Details for: ELP1

Gene ID: 8518

Symbol: ELP1

Ensembl ID: ENSG00000070061

Description: elongator acetyltransferase complex subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.7501
    Cell Significance Index: -23.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.4883
    Cell Significance Index: -21.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.7601
    Cell Significance Index: -21.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5022
    Cell Significance Index: -25.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6646
    Cell Significance Index: -20.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5646
    Cell Significance Index: -9.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3598
    Cell Significance Index: 468.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2745
    Cell Significance Index: 37.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6407
    Cell Significance Index: 329.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1044
    Cell Significance Index: 23.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9096
    Cell Significance Index: 821.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8968
    Cell Significance Index: 321.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7834
    Cell Significance Index: 29.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7485
    Cell Significance Index: 33.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6541
    Cell Significance Index: 71.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6507
    Cell Significance Index: 105.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5667
    Cell Significance Index: 34.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5182
    Cell Significance Index: 31.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4968
    Cell Significance Index: 27.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4944
    Cell Significance Index: 48.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4887
    Cell Significance Index: 338.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4886
    Cell Significance Index: 6.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4366
    Cell Significance Index: 33.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4088
    Cell Significance Index: 27.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3707
    Cell Significance Index: 8.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3207
    Cell Significance Index: 9.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3106
    Cell Significance Index: 8.6800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2965
    Cell Significance Index: 14.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2901
    Cell Significance Index: 20.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2724
    Cell Significance Index: 17.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1997
    Cell Significance Index: 9.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1865
    Cell Significance Index: 4.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1335
    Cell Significance Index: 181.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1290
    Cell Significance Index: 4.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1261
    Cell Significance Index: 68.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1175
    Cell Significance Index: 21.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0998
    Cell Significance Index: 1.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0998
    Cell Significance Index: 13.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0974
    Cell Significance Index: 1.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0953
    Cell Significance Index: 1.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0932
    Cell Significance Index: 4.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0931
    Cell Significance Index: 17.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0855
    Cell Significance Index: 2.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0797
    Cell Significance Index: 50.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0653
    Cell Significance Index: 3.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0624
    Cell Significance Index: 117.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0428
    Cell Significance Index: 18.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0427
    Cell Significance Index: 65.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0326
    Cell Significance Index: 4.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0291
    Cell Significance Index: 53.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0281
    Cell Significance Index: 12.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0207
    Cell Significance Index: -15.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0273
    Cell Significance Index: -20.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0338
    Cell Significance Index: -19.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0406
    Cell Significance Index: -0.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0443
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0461
    Cell Significance Index: -28.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0502
    Cell Significance Index: -8.5700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0563
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0717
    Cell Significance Index: -8.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0766
    Cell Significance Index: -22.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0839
    Cell Significance Index: -2.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0930
    Cell Significance Index: -9.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0990
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1155
    Cell Significance Index: -24.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1211
    Cell Significance Index: -14.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1305
    Cell Significance Index: -14.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1459
    Cell Significance Index: -7.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1508
    Cell Significance Index: -3.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1510
    Cell Significance Index: -2.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1526
    Cell Significance Index: -19.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1721
    Cell Significance Index: -8.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1849
    Cell Significance Index: -13.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1874
    Cell Significance Index: -19.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1912
    Cell Significance Index: -12.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2024
    Cell Significance Index: -10.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2163
    Cell Significance Index: -4.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2533
    Cell Significance Index: -18.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2533
    Cell Significance Index: -6.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2660
    Cell Significance Index: -5.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2668
    Cell Significance Index: -3.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2777
    Cell Significance Index: -21.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2972
    Cell Significance Index: -9.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3159
    Cell Significance Index: -10.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3250
    Cell Significance Index: -10.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3254
    Cell Significance Index: -6.9600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3312
    Cell Significance Index: -4.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3320
    Cell Significance Index: -20.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3447
    Cell Significance Index: -5.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3497
    Cell Significance Index: -7.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3582
    Cell Significance Index: -9.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3601
    Cell Significance Index: -9.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4175
    Cell Significance Index: -8.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4235
    Cell Significance Index: -5.6500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4238
    Cell Significance Index: -6.3400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4635
    Cell Significance Index: -5.8500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4658
    Cell Significance Index: -11.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4703
    Cell Significance Index: -6.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ELP1 is a member of the elongator complex, a hetero-oligomeric enzyme complex that plays a central role in the regulation of gene expression. The elongator complex is involved in the acetylation of histones, which is a key epigenetic modification that regulates chromatin structure and transcriptional activity. ELP1 is a catalytic subunit of the elongator complex, responsible for the transfer of acetyl groups to lysine residues on histones. The protein has a unique structure, consisting of two distinct domains: a C-terminal domain that interacts with the histone acetyltransferase (HAT) domain, and an N-terminal domain that interacts with other elongator complex subunits. **Pathways and Functions** The elongator complex, including ELP1, is involved in several key cellular processes, including: 1. **Histone acetylation**: ELP1 plays a critical role in the acetylation of histones, which is a key epigenetic modification that regulates chromatin structure and transcriptional activity. 2. **Transcriptional regulation**: The elongator complex, including ELP1, regulates transcriptional activity by modifying histones and other chromatin-associated proteins. 3. **Protein modification**: ELP1 is involved in the modification of proteins, including the acetylation of proteins and the transfer of other post-translational modifications. 4. **RNA processing**: ELP1 has been shown to interact with RNA-binding proteins and influence RNA processing, including the modification of tRNA and the regulation of translation. **Clinical Significance** Dysregulation of the elongator complex, including ELP1, has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in the ELP1 gene have been associated with neurodegenerative disorders, including Huntington's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: The elongator complex, including ELP1, has been shown to play a role in the regulation of cancer cell growth and survival. 3. **Metabolic disorders**: Dysregulation of the elongator complex has been implicated in metabolic disorders, including diabetes and obesity. In conclusion, ELP1 is a critical component of the elongator complex, playing a central role in the regulation of gene expression, histone acetylation, and protein modification. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in human health and disease. Further research is needed to fully understand the role of ELP1 in human biology and disease.

