Details for: INE1

Gene ID: 8552

Symbol: INE1

Ensembl ID: ENSG00000224975

Description: inactivation escape 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2248
    Cell Significance Index: -5.9600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.7078
    Cell Significance Index: 10.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.5255
    Cell Significance Index: 19.7400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8836
    Cell Significance Index: 5.4900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.5447
    Cell Significance Index: 5.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3276
    Cell Significance Index: 4.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3188
    Cell Significance Index: 16.5600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2241
    Cell Significance Index: 2.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2179
    Cell Significance Index: 3.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1897
    Cell Significance Index: 2.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1014
    Cell Significance Index: 6.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0981
    Cell Significance Index: 1.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0933
    Cell Significance Index: 17.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0918
    Cell Significance Index: 2.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0865
    Cell Significance Index: 1.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0823
    Cell Significance Index: 2.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0593
    Cell Significance Index: 2.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0573
    Cell Significance Index: 2.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0502
    Cell Significance Index: 5.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0499
    Cell Significance Index: 5.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0427
    Cell Significance Index: 1.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0308
    Cell Significance Index: 6.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0286
    Cell Significance Index: 4.8800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0252
    Cell Significance Index: 0.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0157
    Cell Significance Index: 1.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0124
    Cell Significance Index: 11.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0113
    Cell Significance Index: 4.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0034
    Cell Significance Index: 0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0031
    Cell Significance Index: 0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0057
    Cell Significance Index: -0.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0068
    Cell Significance Index: -0.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0071
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0121
    Cell Significance Index: -1.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0177
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0180
    Cell Significance Index: -3.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0227
    Cell Significance Index: -3.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0286
    Cell Significance Index: -3.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0311
    Cell Significance Index: -2.1500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0334
    Cell Significance Index: -0.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0356
    Cell Significance Index: -0.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0365
    Cell Significance Index: -0.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0383
    Cell Significance Index: -3.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0474
    Cell Significance Index: -0.9900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0478
    Cell Significance Index: -0.5500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0492
    Cell Significance Index: -0.7000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0525
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0538
    Cell Significance Index: -0.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0587
    Cell Significance Index: -3.6100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0663
    Cell Significance Index: -0.9200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0678
    Cell Significance Index: -0.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0715
    Cell Significance Index: -3.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0809
    Cell Significance Index: -4.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0870
    Cell Significance Index: -2.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0933
    Cell Significance Index: -2.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1135
    Cell Significance Index: -1.7100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1188
    Cell Significance Index: -1.5300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1214
    Cell Significance Index: -1.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1252
    Cell Significance Index: -5.1300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1263
    Cell Significance Index: -2.5700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1300
    Cell Significance Index: -1.9500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1312
    Cell Significance Index: -1.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1359
    Cell Significance Index: -3.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1376
    Cell Significance Index: -2.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1392
    Cell Significance Index: -4.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1476
    Cell Significance Index: -3.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1559
    Cell Significance Index: -3.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1564
    Cell Significance Index: -3.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1595
    Cell Significance Index: -2.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1617
    Cell Significance Index: -5.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1756
    Cell Significance Index: -3.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1840
    Cell Significance Index: -4.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1854
    Cell Significance Index: -3.6500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1862
    Cell Significance Index: -1.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2028
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2128
    Cell Significance Index: -2.6800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2184
    Cell Significance Index: -3.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2213
    Cell Significance Index: -4.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2228
    Cell Significance Index: -3.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2229
    Cell Significance Index: -5.6800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2257
    Cell Significance Index: -2.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2271
    Cell Significance Index: -4.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2294
    Cell Significance Index: -3.3000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2327
    Cell Significance Index: -2.4000
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.2332
    Cell Significance Index: -2.8200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2351
    Cell Significance Index: -3.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2452
    Cell Significance Index: -5.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2456
    Cell Significance Index: -5.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2461
    Cell Significance Index: -3.3800
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: -0.2498
    Cell Significance Index: -2.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2516
    Cell Significance Index: -5.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2604
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2660
    Cell Significance Index: -3.8200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2695
    Cell Significance Index: -3.5300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2714
    Cell Significance Index: -3.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2786
    Cell Significance Index: -4.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** INE1 is predominantly expressed in the intestinal epithelium, with notable expression in colon goblet cells, intestinal crypt stem cells, and absorptive cells. 2. **Cell Type-Specific Expression:** In addition to its widespread expression, INE1 is also detected in specific cell types, such as BEST4+ intestinal epithelial cells and tuft cells of the colon. 3. **Evolutionary Conservation:** The INE1 gene has conserved its function across species, suggesting its importance in maintaining intestinal homeostasis. **Pathways and Functions:** 1. **Cell Cycle Regulation:** INE1 is involved in the regulation of cell cycle progression, particularly in the G2/M phase, where it acts as a negative regulator of cell proliferation. 2. **DNA Damage Response:** INE1 plays a role in the DNA damage response, helping to maintain genome stability and prevent mutations that can lead to cancer. 3. **Apoptosis:** INE1 has been implicated in the regulation of apoptosis, or programmed cell death, in the intestinal epithelium. 4. **Intestinal Homeostasis:** By regulating cell proliferation and differentiation, INE1 helps maintain the delicate balance between these processes, ensuring the integrity of the intestinal epithelium. **Clinical Significance:** 1. **Inflammatory Bowel Disease (IBD):** Dysregulation of INE1 has been linked to the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. Understanding INE1's role in IBD may lead to the development of novel therapeutic strategies. 2. **Colorectal Cancer:** INE1's involvement in DNA damage response and apoptosis suggests that alterations in this gene may contribute to the development of colorectal cancer. 3. **Intestinal Stem Cell Maintenance:** INE1's expression in intestinal crypt stem cells highlights its potential role in maintaining the stem cell compartment, which is essential for tissue regeneration and repair. 4. **Diagnostic and Therapeutic Applications:** Further research on INE1 may lead to the development of diagnostic biomarkers for IBD and colorectal cancer, as well as novel therapeutic targets for these diseases. In conclusion, INE1 is a critical gene that plays a pivotal role in maintaining intestinal homeostasis and preventing disease. Further investigation into its pathways and functions will be essential for the development of novel therapeutic strategies and diagnostic biomarkers for intestinal disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.