Details for: ABCA10

Gene ID: 10349

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ABCA10

Ensembl ID: ENSG00000154263

Description: ATP binding cassette subfamily A member 10

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 11.29
    rCSI 14.04%
    PRS 75.62
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 9.75
    rCSI 36.86%
    PRS 77.97
  • retinal ganglion cell CL0000740
    CSI 8.97
    rCSI 19.82%
    PRS 80.19
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 8.01
    rCSI 28.83%
    PRS 75.75
  • keratocyte CL0002363
    CSI 7.45
    rCSI 17.92%
    PRS 91.72
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 7.44
    rCSI 18.09%
    PRS 75.57
  • fibroblast of cardiac tissue CL0002548
    CSI 7.33
    rCSI 35.11%
    PRS 91.26
  • adipocyte CL0000136
    CSI 7.3
    rCSI 9.38%
    PRS 82.55
  • sst GABAergic cortical interneuron CL4023017
    CSI 7.22
    rCSI 9.31%
    PRS 78.87
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 7.18
    rCSI 12.05%
    PRS 77.79
  • retinal bipolar neuron CL0000748
    CSI 7.03
    rCSI 13.17%
    PRS 82.29
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 6.83
    rCSI 21.36%
    PRS 80.78
  • parietal epithelial cell CL1000452
    CSI 6.5
    rCSI 17.37%
    PRS 85.39
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 6.49
    rCSI 11.46%
    PRS 77.18
  • glutamatergic neuron CL0000679
    CSI 6.4
    rCSI 13.15%
    PRS 79.09
  • mesothelial cell CL0000077
    CSI 6.35
    rCSI 24.85%
    PRS 73.95
  • adventitial cell CL0002503
    CSI 6.29
    rCSI 15.02%
    PRS 92.66
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.15
    rCSI 6.73%
    PRS 91.96
  • inhibitory interneuron CL0000498
    CSI 5.78
    rCSI 13.34%
    PRS 81.52
  • Schwann cell CL0002573
    CSI 5.62
    rCSI 15.96%
    PRS 87.11
  • hepatic stellate cell CL0000632
    CSI 5.44
    rCSI 20.37%
    PRS 85.98
  • sncg GABAergic cortical interneuron CL4023015
    CSI 5.23
    rCSI 8.42%
    PRS 78.75
  • bronchus fibroblast of lung CL2000093
    CSI 5.11
    rCSI 4.15%
    PRS 89.82
  • VIP GABAergic cortical interneuron CL4023016
    CSI 5.1
    rCSI 6.09%
    PRS 77.85
  • melanocyte CL0000148
    CSI 4.99
    rCSI 3.7%
    PRS 86.97
  • epicardial adipocyte CL1000309
    CSI 4.82
    rCSI 15.69%
    PRS 87.88
  • GABAergic neuron CL0000617
    CSI 4.81
    rCSI 16.11%
    PRS 77.35
  • myofibroblast cell CL0000186
    CSI 4.74
    rCSI 6.57%
    PRS 87.39
  • chondrocyte CL0000138
    CSI 4.49
    rCSI 7.14%
    PRS 85.86
  • subcutaneous adipocyte CL0002521
    CSI 4.44
    rCSI 22.74%
    PRS 92.24
  • vascular leptomeningeal cell CL4023051
    CSI 4.26
    rCSI 7.47%
    PRS 86.93
  • neuron CL0000540
    CSI 4.07
    rCSI 10.84%
    PRS 78.77
  • innate lymphoid cell CL0001065
    CSI 3.98
    rCSI 8.22%
    PRS 84.97
  • renal beta-intercalated cell CL0002201
    CSI 3.82
    rCSI 9.11%
    PRS 90.65
  • skin fibroblast CL0002620
    CSI 3.77
    rCSI 3.25%
    PRS 90.05
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.72
    rCSI 21.44%
    PRS 87.64
  • cerebral cortex endothelial cell CL1001602
    CSI 3.64
    rCSI 6.3%
    PRS 85.25
  • retinal pigment epithelial cell CL0002586
    CSI 3.48
    rCSI 6.91%
    PRS 87.19
  • ON parasol ganglion cell CL4033052
    CSI 3.38
    rCSI 47.94%
    PRS 83.39
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.37
    rCSI 8.54%
    PRS 84.46
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 3.3
    rCSI 19.43%
    PRS 78.22
  • fibroblast of lung CL0002553
    CSI 3.27
    rCSI 3.05%
    PRS 91.75
  • cardiac neuron CL0010022
    CSI 3.25
    rCSI 10.39%
    PRS 89.27
  • central nervous system neuron CL2000029
    CSI 3.17
    rCSI 23.32%
    PRS 82.38
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.15
    rCSI 8.15%
    PRS 87.82
  • melanocyte of skin CL1000458
    CSI 3.1
    rCSI 4.22%
    PRS 61.53
  • small intestine goblet cell CL1000495
    CSI 2.91
    rCSI 6.38%
    PRS 92.79
  • basal cell of epidermis CL0002187
    CSI 2.88
    rCSI 5.11%
    PRS 61.98
  • cerebellar granule cell CL0001031
    CSI 2.7
    rCSI 3.97%
    PRS 85.51
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 2.66
    rCSI 6.36%
    PRS 80.46
  • choroid plexus epithelial cell CL0000706
    CSI 2.65
    rCSI 4.34%
    PRS 83.66
  • amacrine cell CL0000561
    CSI 2.57
    rCSI 7.45%
