Details for: KCNU1

Gene ID: 157855

Symbol: KCNU1

Ensembl ID: ENSG00000215262

Description: potassium calcium-activated channel subfamily U member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.2959
    Cell Significance Index: 55.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2253
    Cell Significance Index: 29.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7505
    Cell Significance Index: 148.9400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3455
    Cell Significance Index: 4.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1891
    Cell Significance Index: 3.2400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1646
    Cell Significance Index: 1.8600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0705
    Cell Significance Index: 1.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0601
    Cell Significance Index: 1.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0510
    Cell Significance Index: 0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0205
    Cell Significance Index: 0.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0129
    Cell Significance Index: 8.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0102
    Cell Significance Index: 2.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0091
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0070
    Cell Significance Index: 2.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0053
    Cell Significance Index: 0.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0048
    Cell Significance Index: 2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0044
    Cell Significance Index: 0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0008
    Cell Significance Index: 1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0016
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0018
    Cell Significance Index: -0.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0027
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0029
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0087
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0137
    Cell Significance Index: -1.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0165
    Cell Significance Index: -1.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0247
    Cell Significance Index: -1.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0254
    Cell Significance Index: -1.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0267
    Cell Significance Index: -1.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0294
    Cell Significance Index: -0.9300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0297
    Cell Significance Index: -0.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0303
    Cell Significance Index: -1.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0305
    Cell Significance Index: -1.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0313
    Cell Significance Index: -1.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0330
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0333
    Cell Significance Index: -1.0900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0345
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0347
    Cell Significance Index: -1.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0353
    Cell Significance Index: -1.6000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0369
    Cell Significance Index: -0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0376
    Cell Significance Index: -1.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0384
    Cell Significance Index: -1.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0386
    Cell Significance Index: -0.4000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0390
    Cell Significance Index: -0.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0392
    Cell Significance Index: -2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0403
    Cell Significance Index: -1.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0417
    Cell Significance Index: -1.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0433
    Cell Significance Index: -1.0800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0446
    Cell Significance Index: -0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0448
    Cell Significance Index: -0.9500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0462
    Cell Significance Index: -0.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0464
    Cell Significance Index: -1.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0464
    Cell Significance Index: -1.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0467
    Cell Significance Index: -1.0100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0474
    Cell Significance Index: -0.6400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0546
    Cell Significance Index: -1.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0546
    Cell Significance Index: -1.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0548
    Cell Significance Index: -1.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0551
    Cell Significance Index: -0.6700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0554
    Cell Significance Index: -0.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0565
    Cell Significance Index: -1.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0576
    Cell Significance Index: -0.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0582
    Cell Significance Index: -1.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0583
    Cell Significance Index: -1.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0594
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0595
    Cell Significance Index: -1.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0603
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0613
    Cell Significance Index: -1.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0618
    Cell Significance Index: -0.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0619
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0648
    Cell Significance Index: -1.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0648
    Cell Significance Index: -1.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0652
    Cell Significance Index: -0.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0662
    Cell Significance Index: -1.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0670
    Cell Significance Index: -1.3100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0671
    Cell Significance Index: -0.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0677
    Cell Significance Index: -0.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0682
    Cell Significance Index: -1.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0691
    Cell Significance Index: -1.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0695
    Cell Significance Index: -1.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0704
    Cell Significance Index: -1.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0710
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0719
    Cell Significance Index: -2.0600
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0728
    Cell Significance Index: -0.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0765
    Cell Significance Index: -0.9900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0773
    Cell Significance Index: -1.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0776
    Cell Significance Index: -1.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0787
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Channel Subfamily U Member 1:** KCNU1 belongs to the potassium calcium-activated channel subfamily U, which is characterized by its ability to respond to calcium ions and regulate potassium ion channels. 2. **Large Conductance:** KCNU1 channels have a large conductance, allowing for the efficient movement of potassium ions across the cell membrane. 3. **Calcium-Activated:** The channels are activated by calcium ions, which play a crucial role in various cellular signaling pathways. 4. **Multiple Cell Types:** KCNU1 is expressed in a wide range of cell types, including progenitor cells, cardiac endothelial cells, and GABAergic interneurons. **Pathways and Functions:** 1. **Fertilization and Sperm Motility:** KCNU1 channels play a crucial role in regulating sperm motility and fertilization. The channels help to modulate the electrical activity of sperm, allowing for optimal fertilization and development. 2. **Reproductive Process:** KCNU1 is involved in various reproductive processes, including ovulation, fertilization, and embryogenesis. 3. **Neurotransmission:** KCNU1 channels are expressed in GABAergic interneurons, where they regulate the electrical activity of these cells, influencing neurotransmission and synaptic plasticity. 4. **Cardiovascular Function:** KCNU1 channels are also expressed in cardiac endothelial cells, where they help to regulate blood pressure and vascular tone. **Clinical Significance:** 1. **Reproductive Disorders:** Dysregulation of KCNU1 channels has been implicated in various reproductive disorders, including infertility, premature birth, and miscarriage. 2. **Neurological Disorders:** KCNU1 channels have been linked to several neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 3. **Cardiovascular Disease:** KCNU1 channels may play a role in the development of cardiovascular disease, including hypertension and atherosclerosis. 4. **Cancer:** KCNU1 channels have been implicated in cancer progression and metastasis, highlighting the potential for therapeutic targeting of these channels in cancer treatment. In conclusion, KCNU1 is a critical gene that plays a pivotal role in various cellular processes, including fertilization, sperm motility, and reproductive processes. Its dysregulation has been implicated in various clinical disorders, including reproductive, neurological, and cardiovascular diseases. Further research is necessary to fully elucidate the function and clinical significance of KCNU1, but its importance as a therapeutic target is clear.

