Details for: DLG3

Gene ID: 1741

Symbol: DLG3

Ensembl ID: ENSG00000082458

Description: discs large MAGUK scaffold protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.04
    Marker Score: 3556
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.85
    Marker Score: 1698
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.44
    Marker Score: 1590
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.34
    Marker Score: 12594
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12313
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.29
    Marker Score: 11058
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.28
    Marker Score: 856
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.28
    Marker Score: 1974
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.23
    Marker Score: 4227
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.16
    Marker Score: 17345
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.15
    Marker Score: 4752
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 70031
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.13
    Marker Score: 1418
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.13
    Marker Score: 4362
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1
    Marker Score: 2332
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.1
    Marker Score: 40483.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.08
    Marker Score: 2455
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.07
    Marker Score: 4343
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 665
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.04
    Marker Score: 39659
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.04
    Marker Score: 20751
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.03
    Marker Score: 7931
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.03
    Marker Score: 10611
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16066
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2728
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.89
    Marker Score: 418
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.89
    Marker Score: 1581
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.89
    Marker Score: 925
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5044
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.88
    Marker Score: 926
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.87
    Marker Score: 429
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.87
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1350
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.83
    Marker Score: 7183
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.82
    Marker Score: 237
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 620.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.8
    Marker Score: 3719
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 446
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.78
    Marker Score: 3242
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.77
    Marker Score: 771
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1743
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.73
    Marker Score: 2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3030
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.72
    Marker Score: 1030
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.72
    Marker Score: 416
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.72
    Marker Score: 24810
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.71
    Marker Score: 273
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1041
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.7
    Marker Score: 1863.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.69
    Marker Score: 1524.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 444
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.69
    Marker Score: 287
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.68
    Marker Score: 216
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.68
    Marker Score: 477
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.66
    Marker Score: 1212
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.65
    Marker Score: 1243
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.65
    Marker Score: 328
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.65
    Marker Score: 21857
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 835
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.64
    Marker Score: 4735
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.63
    Marker Score: 527
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.62
    Marker Score: 2976
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.62
    Marker Score: 3948
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.62
    Marker Score: 1403
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.6
    Marker Score: 460
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 304
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.58
    Marker Score: 620
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.56
    Marker Score: 485
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.55
    Marker Score: 376
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.53
    Marker Score: 2792
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.53
    Marker Score: 2213
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3419
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.52
    Marker Score: 734
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1052
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 245
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.51
    Marker Score: 488
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.51
    Marker Score: 119
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5
    Marker Score: 144
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 299
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.49
    Marker Score: 1171
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.49
    Marker Score: 268
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.48
    Marker Score: 486
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1191
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.46
    Marker Score: 162
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.46
    Marker Score: 493
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.46
    Marker Score: 219

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Other Information

**Key characteristics** * DLG3 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the MAGUK family of cell adhesion molecules. * DLG3 is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. * It is known to interact with a number of other proteins, including NMDA receptors, Kainate receptors, and MAPK signaling proteins. **Pathways and functions** * DLG3 is involved in the activation of NMDA receptors and postsynaptic events. * It is also involved in the development and function of the cerebral cortex. * DLG3 is thought to play a role in the regulation of synaptic plasticity and learning and memory. **Clinical significance** * Mutations in DLG3 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * DLG3 is a potential therapeutic target for these disorders. **Additional information** * DLG3 is a highly conserved protein with a similar sequence in other mammals. * It is a promising target for the development of new treatments for neurological disorders.

Genular Protein ID: 3189669499

Symbol: DLG3_HUMAN

Name: Disks large homolog 3

UniProtKB Accession Codes:

Q92796 B4E0H1 D3DVU5 Q5JUW6 Q5JUW7 Q9ULI8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIRSF 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 5 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9188857

Title: Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.

PubMed ID: 9188857

DOI: 10.1038/sj.onc.1201087

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9278515

Title: Binding of neuroligins to PSD-95.

PubMed ID: 9278515

DOI: 10.1126/science.277.5331.1511

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 15185169

Title: Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation.