Genular Protein ID: 1796932107

Symbol: ELP1_HUMAN

Name: Elongator complex protein 1

UniProtKB Accession Codes:

O95163 Q5JSV2 Q9H327 Q9UG87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9751059

Title: IKAP is a scaffold protein of the IkappaB kinase complex.

PubMed ID: 9751059

DOI: 10.1038/26254

PubMed ID: 11179008

Title: Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.

PubMed ID: 11179008

DOI: 10.1086/318810

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11714725

Title: Purification and characterization of the human elongator complex.

PubMed ID: 11714725

DOI: 10.1074/jbc.m110445200

PubMed ID: 11818576

Title: Human Elongator facilitates RNA polymerase II transcription through chromatin.

PubMed ID: 11818576

DOI: 10.1073/pnas.251672198

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22854966

Title: DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.

PubMed ID: 22854966

DOI: 10.1074/jbc.m112.402727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25960406

Title: The Elp2 subunit is essential for elongator complex assembly and functional regulation.

PubMed ID: 25960406

DOI: 10.1016/j.str.2015.03.018

PubMed ID: 29332244

Title: Structural insights into the function of Elongator.

PubMed ID: 29332244

DOI: 10.1007/s00018-018-2747-6

PubMed ID: 32296180

Title: Germline Elongator mutations in Sonic Hedgehog medulloblastoma.

PubMed ID: 32296180

DOI: 10.1038/s41586-020-2164-5

PubMed ID: 26261306

Title: Dimerization of elongator protein 1 is essential for Elongator complex assembly.

PubMed ID: 26261306

DOI: 10.1073/pnas.1502597112

PubMed ID: 11179021

Title: Familial dysautonomia is caused by mutations of the IKAP gene.

PubMed ID: 11179021

DOI: 10.1086/318808

PubMed ID: 12687659

Title: Identification of the first non-Jewish mutation in familial Dysautonomia.

