Details for: DNASE1L2

Gene ID: 1775

Symbol: DNASE1L2

Ensembl ID: ENSG00000167968

Description: deoxyribonuclease 1 like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.13
    Marker Score: 2145
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.76
    Marker Score: 685.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7684
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 423
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 464
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.71
    Marker Score: 1467
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 475
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8443
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 574.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 436
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.28
    Marker Score: 1121
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.25
    Marker Score: 155
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.25
    Marker Score: 913
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 489
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 462
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.19
    Marker Score: 1609
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.19
    Marker Score: 11383
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.17
    Marker Score: 6410
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.17
    Marker Score: 1613
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.17
    Marker Score: 1612
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.16
    Marker Score: 1655
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.15
    Marker Score: 591
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.14
    Marker Score: 5338
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.14
    Marker Score: 582
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.12
    Marker Score: 1807
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.12
    Marker Score: 2373
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.12
    Marker Score: 887
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1
    Marker Score: 275
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 53
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 168
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 113
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.08
    Marker Score: 1740
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 95
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 143
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.06
    Marker Score: 351.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.05
    Marker Score: 34

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a transmembrane protein with a molecular weight of approximately 450 kDa. - It is expressed in high levels in the blood vessel endothelial cells, enterocytes of the epithelium of large intestine, and neuroendocrine cells. - It is expressed in lower levels in the colon goblet cells, intestinal crypt stem cells of the small intestine, goblet cells, and enterocytes of the epithelium of small intestine. - It is a key regulator of calcium signaling in these cells. **Pathways and functions:** - It is a key regulator of calcium signaling in the blood vessel endothelial cells. - It is expressed in the blood vessel endothelial cells, which are responsible for maintaining blood pressure and regulating blood flow. - It is involved in the regulation of calcium signaling in enterocytes of the epithelium of large intestine and colon goblet cells. - It is involved in the regulation of calcium signaling in intestinal crypt stem cells of the small intestine. - It is involved in the regulation of calcium signaling in goblet cells. - It is involved in the regulation of calcium signaling in enterocytes of the epithelium of small intestine. **Clinical significance:** - Mutations in DNASE1L2 have been linked to a number of human diseases, including hypertension, heart failure, and cancer. - It is a potential therapeutic target for these diseases.

Genular Protein ID: 2715500304

Symbol: DNSL2_HUMAN

Name: Deoxyribonuclease-1-like 2

UniProtKB Accession Codes:

Q92874 E9PBY4 Q6JVM2 Q6JVM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205125

Title: Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.

PubMed ID: 9205125

DOI: 10.1006/geno.1997.4748

PubMed ID: 15203207

Title: Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines.

PubMed ID: 15203207

DOI: 10.1016/j.ygeno.2004.02.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16902420

Title: DNase1L2 degrades nuclear DNA during corneocyte formation.

PubMed ID: 16902420

DOI: 10.1038/sj.jid.5700503

Sequence Information:

  • Length: 299
  • Mass: 32853
  • Checksum: 1B66A5590D33D0A6
  • Sequence:
    • MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE 
VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD 
PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI 
DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV 
GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.