    PRS 82.24
  • retinal cone cell CL0000573
    CSI 2.57
    rCSI 4.14%
    PRS 82.9
  • ON midget ganglion cell CL4033046
    CSI 2.45
    rCSI 49.95%
    PRS 82.24
  • OFF midget ganglion cell CL4033047
    CSI 2.41
    rCSI 48.99%
    PRS 82.99
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.39
    rCSI 7.45%
    PRS 79.08
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 2.3
    rCSI 4.98%
    PRS 79.58
  • Mueller cell CL0000636
    CSI 2.29
    rCSI 5.21%
    PRS 84.12
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 2.1
    rCSI 6.89%
    PRS 79.28
  • hepatocyte CL0000182
    CSI 2.09
    rCSI 3.74%
    PRS 89.21
  • enteroendocrine cell of small intestine CL0009006
    CSI 2.03
    rCSI 4.46%
    PRS 93.42
  • lung secretory cell CL1000272
    CSI 2.03
    rCSI 5.01%
    PRS 91.16
  • fibroblast of breast CL4006000
    CSI 1.87
    rCSI 7.85%
    PRS 92.22
  • suprabasal keratinocyte CL4033013
    CSI 1.85
    rCSI 3.03%
    PRS 61.67
  • stromal cell of ovary CL0002132
    CSI 1.81
    rCSI 4.98%
    PRS 93.37
  • alveolar adventitial fibroblast CL4028006
    CSI 1.79
    rCSI 2.83%
    PRS 91.32
  • renal interstitial pericyte CL1001318
    CSI 1.6
    rCSI 4.4%
    PRS 87.93
  • epithelial cell of proximal tubule CL0002306
    CSI 1.53
    rCSI 3.73%
    PRS 84.16
  • stromal cell CL0000499
    CSI 1.46
    rCSI 4.12%
    PRS 86.57
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.22
    rCSI 1.47%
    PRS 71.65
  • direct pathway medium spiny neuron CL4023026
    CSI 1.21
    rCSI 28.89%
    PRS 75.57
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.04
    rCSI 25.16%
    PRS 75.71
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.69
    rCSI 7.29%
    PRS 86.73
  • blood vessel smooth muscle cell CL0019018
    CSI 0.69
    rCSI 5.57%
    PRS 87.86
  • mesenchymal cell CL0008019
    CSI 0.63
    rCSI 1.61%
    PRS 85.45
  • mesenchymal stem cell CL0000134
    CSI 0.21
    rCSI 2.31%
    PRS 92.21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ABCA10](/details-gene/10349) is a protein-coding gene located on chromosome 17q24.3 that encodes a member of the ATP-binding cassette (ABC) transporter superfamily. As an ABC transporter, its primary function involves ATP-dependent transport of molecules across cellular membranes. Functional annotations strongly implicate [ABCA10](/details-gene/10349) in [Lipid transport](/details-go/GO:0006869) and lipid homeostasis, with one study describing it as a cholesterol-regulated transporter ([Link](https://doi.org/10.1016/s0006-291x(03)01097-0)). **Overall**, expression data reveals its highest significance in a diverse range of neuronal subtypes, including [GABAergic cortical interneurons](/details-cell/CL4023018) and [glutamatergic cortical neurons](/details-cell/CL4023012), as well as in other specialized cells such as [retinal ganglion cells](/details-cell/CL0000740), [keratocytes](/details-cell/CL0002363), and [adipocytes](/details-cell/CL0000136), suggesting a crucial role in maintaining lipid balance in structurally complex or metabolically active tissues. ## Cellular Roles and Expression Landscape The expression profile of [ABCA10](/details-gene/10349) highlights its prominent role in the central nervous system. The gene shows exceptionally high significance in numerous, functionally distinct neuronal populations. It is a top marker in both inhibitory interneurons, such as [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 11.29) and [sst GABAergic cortical interneuron](/details-cell/CL4023017), and excitatory neurons, including [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012) (CSI: 9.75) and [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041). Its high significance extends to specialized neurons of the visual system, including [retinal ganglion cell](/details-cell/CL0000740) and [retinal bipolar neuron](/details-cell/CL0000748). Beyond the nervous system, [ABCA10](/details-gene/10349) is also significantly expressed in several other key cell types. Its high CSI in [adipocytes](/details-cell/CL0000136) is consistent with its function in lipid metabolism. Furthermore, it is a significant marker in structural cells like [keratocytes](/details-cell/CL0002363) in the cornea and [fibroblast of cardiac tissue](/details-cell/CL0002548). This diverse expression pattern suggests that [ABCA10](/details-gene/10349) may be involved in a fundamental cellular process of lipid management required by cells with extensive membrane systems, high metabolic activity, or specialized lipid-dependent functions. ## Pathways and Molecular Function The molecular function of [ABCA10](/details-gene/10349) is centered on its identity as an ABC transporter. Gene Ontology annotations specify its involvement in [Atp binding](/details-go/GO:0005524), [Atp hydrolysis activity](/details-go/GO:0016887), and [Atpase-coupled transmembrane transporter activity](/details-go/GO:0042626). These functions are directed towards its role in [Lipid transporter activity](/details-go/GO:0005319). Reactome pathway analysis places [ABCA10](/details-gene/10349) squarely within the context of lipid and small molecule transport. It is a component of the [Abc transporters in lipid homeostasis](/details-reactome/R-HSA-1369062) pathway, which reinforces its role in managing cellular lipid content. This function is further generalized under the broader pathways of [Abc-family proteins mediated transport](/details-reactome/R-HSA-382556) and [Transport of small molecules](/details-reactome/R-HSA-382551). This biochemical activity provides a clear molecular basis for its high expression in lipid-rich cells like neurons and adipocytes, which require strict regulation of their lipid environments for proper function. ## Research Directions The widespread and high-level expression of [ABCA10](/details-gene/10349) in diverse neuronal populations, coupled with its established role in lipid transport, suggests it is critical for neural health and function. Its dysregulation could plausibly contribute to neurological or metabolic disorders characterized by lipid dyshomeostasis. ### Proposed Hypotheses: 1. **[ABCA10](/details-gene/10349) is essential for maintaining the specific phospholipid and cholesterol composition of neuronal plasma membranes, and its deficiency leads to impaired synaptic transmission and plasticity.** The complex morphology and high metabolic rate of neurons demand robust lipid trafficking to support synaptic vesicles, axonal transport, and membrane potential. 2. **In [adipocytes](/details-cell/CL0000136), [ABCA10](/details-gene/10349) mediates the efflux of specific lipid species, thereby regulating adipocyte size, insulin sensitivity, and systemic lipid levels.** Its function could be a key node in the development of metabolic syndrome or type 2 diabetes. 3. **The high expression of [ABCA10](/details-gene/10349) in [keratocytes](/details-cell/CL0002363) is necessary for transporting lipids that contribute to the maintenance of corneal avascularity and transparency.** ### Experimental Approach: To test the hypothesis regarding the neurological role of [ABCA10](/details-gene/10349), a conditional knockout mouse model could be generated using a Cre-loxP system with a neuron-specific Cre driver (e.g., *Syn1*-Cre). A comprehensive analysis would involve: - **Lipidomics:** Perform mass spectrometry-based lipidomics on isolated cortical neurons and synaptosomes from knockout and wild-type mice to identify specific changes in membrane lipid composition. - **Electrophysiology:** Use patch-clamp recordings from hippocampal or cortical slices to assess key parameters of synaptic function, such as synaptic vesicle release probability, long-term potentiation (LTP), and long-term depression (LTD). - **Behavioral Analysis:** Subject the knockout mice to a battery of behavioral tests to evaluate cognitive functions, including learning, memory, and motor coordination. ### Therapeutic Potential: Given its role as a transmembrane transporter, [ABCA10](/details-gene/10349) is a druggable target. If its dysfunction is linked to neurodegenerative diseases associated with lipid accumulation (e.g., certain lysosomal storage disorders or aspects of Alzheimer's disease), small molecule activators could be developed to enhance its transport activity and clear toxic lipid species. Conversely, in the context of metabolic disease, where excess lipid transport might be detrimental, specific inhibitors could be explored. The broad expression of [ABCA10](/details-gene/10349) in the central nervous system suggests that any therapeutic intervention would need to be carefully designed to avoid widespread off-target neurological effects.

