Details for: TNKS

Gene ID: 8658

Symbol: TNKS

Ensembl ID: ENSG00000173273

Description: tankyrase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 458.8376
    Cell Significance Index: -71.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 280.5514
    Cell Significance Index: -71.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 154.9809
    Cell Significance Index: -73.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 139.8129
    Cell Significance Index: -56.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.8467
    Cell Significance Index: -67.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 109.0277
    Cell Significance Index: -73.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.6077
    Cell Significance Index: -56.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.5666
    Cell Significance Index: -72.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.1343
    Cell Significance Index: -70.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.7770
    Cell Significance Index: -73.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.4058
    Cell Significance Index: -72.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.8785
    Cell Significance Index: -36.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.1429
    Cell Significance Index: 232.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.4567
    Cell Significance Index: 1239.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2182
    Cell Significance Index: 638.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.9936
    Cell Significance Index: 44.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7656
    Cell Significance Index: 71.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7008
    Cell Significance Index: 541.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2059
    Cell Significance Index: 97.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1110
    Cell Significance Index: 79.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.0587
    Cell Significance Index: 25.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6642
    Cell Significance Index: 127.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6504
    Cell Significance Index: 192.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6306
    Cell Significance Index: 1127.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5527
    Cell Significance Index: 30.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4993
    Cell Significance Index: 103.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1910
    Cell Significance Index: 20.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9998
    Cell Significance Index: 21.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9668
    Cell Significance Index: 27.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8793
    Cell Significance Index: 143.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7827
    Cell Significance Index: 13.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7599
    Cell Significance Index: 82.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7125
    Cell Significance Index: 1341.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6175
    Cell Significance Index: 111.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5827
    Cell Significance Index: 71.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5361
    Cell Significance Index: 27.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4591
    Cell Significance Index: 291.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4097
    Cell Significance Index: 630.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3707
    Cell Significance Index: 683.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3504
    Cell Significance Index: 159.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3184
    Cell Significance Index: 19.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2986
    Cell Significance Index: 163.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2703
    Cell Significance Index: 244.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2478
    Cell Significance Index: 336.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0897
    Cell Significance Index: 12.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0632
    Cell Significance Index: 27.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0584
    Cell Significance Index: 5.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0414
    Cell Significance Index: 7.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0097
    Cell Significance Index: 1.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0073
    Cell Significance Index: 0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0284
    Cell Significance Index: -17.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0353
    Cell Significance Index: -5.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0393
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0406
    Cell Significance Index: -30.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0494
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0639
    Cell Significance Index: -10.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0705
    Cell Significance Index: -51.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0857
    Cell Significance Index: -48.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0960
    Cell Significance Index: -72.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1418
    Cell Significance Index: -14.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1446
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1779
    Cell Significance Index: -37.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2116
    Cell Significance Index: -27.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2146
    Cell Significance Index: -61.7600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2304
    Cell Significance Index: -2.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2825
    Cell Significance Index: -8.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2831
    Cell Significance Index: -13.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3452
    Cell Significance Index: -9.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3790
    Cell Significance Index: -23.8900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4056
    Cell Significance Index: -5.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4146
    Cell Significance Index: -19.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4216
    Cell Significance Index: -43.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4336
    Cell Significance Index: -27.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4575
    Cell Significance Index: -59.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4752
    Cell Significance Index: -54.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4770
    Cell Significance Index: -6.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5046
    Cell Significance Index: -11.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5096
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5101
    Cell Significance Index: -58.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5216
    Cell Significance Index: -7.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5487
    Cell Significance Index: -10.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5727
    Cell Significance Index: -29.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5918
    Cell Significance Index: -7.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6740
    Cell Significance Index: -35.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7429
    Cell Significance Index: -23.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7440
    Cell Significance Index: -24.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7600
    Cell Significance Index: -56.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7811
    Cell Significance Index: -61.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7844
    Cell Significance Index: -19.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8052
    Cell Significance Index: -25.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8059
    Cell Significance Index: -16.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8725
    Cell Significance Index: -53.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8826
    Cell Significance Index: -11.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9076
    Cell Significance Index: -64.1900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9081
    Cell Significance Index: -13.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9270
    Cell Significance Index: -48.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9446
    Cell Significance Index: -11.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9769
    Cell Significance Index: -16.8900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9962
    Cell Significance Index: -6.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0788
    Cell Significance Index: -22.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Role:** Tankyrase exhibits both NAD+-dependent and NAD+-independent activities, enabling its participation in multiple cellular processes. 2. **Telomere Maintenance:** TNKS is crucial for maintaining telomere length and stability, which is essential for cellular aging and cancer development. 3. **Mitotic Spindle Organization:** Tankyrase regulates the organization of the mitotic spindle, ensuring proper chromosome segregation and cell division. 4. **Signaling Pathways:** TNKS interacts with various signaling molecules, including Wnt and PI3K/AKT, influencing cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Telomere Maintenance:** TNKS is involved in the regulation of telomerase activity, telomere capping, and telomere lengthening, ensuring telomere stability and preventing telomere shortening. 2. **Mitotic Spindle Organization:** Tankyrase regulates the assembly and disassembly of the mitotic spindle, ensuring proper chromosome segregation and cell division. 3. **Signaling Pathways:** TNKS interacts with Wnt and PI3K/AKT signaling pathways, influencing cell growth, differentiation, and survival. 4. **Protein Regulation:** Tankyrase regulates the stability and activity of various proteins, including PI3K, AKT, and Wnt proteins. **Clinical Significance:** 1. **Cancer:** TNKS overexpression has been linked to various cancers, including breast, lung, and colon cancers, suggesting its role in tumorigenesis and cancer progression. 2. **Aging and Cellular Senescence:** Telomere shortening and telomere maintenance dysregulation contribute to cellular aging and senescence, highlighting the importance of TNKS in maintaining cellular homeostasis. 3. **Neurological Disorders:** TNKS has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, suggesting its role in neuronal function and plasticity. 4. **Immunological Disorders:** Tankyrase's involvement in immune cell regulation and signaling pathways highlights its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency. In conclusion, the TNKS gene plays a multifaceted role in cellular regulation, including telomere maintenance, mitotic spindle organization, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, aging, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which TNKS influences cellular processes and to explore its therapeutic potential.

