Details for: ULK1

Gene ID: 8408

Symbol: ULK1

Ensembl ID: ENSG00000177169

Description: unc-51 like autophagy activating kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 158.0248
    Cell Significance Index: -24.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.1837
    Cell Significance Index: -24.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0206
    Cell Significance Index: -21.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.4353
    Cell Significance Index: -24.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2440
    Cell Significance Index: -24.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2297
    Cell Significance Index: -24.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1725
    Cell Significance Index: -22.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4774
    Cell Significance Index: -25.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2643
    Cell Significance Index: -13.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6771
    Cell Significance Index: 74.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5776
    Cell Significance Index: 59.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5687
    Cell Significance Index: 182.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4182
    Cell Significance Index: 19.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3088
    Cell Significance Index: 262.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1644
    Cell Significance Index: 231.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1456
    Cell Significance Index: 113.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6499
    Cell Significance Index: 105.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5982
    Cell Significance Index: 65.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5774
    Cell Significance Index: 207.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5551
    Cell Significance Index: 31.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5248
    Cell Significance Index: 40.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5180
    Cell Significance Index: 14.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4902
    Cell Significance Index: 13.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4601
    Cell Significance Index: 29.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4488
    Cell Significance Index: 80.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4258
    Cell Significance Index: 28.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3968
    Cell Significance Index: 23.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3968
    Cell Significance Index: 54.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3881
    Cell Significance Index: 350.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3537
    Cell Significance Index: 10.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3321
    Cell Significance Index: 40.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3259
    Cell Significance Index: 7.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3130
    Cell Significance Index: 216.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3045
    Cell Significance Index: 13.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3007
    Cell Significance Index: 8.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2951
    Cell Significance Index: 20.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2793
    Cell Significance Index: 7.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2668
    Cell Significance Index: 4.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2297
    Cell Significance Index: 14.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2242
    Cell Significance Index: 13.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1839
    Cell Significance Index: 31.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1783
    Cell Significance Index: 9.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1498
    Cell Significance Index: 81.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1234
    Cell Significance Index: 5.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1216
    Cell Significance Index: 53.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1157
    Cell Significance Index: 22.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1139
    Cell Significance Index: 2.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0933
    Cell Significance Index: 1.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0923
    Cell Significance Index: 173.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0480
    Cell Significance Index: 73.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0478
    Cell Significance Index: 5.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0474
    Cell Significance Index: 21.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0467
    Cell Significance Index: 86.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0461
    Cell Significance Index: 29.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0196
    Cell Significance Index: 26.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0089
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0098
    Cell Significance Index: -5.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0099
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0103
    Cell Significance Index: -6.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0316
    Cell Significance Index: -23.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0367
    Cell Significance Index: -0.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0484
    Cell Significance Index: -0.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0516
    Cell Significance Index: -6.6100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0564
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0657
    Cell Significance Index: -13.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0706
    Cell Significance Index: -7.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0743
    Cell Significance Index: -21.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0875
    Cell Significance Index: -9.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1040
    Cell Significance Index: -13.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1076
    Cell Significance Index: -2.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1358
    Cell Significance Index: -10.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1373
    Cell Significance Index: -3.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1619
    Cell Significance Index: -2.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1627
    Cell Significance Index: -3.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1689
    Cell Significance Index: -5.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1707
    Cell Significance Index: -17.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1728
    Cell Significance Index: -2.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1793
    Cell Significance Index: -12.6800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1900
    Cell Significance Index: -4.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1934
    Cell Significance Index: -22.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2353
    Cell Significance Index: -3.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2445
    Cell Significance Index: -3.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2596
    Cell Significance Index: -20.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2962
    Cell Significance Index: -15.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3085
    Cell Significance Index: -9.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3139
    Cell Significance Index: -8.5500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3173
    Cell Significance Index: -5.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3203
    Cell Significance Index: -2.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3293
    Cell Significance Index: -8.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3322
    Cell Significance Index: -6.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3526
    Cell Significance Index: -21.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3609
    Cell Significance Index: -7.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3800
    Cell Significance Index: -6.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4032
    Cell Significance Index: -21.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4135
    Cell Significance Index: -13.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4168
    Cell Significance Index: -10.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4256
    Cell Significance Index: -13.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ULK1 is a serine/threonine kinase that is activated by the mTOR (mechanistic target of rapamycin) complex, which is a central regulator of cellular metabolism and growth. ULK1 is also a key component of the Atg1/ULK1 kinase complex, which is involved in the regulation of autophagy. ULK1 is highly expressed in various cell types, including neurons, muscle cells, and immune cells, and is involved in the regulation of cellular responses to nutrient levels, stress, and disease. **Pathways and Functions:** ULK1 is involved in several key pathways that regulate autophagy and cellular homeostasis, including: 1. **Autophagosome formation:** ULK1 is a key component of the autophagosome formation machinery, and its activation is necessary for the formation of autophagosomes, which are double-membraned structures that engulf and degrade cellular components. 2. **Autophagy regulation:** ULK1 is involved in the regulation of autophagy, including the regulation of autophagosome assembly, autophagosome membrane formation, and autophagosome degradation. 3. **Cellular response to nutrient levels:** ULK1 is involved in the regulation of cellular responses to nutrient levels, including the regulation of glucose and amino acid metabolism. 4. **Stress response:** ULK1 is involved in the regulation of cellular responses to stress, including the regulation of apoptosis, autophagy, and inflammation. **Clinical Significance:** Dysregulation of ULK1 has been implicated in various diseases, including: 1. **Cancer:** ULK1 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and poor response to therapy. 2. **Neurodegenerative disorders:** ULK1 has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Metabolic disorders:** ULK1 has been implicated in the regulation of glucose and lipid metabolism, and dysregulation of ULK1 has been associated with metabolic disorders, including type 2 diabetes and obesity. In conclusion, ULK1 is a critical regulator of autophagy and cellular homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which ULK1 regulates autophagy and cellular homeostasis, and to explore the therapeutic potential of ULK1 as a target for the treatment of various diseases. **References:** * Wang, Y., et al. (2019). ULK1 is a critical regulator of autophagy in cancer cells. Cell Death & Disease, 10(1), 1-12. * Li, J., et al. (2020). ULK1 is involved in the regulation of autophagy in neuronal cells. Autophagy, 16(1), 145-156. * Zhang, Y., et al. (2020). ULK1 is a key component of the autophagosome formation machinery. Autophagy, 16(1), 157-168.

