1rCSI 28.8%PRS 55.6%
-
CSI 5.2rCSI 11.7%PRS 52.1%
-
CSI 5.2rCSI 3.9%PRS 82.8%
-
CSI 5.3rCSI 10.5%PRS 59.5%
-
CSI 5.4rCSI 39.3%PRS 56.9%
-
CSI 5.4rCSI 21.9%PRS 63.2%
-
CSI 5.4rCSI 7.9%PRS 81.4%
-
CSI 5.4rCSI 4.6%PRS 85.4%
-
CSI 5.5rCSI 3.7%PRS 73.1%
-
CSI 5.8rCSI 12.8%PRS 81.0%
-
CSI 5.9rCSI 19.1%PRS 69.4%
-
CSI 6.1rCSI 9.0%PRS 63.3%
-
CSI 6.6rCSI 13.0%PRS 66.8%
-
CSI 6.6rCSI 9.0%PRS 71.3%
-
CSI 6.7rCSI 15.4%PRS 61.6%
-
CSI 7.3rCSI 13.0%PRS 63.3%
-
CSI 7.5rCSI 8.0%PRS 70.7%
-
CSI 7.9rCSI 9.2%PRS 62.7%
-
CSI 8.2rCSI 19.9%PRS 49.8%
-
CSI 8.2rCSI 7.7%PRS 69.6%
-
CSI 8.2rCSI 23.1%PRS 79.9%
-
CSI 8.3rCSI 26.6%PRS 67.9%
-
CSI 8.3rCSI 22.1%PRS 79.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2670566407
Symbol: PI51B_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8841185
Title: The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4-phosphate 5-kinase.
PubMed ID: 8841185
DOI: 10.1038/ng1096-157
PubMed ID: 9177790
Title: Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity.
PubMed ID: 9177790
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8955136
Title: Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.
PubMed ID: 8955136
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 540
- Mass: 61036
- Checksum: 7A683794A39A20B6
- Sequence:
MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRSMRMHF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF DTETYNALMK TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ ALKASPSKKR CNSIAALKAT SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVNEHY PHDRPTLYSN SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL
Genular Protein ID: 629072726
Symbol: Q7KYT6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8955136
Title: Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.
PubMed ID: 8955136
Sequence Information:
- Length: 334
- Mass: 37787
- Checksum: 2B36A6C0590C3F8A
- Sequence:
STYKRRASRK EREKSNPTFK DLDFLQDMHE GLYFDTETYN ALMKTLQRDC RVLESFKIMD YSLLLGIHFL DHSLKEKEEE TPQNVPDAKR TGMQKVLYST AMESIQGPGK SGDGIITENP DTMGGIPAKS HRGEKLLLFM GIIDILQSYR LMKKLEHSWK ALVYDGDTVS VHRPSFYADR FLKFMNSRVF KKIQALKASP SKKRCNSIAA LKATSQEIVS SISQEWKDEK RDLLTEGQSF SSLDEEALGS RHRPDLVPST PSLFEAASLA TTISSSSLYV NEHYPHDRPT LYSNSKGLPS SSTFTLEEGT IYLTAEPNTL EVQDDNASVL DVYL