Details for: DAPK1

Gene ID: 1612

Symbol: DAPK1

Ensembl ID: ENSG00000196730

Description: death associated protein kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 323.4429
    Cell Significance Index: -50.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.2280
    Cell Significance Index: -45.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.6967
    Cell Significance Index: -39.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.1574
    Cell Significance Index: -46.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.5609
    Cell Significance Index: -39.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.8368
    Cell Significance Index: -50.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1089
    Cell Significance Index: -28.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7900
    Cell Significance Index: -50.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 4.7714
    Cell Significance Index: 114.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.3841
    Cell Significance Index: 294.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.2740
    Cell Significance Index: 262.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.2340
    Cell Significance Index: 187.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.9399
    Cell Significance Index: 149.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.4649
    Cell Significance Index: 194.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5919
    Cell Significance Index: 514.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5087
    Cell Significance Index: 71.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4132
    Cell Significance Index: 484.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1171
    Cell Significance Index: 402.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8583
    Cell Significance Index: 666.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7618
    Cell Significance Index: 1218.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3728
    Cell Significance Index: 30.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1921
    Cell Significance Index: 117.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1195
    Cell Significance Index: 1010.8500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.8185
    Cell Significance Index: 11.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7465
    Cell Significance Index: 38.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6169
    Cell Significance Index: 100.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5710
    Cell Significance Index: 11.1500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5545
    Cell Significance Index: 1.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4883
    Cell Significance Index: 900.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4265
    Cell Significance Index: 46.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3929
    Cell Significance Index: 11.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3688
    Cell Significance Index: 66.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3001
    Cell Significance Index: 163.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2696
    Cell Significance Index: 5.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1846
    Cell Significance Index: 284.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1646
    Cell Significance Index: 309.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1389
    Cell Significance Index: 4.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1303
    Cell Significance Index: 1.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1243
    Cell Significance Index: 8.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1001
    Cell Significance Index: 1.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0801
    Cell Significance Index: 50.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0750
    Cell Significance Index: 9.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0458
    Cell Significance Index: 2.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0079
    Cell Significance Index: 1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0029
    Cell Significance Index: 4.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0206
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0214
    Cell Significance Index: -13.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0243
    Cell Significance Index: -0.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0299
    Cell Significance Index: -13.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0335
    Cell Significance Index: -24.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0467
    Cell Significance Index: -35.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0599
    Cell Significance Index: -33.7800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0694
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0881
    Cell Significance Index: -39.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0896
    Cell Significance Index: -13.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1415
    Cell Significance Index: -40.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1642
    Cell Significance Index: -16.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1643
    Cell Significance Index: -34.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1737
    Cell Significance Index: -23.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2137
    Cell Significance Index: -3.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2169
    Cell Significance Index: -11.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2188
    Cell Significance Index: -25.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2265
    Cell Significance Index: -25.9500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2834
    Cell Significance Index: -3.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3312
    Cell Significance Index: -42.4600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3484
    Cell Significance Index: -5.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3649
    Cell Significance Index: -47.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3924
    Cell Significance Index: -44.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4104
    Cell Significance Index: -8.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4191
    Cell Significance Index: -49.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4309
    Cell Significance Index: -11.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4612
    Cell Significance Index: -48.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4934
    Cell Significance Index: -37.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4964
    Cell Significance Index: -9.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5246
    Cell Significance Index: -14.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5285
    Cell Significance Index: -4.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5293
    Cell Significance Index: -41.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5383
    Cell Significance Index: -7.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5701
    Cell Significance Index: -40.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6089
    Cell Significance Index: -15.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6116
    Cell Significance Index: -10.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6332
    Cell Significance Index: -47.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6374
    Cell Significance Index: -20.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6390
    Cell Significance Index: -41.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6471
    Cell Significance Index: -20.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6485
    Cell Significance Index: -13.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6917
    Cell Significance Index: -18.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7622
    Cell Significance Index: -11.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8142
    Cell Significance Index: -49.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8251
    Cell Significance Index: -43.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8255
    Cell Significance Index: -38.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8406
    Cell Significance Index: -52.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8908
    Cell Significance Index: -15.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9290
    Cell Significance Index: -19.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9400
    Cell Significance Index: -32.9300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9838
    Cell Significance Index: -42.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0134
    Cell Significance Index: -12.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0143
    Cell Significance Index: -21.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0289
    Cell Significance Index: -11.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DAPK1 is a member of the protein kinase C (PKC) family and is characterized by its ability to phosphorylate and regulate various proteins involved in apoptosis, autophagy, and cellular stress response. DAPK1 is a cytoplasmic protein that is localized to the mitochondria and the endoplasmic reticulum, where it interacts with various proteins involved in apoptosis and autophagy. DAPK1 is also known to be involved in the regulation of the actin cytoskeleton and the regulation of the NMDA receptor activity. **Pathways and Functions:** DAPK1 is involved in several signaling pathways, including: 1. **Apoptotic signaling pathway**: DAPK1 is a key component of the apoptotic machinery and is involved in the regulation of caspase activation, mitochondrial outer membrane permeabilization, and the initiation of programmed cell death. 2. **Autophagy**: DAPK1 has been shown to regulate autophagy by interacting with autophagy-related proteins and modulating the activity of the autophagy-related kinase, mTOR. 3. **Stress response**: DAPK1 is involved in the cellular response to stress, including oxidative stress and endoplasmic reticulum stress. 4. **Actin cytoskeleton regulation**: DAPK1 regulates the actin cytoskeleton by interacting with actin-binding proteins and modulating the activity of the cytoskeleton. 5. **NMDA receptor activity**: DAPK1 regulates the activity of the NMDA receptor by interacting with the receptor and modulating its activity. **Clinical Significance:** DAPK1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. Abnormal expression of DAPK1 has been observed in several types of cancer, including breast, lung, and colon cancer. DAPK1 has also been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In addition, DAPK1 has been shown to play a role in cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In summary, DAPK1 is a critical regulator of apoptosis, autophagy, and cellular stress response. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of DAPK1 in human disease and to explore its potential as a therapeutic target. **Significantly expressed cells:** DAPK1 is expressed in various cell types, including: * Epithelial cells of the lower respiratory tract * Anterior lens cells * Hepatoblasts * SST GABAergic cortical interneurons * Corneal endothelial cells * Cerebral cortex neurons * Astrocytes of the cerebral cortex * Purkinje cells * Renal principal cells * Chandelier Pvalb GABAergic cortical interneurons **Proteins:** DAPK1 is also known by the following protein names: * DAPK1_HUMAN (Death-associated protein kinase 1) * Q59H88_HUMAN * B4DHI4_HUMAN

