Details for: TNFRSF25

Gene ID: 8718

Symbol: TNFRSF25

Ensembl ID: ENSG00000215788

Description: TNF receptor superfamily member 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.6483
    Cell Significance Index: -12.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.7405
    Cell Significance Index: -12.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.5041
    Cell Significance Index: -11.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.3653
    Cell Significance Index: -12.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6382
    Cell Significance Index: -12.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.8565
    Cell Significance Index: -11.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3350
    Cell Significance Index: -13.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9151
    Cell Significance Index: -6.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8618
    Cell Significance Index: 54.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7116
    Cell Significance Index: 118.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2811
    Cell Significance Index: 256.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2153
    Cell Significance Index: 34.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1885
    Cell Significance Index: 53.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1284
    Cell Significance Index: 32.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1261
    Cell Significance Index: 31.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1221
    Cell Significance Index: 122.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9305
    Cell Significance Index: 62.5700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.8218
    Cell Significance Index: 8.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8124
    Cell Significance Index: 48.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8085
    Cell Significance Index: 8.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6376
    Cell Significance Index: 228.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6129
    Cell Significance Index: 10.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5710
    Cell Significance Index: 7.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5075
    Cell Significance Index: 7.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4988
    Cell Significance Index: 49.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4254
    Cell Significance Index: 384.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3735
    Cell Significance Index: 13.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3667
    Cell Significance Index: 19.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3259
    Cell Significance Index: 7.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3221
    Cell Significance Index: 19.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3014
    Cell Significance Index: 6.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2894
    Cell Significance Index: 6.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1257
    Cell Significance Index: 4.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1169
    Cell Significance Index: 2.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1020
    Cell Significance Index: 19.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0800
    Cell Significance Index: 5.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0684
    Cell Significance Index: 1.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0683
    Cell Significance Index: 3.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0626
    Cell Significance Index: 3.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0602
    Cell Significance Index: 92.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0598
    Cell Significance Index: 26.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0553
    Cell Significance Index: 101.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0431
    Cell Significance Index: 0.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0431
    Cell Significance Index: 8.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0384
    Cell Significance Index: 6.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0370
    Cell Significance Index: 20.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0309
    Cell Significance Index: 0.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0264
    Cell Significance Index: 3.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0248
    Cell Significance Index: 33.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0176
    Cell Significance Index: 33.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0069
    Cell Significance Index: 0.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0059
    Cell Significance Index: 0.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0075
    Cell Significance Index: -0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0111
    Cell Significance Index: -1.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0133
    Cell Significance Index: -0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0196
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0237
    Cell Significance Index: -13.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0261
    Cell Significance Index: -3.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0314
    Cell Significance Index: -4.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0401
    Cell Significance Index: -11.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0447
    Cell Significance Index: -5.2100
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.0510
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0647
    Cell Significance Index: -13.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0718
    Cell Significance Index: -12.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0749
    Cell Significance Index: -5.3000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0754
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0811
    Cell Significance Index: -3.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0928
    Cell Significance Index: -10.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0956
    Cell Significance Index: -12.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0992
    Cell Significance Index: -11.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1056
    Cell Significance Index: -2.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1112
    Cell Significance Index: -11.3600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1140
    Cell Significance Index: -1.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1216
    Cell Significance Index: -12.6600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1236
    Cell Significance Index: -1.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1351
    Cell Significance Index: -6.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1355
    Cell Significance Index: -4.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1436
    Cell Significance Index: -4.7000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1479
    Cell Significance Index: -2.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1481
    Cell Significance Index: -3.2000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1512
    Cell Significance Index: -1.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1534
    Cell Significance Index: -11.4300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1534
    Cell Significance Index: -1.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1572
    Cell Significance Index: -1.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1687
    Cell Significance Index: -8.8600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1715
    Cell Significance Index: -0.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1761
    Cell Significance Index: -10.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1991
    Cell Significance Index: -5.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2223
    Cell Significance Index: -3.3500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2247
    Cell Significance Index: -2.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2280
    Cell Significance Index: -4.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2354
    Cell Significance Index: -6.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2366
    Cell Significance Index: -6.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2401
    Cell Significance Index: -8.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF25 is a type II transmembrane receptor, which distinguishes it from other members of the tumor necrosis factor receptor superfamily. Its extracellular domain contains an immunoglobulin-like motif, while its intracellular domain is characterized by a cytoplasmic tail with a unique sequence. This structure allows TNFRSF25 to interact with various signaling molecules, influencing cell surface receptor signaling pathways. **Pathways and Functions:** TNFRSF25 is involved in multiple signaling pathways, including: 1. **Apoptotic signaling pathway:** TNFRSF25 can modulate the extrinsic pathway of apoptosis, influencing cell death and survival. 2. **Cytokine signaling in the immune system:** TNFRSF25 interacts with cytokines, such as tumor necrosis factor-alpha (TNF-α), to regulate immune responses. 3. **Non-canonical NF-κB pathway:** TNFRSF25 is implicated in the activation of the non-canonical NF-κB pathway, which plays a crucial role in immune cell development and function. 4. **Tumor necrosis factor-mediated signaling pathway:** TNFRSF25 participates in the regulation of TNF-α-mediated signaling, influencing inflammation and immune responses. **Signaling Mechanisms:** TNFRSF25's signaling mechanisms involve the interaction with various molecules, including: 1. **TNF-α:** TNFRSF25 binds to TNF-α, leading to the activation of downstream signaling pathways. 2. **TRAF6:** TNFRSF25 interacts with TRAF6, a key adaptor molecule in the TNF-α signaling pathway. 3. **NF-κB:** TNFRSF25 activates the non-canonical NF-κB pathway, which regulates gene expression and immune responses. **Clinical Significance:** TNFRSF25's involvement in immune regulation and cellular homeostasis makes it a potential target for the treatment of various diseases, including: 1. **Autoimmune disorders:** TNFRSF25's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** TNFRSF25's involvement in apoptosis and immune regulation may influence cancer development and progression. 3. **Neurological disorders:** TNFRSF25's expression in neurons and its role in signaling pathways may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TNFRSF25 is a multifaceted gene with significant implications for immune regulation, cellular homeostasis, and disease pathogenesis. Further research is needed to fully elucidate its functions and potential therapeutic applications.