PubMed ID: 12687659

DOI: 10.1002/ajmg.a.20052

Sequence Information:

  • Length: 1332
  • Mass: 150254
  • Checksum: 5BAC580433CC8641
  • Sequence:
    • MRNLKLFRTL EFRDIQGPGN PQCFSLRTEQ GTVLIGSEHG LIEVDPVSRE VKNEVSLVAE 
GFLPEDGSGR IVGVQDLLDQ ESVCVATASG DVILCSLSTQ QLECVGSVAS GISVMSWSPD 
QELVLLATGQ QTLIMMTKDF EPILEQQIHQ DDFGESKFIT VGWGRKETQF HGSEGRQAAF 
QMQMHESALP WDDHRPQVTW RGDGQFFAVS VVCPETGARK VRVWNREFAL QSTSEPVAGL 
GPALAWKPSG SLIASTQDKP NQQDIVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV 
LAVWLEDLQR EESSIPKTCV QLWTVGNYHW YLKQSLSFST CGKSKIVSLM WDPVTPYRLH 
VLCQGWHYLA YDWHWTTDRS VGDNSSDLSN VAVIDGNRVL VTVFRQTVVP PPMCTYQLLF 
PHPVNQVTFL AHPQKSNDLA VLDASNQISV YKCGDCPSAD PTVKLGAVGG SGFKVCLRTP 
HLEKRYKIQF ENNEDQDVNP LKLGLLTWIE EDVFLAVSHS EFSPRSVIHH LTAASSEMDE 
EHGQLNVSSS AAVDGVIISL CCNSKTKSVV LQLADGQIFK YLWESPSLAI KPWKNSGGFP 
VRFPYPCTQT ELAMIGEEEC VLGLTDRCRF FINDIEVASN ITSFAVYDEF LLLTTHSHTC 
QCFCLRDASF KTLQAGLSSN HVSHGEVLRK VERGSRIVTV VPQDTKLVLQ MPRGNLEVVH 
HRALVLAQIR KWLDKLMFKE AFECMRKLRI NLNLIYDHNP KVFLGNVETF IKQIDSVNHI 
NLFFTELKEE DVTKTMYPAP VTSSVYLSRD PDGNKIDLVC DAMRAVMESI NPHKYCLSIL 
TSHVKKTTPE LEIVLQKVHE LQGNAPSDPD AVSAEEALKY LLHLVDVNEL YDHSLGTYDF 
DLVLMVAEKS QKDPKEYLPF LNTLKKMETN YQRFTIDKYL KRYEKAIGHL SKCGPEYFPE 
CLNLIKDKNL YNEALKLYSP SSQQYQDISI AYGEHLMQEH MYEPAGLMFA RCGAHEKALS 
AFLTCGNWKQ ALCVAAQLNF TKDQLVGLGR TLAGKLVEQR KHIDAAMVLE ECAQDYEEAV 
LLLLEGAAWE EALRLVYKYN RLDIIETNVK PSILEAQKNY MAFLDSQTAT FSRHKKRLLV 
VRELKEQAQQ AGLDDEVPHG QESDLFSETS SVVSGSEMSG KYSHSNSRIS ARSSKNRRKA 
ERKKHSLKEG SPLEDLALLE ALSEVVQNTE NLKDEVYHIL KVLFLFEFDE QGRELQKAFE 
DTLQLMERSL PEIWTLTYQQ NSATPVLGPN STANSIMASY QQQKTSVPVL DAELFIPPKI 
NRRTQWKLSL LD

Genular Protein ID: 4168539915

Symbol: Q4LE38_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE38

Database IDs:

