Details for: PEX3

Gene ID: 8504

Symbol: PEX3

Ensembl ID: ENSG00000034693

Description: peroxisomal biogenesis factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 172.1686
    Cell Significance Index: -26.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.7033
    Cell Significance Index: -26.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.1629
    Cell Significance Index: -27.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.1775
    Cell Significance Index: -22.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1005
    Cell Significance Index: -22.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2879
    Cell Significance Index: -27.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9926
    Cell Significance Index: -24.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3385
    Cell Significance Index: -22.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0070
    Cell Significance Index: -27.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6925
    Cell Significance Index: -10.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1661
    Cell Significance Index: 58.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6728
    Cell Significance Index: 335.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4010
    Cell Significance Index: 138.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0555
    Cell Significance Index: 378.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0136
    Cell Significance Index: 915.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9338
    Cell Significance Index: 12.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9037
    Cell Significance Index: 34.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8376
    Cell Significance Index: 37.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8119
    Cell Significance Index: 161.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7348
    Cell Significance Index: 119.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6234
    Cell Significance Index: 38.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6010
    Cell Significance Index: 13.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5462
    Cell Significance Index: 13.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4719
    Cell Significance Index: 31.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4577
    Cell Significance Index: 28.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4553
    Cell Significance Index: 25.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4532
    Cell Significance Index: 313.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4084
    Cell Significance Index: 28.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3860
    Cell Significance Index: 20.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3397
    Cell Significance Index: 39.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3281
    Cell Significance Index: 59.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3043
    Cell Significance Index: 23.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2896
    Cell Significance Index: 20.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2821
    Cell Significance Index: 34.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2724
    Cell Significance Index: 120.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2315
    Cell Significance Index: 6.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2270
    Cell Significance Index: 10.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2255
    Cell Significance Index: 6.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1699
    Cell Significance Index: 4.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1475
    Cell Significance Index: 80.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1392
    Cell Significance Index: 3.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1328
    Cell Significance Index: 3.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1316
    Cell Significance Index: 2.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1247
    Cell Significance Index: 17.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1184
    Cell Significance Index: 2.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0931
    Cell Significance Index: 1.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0860
    Cell Significance Index: 132.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0815
    Cell Significance Index: 3.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0751
    Cell Significance Index: 102.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0744
    Cell Significance Index: 47.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0709
    Cell Significance Index: 13.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0643
    Cell Significance Index: 121.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0549
    Cell Significance Index: 7.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0508
    Cell Significance Index: 5.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0436
    Cell Significance Index: 80.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0206
    Cell Significance Index: 0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0079
    Cell Significance Index: 3.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0146
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0203
    Cell Significance Index: -2.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0274
    Cell Significance Index: -20.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0350
    Cell Significance Index: -25.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0451
    Cell Significance Index: -25.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0504
    Cell Significance Index: -31.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0669
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0820
    Cell Significance Index: -23.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0865
    Cell Significance Index: -8.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0901
    Cell Significance Index: -4.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0971
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1028
    Cell Significance Index: -17.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1122
    Cell Significance Index: -2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1175
    Cell Significance Index: -15.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1446
    Cell Significance Index: -30.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1465
    Cell Significance Index: -3.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1609
    Cell Significance Index: -18.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1692
    Cell Significance Index: -5.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1853
    Cell Significance Index: -13.8100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2052
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2087
    Cell Significance Index: -21.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2577
    Cell Significance Index: -16.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2709
    Cell Significance Index: -21.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2737
    Cell Significance Index: -16.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2820
    Cell Significance Index: -14.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2869
    Cell Significance Index: -3.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2883
    Cell Significance Index: -7.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2974
    Cell Significance Index: -6.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3143
    Cell Significance Index: -10.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3332
    Cell Significance Index: -6.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3388
    Cell Significance Index: -6.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3459
    Cell Significance Index: -11.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3655
    Cell Significance Index: -19.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3727
    Cell Significance Index: -12.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4055
    Cell Significance Index: -8.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4602
    Cell Significance Index: -12.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4623
    Cell Significance Index: -6.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4739
    Cell Significance Index: -5.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5139
    Cell Significance Index: -10.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5214
    Cell Significance Index: -5.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5292
    Cell Significance Index: -18.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PEX3 is a hydrophobic protein that belongs to the PEX family of proteins, which are essential for peroxisomal biogenesis. It is characterized by a high degree of sequence similarity to other PEX proteins, including PEX1, PEX2, and PEX14. PEX3 is primarily expressed in cells of the nervous system, including neurons, and is also found in fibroblasts of cardiac tissue and adrenal gland cells. The protein is localized to the peroxisomal membrane and interacts with other PEX proteins to facilitate peroxisomal assembly and function. **Pathways and Functions:** PEX3 is involved in the following pathways: 1. **Abc-family proteins mediated transport:** PEX3 interacts with ABC transporter proteins to facilitate the transport of peroxisomal proteins across the peroxisomal membrane. 2. **Class i peroxisomal membrane protein import:** PEX3 is involved in the import of peroxisomal membrane proteins into the peroxisomal matrix. 3. **Protein binding and localization:** PEX3 binds to other PEX proteins and peroxisomal proteins, ensuring their proper localization to the peroxisomal membrane. 4. **Protein import into peroxisome membrane:** PEX3 plays a crucial role in the targeting of peroxisomal proteins to the peroxisomal membrane. **Functions:** PEX3 has several functions, including: 1. **Peroxisomal biogenesis:** PEX3 is essential for the assembly and targeting of peroxisomal proteins to the peroxisomal membrane. 2. **Fatty acid oxidation:** PEX3 is involved in the regulation of fatty acid oxidation, a critical process in energy metabolism. 3. **Detoxification:** PEX3 plays a role in the detoxification of harmful substances, such as bile acids and cholesterol. **Clinical Significance:** Dysregulation of PEX3 has been implicated in several neurodegenerative disorders, including: 1. **Peroxisomal biogenesis disorders (PBDs):** PEX3 mutations have been associated with PBDs, which are characterized by impaired peroxisomal function and accumulation of toxic substances. 2. **Neurodegenerative diseases:** PEX3 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where impaired peroxisomal function contributes to disease progression. 3. **Cancer:** PEX3 has been implicated in cancer development and progression, where impaired peroxisomal function can lead to the accumulation of toxic substances and the promotion of tumorigenesis. In conclusion, PEX3 is a critical protein involved in peroxisomal biogenesis and function. Its dysregulation has been implicated in several neurodegenerative disorders and cancer. Further research is needed to fully understand the role of PEX3 in human disease and to develop therapeutic strategies to target this protein.