Genular Protein ID: 3517464930

Symbol: TNKS1_HUMAN

Name: TNKS-1

UniProtKB Accession Codes:

O95271 O95272 Q4G0F2 Q59FX0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 ELM 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9822378

Title: Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.

PubMed ID: 9822378

DOI: 10.1126/science.282.5393.1484

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10523501

Title: Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes.

PubMed ID: 10523501

DOI: 10.1242/jcs.112.21.3649

PubMed ID: 10988299

Title: Tankyrase is a Golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.

PubMed ID: 10988299

DOI: 10.1074/jbc.m007635200

PubMed ID: 12080061

Title: Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.

PubMed ID: 12080061

DOI: 10.1074/jbc.m203916200

PubMed ID: 11739745

Title: Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.

PubMed ID: 11739745

DOI: 10.1128/mcb.22.1.332-342.2002

PubMed ID: 12768206

Title: POT1 as a terminal transducer of TRF1 telomere length control.

PubMed ID: 12768206

DOI: 10.1038/nature01688

PubMed ID: 16076287

Title: NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.

PubMed ID: 16076287

DOI: 10.1042/bj20050885

PubMed ID: 19759537

Title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

PubMed ID: 19759537

DOI: 10.1038/nature08356

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 21478859

Title: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

PubMed ID: 21478859

DOI: 10.1038/ncb2222

PubMed ID: 21799911

Title: Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

PubMed ID: 21799911

DOI: 10.1371/journal.pone.0022595

PubMed ID: 22864114

Title: Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.