Genular Protein ID: 3306284114

Symbol: TNR25_HUMAN

Name: Tumor necrosis factor receptor superfamily member 25

UniProtKB Accession Codes:

Q93038 B1ALX2 B1ALX3 B7ZLL7 O00275 O00276 O00277 O00278 O00279 O00280 O14865 O14866 P78507 P78515 Q17RU4 Q92983 Q93036 Q93037 Q99722 Q99830 Q99831 Q9BY86 Q9UME0 Q9UME1 Q9UME5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 32 Ensembl 10 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8934525

Title: A death-domain-containing receptor that mediates apoptosis.

PubMed ID: 8934525

DOI: 10.1038/384372a0

PubMed ID: 8875942

Title: Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.

PubMed ID: 8875942

DOI: 10.1126/science.274.5289.990

PubMed ID: 8994832

Title: Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa-B.

PubMed ID: 8994832

DOI: 10.1016/s0960-9822(02)70791-4

PubMed ID: 9114039

Title: LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.

PubMed ID: 9114039

DOI: 10.1073/pnas.94.9.4615

PubMed ID: 9446802

Title: A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas.

PubMed ID: 9446802

DOI: 10.1006/bbrc.1997.7948

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9052839

Title: TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

PubMed ID: 9052839

DOI: 10.1016/s1074-7613(00)80244-7

PubMed ID: 9915703

Title: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains.

PubMed ID: 9915703

DOI: 10.1126/science.283.5401.543

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 30979585

Title: Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector.

PubMed ID: 30979585

DOI: 10.1016/j.molcel.2019.03.028

Sequence Information:

  • Length: 417
  • Mass: 45385
  • Checksum: 5226319DFDB46706
  • Sequence:
    • MEQRPRGCAA VAAALLLVLL GARAQGGTRS PRCDCAGDFH KKIGLFCCRG CPAGHYLKAP 
CTEPCGNSTC LVCPQDTFLA WENHHNSECA RCQACDEQAS QVALENCSAV ADTRCGCKPG 
WFVECQVSQC VSSSPFYCQP CLDCGALHRH TRLLCSRRDT DCGTCLPGFY EHGDGCVSCP 
TSTLGSCPER CAAVCGWRQM FWVQVLLAGL VVPLLLGATL TYTYRHCWPH KPLVTADEAG 
MEALTPPPAT HLSPLDSAHT LLAPPDSSEK ICTVQLVGNS WTPGYPETQE ALCPQVTWSW 
DQLPSRALGP AAAPTLSPES PAGSPAMMLQ PGPQLYDVMD AVPARRWKEF VRTLGLREAE 
IEAVEVEIGR FRDQQYEMLK RWRQQQPAGL GAVYAALERM GLDGCVEDLR SRLQRGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.