PubMed ID: 15185169

DOI: 10.1086/422703

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 19118189

Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

PubMed ID: 19118189

DOI: 10.1523/jneurosci.3112-08.2008

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 817
  • Mass: 90314
  • Checksum: CE125E9BEE3EEC66
  • Sequence:
    • MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PGGGNGASAG YGGYSSQTLP 
SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG SGPSWWPECT CTNRDWYEQV 
NGSDGMFKYE EIVLERGNSG LGFSIAGGID NPHVPDDPGI FITKIIPGGA AAMDGRLGVN 
DCVLRVNEVD VSEVVHSRAV EALKEAGPVV RLVVRRRQPP PETIMEVNLL KGPKGLGFSI 
AGGIGNQHIP GDNSIYITKI IEGGAAQKDG RLQIGDRLLA VNNTNLQDVR HEEAVASLKN 
TSDMVYLKVA KPGSLHLNDM YAPPDYASTF TALADNHISH NSSLGYLGAV ESKVSYPAPP 
QVPPTRYSPI PRHMLAEEDF TREPRKIILH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA 
DLSGELRRGD RILSVNGVNL RNATHEQAAA ALKRAGQSVT IVAQYRPEEY SRFESKIHDL 
REQMMNSSMS SGSGSLRTSE KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD 
DEWWQARLVT PHGESEQIGV IPSKKRVEKK ERARLKTVKF HARTGMIESN RDFPGLSDDY 
YGAKNLKGQE DAILSYEPVT RQEIHYARPV IILGPMKDRV NDDLISEFPH KFGSCVPHTT 
RPRRDNEVDG QDYHFVVSRE QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR AVAERGKHCI 
LDVSGNAIKR LQQAQLYPIA IFIKPKSIEA LMEMNRRQTY EQANKIYDKA MKLEQEFGEY 
FTAIVQGDSL EEIYNKIKQI IEDQSGHYIW VPSPEKL

Genular Protein ID: 998630435

Symbol: Q59FY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FY1

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 4 Genevisible 1 GenomeRNAi 1 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 7 PROSITE-ProRule 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 917
  • Mass: 99796
  • Checksum: DFF5EAD57A2C1196
  • Sequence:
    • APASSLPLGL GPEATTGDTE PPVLEGEPWV RGSVGAEAPG RPPGPRPRSA RAPPRVPPPS 
WSEQCECARE PGGGGGGGGG GGGGVESGVG WGVRAAGGSA MHKHQHCCKC PECYEVTRLA 
ALRRLEPPGY GDWQVPDPYG PGGGNGASAG YGGYSSQTLP SQAGATPTPR TKAKLIPTGR 
DVGPVPPKPV PGKSTPKLNG SGPSWWPECT CTNRDWYEQV NGSDGMFKYE EIVLERGNSG 
LGFSIAGGID NPHVPDDPGI FITKIIPGGA AAMDGRLGVN DCVLRVNEVD VSEVVHSRAV 
EALKEAGPVV RLVVRRRQPP PETIMEVNLL KGPKGLGFSI AGGIGNQHIP GDNSIYITKI 
IEGGAAQKDG RLQIGDRLLA VNNTNLQDVR HEEAVASLKN TSDMVYLKVA KPGSLHLNDM 
YAPPDYASTF TALADNHISH NSSLGYLGAV ESKVSYPAPP QVPPTRYSPI PRHMLAEEDF 
TREPRKIILH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA DLSGELRRGD RILSVNGVNL 
RNATHEQAAA ALKRAGQSVT IVAQYRPEEY SRFESKIHDL REQMMNSSMS SGSGSLRTSE 
KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD DEWWQARLVT PHGESEQIGV 
IPSKKRVEKK ERARLKTVKF HARTGMIESN RDFPGLSDDY YGAKNLKGQE DAILSYEPVT 
RQEIHYARPV IILGPMKDRV NDDLISEFPH KFGSCVPHTT RPRRDNEVDG QDYHFVVSRE 
QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR AVAERGKHCI LDVSGNAIKR LQQAQLYPIA 
IFIKPKSIEA LMEMNRRQTY EQANKIYDKA MKLEQEFGEY FTAIVQGDSL EEIYNKIKQI 
IEDQSGHYIW VPSPEKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.