PubMed ID: 22864114

DOI: 10.1016/j.molcel.2012.06.033

PubMed ID: 23622245

Title: Proteasome regulation by ADP-ribosylation.

PubMed ID: 23622245

DOI: 10.1016/j.cell.2013.03.040

PubMed ID: 25043379

Title: Family-wide analysis of poly(ADP-ribose) polymerase activity.

PubMed ID: 25043379

DOI: 10.1038/ncomms5426

PubMed ID: 18436240

Title: Zinc binding catalytic domain of human tankyrase 1.

PubMed ID: 18436240

DOI: 10.1016/j.jmb.2008.03.058

PubMed ID: 28619731

Title: USP25 regulates Wnt signaling by controlling the stability of tankyrases.

PubMed ID: 28619731

DOI: 10.1101/gad.300889.117

PubMed ID: 33361107

Title: Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.

PubMed ID: 33361107

DOI: 10.1074/jbc.ra120.016573

Sequence Information:

  • Length: 1327
  • Mass: 142039
  • Checksum: 44BDE985C715BEFF
  • Sequence:
    • MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGTTPASPTA SGLAPFASPR 
HGLALPEGDG SRDPPDRPRS PDPVDGTSCC STTSTICTVA AAPVVPAVST SSAAGVAPNP 
AGSGSNNSPS SSSSPTSSSS SSPSSPGSSL AESPEAAGVS STAPLGPGAA GPGTGVPAVS 
GALRELLEAC RNGDVSRVKR LVDAANVNAK DMAGRKSSPL HFAAGFGRKD VVEHLLQMGA 
NVHARDDGGL IPLHNACSFG HAEVVSLLLC QGADPNARDN WNYTPLHEAA IKGKIDVCIV 
LLQHGADPNI RNTDGKSALD LADPSAKAVL TGEYKKDELL EAARSGNEEK LMALLTPLNV 
NCHASDGRKS TPLHLAAGYN RVRIVQLLLQ HGADVHAKDK GGLVPLHNAC SYGHYEVTEL 
LLKHGACVNA MDLWQFTPLH EAASKNRVEV CSLLLSHGAD PTLVNCHGKS AVDMAPTPEL 
RERLTYEFKG HSLLQAAREA DLAKVKKTLA LEIINFKQPQ SHETALHCAV ASLHPKRKQV 
TELLLRKGAN VNEKNKDFMT PLHVAAERAH NDVMEVLHKH GAKMNALDTL GQTALHRAAL 
AGHLQTCRLL LSYGSDPSII SLQGFTAAQM GNEAVQQILS ESTPIRTSDV DYRLLEASKA 
GDLETVKQLC SSQNVNCRDL EGRHSTPLHF AAGYNRVSVV EYLLHHGADV HAKDKGGLVP 
LHNACSYGHY EVAELLVRHG ASVNVADLWK FTPLHEAAAK GKYEICKLLL KHGADPTKKN 
RDGNTPLDLV KEGDTDIQDL LRGDAALLDA AKKGCLARVQ KLCTPENINC RDTQGRNSTP 
LHLAAGYNNL EVAEYLLEHG ADVNAQDKGG LIPLHNAASY GHVDIAALLI KYNTCVNATD 
KWAFTPLHEA AQKGRTQLCA LLLAHGADPT MKNQEGQTPL DLATADDIRA LLIDAMPPEA 
LPTCFKPQAT VVSASLISPA STPSCLSAAS SIDNLTGPLA ELAVGGASNA GDGAAGTERK 
EGEVAGLDMN ISQFLKSLGL EHLRDIFETE QITLDVLADM GHEELKEIGI NAYGHRHKLI 
KGVERLLGGQ QGTNPYLTFH CVNQGTILLD LAPEDKEYQS VEEEMQSTIR EHRDGGNAGG 
IFNRYNVIRI QKVVNKKLRE RFCHRQKEVS EENHNHHNER MLFHGSPFIN AIIHKGFDER 
HAYIGGMFGA GIYFAENSSK SNQYVYGIGG GTGCPTHKDR SCYICHRQML FCRVTLGKSF 
LQFSTMKMAH APPGHHSVIG RPSVNGLAYA EYVIYRGEQA YPEYLITYQI MKPEAPSQTA 
TAAEQKT

