Details for: ADAM9

Gene ID: 8754

Symbol: ADAM9

Ensembl ID: ENSG00000168615

Description: ADAM metallopeptidase domain 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.4651
    Cell Significance Index: -52.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 205.9979
    Cell Significance Index: -52.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.6980
    Cell Significance Index: -56.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.1797
    Cell Significance Index: -42.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 99.1864
    Cell Significance Index: -51.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.9019
    Cell Significance Index: -56.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7660
    Cell Significance Index: -42.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.5806
    Cell Significance Index: -52.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9077
    Cell Significance Index: -53.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3526
    Cell Significance Index: -52.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3733
    Cell Significance Index: -27.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 3.6367
    Cell Significance Index: 29.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1883
    Cell Significance Index: 58.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.0915
    Cell Significance Index: 160.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7417
    Cell Significance Index: 27.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5422
    Cell Significance Index: 309.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2536
    Cell Significance Index: 27.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2120
    Cell Significance Index: 32.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0020
    Cell Significance Index: 359.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9860
    Cell Significance Index: 538.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8943
    Cell Significance Index: 177.4800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8385
    Cell Significance Index: 5.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8044
    Cell Significance Index: 41.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7290
    Cell Significance Index: 21.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7100
    Cell Significance Index: 32.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6643
    Cell Significance Index: 81.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6513
    Cell Significance Index: 64.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6279
    Cell Significance Index: 31.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5365
    Cell Significance Index: 96.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3748
    Cell Significance Index: 42.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3605
    Cell Significance Index: 249.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3356
    Cell Significance Index: 18.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2812
    Cell Significance Index: 518.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2594
    Cell Significance Index: 488.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2512
    Cell Significance Index: 34.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2012
    Cell Significance Index: 273.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1662
    Cell Significance Index: 255.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1407
    Cell Significance Index: 89.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1042
    Cell Significance Index: 47.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0607
    Cell Significance Index: 2.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0581
    Cell Significance Index: 0.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0439
    Cell Significance Index: 19.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0386
    Cell Significance Index: 0.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0321
    Cell Significance Index: 29.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0025
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0083
    Cell Significance Index: -1.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0307
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0325
    Cell Significance Index: -24.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0372
    Cell Significance Index: -28.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0427
    Cell Significance Index: -31.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0496
    Cell Significance Index: -27.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0497
    Cell Significance Index: -0.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0549
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0591
    Cell Significance Index: -36.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0646
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0908
    Cell Significance Index: -9.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1113
    Cell Significance Index: -3.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1194
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1308
    Cell Significance Index: -27.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1332
    Cell Significance Index: -15.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1487
    Cell Significance Index: -21.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1521
    Cell Significance Index: -43.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1910
    Cell Significance Index: -24.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2366
    Cell Significance Index: -27.0100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3117
    Cell Significance Index: -2.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3533
    Cell Significance Index: -4.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3711
    Cell Significance Index: -23.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3961
    Cell Significance Index: -7.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3994
    Cell Significance Index: -41.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4027
    Cell Significance Index: -47.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4416
    Cell Significance Index: -19.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4479
    Cell Significance Index: -23.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4652
    Cell Significance Index: -12.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4927
    Cell Significance Index: -13.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4962
    Cell Significance Index: -35.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5559
    Cell Significance Index: -29.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5798
    Cell Significance Index: -18.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5799
    Cell Significance Index: -45.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5800
    Cell Significance Index: -14.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6304
    Cell Significance Index: -23.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6501
    Cell Significance Index: -7.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6536
    Cell Significance Index: -9.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6632
    Cell Significance Index: -11.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7159
    Cell Significance Index: -43.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7552
    Cell Significance Index: -48.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8325
    Cell Significance Index: -17.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8436
    Cell Significance Index: -12.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9002
    Cell Significance Index: -28.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9041
    Cell Significance Index: -29.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9164
    Cell Significance Index: -26.2700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9166
    Cell Significance Index: -13.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9222
    Cell Significance Index: -32.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9447
    Cell Significance Index: -38.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0573
    Cell Significance Index: -22.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1118
    Cell Significance Index: -40.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1189
    Cell Significance Index: -38.8800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.1689
    Cell Significance Index: -9.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1692
    Cell Significance Index: -24.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface localization**: ADAM9 is a transmembrane protein with a disintegrin domain, which mediates cell-cell and cell-extracellular matrix interactions. 2. **Metalloprotease activity**: ADAM9 possesses metalloprotease activity, which allows it to cleave and regulate the structure of various extracellular matrix proteins. 3. **Integrin binding**: ADAM9 binds to integrins, which are cell surface receptors that facilitate cell adhesion and signaling. 4. **Diverse ligands**: ADAM9 interacts with a range of ligands, including laminin, collagen, and proteoglycans, which are essential components of the extracellular matrix. **Pathways and Functions:** 1. **Cell adhesion and migration**: ADAM9 regulates cell adhesion and migration by cleaving and modulating the structure of extracellular matrix proteins, such as laminin and collagen. 2. **Extracellular matrix organization**: ADAM9 plays a crucial role in maintaining the organization and structure of the extracellular matrix, which is essential for tissue development and homeostasis. 3. **Cell signaling**: ADAM9 interacts with integrins and other cell surface receptors to regulate cell signaling pathways, including the MAPK and PI3K/Akt pathways. 4. **Immune cell regulation**: ADAM9 is expressed on the surface of immune cells, including macrophages and monocytes, and regulates their activation and migration. **Clinical Significance:** 1. **Cancer**: ADAM9 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 2. **Fibrosis**: ADAM9 has been shown to contribute to the development of fibrosis in diseases such as pulmonary fibrosis and liver fibrosis. 3. **Autoimmune disorders**: ADAM9 has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 4. **Wound healing**: ADAM9 plays a crucial role in wound healing, as it regulates the migration and proliferation of fibroblasts and other cells involved in tissue repair. In conclusion, ADAM9 is a multifaceted gene that plays a critical role in regulating cell adhesion, migration, and the extracellular matrix. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ADAM9 and its potential therapeutic applications.

Genular Protein ID: 2745166257

Symbol: ADAM9_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8647900

Title: MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

PubMed ID: 8647900

DOI: 10.1083/jcb.132.4.717

PubMed ID: 8809033

Title: Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.

PubMed ID: 8809033

DOI: 10.1042/bj3180459

PubMed ID: 12054541

Title: A secreted form of human ADAM9 has an alpha-secretase activity for APP.

PubMed ID: 12054541

DOI: 10.1016/s0006-291x(02)00302-9

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9016778

Title: Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.

PubMed ID: 9016778

DOI: 10.1006/bbrc.1996.5957

PubMed ID: 10531379

Title: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.

PubMed ID: 10531379

DOI: 10.1074/jbc.274.44.31693

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19409519

Title: Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice.

PubMed ID: 19409519

DOI: 10.1016/j.ajhg.2009.04.005

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 819
  • Mass: 90556
  • Checksum: BC186641833137FF
  • Sequence:
  • MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR 
    PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV 
    EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK 
    DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI 
    LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS 
    AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG 
    RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK 
    LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC 
    DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF 
    IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC 
    WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK 
    NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR 
    DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA 
    KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.