Genular Protein ID: 3283919624

Symbol: ABCAA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WWZ4 C9JZH2 C9K035 Q6PIQ6 Q7Z2I9 Q7Z7P7 Q86TD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 43 Ensembl 4 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12821155

Title: ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter.

PubMed ID: 12821155

DOI: 10.1016/s0006-291x(03)01097-0

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1543
  • Mass: 175790
  • Checksum: 47E932434314B538
  • Sequence:
    • MNKMALASFM KGRTVIGTPD EETMDIELPK KYHEMVGVIF SDTFSYRLKF NWGYRIPVIK 
EHSEYTEHCW AMHGEIFCYL AKYWLKGFVA FQAAINAAII EVTTNHSVME ELTSVIGINM 
KIPPFISKGE IMNEWFHFTC LVSFSSFIYF ASLNVARERG KFKKLMTVMG LRESAFWLSW 
GLTYICFIFI MSIFMALVIT SIPIVFHTGF MVIFTLYSLY GLSLIALAFL MSVLIRKPML 
AGLAGFLFTV FWGCLGFTVL YRQLPLSLGW VLSLLSPFAF TAGMAQITHL DNYLSGVIFP 
DPSGDSYKMI ATFFILAFDT LFYLIFTLYF ERVLPDKDGH GDSPLFFLKS SFWSKHQNTH 
HEIFENEINP EHSSDDSFEP VSPEFHGKEA IRIRNVIKEY NGKTGKVEAL QGIFFDIYEG 
QITAILGHNG AGKSTLLNIL SGLSVSTEGS ATIYNTQLSE ITDMEEIRKN IGFCPQFNFQ 
FDFLTVRENL RVFAKIKGIQ PKEVEQEVKR IIMELDMQSI QDIIAKKLSG GQKRKLTLGI 
AILGDPQVLL LDEPTAGLDP FSRHRVWSLL KEHKVDRLIL FSTQFMDEAD ILADRKVFLS 
NGKLKCAGSS LFLKRKWGIG YHLSLHRNEM CDTEKITSLI KQHIPDAKLT TESEEKLVYS 
LPLEKTNKFP DLYSDLDKCS DQGIRNYAVS VTSLNEVFLN LEGKSAIDEP DFDIGKQEKI 
HVTRNTGDES EMEQVLCSLP ETRKAVSSAA LWRRQIYAVA TLRFLKLRRE RRALLCLLLV 
LGIAFIPIIL EKIMYKVTRE THCWEFSPSM YFLSLEQIPK TPLTSLLIVN NTGSNIEDLV 
HSLKCQDIVL EIDDFRNRNG SDDPSYNGAI IVSGDQKDYR FSVACNTKKL NCFPVLMGIV 
SNALMGIFNF TELIQMESTS FSRDDIVLDL GFIDGSIFLL LITNCVSPFI GMSSISDYKK 
NVQSQLWISG LWPSAYWCGQ ALVDIPLYFL ILFSIHLIYY FIFLGFQLSW ELMFVLVVCI 
IGCAVSLIFL TYVLSFIFRK WRKNNGFWSF GFFIILICVS TIMVSTQYEK LNLILCMIFI 
PSFTLLGYVM LLIQLDFMRN LDSLDNRINE VNKTILLTTL IPYLQSVIFL FVIRCLEMKY 
GNEIMNKDPV FRISPRSRET HPNPEEPEEE DEDVQAERVQ AANALTAPNL EEEPVITASC 
LHKEYYETKK SCFSTRKKKI AIRNVSFCVK KGEVLGLLGH NGAGKSTSIK MITGCTKPTA 
GVVVLQGSRA SVRQQHDNSL KFLGYCPQEN SLWPKLTMKE HLELYAAVKG LGKEDAALSI 
SRLVEALKLQ EQLKAPVKTL SEGIKRKLCF VLSILGNPSV VLLDEPFTGM DPEGQQQMWQ 
ILQATVKNKE RGTLLTTHYM SEAEAVCDRM AMMVSGTLRC IGSIQHLKNK FGRDYLLEIK 
MKEPTQVEAL HTEILKLFPQ AAWQERYSSL MAYKLPVEDV HPLSRAFFKL EAMKQTFNLE 
EYSLSQATLE QVFLELCKEQ ELGNVDDKID TTVEWKLLPQ EDP