ARBA 6 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 1342
  • Mass: 151456
  • Checksum: 58D6B7FB9A77110E
  • Sequence:
    • LYLSRGNHFI MRNLKLFRTL EFRDIQGPGN PQCFSLRTEQ GTVLIGSEHG LIEVDPVSRE 
VKNEVSLVAE GFLPEDGSGR IVGVQDLLDQ ESVCVATASG DVILCSLSTQ QLECVGSVAS 
GISVMSWSPD QELVLLATGQ QTLIMMTKDF EPILEQQIHQ DDFGESKFIT VGWGRKETQF 
HGSEGRQAAF QMQMHESALP WDDHRPQVTW RGDGQFFAVS VVCPETGARK VRVWNREFAL 
QSTSEPVAGL GPALAWKPSG SLIASTQDKP NQQDIVFFEK NGLLHGHFTL PFLKDEVKVN 
DLLWNADSSV LAVWLEDLQR EESSIPKTCV QLWTVGNYHW YLKQSLSFST CGKSKIVSLM 
WDPVTPYRLH VLCQGWHYLA YDWHWTTDRS VGDNSSDLSN VAVIDGNRVL VTVFRQTVVP 
PPMCTYQLLF PHPVNQVTFL AHPQKSNDLA VLDASNQISV YKCGDCPSAD PTVKLGAVGG 
SGFKVCLRTP HLEKRYKIQF ENNEDQDVNP LKLGLLTWIE EDVFLAVSHS EFSPRSVIHH 
LTAASSEMDE EHGQLNVSSS AAVDGVIISL CCNSKTKSVV LQLADGQIFK YLWESPSLAI 
KPWKNSGGFP VRFPYPCTQT ELAMIGEEEC VLGLTDRCRF FINDIEVASN ITSFAVYDEF 
LLLTTHSHTC QCFCLRDASF KTLQAGLSSN HVSHGEVLRK VERGSRIVTV VPQDTKLVLQ 
MPRGNLEVVH HRALVLAQIR KWLDKLMFKE AFECMRKLRI NLNLIYDHNP KVFLGNVETF 
IKQIDSVNHI NLFFTELKEE DVTKTMYPAP VTSSVYLSRD PDGNKIDLVC DAMRAVMESI 
NPHKYCLSIL TSHVKKTTPE LEIVLQKVHE LQGNAPSDPD AVSAEEALKY LLHLVDVNEL 
YDHSLGTYDF DLVLMVAEKS QKDPKEYLPF LNTLKKMETN YQRFTIDKYL KRYEKAIGHL 
SKCGPEYFPE CLNLIKDKNL YNEALKLYSP SSQQYQDISI AYGEHLMQEH MYEPAGLMFA 
RCGAHEKALS AFLTCGNWKQ ALCVAAQLNF TKDQLVGLGR TLAGKLVEQR KHIDAAMVLE 
ECAQDYEEAV LLLLEGAAWE EALRLVYKYN RLDIIETNVK PSILEAQKNY MAFLDSQTAT 
FSRHKKRLLV VRELKEQAQQ AGLDDEVPHG QESDLFSETS SVVSGSEMSG KYSHSNSRIS 
ARSSKNRRKA ERKKHSLKEG SPLEDLALLE ALSEVVQNTE NLKDEVYHIL KVLFLFEFDE 
QGRELQKAFE DTLQLMERSL PEIWTLTYQQ NSATPVLGPN STANSIMASY QQQKTSVPVL 
DAELFIPPKI NRRTQWKLSL LD

Genular Protein ID: 889827065

Symbol: A0A6Q8PGW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A6Q8PGW3

Database IDs:

