Details for: KRT36

Gene ID: 8689

Symbol: KRT36

Ensembl ID: ENSG00000126337

Description: keratin 36

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 2.0153
    Cell Significance Index: 2.3200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.5452
    Cell Significance Index: 6.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5292
    Cell Significance Index: 27.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4782
    Cell Significance Index: 6.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2606
    Cell Significance Index: 4.2200
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.1960
    Cell Significance Index: 1.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1275
    Cell Significance Index: 5.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1180
    Cell Significance Index: 1.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0632
    Cell Significance Index: 11.3900
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.0588
    Cell Significance Index: 0.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0556
    Cell Significance Index: 2.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0484
    Cell Significance Index: 0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0270
    Cell Significance Index: 3.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0259
    Cell Significance Index: 11.4300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0241
    Cell Significance Index: 0.1600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0187
    Cell Significance Index: 0.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0167
    Cell Significance Index: 0.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0163
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0157
    Cell Significance Index: 1.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0101
    Cell Significance Index: 0.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0036
    Cell Significance Index: 0.4900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0053
    Cell Significance Index: -1.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0059
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0077
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0084
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0104
    Cell Significance Index: -0.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0133
    Cell Significance Index: -0.6200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0166
    Cell Significance Index: -0.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0187
    Cell Significance Index: -0.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0200
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0200
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0222
    Cell Significance Index: -0.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0224
    Cell Significance Index: -0.2900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0256
    Cell Significance Index: -0.2800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0274
    Cell Significance Index: -0.6000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0299
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0305
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0311
    Cell Significance Index: -0.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0314
    Cell Significance Index: -1.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0314
    Cell Significance Index: -0.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0345
    Cell Significance Index: -0.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0347
    Cell Significance Index: -0.9300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0363
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0401
    Cell Significance Index: -0.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0405
    Cell Significance Index: -0.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0415
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0419
    Cell Significance Index: -0.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0444
    Cell Significance Index: -0.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0444
    Cell Significance Index: -0.9200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0452
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0457
    Cell Significance Index: -0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0464
    Cell Significance Index: -1.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0488
    Cell Significance Index: -0.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0489
    Cell Significance Index: -1.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0490
    Cell Significance Index: -0.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0492
    Cell Significance Index: -1.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0499
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0499
    Cell Significance Index: -1.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0510
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0521
    Cell Significance Index: -0.5500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0529
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0530
    Cell Significance Index: -0.6300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0533
    Cell Significance Index: -0.6700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0550
    Cell Significance Index: -0.9400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0553
    Cell Significance Index: -0.6500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0555
    Cell Significance Index: -0.6600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0559
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0561
    Cell Significance Index: -0.6100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0580
    Cell Significance Index: -0.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0583
    Cell Significance Index: -0.8300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0603
    Cell Significance Index: -0.6400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0605
    Cell Significance Index: -0.7900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0606
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0607
    Cell Significance Index: -0.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0609
    Cell Significance Index: -1.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0612
    Cell Significance Index: -1.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0620
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0633
    Cell Significance Index: -0.7700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0649
    Cell Significance Index: -0.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0651
    Cell Significance Index: -0.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0653
    Cell Significance Index: -0.8600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0660
    Cell Significance Index: -0.7800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0668
    Cell Significance Index: -1.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT36 belongs to the type I keratin subfamily, which is distinct from type II keratins. Type I keratins are characterized by their ability to form dimers and assemble into coiled-coil structures, providing structural support to epithelial cells. Unlike other keratins, KRT36 is highly expressed in various cell types, including oligodendrocyte precursor cells, blood vessel endothelial cells, and keratinocytes. This widespread expression suggests a multifaceted role of KRT36 in different cellular contexts. **Pathways and Functions:** KRT36 is involved in various cellular processes, including: 1. **Epithelial cell differentiation**: KRT36 plays a crucial role in the differentiation of epithelial cells, particularly during keratinization. The formation of the cornified envelope, a hallmark of keratinocytes, is mediated by the assembly of keratin filaments, including KRT36. 2. **Intermediate filament organization**: KRT36 contributes to the organization and stability of intermediate filaments, which provide mechanical support to epithelial cells. 3. **Regulation of keratinocyte differentiation**: KRT36 is involved in the regulation of keratinocyte differentiation, influencing the expression of other keratin genes and the assembly of keratin filaments. 4. **Cytoskeletal dynamics**: KRT36 interacts with other cytoskeletal proteins, influencing the dynamics of the cytoskeleton and cell shape. **Clinical Significance:** The dysregulation of KRT36 has been implicated in various diseases, including: 1. **Skin disorders**: Mutations in KRT36 have been associated with skin disorders, such as epidermolysis bullosa simplex (EBS). 2. **Cancer**: Altered expression of KRT36 has been observed in various cancers, including breast, lung, and colon cancer. 3. **Neurological disorders**: KRT36 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, KRT36 plays a vital role in epithelial cell differentiation and keratinization, influencing the organization of intermediate filaments and the regulation of keratinocyte differentiation. Further research is necessary to elucidate the mechanisms underlying KRT36's clinical significance and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further studies**: Conduct in-depth studies to elucidate the mechanisms underlying KRT36's role in epithelial cell differentiation and keratinization. 2. **Investigate clinical applications**: Investigate the potential of KRT36 as a therapeutic target for various diseases, including skin disorders and cancers. 3. **Immunological significance**: Explore the immunological significance of KRT36 and its potential role in immune responses. By unraveling the mysteries of KRT36, we can gain a deeper understanding of epithelial cell biology and develop new therapeutic strategies for various diseases.

Genular Protein ID: 556955348

Symbol: KRT36_HUMAN

Name: Keratin, type I cuticular Ha6

UniProtKB Accession Codes:

O76013 Q86XG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 467
  • Mass: 52247
  • Checksum: 492B3B2DE3BCAECD
  • Sequence:
    • MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG 
SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE 
LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT 
KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC 
QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE 
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA 
QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP 
SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.