Details for: PLPP1

Gene ID: 8611

Symbol: PLPP1

Ensembl ID: ENSG00000067113

Description: phospholipid phosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 146.2544
    Cell Significance Index: -69.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 142.3237
    Cell Significance Index: -57.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9406
    Cell Significance Index: -66.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.7799
    Cell Significance Index: -54.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.3993
    Cell Significance Index: -38.0800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 8.8009
    Cell Significance Index: 91.1600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 8.1447
    Cell Significance Index: 30.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 6.4098
    Cell Significance Index: 92.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.0246
    Cell Significance Index: 154.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.1579
    Cell Significance Index: 81.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.8567
    Cell Significance Index: 219.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.3703
    Cell Significance Index: 19.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1606
    Cell Significance Index: 433.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1310
    Cell Significance Index: 422.9000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.8459
    Cell Significance Index: 11.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4865
    Cell Significance Index: 77.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2376
    Cell Significance Index: 223.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1726
    Cell Significance Index: 116.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0587
    Cell Significance Index: 379.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8943
    Cell Significance Index: 1683.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8261
    Cell Significance Index: 571.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8114
    Cell Significance Index: 99.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7593
    Cell Significance Index: 42.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7216
    Cell Significance Index: 6.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7103
    Cell Significance Index: 115.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6489
    Cell Significance Index: 16.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5905
    Cell Significance Index: 64.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4884
    Cell Significance Index: 67.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4757
    Cell Significance Index: 60.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4377
    Cell Significance Index: 198.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4266
    Cell Significance Index: 188.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4108
    Cell Significance Index: 260.8900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3828
    Cell Significance Index: 4.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3731
    Cell Significance Index: 8.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3220
    Cell Significance Index: 21.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1912
    Cell Significance Index: 13.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1549
    Cell Significance Index: 210.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1328
    Cell Significance Index: 119.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0874
    Cell Significance Index: 161.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0815
    Cell Significance Index: 125.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0461
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0315
    Cell Significance Index: 5.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0307
    Cell Significance Index: 1.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0156
    Cell Significance Index: -0.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0228
    Cell Significance Index: -12.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0325
    Cell Significance Index: -0.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0729
    Cell Significance Index: -1.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0735
    Cell Significance Index: -55.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0828
    Cell Significance Index: -60.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0883
    Cell Significance Index: -65.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1150
    Cell Significance Index: -16.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1176
    Cell Significance Index: -2.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1254
    Cell Significance Index: -70.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1341
    Cell Significance Index: -83.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1652
    Cell Significance Index: -19.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1904
    Cell Significance Index: -54.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2023
    Cell Significance Index: -8.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2156
    Cell Significance Index: -8.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2391
    Cell Significance Index: -3.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2535
    Cell Significance Index: -25.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2661
    Cell Significance Index: -4.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2706
    Cell Significance Index: -19.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2972
    Cell Significance Index: -15.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2982
    Cell Significance Index: -4.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3132
    Cell Significance Index: -32.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3280
    Cell Significance Index: -9.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3344
    Cell Significance Index: -43.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3576
    Cell Significance Index: -61.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3662
    Cell Significance Index: -77.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3944
    Cell Significance Index: -45.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4097
    Cell Significance Index: -11.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4156
    Cell Significance Index: -49.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5088
    Cell Significance Index: -23.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5745
    Cell Significance Index: -8.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6703
    Cell Significance Index: -14.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7344
    Cell Significance Index: -34.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7358
    Cell Significance Index: -12.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.7458
    Cell Significance Index: -7.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7645
    Cell Significance Index: -56.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7981
    Cell Significance Index: -63.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8522
    Cell Significance Index: -24.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9170
    Cell Significance Index: -56.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9554
    Cell Significance Index: -61.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9592
    Cell Significance Index: -50.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9618
    Cell Significance Index: -30.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9766
    Cell Significance Index: -28.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9852
    Cell Significance Index: -51.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0003
    Cell Significance Index: -14.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0153
    Cell Significance Index: -63.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1179
    Cell Significance Index: -26.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1611
    Cell Significance Index: -36.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1661
    Cell Significance Index: -24.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1781
    Cell Significance Index: -14.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1917
    Cell Significance Index: -25.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.2003
    Cell Significance Index: -19.7800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2371
    Cell Significance Index: -17.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2416
    Cell Significance Index: -40.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3297
    Cell Significance Index: -22.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3359
    Cell Significance Index: -46.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.3576
    Cell Significance Index: -42.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLPP1 is a protein-coupled enzyme that exhibits a high degree of specificity towards its substrates, including phospholipids, lipids, and sphingolipids. The enzyme is primarily localized to the plasma membrane, where it interacts with various signaling pathways, including androgen receptor signaling, protein kinase C-activating G protein-coupled receptor signaling, and sphingolipid metabolism. PLPP1 exhibits a unique structural organization, consisting of two catalytic domains, which are separated by a linker region. This unique structure allows the enzyme to interact with multiple substrates and signaling molecules, thereby modulating its activity. **Pathways and Functions:** PLPP1 is involved in various cellular processes, including: 1. **Lipid Metabolism:** PLPP1 regulates the hydrolysis of phospholipids, lipids, and sphingolipids, thereby modulating lipid metabolism and signaling pathways. 2. **Cell Signaling:** PLPP1 interacts with various signaling molecules, including androgen receptors, protein kinase C, and G protein-coupled receptors, to modulate cellular responses to external stimuli. 3. **Cell Proliferation:** PLPP1 negatively regulates cell population proliferation by modulating the activity of sphingolipid signaling pathways. 4. **Apoptosis:** PLPP1 may also play a role in regulating apoptosis by modulating the activity of sphingolipid signaling pathways. **Clinical Significance:** Dysregulation of PLPP1 has been implicated in various disease states, including: 1. **Cardiovascular Disease:** PLPP1 has been shown to play a role in the development of cardiovascular disease by regulating lipid metabolism and signaling pathways. 2. **Cancer:** PLPP1 may also play a role in cancer development and progression by modulating cell proliferation and apoptosis. 3. **Neurodegenerative Diseases:** PLPP1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating sphingolipid metabolism and signaling pathways. 4. **Metabolic Disorders:** PLPP1 may also play a role in metabolic disorders, such as obesity and type 2 diabetes, by regulating lipid metabolism and signaling pathways. In conclusion, PLPP1 is a critical enzyme involved in regulating cellular lipid metabolism and signaling pathways. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the function and regulation of PLPP1.