ARBA 3 Bgee 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 4 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1218
  • Mass: 138125
  • Checksum: C647B51D7AB5308E
  • Sequence:
    • MSWSPDQELV LLATGQQTLI MMTKDFEPIL EQQIHQDDFG ESKFITVGWG RKETQFHGSE 
GRQAAFQMQM HESALPWDDH RPQVTWRGDG QFFAVSVVCP ETGARKVRVW NREFALQSTS 
EPVAGLGPAL AWKPSGSLIA STQDKPNQQD IVFFEKNGLL HGHFTLPFLK DEVKVNDLLW 
NADSSVLAVW LEDLQREESS IPKTCVQLWT VGNYHWYLKQ SLSFSTCGKS KIVSLMWDPV 
TPYRLHVLCQ GWHYLAYDWH WTTDRSVGDN SSDLSNVAVI DGNRVLVTVF RQTVVPPPMC 
TYQLLFPHPV NQVTFLAHPQ KSNDLAVLDA SNQISVYKCG DCPSADPTVK LGAVGGSGFK 
VCLRTPHLEK RYKIQFENNE DQDVNPLKLG LLTWIEEDVF LAVSHSEFSP RSVIHHLTAA 
SSEMDEEHGQ LNVSSSAAVD GVIISLCCNS KTKSVVLQLA DGQIFKYLWE SPSLAIKPWK 
NSGGFPVRFP YPCTQTELAM IGEEECVLGL TDRCRFFIND IEVASNITSF AVYDEFLLLT 
THSHTCQCFC LRDASFKTLQ AGLSSNHVSH GEVLRKVERG SRIVTVVPQD TKLVLQMPRG 
NLEVVHHRAL VLAQIRKWLD KLMFKEAFEC MRKLRINLNL IYDHNPKVFL GNVETFIKQI 
DSVNHINLFF TELKEEDVTK TMYPAPVTSS VYLSRDPDGN KIDLVCDAMR AVMESINPHK 
YCLSILTSHV KKTTPELEIV LQKVHELQGN APSDPDAVSA EEALKYLLHL VDVNELYDHS 
LGTYDFDLVL MVAEKSQKDP KEYLPFLNTL KKMETNYQRF TIDKYLKRYE KAIGHLSKCG 
PEYFPECLNL IKDKNLYNEA LKLYSPSSQQ YQDISIAYGE HLMQEHMYEP AGLMFARCGA 
HEKALSAFLT CGNWKQALCV AAQLNFTKDQ LVGLGRTLAG KLVEQRKHID AAMVLEECAQ 
DYEEAVLLLL EGAAWEEALR LVYKYNRLDI IETNVKPSIL EAQKNYMAFL DSQTATFSRH 
KKRLLVVREL KEQAQQAGLD DEVPHGQESD LFSETSSVVS GSEMSGKYSH SNSRISARSS 
KNRRKAERKK HSLKEGSPLE DLALLEALSE VVQNTENLKD EVYHILKVLF LFEFDEQGRE 
LQKAFEDTLQ LMERSLPEIW TLTYQQNSAT PVLGPNSTAN SIMASYQQQK TSVPVLDAEL 
FIPPKINRRT QWKLSLLD

Genular Protein ID: 3398075219

Symbol: B3KNB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNB2

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 UniPathway 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 537
  • Mass: 61088
  • Checksum: 3F3D6D50C25EDE5F
  • Sequence:
    • MYPAPVTSSV YLSRDPDGNK IDLVCDAMRA VMESINPHKY CLSILTSHVK KTTPELEIVL 
QKVHELQGNA PSDPDAVSAE EALKYLLHLV DVNELYDHSL GTYDFDLVLM VAEKSQKDPK 
EYLPFLNTLK KMETNYQRFT IDKYLKRYEK AIGHLSKCGP EYFPECLNLI KDKNLYNEAL 
KLYSPSSQQY QDISIAYGEH LMQEHMYEPA GLMFARCGAH EKALSAFLTC GNWKQALCVA 
AQLNFTKDQL VGLGRTLAGK LVEQRKHIDA AMVLEECAQD YEEAVLLLLE GAAWEEALRL 
VYKYNRLDII ETNVKPSILE AQKNYMAFLD SQTATFSRHK KRLLVVRELK EQAQQAGLDD 
EVPHGQESDL FSETSSVVSG SEMSGKYSHS NSRISARSSK NRRKAERKKH SLKEGSPLED 
LALLEALSEV VQNTENLKDE VYHILKVLFL FEFDEQGREL QKAFEDTLQL MERSLPEIWT 
LTYQQNSATP VLGPNSTANS IMASYQQQKT SVPVLDAELF IPPKINRRTQ WKLSLLD

