Details for: ECM1

Gene ID: 1893

Symbol: ECM1

Ensembl ID: ENSG00000143369

Description: extracellular matrix protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.31
    Marker Score: 19939
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.2
    Marker Score: 1497
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.12
    Marker Score: 16556
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.1
    Marker Score: 3010
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9
    Marker Score: 21434
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.78
    Marker Score: 2451
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.54
    Marker Score: 642
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.44
    Marker Score: 1224
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.29
    Marker Score: 1996
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.29
    Marker Score: 3365
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.18
    Marker Score: 293
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.17
    Marker Score: 293
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.12
    Marker Score: 638
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.11
    Marker Score: 1225
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.09
    Marker Score: 688
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34733
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1
    Marker Score: 246
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.93
    Marker Score: 4021
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5182
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.9
    Marker Score: 340
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.82
    Marker Score: 559
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.8
    Marker Score: 777
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.79
    Marker Score: 950
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 697
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.75
    Marker Score: 909
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3051
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.71
    Marker Score: 173
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.69
    Marker Score: 159
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.69
    Marker Score: 848
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.68
    Marker Score: 25224
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 446
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.65
    Marker Score: 157
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.64
    Marker Score: 978
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.63
    Marker Score: 165
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.62
    Marker Score: 319
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.61
    Marker Score: 5763
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.56
    Marker Score: 217
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.56
    Marker Score: 125
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.56
    Marker Score: 464
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.54
    Marker Score: 1010
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.52
    Marker Score: 121
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.52
    Marker Score: 188
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.48
    Marker Score: 157
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.47
    Marker Score: 203
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 453.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.47
    Marker Score: 546
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.46
    Marker Score: 1310
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28330
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.46
    Marker Score: 1909
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.46
    Marker Score: 483.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.44
    Marker Score: 554
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.43
    Marker Score: 215
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.43
    Marker Score: 4045
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.42
    Marker Score: 120
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.41
    Marker Score: 105
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.41
    Marker Score: 243
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 651
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.41
    Marker Score: 5346
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4
    Marker Score: 182
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.4
    Marker Score: 455
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.39
    Marker Score: 446
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.37
    Marker Score: 1956
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.36
    Marker Score: 94
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 252
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 648
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 1988
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.33
    Marker Score: 3306
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 211
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 279
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3
    Marker Score: 297
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 79
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 184
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.29
    Marker Score: 99
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 581
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.27
    Marker Score: 125
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.27
    Marker Score: 63
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.27
    Marker Score: 539
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.26
    Marker Score: 418
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.26
    Marker Score: 234

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Other Information

**Key characteristics:** - ECM1 is a large protein with a molecular weight of approximately 140 kDa. - It is a key component of the extracellular matrix, a complex network of proteins and polysaccharides that provides structural support, facilitates cell-cell interactions, and regulates various cellular processes. - ECM1 is involved in cell adhesion, migration, proliferation, differentiation, and apoptosis. - It also plays a role in tissue development, wound healing, and inflammation. **Pathways and functions:** - ECM1 is involved in angiogenesis, chondrocyte development, endochondral bone growth, hemostasis, inflammatory response, and tissue remodeling. - It is a key regulator of vascular development and function, and its overexpression is associated with various cardiovascular diseases. - In the context of cancer, ECM1 is often overexpressed on tumor cells, promoting tumor growth, invasion, and metastasis. - It also contributes to the development of inflammatory diseases such as rheumatoid arthritis and atherosclerosis. **Clinical significance:** - Aberrant expression of ECM1 has been linked to several diseases, including cancer, cardiovascular diseases, and inflammatory diseases. - Targeting ECM1 has emerged as a potential therapeutic strategy for these conditions. - Small molecule inhibitors of ECM1 have been shown to inhibit tumor growth and migration in vitro and in vivo. **Additional points:** - ECM1 is a highly conserved protein, with similar sequences found in organisms from humans to fish. - It is a major component of the extracellular matrix, which is a complex network of proteins and polysaccharides that provides structural support for cells and tissues. - The interaction between ECM1 and other proteins in the extracellular matrix is crucial for maintaining tissue integrity and function.

Genular Protein ID: 3840153054

Symbol: ECM1_HUMAN

Name: Extracellular matrix protein 1

UniProtKB Accession Codes:

Q16610 A8K8S0 B4DW49 B4DY60 O43266 Q5T5G4 Q5T5G5 Q5T5G6 Q8IZ60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367673

Title: The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization.

PubMed ID: 9367673

DOI: 10.1006/geno.1997.4918

PubMed ID: 9501329

Title: Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21.

PubMed ID: 9501329

DOI: 10.1016/s0945-053x(97)90017-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11165938

Title: Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro.

PubMed ID: 11165938

DOI: 10.1016/s8756-3282(00)00428-2

PubMed ID: 11292659

Title: Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells.

PubMed ID: 11292659

DOI: 10.1096/fj.99-0934com

PubMed ID: 11929856

Title: Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).

PubMed ID: 11929856

DOI: 10.1093/hmg/11.7.833

PubMed ID: 12604605

Title: Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.

PubMed ID: 12604605

DOI: 10.1074/jbc.m210529200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16512877

Title: Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions.

PubMed ID: 16512877

DOI: 10.1111/j.0906-6705.2006.00409.x

PubMed ID: 19275936

Title: ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.

PubMed ID: 19275936

DOI: 10.1016/j.matbio.2009.02.003

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12603844

Title: Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation.

PubMed ID: 12603844

DOI: 10.1046/j.1523-1747.2003.12073.x

Sequence Information:

  • Length: 540
  • Mass: 60674
  • Checksum: EA575895CDE068BE
  • Sequence:
    • MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP LSRSLPMDHP 
DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK EVGPPLPQEA VPLQKELPSL 
QHPNEQKEGT PAPFGDQSHP EPESWNAAQH CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI 
CLPNRQHVVY GPWNLPQSSY SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA 
MSRFCEAEFS VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP 
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR QGNNHTCTWK 
AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA PYPNYDRDIL TIDIGRVTPN 
LMGHLCGNQR VLTKHKHIPG LIHNMTARCC DLPFPEQACC AEEEKLTFIN DLCGPRRNIW 
RDPALCCYLS PGDEQVNCFN INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.