Genular Protein ID: 2932856456

Symbol: PLPP1_HUMAN

Name: Lipid phosphate phosphohydrolase 1

UniProtKB Accession Codes:

O14494 B7ZKN8 G3XA95 O60457 O60463 Q17RZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 53 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 3 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 26 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9305923

Title: Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.

PubMed ID: 9305923

DOI: 10.1074/jbc.272.39.24572

PubMed ID: 9570154

Title: Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.

PubMed ID: 9570154

DOI: 10.1089/dna.1998.17.377

PubMed ID: 9468526

Title: Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic Adenocarcinoma cell line LNCaP.

PubMed ID: 9468526

DOI: 10.1074/jbc.273.8.4660

PubMed ID: 9705349

Title: Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

PubMed ID: 9705349

DOI: 10.1074/jbc.273.34.22059

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9607309

Title: Identification of a novel human phosphatidic acid phosphatase type 2 isoform.

PubMed ID: 9607309

DOI: 10.1016/s0014-5793(98)00421-9

PubMed ID: 10962286

Title: Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators.

PubMed ID: 10962286

DOI: 10.1016/s1388-1981(00)00081-0

PubMed ID: 14527693

Title: Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.

PubMed ID: 14527693

DOI: 10.1016/s0014-5793(03)00931-1

PubMed ID: 12909631

Title: Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.

PubMed ID: 12909631

DOI: 10.1074/jbc.m306709200

PubMed ID: 15461590

Title: Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

PubMed ID: 15461590

DOI: 10.1042/bj20041160

PubMed ID: 17005594

Title: Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.

PubMed ID: 17005594

DOI: 10.1093/jb/mvj195

PubMed ID: 17379599

Title: Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.

PubMed ID: 17379599

DOI: 10.1074/jbc.m701279200

Sequence Information:

  • Length: 284
  • Mass: 32156
  • Checksum: FC2F00617EE07EB3
  • Sequence:
    • MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG 
GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK 
YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML 
FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI 
LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.