Genular Protein ID: 3808908931

Symbol: F5H2T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H2T0

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 UCSC 1 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 983
  • Mass: 111475
  • Checksum: 98D35E248D5C2336
  • Sequence:
    • MWDPVTPYRL HVLCQGWHYL AYDWHWTTDR SVGDNSSDLS NVAVIDGNRV LVTVFRQTVV 
PPPMCTYQLL FPHPVNQVTF LAHPQKSNDL AVLDASNQIS VYKCGDCPSA DPTVKLGAVG 
GSGFKVCLRT PHLEKRYKIQ FENNEDQDVN PLKLGLLTWI EEDVFLAVSH SEFSPRSVIH 
HLTAASSEMD EEHGQLNVSS SAAVDGVIIS LCCNSKTKSV VLQLADGQIF KYLWESPSLA 
IKPWKNSGGF PVRFPYPCTQ TELAMIGEEE CVLGLTDRCR FFINDIEVAS NITSFAVYDE 
FLLLTTHSHT CQCFCLRDAS FKTLQAGLSS NHVSHGEVLR KVERGSRIVT VVPQDTKLVL 
QMPRGNLEVV HHRALVLAQI RKWLDKLMFK EAFECMRKLR INLNLIYDHN PKVFLGNVET 
FIKQIDSVNH INLFFTELKE EDVTKTMYPA PVTSSVYLSR DPDGNKIDLV CDAMRAVMES 
INPHKYCLSI LTSHVKKTTP ELEIVLQKVH ELQGNAPSDP DAVSAEEALK YLLHLVDVNE 
LYDHSLGTYD FDLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKAIGH 
LSKCGPEYFP ECLNLIKDKN LYNEALKLYS PSSQQYQDIS IAYGEHLMQE HMYEPAGLMF 
ARCGAHEKAL SAFLTCGNWK QALCVAAQLN FTKDQLVGLG RTLAGKLVEQ RKHIDAAMVL 
EECAQDYEEA VLLLLEGAAW EEALRLVYKY NRLDIIETNV KPSILEAQKN YMAFLDSQTA 
TFSRHKKRLL VVRELKEQAQ QAGLDDEVPH GQESDLFSET SSVVSGSEMS GKYSHSNSRI 
SARSSKNRRK AERKKHSLKE GSPLEDLALL EALSEVVQNT ENLKDEVYHI LKVLFLFEFD 
EQGRELQKAF EDTLQLMERS LPEIWTLTYQ QNSATPVLGP NSTANSIMAS YQQQKTSVPV 
LDAELFIPPK INRRTQWKLS LLD

Genular Protein ID: 1258465235

Symbol: Q8N516_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N516

Database IDs:

ARBA 4 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1332
  • Mass: 150223
  • Checksum: 55509840671D60CC
  • Sequence:
    • MRNLKLFRTL EFRDIQGPGN PQCFSLRTEQ GTVLIGSEHG LIEVDPVSRE VKNEVSLVAE 
GFLPEDGSGR IVGVQDLLDQ ESVCVATASG DVILCSLSTQ QLECVGSVAS GISVMSWSPD 
QELVLLATGQ QTLIMMTKDF EPILEQQIHQ DDFGESKFIT VGWGRKETQF HGSEGRQAAF 
QMQMHESALP WDDHRPQVTW RGDGQFFAVS VVCPETGARK VRVWNREFAL QSTSEPVAGL 
GPALAWKPSG GLIASTQDKP NQQDIVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV 
LAVWLEDLQR EKSSIPKTCV QLWTVGNYHW YLKQSLSFST CGKSKIVSLM WDPVTPYRLH 
VLCQGWHYLA YDWHWTTDRS VGDNSSDLSN VAVIDGNRVL VTVFRQTVVP PPMCTYQLLF 
PHPVNQVTFL AHPQKSNDLA VLDASNQISV YKCGDCPSAD PTVKLGAVGG SGFKVCLRTP 
HLEKRYKIQF ENNEDQDVNP LKLGLLTWIE EDVFLAVSHS EFSPRSVIHH LTAASSEMDE 
EHGQLNVSSS AAVDGVIISL CCNSKTKSVV LQLADGQIFK YLWESPSLAI KPWKNSGGFP 
VRFPYPCTQT ELAMIGEEEC VLGLTDRCRF FINDIEVASN ITSFAVYDEF LLLTTHSHTC 
QCFCLRDASF KTLQAGLSSN HVSHGEVLRK VERGSRIVTV VPQDTKLVLQ MPRGNLEVVH 
HRALVLAQIR KWLDKLMFKE AFECMRKLRI NLNLIYDHNP KVFLGNVETF IKQIDSVNHI 
NLFFTELKEE DVTKTMYPAP VTSSVYLSRD PDGNKIDLVC DAMRAVMESI NPHKYCLSIL 
TSHVKKTTPE LEIVLQKVHE LQGNAPSDPD AVSAEEALKY LLHLVDVNEL YDHSLGTYDF 
DLVLMVAEKS QKDPKEYLPF LNTLKKMETN YQRFTIDKYL KRYEKAIGHL SKCGPEYFPE 
CLNLIKDKNL YNEALKLYSP SSQQYQDISI AYGEHLMQEH MYEPAGLMFA RCGAHEKALS 
AFLTCGNWKQ ALCVAAQLNF TKDQLVGLGR TLAGKLVEQR KHIDAAMVLE ECAQDYEEAV 
LLLLEGAAWE EALRLVYKYN RLDIIETNVK PSILEAQKNY MAFLDSQTAT FSRHKKRLLV 
VRELKEQAQQ AGLDDEVPHG QESDLFSETS SVVSGSEMSG KYSHSNSRIS ARSSKNRRKA 
ERKKHSLKEG SPLEDLALLE ALSEVVQNTE NLKDEVYHIL KVLFLFEFDE QGRELQKAFE 
DTLQLMERSL PEIWTLTYQQ NSATPVLGPN STANSIMASY QQQKTSVPVL DAELFIPPKI 
NRRTQWKLSL LD

