Details for: DDC

Gene ID: 1644

Symbol: DDC

Ensembl ID: ENSG00000132437

Description: dopa decarboxylase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.84
    Marker Score: 8102
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.7
    Marker Score: 891
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.64
    Marker Score: 788
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.16
    Marker Score: 3036
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.92
    Marker Score: 2958
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.84
    Marker Score: 6533
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.83
    Marker Score: 18894
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.69
    Marker Score: 581
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.67
    Marker Score: 8011
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.65
    Marker Score: 3926
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.54
    Marker Score: 3633
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.33
    Marker Score: 383
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.28
    Marker Score: 482
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.22
    Marker Score: 296
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.2
    Marker Score: 3757
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.12
    Marker Score: 3675
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1951
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1551
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.93
    Marker Score: 451
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.89
    Marker Score: 885
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.87
    Marker Score: 454
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 644
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13039.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.83
    Marker Score: 431
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.77
    Marker Score: 750
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3194.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.69
    Marker Score: 356
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.65
    Marker Score: 142
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.65
    Marker Score: 261
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.64
    Marker Score: 426
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1295
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.63
    Marker Score: 604
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.61
    Marker Score: 151
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.56
    Marker Score: 140
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 154
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 435
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 209
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 188
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.43
    Marker Score: 300
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 194
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 397
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4
    Marker Score: 835
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.4
    Marker Score: 108
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 126
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.38
    Marker Score: 218
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 201
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.34
    Marker Score: 2185.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.34
    Marker Score: 239
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 321
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1989
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 245
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 125
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.28
    Marker Score: 148.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.26
    Marker Score: 78
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.26
    Marker Score: 72
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.25
    Marker Score: 565
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 243
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.22
    Marker Score: 353
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 78
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.21
    Marker Score: 924
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.21
    Marker Score: 151
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.21
    Marker Score: 438
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 59
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.18
    Marker Score: 537
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.17
    Marker Score: 513
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.17
    Marker Score: 1103
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.17
    Marker Score: 690

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Other Information

**Key characteristics:** * The DDC gene is located on chromosome 17q21.1. * It is a large gene with a length of approximately 2.75 million nucleotides. * The protein encoded by DDC is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a key enzyme in the synthesis of dopamine from precursors such as phenylalanine and tyrosine. **Pathways and functions:** * DDC is involved in the biosynthesis of dopamine, a neurotransmitter that plays a crucial role in various physiological processes, including movement, motivation, and reward. * It is essential for the development and function of the retina, where dopamine is produced by retinal rod cells and acts on photoreceptors. * It is also involved in the regulation of blood pressure, heart rate, and other physiological functions. **Clinical significance:** * Mutations in the DDC gene have been linked to several neurological disorders, including Parkinson's disease, schizophrenia, and depression. * Drugs that target DDC have been investigated as potential treatments for these disorders. * Dysfunction of DDC has been linked to the development of bladder dysfunction in patients with diabetes. **Additional notes:** * DDC is a highly regulated gene, with its expression being controlled by various factors, including growth factors, neurotransmitters, and environmental stimuli. * Mutations in the DDC gene can lead to the production of a defective protein that is unable to function properly, resulting in neurological symptoms. * Understanding the role of DDC in dopamine biosynthesis has opened up new avenues for research into neurodegenerative diseases and the development of therapeutic interventions.

Genular Protein ID: 4071522668

Symbol: DDC_HUMAN

Name: N/A

UniProtKB Accession Codes:

P20711 C9IYA0 E7ER62 E7EU95 Q16723 Q5W5T9 Q75MJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 3 EMBL 22 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 7 Rhea 2 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2590185

Title: Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase.

PubMed ID: 2590185

DOI: 10.1016/0006-291x(89)91772-5

PubMed ID: 1612608

Title: Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs.

PubMed ID: 1612608

DOI: 10.1016/0888-7543(92)90275-w

PubMed ID: 1540578

Title: Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis.

PubMed ID: 1540578

DOI: 10.1021/bi00123a004

PubMed ID: 15532536

Title: Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA.

PubMed ID: 15532536

DOI: 10.1023/b:nere.0000042207.05071.ea

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8510497

Title: Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene.

PubMed ID: 8510497

DOI: 10.1016/0169-328x(93)90006-b

PubMed ID: 1395716

Title: Localisation of the gene for human aromatic L-amino acid decarboxylase (DDC) to chromosome 7p13-->p11 by in situ hybridisation.

PubMed ID: 1395716

DOI: 10.1159/000133384

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22143761

Title: Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.

PubMed ID: 22143761

DOI: 10.1073/pnas.1111456108

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 14991824

Title: Levodopa-responsive aromatic L-amino acid decarboxylase deficiency.

PubMed ID: 14991824

DOI: 10.1002/ana.20055

PubMed ID: 15079002

Title: Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis.

PubMed ID: 15079002

DOI: 10.1212/wnl.62.7.1058

Sequence Information:

  • Length: 480
  • Mass: 53926
  • Checksum: 0A2CFF9A39BDE298
  • Sequence:
    • MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV 
EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD 
WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM 
EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV 
ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN 
PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL 
KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN 
EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE

Genular Protein ID: 3803880510

Symbol: Q53Y41_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53Y41

Database IDs:

ARBA 12 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 4 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 37466248

Title: Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency.

PubMed ID: 37466248

DOI: 10.1002/pro.4732

Sequence Information:

  • Length: 480
  • Mass: 53894
  • Checksum: 898FD4B99A96C13E
  • Sequence:
    • MNASEFRRRG KEMVDYVANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV 
EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD 
WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM 
EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV 
ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN 
PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL 
KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN 
EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE

Genular Protein ID: 3985871827

Symbol: A0A087WV24_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WV24

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 6 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 442
  • Mass: 49697
  • Checksum: 5CC2298848EFE098
  • Sequence:
    • MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV 
EKIIMPGAAS PACTELETVM MDWLGKMLEL PKAFLNEKAG EGGGVIQGSA SEATLVALLA 
ARTKVIHRLQ AASPELTQAA IMEKLVAYSS DQAHSSVERA GLIGGVKLKA IPSDGNFAMR 
ASALQEALER DKAAGLIPFF MVATLGTTTC CSFDNLLEVG PICNKEDIWL HVDAAYAGSA 
FICPEFRHLL NGVEFADSFN FNPHKWLLVN FDCSAMWVKK RTDLTGAFRL DPTYLKHSHQ 
DSGLITDYRH WQIPLGRRFR SLKMWFVFRM YGVKGLQAYI RKHVQLSHEF ESLVRQDPRF 
EICVEVILGL VCFRLKGSNK VNEALLQRIN SAKKIHLVPC HLRDKFVLRF AICSRTVESA 
HVQRAWEHIK ELAADVLRAE RE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.