Gene PLPP1 - ENSG00000067113 | NCBI Gene ID: 8611

Details for: PLPP1

Gene ID: 8611

Symbol: PLPP1

Ensembl ID: ENSG00000067113

Description: phospholipid phosphatase 1

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Sphingolipid catabolism
(R-HSA-9845614)
Sphingolipid metabolism
(R-HSA-428157)
Androgen receptor signaling pathway
(GO:0030521)
Apical plasma membrane
(GO:0016324)
Caveola
(GO:0005901)
Ceramide-1-phosphate phosphatase activity
(GO:0106235)
Ceramide metabolic process
(GO:0006672)
Diacylglycerol diphosphate phosphatase activity
(GO:0000810)
Extracellular exosome
(GO:0070062)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
Lipid phosphatase activity
(GO:0042577)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Negative regulation of cell population proliferation
(GO:0008285)
Phosphatidate phosphatase activity
(GO:0008195)
Phospholipid dephosphorylation
(GO:0046839)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of lipid metabolic process
(GO:0019216)
Signal transduction
(GO:0007165)
Sphingolipid metabolic process
(GO:0006665)
Sphingosine-1-phosphate phosphatase activity
(GO:0042392)
Sphingosine metabolic process
(GO:0006670)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 7.37
Marker Score: 98095
Cell Name: cardiac neuron (CL0010022)
Fold Change: 4.31
Marker Score: 5364.5
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 3.58
Marker Score: 1737
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.92
Marker Score: 678
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.9
Marker Score: 5586
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.9
Marker Score: 64720
Cell Name: decidual cell (CL2000002)
Fold Change: 2.82
Marker Score: 12158
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.71
Marker Score: 1619.5
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.66
Marker Score: 1781.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.61
Marker Score: 55785
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.44
Marker Score: 10209.5
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.42
Marker Score: 2303
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.4
Marker Score: 27021
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.36
Marker Score: 8394
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.28
Marker Score: 5448
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.23
Marker Score: 2562.5
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.19
Marker Score: 568
Cell Name: contractile cell (CL0000183)
Fold Change: 2.17
Marker Score: 1178
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 2.12
Marker Score: 539
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.1
Marker Score: 5270
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.09
Marker Score: 8651
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.08
Marker Score: 4567
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.07
Marker Score: 30997.5
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.99
Marker Score: 2886
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.97
Marker Score: 2906.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.96
Marker Score: 1689
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.93
Marker Score: 1129.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.93
Marker Score: 71206
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.92
Marker Score: 561
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.92
Marker Score: 1067
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.87
Marker Score: 71130
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.86
Marker Score: 1995
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.84
Marker Score: 4830
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.82
Marker Score: 500.5
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.8
Marker Score: 1993
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.79
Marker Score: 35643
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.78
Marker Score: 109558
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.76
Marker Score: 737.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.73
Marker Score: 1009
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.71
Marker Score: 1187
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.68
Marker Score: 15979.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.67
Marker Score: 17214
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.67
Marker Score: 15679.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.66
Marker Score: 14271
Cell Name: fat cell (CL0000136)
Fold Change: 1.66
Marker Score: 928
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.64
Marker Score: 1508
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.64
Marker Score: 514
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.63
Marker Score: 842.5
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.62
Marker Score: 12408
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.57
Marker Score: 590
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.56
Marker Score: 20618
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.54
Marker Score: 1016
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.53
Marker Score: 1988
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.53
Marker Score: 1629
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.52
Marker Score: 2352
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.52
Marker Score: 4767
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.5
Marker Score: 9788
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.5
Marker Score: 6926
Cell Name: neural cell (CL0002319)
Fold Change: 1.48
Marker Score: 713
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.47
Marker Score: 611
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167509
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.45
Marker Score: 529
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.44
Marker Score: 324
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.44
Marker Score: 1803.5
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.43
Marker Score: 453
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.43
Marker Score: 390
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.42
Marker Score: 5480
Cell Name: keratocyte (CL0002363)
Fold Change: 1.42
Marker Score: 326
Cell Name: neuron (CL0000540)
Fold Change: 1.4
Marker Score: 5717
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.4
Marker Score: 356
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.39
Marker Score: 1185
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.37
Marker Score: 1059
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.36
Marker Score: 1470
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.36
Marker Score: 275
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.33
Marker Score: 1194
Cell Name: supporting cell (CL0000630)
Fold Change: 1.33
Marker Score: 2501
Cell Name: podocyte (CL0000653)
Fold Change: 1.32
Marker Score: 489
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.32
Marker Score: 1645
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.3
Marker Score: 441
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.28
Marker Score: 2562.5
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.28
Marker Score: 2162
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.27
Marker Score: 1711
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.27
Marker Score: 336
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.26
Marker Score: 627
Cell Name: fibroblast (CL0000057)
Fold Change: 1.26
Marker Score: 1216
Cell Name: male germ cell (CL0000015)
Fold Change: 1.25
Marker Score: 360
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.25
Marker Score: 303
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.25
Marker Score: 8027
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.25
Marker Score: 1715
Cell Name: astrocyte (CL0000127)
Fold Change: 1.25
Marker Score: 1079
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.23
Marker Score: 19255
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.23
Marker Score: 3120
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.21
Marker Score: 265
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.2
Marker Score: 2836
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.2
Marker Score: 1084.5
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.2
Marker Score: 749
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.19
Marker Score: 3409
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.17
Marker Score: 1257
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.16
Marker Score: 765
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.15
Marker Score: 1390