Genular Protein ID: 2700333493

Symbol: B4E3I9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3I9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 1218
  • Mass: 138109
  • Checksum: AA47B51C2BB5359E
  • Sequence:
    • MSWSPDQELV LLATGQQTLI MMTKDFEPIL EQQIHQDDFG ESKFITVGWG RKETQFHGSE 
GRQAAFQMQM HESALPWDDH RPQVTWRGDG QFFAVSVVCP ETGARKVRVW NREFALQSTS 
EPVAGLGPAL AWKPSGSLIA STQDKPNQQD IVFFEKNGLL HGHFTLPFLK DEVKVNDLLW 
NADSSVLAVW PEDLQREESS IPKTCVQLWT VGNYHWYLKQ SLSFSTCGKS KIVSLMWDPV 
TPYRLHVLCQ GWHYLAYDWH WTTDRSVGDN SSDLSNVAVI DGNRVLVTVF RQTVVPPPMC 
TYQLLFPHPV NQVTFLAHPQ KSNDLAVLDA SNQISVYKCG DCPSADPTVK LGAVGGSGFK 
VCLRTPHLEK RYKIQFENNE DQDVNPLKLG LLTWIEEDVF LAVSHSEFSP RSVIHHLTAA 
SSEMDEEHGQ LNVSSSAAVD GVIISLCCNS KTKSVVLQLA DGQIFKYLWE SPSLAIKPWK 
NSGGFPVRFP YPCTQTELAM IGEEECVLGL TDRCRFFIND IEVASNITSF AVYDEFLLLT 
THSHTCQCFC LRDASFKTLQ AGLSSNHVSH GEVLRKVERG SRIVTVVPQD TKLVLQMPRG 
NLEVVHHRAL VLAQIRKWLD KLMFKEAFEC MRKLRINLNL IYDHNPKVFL GNVETFIKQI 
DSVNHINLFF TELKEEDVTK TMYPAPVTSS VYLSRDPDGN KIDLVCDAMR AVMESINPHK 
YCLSILTSHV KKTTPELEIV LQKVHELQGN APSDPDAVSA EEALKYLLHL VDVNELYDHS 
LGTYDFDLVL MVAEKSQKDP KEYLPFLNTL KKMETNYQRF TIDKYLKRYE KAIGHLSKCG 
PEYFPECLNL IKDKNLYNEA LKLYSPSSQQ YQDISIAYGE HLMQEHMYEP AGLMFARCGA 
HEKALSAFLT CGNWKQALCV AAQLNFTKDQ LVGLGRTLAG KLVEQRKHID AAMVLEECAQ 
DYEEAVLLLL EGAAWEEALR LVYKYNRLDI IETNVKPSIL EAQKNYMAFL DSQTATFSRH 
KKRLLVVREL KEQAQQAGLD DEVPHGQESD LFSETSSVVS GSEMSGKYSH SNSRISARSS 
KNRRKAERKK HSLKEGSPLE DLALLEALSE VVQNTENLKD EVYHILKVLF LFEFDEQGRE 
LQKAFEDTLQ LMERSLPEIW TLTYQQNSAT PVLGPNSTAN SIMASYQQQK TSVPVLDAEL 
FIPPKINRRT QWKLSLLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.