Genular Protein ID: 2431997141

Symbol: ULK1_HUMAN

Name: Autophagy-related protein 1 homolog

UniProtKB Accession Codes:

O75385 Q9UQ28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 3 EMDB 4 Ensembl 1 EvolutionaryTrace 1 GO 44 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693035

Title: Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.

PubMed ID: 9693035

DOI: 10.1006/geno.1998.5340

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 11146101

Title: Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

PubMed ID: 11146101

DOI: 10.1016/s0169-328x(00)00218-7

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19287211

Title: A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.

PubMed ID: 19287211

DOI: 10.4161/auto.5.5.8249

PubMed ID: 19597335

Title: Atg101, a novel mammalian autophagy protein interacting with Atg13.

PubMed ID: 19597335

DOI: 10.4161/auto.5.7.9296

PubMed ID: 19211835

Title: Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

PubMed ID: 19211835

DOI: 10.1091/mbc.e08-12-1248

PubMed ID: 18936157

Title: Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

PubMed ID: 18936157

DOI: 10.1128/mcb.01082-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20921139

Title: The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.

PubMed ID: 20921139

DOI: 10.1083/jcb.201002100

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21795849

Title: ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

PubMed ID: 21795849

DOI: 10.4161/auto.7.10.16660

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21205641

Title: Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

PubMed ID: 21205641

DOI: 10.1126/science.1196371

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 22613832

Title: TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.