Genular Protein ID: 3650486648

Symbol: KCNU1_HUMAN

Name: Potassium channel subfamily U member 1

UniProtKB Accession Codes:

A8MYU2 B4DYE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 9452476

Title: Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes.

PubMed ID: 9452476

DOI: 10.1074/jbc.273.6.3509

PubMed ID: 23129643

Title: Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.

PubMed ID: 23129643

DOI: 10.1073/pnas.1215078109

PubMed ID: 24670955

Title: The Ca2+-activated K+ current of human sperm is mediated by Slo3.

PubMed ID: 24670955

DOI: 10.7554/elife.01438

PubMed ID: 36649421

Title: A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.

PubMed ID: 36649421

DOI: 10.1073/pnas.2212338120

PubMed ID: 38267364

Title: LRRC52 is likely a functional component of human KSper.

PubMed ID: 38267364

DOI: 10.1093/biolre/ioae004

PubMed ID: 35551387

Title: Bi-allelic variants in KCNU1 cause impaired acrosome reactions and male infertility.

PubMed ID: 35551387

DOI: 10.1093/humrep/deac102

PubMed ID: 34980136

Title: Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations.

PubMed ID: 34980136

DOI: 10.1186/s12958-021-00880-4

Sequence Information:

  • Length: 1149
  • Mass: 129543
  • Checksum: BA527F41498B6AA7
  • Sequence:
    • MFQTKLRNET WEDLPKMSCT TEIQAAFILS SFVTFFSGLI ILLIFRLIWR SVKKWQIIKG 
TGIILELFTS GTIARSHVRS LHFQGQFRDH IEMLLSAQTF VGQVLVILVF VLSIGSLIIY 
FINSADPVGS CSSYEDKTIP IDLVFNAFFS FYFGLRFMAA DDKIKFWLEM NSIVDIFTIP 
PTFISYYLKS NWLGLRFLRA LRLLELPQIL QILRAIKTSN SVKFSKLLSI ILSTWFTAAG 
FIHLVENSGD PWLKGRNSQN ISYFESIYLV MATTSTVGFG DVVAKTSLGR TFIMFFTLGS 
LILFANYIPE MVELFANKRK YTSSYEALKG KKFIVVCGNI TVDSVTAFLR NFLRDKSGEI 
NTEIVFLGET PPSLELETIF KCYLAYTTFI SGSAMKWEDL RRVAVESAEA CLIIANPLCS 
DSHAEDISNI MRVLSIKNYD STTRIIIQIL QSHNKVYLPK IPSWNWDTGD NIICFAELKL 
GFIAQGCLVP GLCTFLTSLF VEQNKKVMPK QTWKKHFLNS MKNKILTQRL SDDFAGMSFP 
EVARLCFLKM HLLLIAIEYK SLFTDGFCGL ILNPPPQVRI RKNTLGFFIA ETPKDVRRAL 
FYCSVCHDDV FIPELITNCG CKSRSRQHIT VPSVKRMKKC LKGISSRISG QDSPPRVSAS 
TSSISNFTTR TLQHDVEQDS DQLDSSGMFH WCKPTSLDKV TLKRTGKSKY KFRNHIVACV 
FGDAHSAPMG LRNFVMPLRA SNYTRKELKD IVFIGSLDYL QREWRFLWNF PQIYILPGCA 
LYSGDLHAAN IEQCSMCAVL SPPPQPSSNQ TLVDTEAIMA TLTIGSLQID SSSDPSPSVS 
EETPGYTNGH NEKSNCRKVP ILTELKNPSN IHFIEQLGGL EGSLQETNLH LSTAFSTGTV 
FSGSFLDSLL ATAFYNYHVL ELLQMLVTGG VSSQLEQHLD KDKVYGVADS CTSLLSGRNR 
CKLGLLSLHE TILSDVNPRN TFGQLFCGSL DLFGILCVGL YRIIDEEELN PENKRFVITR 
PANEFKLLPS DLVFCAIPFS TACYKRNEEF SLQKSYEIVN KASQTTETHS DTNCPPTIDS 
VTETLYSPVY SYQPRTNSLS FPKQIAWNQS RTNSIISSQI PLGDNAKENE RKTSDEVYDE 
DPFAYSEPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.