Genular Protein ID: 4111953955

Symbol: DAPK1_HUMAN

Name: Death-associated protein kinase 1

UniProtKB Accession Codes:

P53355 B7ZLD2 B7ZLE7 Q14CQ7 Q1W5W0 Q68CP8 Q6ZRZ3 Q9BTL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 12 EMDB 4 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 69 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828849

Title: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

PubMed ID: 7828849

DOI: 10.1101/gad.9.1.15

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10629061

Title: Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.

PubMed ID: 10629061

DOI: 10.1128/mcb.20.3.1044-1054.2000

PubMed ID: 11579085

Title: The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.

PubMed ID: 11579085

DOI: 10.1074/jbc.m105133200

PubMed ID: 11980920

Title: DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.

PubMed ID: 11980920

DOI: 10.1083/jcb.200109094

PubMed ID: 12730201

Title: Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18.

PubMed ID: 12730201

DOI: 10.1074/jbc.m300492200

PubMed ID: 15367680

Title: Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.

PubMed ID: 15367680

DOI: 10.1128/mcb.24.19.8611-8626.2004

PubMed ID: 16132846

Title: Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway.

PubMed ID: 16132846

DOI: 10.1007/s10529-005-7869-x

PubMed ID: 16213824

Title: The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.

PubMed ID: 16213824

DOI: 10.1016/j.cub.2005.08.050

PubMed ID: 15616583

Title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.

