Details for: KRT36

Gene ID: 8689

Symbol: KRT36

Ensembl ID: ENSG00000126337

Description: keratin 36

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,283
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,180
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.54
    Marker Score: 4,378
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,226
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.8
    Marker Score: 1,500
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1,193
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2,478
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6,425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.77
    Marker Score: 444
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 523
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1,303
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4,857
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.26
    Marker Score: 492
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 459
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.22
    Marker Score: 234
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 80
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 696
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1
    Marker Score: 153
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.07
    Marker Score: 112
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.06
    Marker Score: 31
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 40
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 69
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.04
    Marker Score: 71
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 116
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 96
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 121
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.04
    Marker Score: 276
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 101
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 133

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT36 belongs to the type I keratin subfamily, which is distinct from type II keratins. Type I keratins are characterized by their ability to form dimers and assemble into coiled-coil structures, providing structural support to epithelial cells. Unlike other keratins, KRT36 is highly expressed in various cell types, including oligodendrocyte precursor cells, blood vessel endothelial cells, and keratinocytes. This widespread expression suggests a multifaceted role of KRT36 in different cellular contexts. **Pathways and Functions:** KRT36 is involved in various cellular processes, including: 1. **Epithelial cell differentiation**: KRT36 plays a crucial role in the differentiation of epithelial cells, particularly during keratinization. The formation of the cornified envelope, a hallmark of keratinocytes, is mediated by the assembly of keratin filaments, including KRT36. 2. **Intermediate filament organization**: KRT36 contributes to the organization and stability of intermediate filaments, which provide mechanical support to epithelial cells. 3. **Regulation of keratinocyte differentiation**: KRT36 is involved in the regulation of keratinocyte differentiation, influencing the expression of other keratin genes and the assembly of keratin filaments. 4. **Cytoskeletal dynamics**: KRT36 interacts with other cytoskeletal proteins, influencing the dynamics of the cytoskeleton and cell shape. **Clinical Significance:** The dysregulation of KRT36 has been implicated in various diseases, including: 1. **Skin disorders**: Mutations in KRT36 have been associated with skin disorders, such as epidermolysis bullosa simplex (EBS). 2. **Cancer**: Altered expression of KRT36 has been observed in various cancers, including breast, lung, and colon cancer. 3. **Neurological disorders**: KRT36 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, KRT36 plays a vital role in epithelial cell differentiation and keratinization, influencing the organization of intermediate filaments and the regulation of keratinocyte differentiation. Further research is necessary to elucidate the mechanisms underlying KRT36's clinical significance and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further studies**: Conduct in-depth studies to elucidate the mechanisms underlying KRT36's role in epithelial cell differentiation and keratinization. 2. **Investigate clinical applications**: Investigate the potential of KRT36 as a therapeutic target for various diseases, including skin disorders and cancers. 3. **Immunological significance**: Explore the immunological significance of KRT36 and its potential role in immune responses. By unraveling the mysteries of KRT36, we can gain a deeper understanding of epithelial cell biology and develop new therapeutic strategies for various diseases.

Genular Protein ID: 556955348

Symbol: KRT36_HUMAN

Name: Keratin, type I cuticular Ha6

UniProtKB Accession Codes:

O76013 Q86XG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 467
  • Mass: 52247
  • Checksum: 492B3B2DE3BCAECD
  • Sequence:
    • MATQTCTPTF STGSIKGLCG TAGGISRVSS IRSVGSCRVP SLAGAAGYIS SARSGLSGLG 
SCLPGSYLSS ECHTSGFVGS GGWFCEGSFN GSEKETMQFL NDRLANYLEK VRQLERENAE 
LESRIQEWYE FQIPYICPDY QSYFKTIEDF QQKILLTKSE NARLVLQIDN AKLAADDFRT 
KYETELSLRQ LVEADINGLR RILDELTLCK ADLEAQVESL KEELMCLKKN HEEEVSVLRC 
QLGDRLNVEV DAAPPVDLNK ILEDMRCQYE ALVENNRRDV EAWFNTQTEE LNQQVVSSSE 
QLQCCQTEII ELRRTVNALE IELQAQHSMR NSLESTLAET EARYSSQLAQ MQCLISNVEA 
QLSEIRCDLE RQNQEYQVLL DVKARLEGEI ATYRHLLEGE DCKLPPQPCA TACKPVIRVP 
SVPPVPCVPS VPCTPAPQVG TQIRTITEEI RDGKVISSRE HVQSRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.