Details for: ADAM9
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 335.4651
Cell Significance Index: -52.1800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 205.9979
Cell Significance Index: -52.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 118.6980
Cell Significance Index: -56.0400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 105.1797
Cell Significance Index: -42.7300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 99.1864
Cell Significance Index: -51.0200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 83.9019
Cell Significance Index: -56.3000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 44.7660
Cell Significance Index: -42.7400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 42.5806
Cell Significance Index: -52.5000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.9077
Cell Significance Index: -53.3300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.3526
Cell Significance Index: -52.6900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.3733
Cell Significance Index: -27.0800 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 3.6367
Cell Significance Index: 29.6600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.1883
Cell Significance Index: 58.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.0915
Cell Significance Index: 160.5000 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.7417
Cell Significance Index: 27.9400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5422
Cell Significance Index: 309.3700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.2536
Cell Significance Index: 27.1600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2120
Cell Significance Index: 32.9900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0020
Cell Significance Index: 359.4200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9860
Cell Significance Index: 538.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8943
Cell Significance Index: 177.4800 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.8385
Cell Significance Index: 5.2100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8044
Cell Significance Index: 41.7900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7290
Cell Significance Index: 21.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7100
Cell Significance Index: 32.1800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6643
Cell Significance Index: 81.6800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6513
Cell Significance Index: 64.4300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.6279
Cell Significance Index: 31.7300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5365
Cell Significance Index: 96.7200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.3748
Cell Significance Index: 42.9400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3605
Cell Significance Index: 249.3100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3356
Cell Significance Index: 18.8300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2812
Cell Significance Index: 518.5200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2594
Cell Significance Index: 488.4700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2512
Cell Significance Index: 34.4900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2012
Cell Significance Index: 273.5600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1662
Cell Significance Index: 255.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1407
Cell Significance Index: 89.3300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1042
Cell Significance Index: 47.2800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0777
Cell Significance Index: 2.7300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0607
Cell Significance Index: 2.8300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0581
Cell Significance Index: 0.9900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0439
Cell Significance Index: 19.4300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0386
Cell Significance Index: 0.5700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0321
Cell Significance Index: 29.0200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0025
Cell Significance Index: -0.4800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0074
Cell Significance Index: -1.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0083
Cell Significance Index: -1.3500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0307
Cell Significance Index: -2.2900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0325
Cell Significance Index: -24.0900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0372
Cell Significance Index: -28.1900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0427
Cell Significance Index: -31.3200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0496
Cell Significance Index: -27.9800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0497
Cell Significance Index: -0.3000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0549
Cell Significance Index: -7.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0591
Cell Significance Index: -36.9000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0646
Cell Significance Index: -3.0400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0908
Cell Significance Index: -9.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1113
Cell Significance Index: -3.1100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1194
Cell Significance Index: -3.0700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1308
Cell Significance Index: -27.5500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1332
Cell Significance Index: -15.5200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1487
Cell Significance Index: -21.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1521
Cell Significance Index: -43.7500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1910
Cell Significance Index: -24.4800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2366
Cell Significance Index: -27.0100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3117
Cell Significance Index: -2.8700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3533
Cell Significance Index: -4.8200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3711
Cell Significance Index: -23.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3961
Cell Significance Index: -7.7300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3994
Cell Significance Index: -41.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4027
Cell Significance Index: -47.4900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4416
Cell Significance Index: -19.5400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4479
Cell Significance Index: -23.3300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4652
Cell Significance Index: -12.4700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4927
Cell Significance Index: -13.1800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4962
Cell Significance Index: -35.0900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5559
Cell Significance Index: -29.1900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5798
Cell Significance Index: -18.5700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5799
Cell Significance Index: -45.9300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5800
Cell Significance Index: -14.5000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6304
Cell Significance Index: -23.8700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6501
Cell Significance Index: -7.7500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.6536
Cell Significance Index: -9.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6632
Cell Significance Index: -11.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7159
Cell Significance Index: -43.8900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7552
Cell Significance Index: -48.7200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.8325
Cell Significance Index: -17.8000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.8436
Cell Significance Index: -12.6400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9002
Cell Significance Index: -28.6700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9041
Cell Significance Index: -29.6000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9164
Cell Significance Index: -26.2700 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.9166
Cell Significance Index: -13.9500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9222
Cell Significance Index: -32.3100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.9447
Cell Significance Index: -38.7100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.0573
Cell Significance Index: -22.4400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1118
Cell Significance Index: -40.8200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1189
Cell Significance Index: -38.8800 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -1.1689
Cell Significance Index: -9.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.1692
Cell Significance Index: -24.9000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2745166257
Symbol: ADAM9_HUMAN
Name: Disintegrin and metalloproteinase domain-containing protein 9
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8647900
Title: MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
PubMed ID: 8647900
PubMed ID: 8809033
Title: Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.
PubMed ID: 8809033
DOI: 10.1042/bj3180459
PubMed ID: 12054541
Title: A secreted form of human ADAM9 has an alpha-secretase activity for APP.
PubMed ID: 12054541
PubMed ID: 7584026
Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
PubMed ID: 7584026
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9016778
Title: Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.
PubMed ID: 9016778
PubMed ID: 10531379
Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
PubMed ID: 10531379
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19409519
Title: Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice.
PubMed ID: 19409519
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 819
- Mass: 90556
- Checksum: BC186641833137FF
- Sequence:
MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.