PubMed ID: 15616583

DOI: 10.1038/sj.emboj.7600510

PubMed ID: 15729359

Title: The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.

PubMed ID: 15729359

DOI: 10.1038/sj.emboj.7600584

PubMed ID: 16756490

Title: The death-associated protein kinases: structure, function, and beyond.

PubMed ID: 16756490

DOI: 10.1146/annurev.biochem.75.103004.142615

PubMed ID: 17056602

Title: Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation.

PubMed ID: 17056602

DOI: 10.1074/jbc.m605097200

PubMed ID: 17703233

Title: DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress.

PubMed ID: 17703233

DOI: 10.1038/sj.cdd.4402212

PubMed ID: 17895359

Title: DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress.

PubMed ID: 17895359

DOI: 10.1242/jcs.003251

PubMed ID: 18422656

Title: An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing.

PubMed ID: 18422656

DOI: 10.1111/j.1742-4658.2008.06404.x

PubMed ID: 18195017

Title: DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.

PubMed ID: 18195017

DOI: 10.1074/jbc.m706040200

PubMed ID: 18995835

Title: DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression.

PubMed ID: 18995835

DOI: 10.1016/j.molcel.2008.09.019

PubMed ID: 19180116

Title: DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

PubMed ID: 19180116

DOI: 10.1038/embor.2008.246

PubMed ID: 18974095

Title: Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling.

PubMed ID: 18974095

DOI: 10.1074/jbc.m805165200

PubMed ID: 20389280

Title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.

PubMed ID: 20389280

DOI: 10.1038/emboj.2010.62

PubMed ID: 19878313

Title: Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.

PubMed ID: 19878313

DOI: 10.1111/j.1742-4658.2009.07411.x

PubMed ID: 21497122

Title: Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.

PubMed ID: 21497122

DOI: 10.1016/j.molcel.2011.03.005

PubMed ID: 21408167

Title: New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform.

PubMed ID: 21408167

DOI: 10.1371/journal.pone.0017344

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27068745

Title: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.

PubMed ID: 27068745

DOI: 10.1074/jbc.m115.698092

PubMed ID: 11573098

Title: Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.

PubMed ID: 11573098

DOI: 10.1038/nsb1001-899

PubMed ID: 14505650

Title: An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

PubMed ID: 14505650

DOI: 10.1016/s0960-894x(03)00733-9

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1430
  • Mass: 160046
  • Checksum: E2C4246E7C78A6D2
  • Sequence:
    • MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED 
IEREVSILKE IQHPNVITLH EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL 
KQILNGVYYL HSLQIAHFDL KPENIMLLDR NVPKPRIKII DFGLAHKIDF GNEFKNIFGT 
PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEDEY 
FSNTSALAKD FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA 
ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 
QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK RGSRIDVQDK GGSNAVYWAA 
RHGHVDTLKF LSENKCPLDV KDKSGEMALH VAARYGHADV AQLLCSFGSN PNIQDKEEET 
PLHCAAWHGY YSVAKALCEA GCNVNIKNRE GETPLLTASA RGYHDIVECL AEHGADLNAC 
DKDGHIALHL AVRRCQMEVI KTLLSQGCFV DYQDRHGNTP LHVACKDGNM PIVVALCEAN 
CNLDISNKYG RTPLHLAANN GILDVVRYLC LMGASVEALT TDGKTAEDLA RSEQHEHVAG 
LLARLRKDTH RGLFIQQLRP TQNLQPRIKL KLFGHSGSGK TTLVESLKCG LLRSFFRRRR 
PRLSSTNSSR FPPSPLASKP TVSVSINNLY PGCENVSVRS RSMMFEPGLT KGMLEVFVAP 
THHPHCSADD QSTKAIDIQN AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSIHVVVF 
SLEEPYEIQL NQVIFWLSFL KSLVPVEEPI AFGGKLKNPL QVVLVATHAD IMNVPRPAGG 
EFGYDKDTSL LKEIRNRFGN DLHISNKLFV LDAGASGSKD MKVLRNHLQE IRSQIVSVCP 
PMTHLCEKII STLPSWRKLN GPNQLMSLQQ FVYDVQDQLN PLASEEDLRR IAQQLHSTGE 
INIMQSETVQ DVLLLDPRWL CTNVLGKLLS VETPRALHHY RGRYTVEDIQ RLVPDSDVEE 
LLQILDAMDI CARDLSSGTM VDVPALIKTD NLHRSWADEE DEVMVYGGVR IVPVEHLTPF 
PCGIFHKVQV NLCRWIHQQS TEGDADIRLW VNGCKLANRG AELLVLLVNH GQGIEVQVRG 
LETEKIKCCL LLDSVCSTIE NVMATTLPGL LTVKHYLSPQ QLREHHEPVM IYQPRDFFRA 
QTLKETSLTN TMGGYKESFS SIMCFGCHDV YSQASLGMDI HASDLNLLTR RKLSRLLDPP 
DPLGKDWCLL AMNLGLPDLV AKYNTSNGAP KDFLPSPLHA LLREWTTYPE STVGTLMSKL 
RELGRRDAAD FLLKASSVFK INLDGNGQEA YASSCNSGTS YNSISSVVSR

