Details for: TMEFF1

Gene ID: 8577

Symbol: TMEFF1

Ensembl ID: ENSG00000241697

Description: transmembrane protein with EGF like and two follistatin like domains 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6651
    Cell Significance Index: 149.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1235
    Cell Significance Index: 130.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8505
    Cell Significance Index: 371.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8393
    Cell Significance Index: 44.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5369
    Cell Significance Index: 58.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3902
    Cell Significance Index: 61.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1741
    Cell Significance Index: 421.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6927
    Cell Significance Index: 16.7800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5885
    Cell Significance Index: 6.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1608
    Cell Significance Index: 8.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0784
    Cell Significance Index: 0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0292
    Cell Significance Index: -54.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0334
    Cell Significance Index: -61.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0378
    Cell Significance Index: -28.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0399
    Cell Significance Index: -61.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0453
    Cell Significance Index: -61.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0630
    Cell Significance Index: -40.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0807
    Cell Significance Index: -45.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0864
    Cell Significance Index: -9.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0923
    Cell Significance Index: -50.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0966
    Cell Significance Index: -60.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1118
    Cell Significance Index: -32.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1181
    Cell Significance Index: -15.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1292
    Cell Significance Index: -58.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1417
    Cell Significance Index: -3.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1425
    Cell Significance Index: -27.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1568
    Cell Significance Index: -28.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1576
    Cell Significance Index: -6.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1793
    Cell Significance Index: -1.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1898
    Cell Significance Index: -22.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2364
    Cell Significance Index: -38.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2435
    Cell Significance Index: -51.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2479
    Cell Significance Index: -30.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2519
    Cell Significance Index: -3.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2754
    Cell Significance Index: -40.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2764
    Cell Significance Index: -3.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2948
    Cell Significance Index: -40.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3793
    Cell Significance Index: -41.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4208
    Cell Significance Index: -32.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4368
    Cell Significance Index: -43.2100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5103
    Cell Significance Index: -3.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5103
    Cell Significance Index: -60.1900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5213
    Cell Significance Index: -4.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6284
    Cell Significance Index: -43.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6330
    Cell Significance Index: -38.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6621
    Cell Significance Index: -21.2100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.6705
    Cell Significance Index: -7.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6789
    Cell Significance Index: -43.8000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7096
    Cell Significance Index: -17.7000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7340
    Cell Significance Index: -8.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8088
    Cell Significance Index: -26.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8337
    Cell Significance Index: -10.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8609
    Cell Significance Index: -52.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9050
    Cell Significance Index: -41.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9247
    Cell Significance Index: -48.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9312
    Cell Significance Index: -43.7700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.9856
    Cell Significance Index: -8.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0113
    Cell Significance Index: -16.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0305
    Cell Significance Index: -29.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0305
    Cell Significance Index: -21.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0437
    Cell Significance Index: -33.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0469
    Cell Significance Index: -21.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0644
    Cell Significance Index: -28.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.0842
    Cell Significance Index: -13.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0983
    Cell Significance Index: -23.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1252
    Cell Significance Index: -32.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1521
    Cell Significance Index: -22.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1667
    Cell Significance Index: -40.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2075
    Cell Significance Index: -41.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2613
    Cell Significance Index: -27.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.3175
    Cell Significance Index: -46.3000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.3440
    Cell Significance Index: -8.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3912
    Cell Significance Index: -28.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3913
    Cell Significance Index: -64.8700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.3921
    Cell Significance Index: -17.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4332
    Cell Significance Index: -35.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.4505
    Cell Significance Index: -29.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4555
    Cell Significance Index: -42.8700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.5100
    Cell Significance Index: -16.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.6132
    Cell Significance Index: -43.9100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -1.6577
    Cell Significance Index: -17.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.6715
    Cell Significance Index: -28.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7058
    Cell Significance Index: -42.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7524
    Cell Significance Index: -30.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.9058
    Cell Significance Index: -47.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9204
    Cell Significance Index: -41.6100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -1.9223
    Cell Significance Index: -26.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.9511
    Cell Significance Index: -49.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.9838
    Cell Significance Index: -42.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.9878
    Cell Significance Index: -43.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -2.0430
    Cell Significance Index: -22.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -2.0771
    Cell Significance Index: -29.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -2.1215
    Cell Significance Index: -31.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.1701
    Cell Significance Index: -55.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.2101
    Cell Significance Index: -43.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.2167
    Cell Significance Index: -43.3400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.2457
    Cell Significance Index: -45.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.2793
    Cell Significance Index: -52.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -2.2795
    Cell Significance Index: -29.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane structure**: TMEFF1 possesses a characteristic transmembrane domain, allowing it to interact with the plasma membrane and potentially influence cellular signaling pathways. 2. **EGF-like and follistatin-like domains**: The presence of these domains suggests that TMEFF1 may engage in protein-protein interactions, modulating cellular responses to growth factors and other signaling molecules. 3. **Widespread expression**: TMEFF1 is expressed in various cell types, including immune cells (T cells), neurons (GABAergic cortical interneurons), and epithelial cells (luminal epithelial cells of the mammary gland and enterocytes). 4. **Cell-type specificity**: The differential expression of TMEFF1 across different cell types implies that it may serve distinct functions in each cell type, highlighting the complexity of its role in cellular regulation. **Pathways and Functions:** 1. **Immune regulation**: TMEFF1's expression in T cells and other immune cells suggests that it may play a role in modulating immune responses, potentially influencing the activity of immune cells or the regulation of immune-related signaling pathways. 2. **Neuronal function**: The presence of TMEFF1 in GABAergic cortical interneurons indicates that it may contribute to the regulation of neuronal activity, possibly influencing the excitability of these cells or their interaction with other neurons. 3. **Cellular differentiation**: TMEFF1's expression in oligodendrocytes and enterocytes suggests that it may be involved in the regulation of cellular differentiation, potentially influencing the development or maturation of these cell types. 4. **Cell-cell interactions**: The EGF-like and follistatin-like domains of TMEFF1 may facilitate protein-protein interactions, modulating cell-cell interactions and influencing cellular behavior. **Clinical Significance:** The identification of TMEFF1 as a multifunctional gene with implications for immune regulation, neuronal function, and cellular differentiation has significant implications for our understanding of various diseases. Potential areas of clinical significance include: 1. **Immunotherapy**: TMEFF1's role in immune regulation may make it a target for immunotherapeutic interventions, potentially influencing the activity of immune cells or the regulation of immune-related signaling pathways. 2. **Neurological disorders**: The involvement of TMEFF1 in neuronal function suggests that it may play a role in the pathogenesis of neurological disorders, such as epilepsy or Alzheimer's disease. 3. **Cancer**: The expression of TMEFF1 in various epithelial cell types raises the possibility that it may contribute to the development or progression of cancer, potentially influencing cell growth, differentiation, or survival. In conclusion, the TMEFF1 gene represents a fascinating example of a multifunctional protein with far-reaching implications for our understanding of immune regulation, neuronal function, and cellular differentiation. Further investigation into the mechanisms of action of TMEFF1 is warranted, with potential applications in the development of novel therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.