Genular Protein ID: 2462375233

Symbol: H0YAW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YAW5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 EC 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 1316
  • Mass: 140762
  • Checksum: B2A66C88C8A1C317
  • Sequence:
    • MAASRRSQHH HHHHQQQLQP APGASAPPPP PPPPLSPGLA PGTTPASPTA SGLAPFASPR 
HGLALPEGDG SRDPPDRPRS PDPVDGTSCC STTSTICTVA AAPVVPAVST SSAAGVAPNP 
AGSGSNNSPS SSSSPTSSSS SSPSSPGSSL AESPEAAGVS STAPLGPGAA GPGTGVPAVS 
GALRELLEAC RNGDVSRVKR LVDAANVNAK DMAGRKSSPL HFAAGFGRKD VVEHLLQMGA 
NVHARDDGGL IPLHNACSFG HAEVVSLLLC QGADPNARDN WNYTPLHEAA IKGKIDVCIV 
LLQHGADPNI RNTDGKSALD LADPSAKAVL TGEYKKDELL EAARSGNEEK LMALLTPLNV 
NCHASDGRKS TPLHLAAGYN RVRIVQLLLQ HGADVHAKDK GGLVPLHNAC SYGHYEVTEL 
LLKHGACVNA MDLWQFTPLH EAASKNRVEV CSLLLSHGAD PTLVNCHGKS AVDMAPTPEL 
RERLTYEFKG HSLLQAAREA DLAKVKKTLA LEIINFKQPQ SHETALHCAV ASLHPKRKQV 
TELLLRKGAN VNEKNKDFMT PLHVAAERAH NDVMEVLHKH GAKMNALDTL GQTALHRAAL 
AGHLQTCRLL LSYGSDPSII SLQGFTAAQM GNEAVQQILS ESTPIRTSDV DYRLLEASKA 
GDLETVKQLC SSQNVNCRDL EGRHSTPLHF AAGYNRVSVV EYLLHHGADV HAKDKGGLVP 
LHNACSYGHY EVAELLVRHG ASVNVADLWK FTPLHEAAAK GKYEICKLLL KHGADPTKKN 
RDGNTPLDLV KEGDTDIQDL LRGDAALLDA AKKGCLARVQ KLCTPENINC RDTQGRNSTP 
LHLAAGYNNL EVAEYLLEHG ADVNAQDKGG LIPLHNAASY GHVDIAALLI KYNTCVNATD 
KWAFTPLHEA AQKGRTQLCA LLLAHGADPT MKNQEGQTPL DLATADDIRA LLIDAMPPEA 
LPTCFKPQAT VVSASLISPA STPSCLSAAS SIDNLTGPLA ELAVGGASNA GDGAAGTERK 
EGEVAGLDMN ISQFLKSLGL EHLRDIFETE QITLDVLADM GHEELKEIGI NAYGHRHKLI 
KGVERLLGGQ QGTNPYLTFH CVNQGTILLD LAPEDKEYQS VEEEMQSTIR EHRDGGNAGG 
IFNRYNVIRI QKVVNKKLRE RFCHRQKEVS EENHNHHNER MLFHGSPFIN AIIHKGFDER 
HAYIGGMFGA GIYFAENSSK SNQYVYGIGG GTGCPTHKDR SCYICHRQML FCRVTLGKSF 
LQFSTMKMAH APPGHHSVIG RPSVNGLAYA EYVIYRGEQV DTLKARHLCS IPAKNT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.