Genular Protein ID: 3135518335

Symbol: Q59H88_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H88

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 9 Gene3D 5 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 6 SMART 3 SUPFAM 4

Sequence Information:

  • Length: 1433
  • Mass: 160462
  • Checksum: B7A0325176338531
  • Sequence:
    • QFIMTVFRQE NVDDYYDTGE ELGSGQFAVV KKCREKSTGL QYAAKFIKKR RTKSSRRGVS 
REDIEREVSI LKEIQHPNVI TLHEVYENKT DVILILELVA GGELFDFLAE KESLTEEEAT 
EFLKQILNGV YYLHSLQIAH FDLKPENIML LDRNVPKPRI KIIDFGLAHK IDFGNEFKNI 
FGTPEFVAPE IVNYEPLGLE ADMWSIGVIT YILLSGASPF LGDTKQETLA NVSAVNYEFE 
DEYFSNTSAL AKDFIRRLLV KDPKKRMTIQ DSLQHPWIKP KDTQQALSRK ASAVNMEKFK 
KFAARKKWKQ SVRLISLCQR LSRSFLSRSN MSVARSDDTL DEEDSFVMKA IIHAINDDNV 
PGLQHLLGSL SNYDVNQPNK HGTPPLLIAA GCGNIQILQL LIKRGSRIDV QDKGGSNAVY 
WAARHGHVDT LKFLSENKCP LDVKDKSGEM ALHVAARYGH ADVAQLLCSF GSNPNIQDKE 
EETPLHCAAW HGYYSVAKAL CEAGCNVNIK NREGETPLLT ASARGYHDIV ECLAEHGADL 
NACDKDGHIA LHLAVRRCQM EVIKTLLSQG CFVDYQDRHG NTPLHVACKD GNMPIVVALC 
EANCNLDISN KYGRTPLHLA ANNGILDVVR YLCLMGASVE ALTTDGKTAE DLARSEQHEH 
VAGLLARLRK DTHRGLFIQQ LRPTQNLQPR IKLKLFGHSG SGKTTLVESL KCGLLRSFFR 
RRRPRLSSTN SSRFPPSPLA SKPTVSVSIN NLYPGCENVS VRSRSMMFEP GLTKGMLEVF 
VAPTHHPHCS ADDQSTKAID IQNAYLNGVG DFSVWEFSGN PVYFCCYDYF AANDPTSIHV 
VVFSLEEPYE IQLNQVIFWL SFLKSLVPVE EPIAFGGKLK NPLQVVLVAT HADIMNVPRP 
AGGEFGYDKD TSLLKEIRNR FGNDLHISNK LFVLDAGASG SKDMKVLRNH LQEIRSQIVS 
VCPPMTHLCE KIISTLPSWR KLNGPNQLMS LQQFVYDVQD QLNPLASEED LRRIAQQLHS 
TGEINIMQSE TVQDVLLLDP RWLCTNVLGK LLSVETPRAL HHYRGRYTVE DIQRLVPDSD 
VEELLQILDA MDICARDLSS GTMVDVPALI KTDNLHRSWA DEEDEVMVYG GVRIVPVEHL 
TPFPCGIFHK VQVNLCRWIH QQSTEGDADI RLWVNGCKLA NRGAELLVLL VNHGQGIEVQ 
VRGLETEKIK CCLLLDSVCS TIENVMATTL PGLLTVKHYL SPQQLREHHE PVMIYQPRDF 
FRAQTLKETS LTNTMGGYKE SFSSIMCFGC HDVYSQASLG MDIHASDLNL LTRRKLSRLL 
DPPDPLGKDW CLLAMNLGLP DLVAKYNTNN GAPKDFLPSP LHALLREWTT YPESTVGTLM 
SKLRELGRRD AADFLLKASS VFKINLDGNG QEAYASSCNS GTSYNSISSV VSR

