DAPK1 | ENSG00000196730 | NCBI 1612

Details for: DAPK1

Gene ID: 1612

Symbol: DAPK1

Ensembl ID: ENSG00000196730

Description: death associated protein kinase 1

Associated with

Apoptosis
(R-HSA-109581)
Caspase activation via dependence receptors in the absence of ligand
(R-HSA-418889)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Programmed cell death
(R-HSA-5357801)
Actin cytoskeleton
(GO:0015629)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Atp binding
(GO:0005524)
Calcium/calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cellular response to hydroperoxide
(GO:0071447)
Cellular response to type ii interferon
(GO:0071346)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dapk1-calmodulin complex
(GO:1990722)
Defense response to tumor cell
(GO:0002357)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Glutamatergic synapse
(GO:0098978)
Gtp binding
(GO:0005525)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of translation
(GO:0017148)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagic cell death
(GO:1904094)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Postsynaptic density
(GO:0014069)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of apoptotic process
(GO:0042981)
Regulation of autophagy
(GO:0010506)
Regulation of nmda receptor activity
(GO:2000310)
Regulation of response to tumor cell
(GO:0002834)
Syntaxin-1 binding
(GO:0017075)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.17
Cell Significance Index: 1
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.13
Cell Significance Index: 2
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: chandelier cell (CL4023083)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1
Cell Significance Index: 1
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: secretory cell (CL0000151)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** DAPK1 is a member of the protein kinase C (PKC) family and is characterized by its ability to phosphorylate and regulate various proteins involved in apoptosis, autophagy, and cellular stress response. DAPK1 is a cytoplasmic protein that is localized to the mitochondria and the endoplasmic reticulum, where it interacts with various proteins involved in apoptosis and autophagy. DAPK1 is also known to be involved in the regulation of the actin cytoskeleton and the regulation of the NMDA receptor activity. **Pathways and Functions:** DAPK1 is involved in several signaling pathways, including: 1. **Apoptotic signaling pathway**: DAPK1 is a key component of the apoptotic machinery and is involved in the regulation of caspase activation, mitochondrial outer membrane permeabilization, and the initiation of programmed cell death. 2. **Autophagy**: DAPK1 has been shown to regulate autophagy by interacting with autophagy-related proteins and modulating the activity of the autophagy-related kinase, mTOR. 3. **Stress response**: DAPK1 is involved in the cellular response to stress, including oxidative stress and endoplasmic reticulum stress. 4. **Actin cytoskeleton regulation**: DAPK1 regulates the actin cytoskeleton by interacting with actin-binding proteins and modulating the activity of the cytoskeleton. 5. **NMDA receptor activity**: DAPK1 regulates the activity of the NMDA receptor by interacting with the receptor and modulating its activity. **Clinical Significance:** DAPK1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. Abnormal expression of DAPK1 has been observed in several types of cancer, including breast, lung, and colon cancer. DAPK1 has also been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In addition, DAPK1 has been shown to play a role in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In summary, DAPK1 is a critical regulator of apoptosis, autophagy, and cellular stress response. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of DAPK1 in human disease and to explore its potential as a therapeutic target. **Significantly expressed cells:** DAPK1 is expressed in various cell types, including: * Epithelial cells of the lower respiratory tract * Anterior lens cells * Hepatoblasts * SST GABAergic cortical interneurons * Corneal endothelial cells * Cerebral cortex neurons * Astrocytes of the cerebral cortex * Purkinje cells * Renal principal cells * Chandelier Pvalb GABAergic cortical interneurons **Proteins:** DAPK1 is also known by the following protein names: * DAPK1_HUMAN (Death-associated protein kinase 1) * Q59H88_HUMAN * B4DHI4_HUMAN

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.