Genular Protein ID: 3850807195

Symbol: PEX3_HUMAN

Name: Peroxisomal biogenesis factor 3

UniProtKB Accession Codes:

P56589 Q6FGP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9657383

Title: Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p.

PubMed ID: 9657383

DOI: 10.1016/s0014-5793(98)00557-2

PubMed ID: 10430017

Title: Identification and characterization of the human peroxin PEX3.

PubMed ID: 10430017

DOI: 10.1016/s0171-9335(99)80078-8

PubMed ID: 10679269

Title: The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes.

PubMed ID: 10679269

DOI: 10.1006/bbrc.2000.2193

PubMed ID: 10848631

Title: The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.

PubMed ID: 10848631

DOI: 10.1091/mbc.11.6.2085

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11390669

Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.

PubMed ID: 11390669

DOI: 10.1128/mcb.21.13.4413-4424.2001

PubMed ID: 15007061

Title: PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.

PubMed ID: 15007061

DOI: 10.1083/jcb.200311131

PubMed ID: 10958759

Title: Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G.

PubMed ID: 10958759

DOI: 10.1086/303071

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21768384

Title: Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.

PubMed ID: 21768384

DOI: 10.1073/pnas.1103283108

PubMed ID: 27557811

Title: Novel PEX3 gene mutations resulting in a moderate Zellweger spectrum disorder.

PubMed ID: 27557811

DOI: 10.1007/8904_2016_10

PubMed ID: 21102411

Title: Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.

PubMed ID: 21102411

DOI: 10.1038/emboj.2010.293

PubMed ID: 20554521

Title: Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.

PubMed ID: 20554521

DOI: 10.1074/jbc.m110.138503

Sequence Information:

  • Length: 373
  • Mass: 42140
  • Checksum: 3515A1F29656B7CC
  • Sequence:
    • MLRSVWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES 
NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK LEIWEDLKII SFTRSTVAVY 
STCMLVVLLR VQLNIIGGYI YLDNAAVGKN GTTILAPPDV QQQYLSSIQH LLGDGLTELI 
TVIKQAVQKV LGSVSLKHSL SLLDLEQKLK EIRNLVEQHK SSSWINKDGS KPLLCHYMMP 
DEETPLAVQA CGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR 
PTEQDLQHGN SMNSLSSVSL PLAKIIPIVN GQIHSVCSET PSHFVQDLLT MEQVKDFAAN 
VYEAFSTPQQ LEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.