Genular Protein ID: 901652560

Symbol: B4DHI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DHI4

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 9 Gene3D 5 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 RefSeq 1 Rhea 6 SMART 3 SUPFAM 4

Sequence Information:

  • Length: 1430
  • Mass: 160059
  • Checksum: 193847FD5DB20CA6
  • Sequence:
    • MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED 
IEREVSILKE IQHPNVITLH EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL 
KQILNGVYYL HSLQIAHFDL KPENIMLLDR NVPKPRIKII DFGLAHKIDF GNEFKNIFGT 
PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEDEY 
FSNTSALAKD FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRNASA VNMEKFKKFA 
ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 
QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK RGSRIDVQDK GGSNAVYWAA 
RHGHVDTLKF LSENKCPLDV KDKSGEMALH VAARYGHADV AQLLCSFGSN PNIQDKEEET 
PLHCAAWHGY YSVAKALCEA GCNVNIKNRE GETPLLTASA RGYHDIVECL AEHGADLNAC 
DKDGHIALHL AVRRCQMEVI KTLLSQGCFV DYQDRHGNTP LHVACKDGNM PIVVALCEAN 
CNLDISNKYG RTPLHLAANN GILDVVRYLC LMGASVEALT TDGKTAEDLA RSEQHEHVAG 
LLARLRKDTH RGLFIQQLRP TQNLQPRIKL KLFGHSGSGK TTLVESLKCG LLRSFFRRRR 
PRLSSTNSSR FPPSPLASKP TVSVSINNLY PGCENVSVRS RSMMFEPGLT KGMLEVFVAP 
THHPHCSADD QSTKAIDIQN AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSIHVVVF 
SLEEPYEIQL NQVIFWLSFL KSLVPVEEPI AFGGKLKNPL QVVLVATHAD IMNVPRPAGG 
EFGYDKDTSL LKEIRNRFGN DLHISNKLFV LDAGASGSKD MKVLRNHLQE IRSQIVSVCP 
PMTHLCEKII STLPSWRKLN GPNQLMSLQQ FVYDVQDQLN PLASEEDLRR IAQQLHSTGE 
INIMQSETVQ DVLLLDPRWL CTNVLGKLLS VETPRALHHY RGRYTVEDIQ RLVPDSDVEE 
LLQILDAMDI CARDLSSGTM VDVPALIKTD NLHRSWADEE DEVMVYGGVR IVPVEHLTPF 
PCGIFHKVQV NLCRWIHQQS TEGDADIRLW VNGCKLANRG AELLVLLVNH GQGIEVQVRG 
LETEKIKCCL LLDSVCSTIE NVMATTLPGL LTVKHYLSPQ QLREHHEPVM IYQPRDFFRA 
QTLKETSLTN TMGGYKESFS SIMCFGCHDV YSQASLGMDI HASDLNLLTR RKLSRLLDPP 
DPLGKDWCLL AMNLGLPDLV AKYNTNNGAP KDFLPSPLHA LLREWTTYPE STVGTLMSKL 
RELGRRDAAD FLLKASSVFK INLDGNGQEA YASSCNSGTS YNSISSVVSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.