PubMed ID: 22613832

DOI: 10.1083/jcb.201111079

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23524951

Title: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

PubMed ID: 23524951

DOI: 10.1038/ncb2708

PubMed ID: 25126726

Title: FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.

PubMed ID: 25126726

DOI: 10.4161/auto.29640

PubMed ID: 24767988

Title: A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

PubMed ID: 24767988

DOI: 10.1016/j.celrep.2014.03.065

PubMed ID: 25040165

Title: Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

PubMed ID: 25040165

DOI: 10.1111/febs.12905

PubMed ID: 25127057

Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

PubMed ID: 25127057

DOI: 10.1016/j.devcel.2014.06.013

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 25891078

Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.

PubMed ID: 25891078

DOI: 10.1016/j.molcel.2015.03.020

PubMed ID: 25438055

Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.

PubMed ID: 25438055

DOI: 10.1038/ncb3072

PubMed ID: 27334615

Title: The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

PubMed ID: 27334615

DOI: 10.15252/embj.201694401

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 28821708

Title: A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B.

PubMed ID: 28821708

DOI: 10.1038/s41467-017-00303-2

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 29487085

Title: The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.

PubMed ID: 29487085

DOI: 10.15252/embr.201744378

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 31123703

Title: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.

PubMed ID: 31123703

DOI: 10.1126/sciadv.aau8857

PubMed ID: 37306101

Title: Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.

PubMed ID: 37306101

DOI: 10.15252/embj.2022113349

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1050
  • Mass: 112631
  • Checksum: AED9BD5139F2DB92
  • Sequence:
    • MEPGRGGTET VGKFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK KNLAKSQTLL 
GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL ADYLHAMRTL SEDTIRLFLQ 
QIAGAMRLLH SKGIIHRDLK PQNILLSNPA GRRANPNSIR VKIADFGFAR YLQSNMMAAT 
LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQASSPQDLR LFYEKNKTLV 
PTIPRETSAP LRQLLLALLQ RNHKDRMDFD EFFHHPFLDA SPSVRKSPPV PVPSYPSSGS 
GSSSSSSSTS HLASPPSLGE MQQLQKTLAS PADTAGFLHS SRDSGGSKDS SCDTDDFVMV 
PAQFPGDLVA EAPSAKPPPD SLMCSGSSLV ASAGLESHGR TPSPSPPCSS SPSPSGRAGP 
FSSSRCGASV PIPVPTQVQN YQRIERNLQS PTQFQTPRSS AIRRSGSTSP LGFARASPSP 
PAHAEHGGVL ARKMSLGGGR PYTPSPQVGT IPERPGWSGT PSPQGAEMRG GRSPRPGSSA 
PEHSPRTSGL GCRLHSAPNL SDLHVVRPKL PKPPTDPLGA VFSPPQASPP QPSHGLQSCR 
NLRGSPKLPD FLQRNPLPPI LGSPTKAVPS FDFPKTPSSQ NLLALLARQG VVMTPPRNRT 
LPDLSEVGPF HGQPLGPGLR PGEDPKGPFG RSFSTSRLTD LLLKAAFGTQ APDPGSTESL 
QEKPMEIAPS AGFGGSLHPG ARAGGTSSPS PVVFTVGSPP SGSTPPQGPR TRMFSAGPTG 
SASSSARHLV PGPCSEAPAP ELPAPGHGCS FADPITANLE GAVTFEAPDL PEETLMEQEH 
TEILRGLRFT LLFVQHVLEI AALKGSASEA AGGPEYQLQE SVVADQISLL SREWGFAEQL 
VLYLKVAELL SSGLQSAIDQ IRAGKLCLSS TVKQVVRRLN ELYKASVVSC QGLSLRLQRF 
FLDKQRLLDR IHSITAERLI FSHAVQMVQS AALDEMFQHR EGCVPRYHKA LLLLEGLQHM 
LSDQADIENV TKCKLCIERR LSALLTGICA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.