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**Key Characteristics:** PLPP1 is a protein-coupled enzyme that exhibits a high degree of specificity towards its substrates, including phospholipids, lipids, and sphingolipids. The enzyme is primarily localized to the plasma membrane, where it interacts with various signaling pathways, including androgen receptor signaling, protein kinase C-activating G protein-coupled receptor signaling, and sphingolipid metabolism. PLPP1 exhibits a unique structural organization, consisting of two catalytic domains, which are separated by a linker region. This unique structure allows the enzyme to interact with multiple substrates and signaling molecules, thereby modulating its activity. **Pathways and Functions:** PLPP1 is involved in various cellular processes, including: 1. **Lipid Metabolism:** PLPP1 regulates the hydrolysis of phospholipids, lipids, and sphingolipids, thereby modulating lipid metabolism and signaling pathways. 2. **Cell Signaling:** PLPP1 interacts with various signaling molecules, including androgen receptors, protein kinase C, and G protein-coupled receptors, to modulate cellular responses to external stimuli. 3. **Cell Proliferation:** PLPP1 negatively regulates cell population proliferation by modulating the activity of sphingolipid signaling pathways. 4. **Apoptosis:** PLPP1 may also play a role in regulating apoptosis by modulating the activity of sphingolipid signaling pathways. **Clinical Significance:** Dysregulation of PLPP1 has been implicated in various disease states, including: 1. **Cardiovascular Disease:** PLPP1 has been shown to play a role in the development of cardiovascular disease by regulating lipid metabolism and signaling pathways. 2. **Cancer:** PLPP1 may also play a role in cancer development and progression by modulating cell proliferation and apoptosis. 3. **Neurodegenerative Diseases:** PLPP1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating sphingolipid metabolism and signaling pathways. 4. **Metabolic Disorders:** PLPP1 may also play a role in metabolic disorders, such as obesity and type 2 diabetes, by regulating lipid metabolism and signaling pathways. In conclusion, PLPP1 is a critical enzyme involved in regulating cellular lipid metabolism and signaling pathways. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the function and regulation of PLPP1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lipid phosphate phosphohydrolase 1

Genular Protein ID: 2932856456

Symbol: PLPP1_HUMAN

Name: Lipid phosphate phosphohydrolase 1

UniProtKB Accession Codes:

O14494 B7ZKN8 G3XA95 O60457 O60463 Q17RZ4

Database IDs:

Citations:

PubMed ID: 9305923

Title: Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.

PubMed ID: 9305923

DOI: 10.1074/jbc.272.39.24572

PubMed ID: 9570154

Title: Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.

PubMed ID: 9570154

DOI: 10.1089/dna.1998.17.377

PubMed ID: 9468526

Title: Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP.

PubMed ID: 9468526

DOI: 10.1074/jbc.273.8.4660

PubMed ID: 9705349

Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

PubMed ID: 9705349

DOI: 10.1074/jbc.273.34.22059

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9607309

Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.

PubMed ID: 9607309

DOI: 10.1016/s0014-5793(98)00421-9

PubMed ID: 10962286

Title: Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators.

PubMed ID: 10962286

DOI: 10.1016/s1388-1981(00)00081-0

PubMed ID: 14527693

Title: Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

PubMed ID: 14527693

DOI: 10.1016/s0014-5793(03)00931-1

PubMed ID: 12909631

Title: Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.

PubMed ID: 12909631

DOI: 10.1074/jbc.m306709200

PubMed ID: 15461590

Title: Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

PubMed ID: 15461590

DOI: 10.1042/bj20041160

PubMed ID: 17005594

Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.

PubMed ID: 17005594

DOI: 10.1093/jb/mvj195

PubMed ID: 17379599

Title: Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.

PubMed ID: 17379599

DOI: 10.1074/jbc.m701279200

Sequence Information:

Length: 284
Mass: 32156
Checksum: FC2F00617EE07EB3
Sequence:

MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG 
GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK 
YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML 
FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI 
LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PLPP1

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. PubMed ID: 9305923

Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells. PubMed ID: 9570154

Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP. PubMed ID: 9468526

Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. PubMed ID: 9705349

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a novel human phosphatidic acid phosphatase type 2 isoform. PubMed ID: 9607309

Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. PubMed ID: 10962286

Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells. PubMed ID: 14527693

Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. PubMed ID: 12909631

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. PubMed ID: 15461590

Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts. PubMed ID: 17005594

Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. PubMed ID: 17379599