Details for: DNASE1L2

Gene ID: 1775

Symbol: DNASE1L2

Ensembl ID: ENSG00000167968

Description: deoxyribonuclease 1 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 15.6868
    Cell Significance Index: -2.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.7775
    Cell Significance Index: -2.4800
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 7.9397
    Cell Significance Index: 9.1400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 4.5367
    Cell Significance Index: 5.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8755
    Cell Significance Index: 28.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5521
    Cell Significance Index: 12.0900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3205
    Cell Significance Index: 0.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1790
    Cell Significance Index: 2.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1691
    Cell Significance Index: 2.4600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1607
    Cell Significance Index: 2.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1233
    Cell Significance Index: 12.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1231
    Cell Significance Index: 23.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1127
    Cell Significance Index: 22.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1089
    Cell Significance Index: 1.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0957
    Cell Significance Index: 86.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0713
    Cell Significance Index: 1.9100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0568
    Cell Significance Index: 0.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0556
    Cell Significance Index: 24.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0555
    Cell Significance Index: 3.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0540
    Cell Significance Index: 19.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0462
    Cell Significance Index: 1.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0387
    Cell Significance Index: 6.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0302
    Cell Significance Index: 3.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0297
    Cell Significance Index: 0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0277
    Cell Significance Index: 1.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0265
    Cell Significance Index: 18.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0247
    Cell Significance Index: 0.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0202
    Cell Significance Index: 0.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0068
    Cell Significance Index: 0.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0040
    Cell Significance Index: 2.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0039
    Cell Significance Index: 0.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0012
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0021
    Cell Significance Index: -0.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0031
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0035
    Cell Significance Index: -2.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0056
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0060
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0088
    Cell Significance Index: -0.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0099
    Cell Significance Index: -1.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0105
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0127
    Cell Significance Index: -2.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0145
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0147
    Cell Significance Index: -2.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0151
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0155
    Cell Significance Index: -1.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0155
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0161
    Cell Significance Index: -1.8400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0170
    Cell Significance Index: -0.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0190
    Cell Significance Index: -0.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0197
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0201
    Cell Significance Index: -1.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0202
    Cell Significance Index: -2.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0235
    Cell Significance Index: -0.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0258
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0272
    Cell Significance Index: -0.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0293
    Cell Significance Index: -1.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0315
    Cell Significance Index: -2.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0320
    Cell Significance Index: -1.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0333
    Cell Significance Index: -0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0335
    Cell Significance Index: -2.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0354
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0362
    Cell Significance Index: -2.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0368
    Cell Significance Index: -1.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0402
    Cell Significance Index: -2.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0413
    Cell Significance Index: -1.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0419
    Cell Significance Index: -0.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0426
    Cell Significance Index: -0.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0428
    Cell Significance Index: -0.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0428
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0441
    Cell Significance Index: -2.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0553
    Cell Significance Index: -0.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0561
    Cell Significance Index: -1.4000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0568
    Cell Significance Index: -0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0571
    Cell Significance Index: -1.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0607
    Cell Significance Index: -1.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0630
    Cell Significance Index: -1.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0633
    Cell Significance Index: -0.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0646
    Cell Significance Index: -0.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0648
    Cell Significance Index: -1.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0673
    Cell Significance Index: -2.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNASE1L2 is a member of the deoxyribonuclease family, which consists of enzymes that break down DNA into smaller fragments. The DNASE1L2 protein shares a high degree of sequence similarity with DNASE1, suggesting a conserved evolutionary function. DNASE1L2 is primarily expressed in cells of the hematopoietic system, including blood vessel endothelial cells, enterocytes, and neuroendocrine cells. Its expression is also observed in other tissues, such as the skin, intestinal epithelium, and the central nervous system. **Pathways and Functions:** DNASE1L2 is involved in several biological pathways, including: 1. **Calcium ion binding:** DNASE1L2 interacts with calcium ions, which are essential for various cellular processes, including DNA degradation. 2. **Corneocyte development:** DNASE1L2 is expressed in the skin, where it contributes to the development and maintenance of corneocytes, the cells that make up the outermost layer of the cornea. 3. **Cytoplasm:** DNASE1L2 is localized to the cytoplasm, where it can interact with DNA and other cellular components. 4. **Deoxyribonuclease i activity:** DNASE1L2 possesses deoxyribonuclease i activity, which is responsible for the degradation of DNA into smaller fragments. 5. **DNA binding:** DNASE1L2 can bind to DNA, allowing it to interact with and degrade DNA molecules. 6. **DNA catabolic process:** DNASE1L2 is involved in the catabolism of DNA, breaking down DNA into smaller fragments that can be recycled. 7. **DNA metabolic process:** DNASE1L2 contributes to the metabolic processing of DNA, allowing cells to regulate their DNA content. **Clinical Significance:** DNASE1L2 has been implicated in various diseases and disorders, including: 1. **Hematological disorders:** DNASE1L2 mutations have been associated with hematological disorders, such as leukemia and lymphoma. 2. **Neurological disorders:** DNASE1L2 expression has been observed in the central nervous system, where it may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Skin disorders:** DNASE1L2 is expressed in the skin, where it may contribute to the development of skin disorders, such as psoriasis and atopic dermatitis. 4. **Cancer:** DNASE1L2 has been implicated in cancer, where it may contribute to the degradation of DNA and the promotion of tumor growth. In conclusion, DNASE1L2 is a gene that plays a crucial role in various cellular processes, including DNA degradation and catabolism. Its expression and function have been implicated in multiple diseases and disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the functions of DNASE1L2 and its role in human disease.

Genular Protein ID: 2715500304

Symbol: DNSL2_HUMAN

Name: Deoxyribonuclease-1-like 2

UniProtKB Accession Codes:

Q92874 E9PBY4 Q6JVM2 Q6JVM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9205125

Title: Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.

PubMed ID: 9205125

DOI: 10.1006/geno.1997.4748

PubMed ID: 15203207

Title: Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines.

PubMed ID: 15203207

DOI: 10.1016/j.ygeno.2004.02.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16902420

Title: DNase1L2 degrades nuclear DNA during corneocyte formation.

PubMed ID: 16902420

DOI: 10.1038/sj.jid.5700503

Sequence Information:

  • Length: 299
  • Mass: 32853
  • Checksum: 1B66A5590D33D0A6
  • Sequence:
    • MGGPRALLAA LWALEAAGTA ALRIGAFNIQ SFGDSKVSDP ACGSIIAKIL AGYDLALVQE 
VRDPDLSAVS ALMEQINSVS EHEYSFVSSQ PLGRDQYKEM YLFVYRKDAV SVVDTYLYPD 
PEDVFSREPF VVKFSAPGTG ERAPPLPSRR ALTPPPLPAA AQNLVLIPLH AAPHQAVAEI 
DALYDVYLDV IDKWGTDDML FLGDFNADCS YVRAQDWAAI RLRSSEVFKW LIPDSADTTV 
GNSDCAYDRI VACGARLRRS LKPQSATVHD FQEEFGLDQT QALAISDHFP VEVTLKFHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.