Details for: ECM1

Gene ID: 1893

Symbol: ECM1

Ensembl ID: ENSG00000143369

Description: extracellular matrix protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.3719
    Cell Significance Index: -17.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.6504
    Cell Significance Index: -17.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.2917
    Cell Significance Index: -15.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.4736
    Cell Significance Index: -17.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5365
    Cell Significance Index: -7.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.2907
    Cell Significance Index: 35.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9168
    Cell Significance Index: 13.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8651
    Cell Significance Index: 24.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6112
    Cell Significance Index: 71.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5515
    Cell Significance Index: 104.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4650
    Cell Significance Index: 6.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3812
    Cell Significance Index: 37.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3130
    Cell Significance Index: 282.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2685
    Cell Significance Index: 5.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2226
    Cell Significance Index: 1.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2147
    Cell Significance Index: 6.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1893
    Cell Significance Index: 30.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1854
    Cell Significance Index: 37.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1220
    Cell Significance Index: 187.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0918
    Cell Significance Index: 63.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0860
    Cell Significance Index: 11.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0813
    Cell Significance Index: 8.8500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0674
    Cell Significance Index: 1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0539
    Cell Significance Index: 19.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0538
    Cell Significance Index: 2.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0499
    Cell Significance Index: 3.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0465
    Cell Significance Index: 1.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0447
    Cell Significance Index: 19.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0404
    Cell Significance Index: 0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0363
    Cell Significance Index: 4.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0125
    Cell Significance Index: 0.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0076
    Cell Significance Index: -14.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0110
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0159
    Cell Significance Index: -21.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0228
    Cell Significance Index: -16.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0261
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0296
    Cell Significance Index: -16.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0309
    Cell Significance Index: -6.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0349
    Cell Significance Index: -19.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0408
    Cell Significance Index: -18.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0419
    Cell Significance Index: -26.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0420
    Cell Significance Index: -1.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0466
    Cell Significance Index: -1.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0476
    Cell Significance Index: -1.1900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0486
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0530
    Cell Significance Index: -15.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0595
    Cell Significance Index: -10.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0723
    Cell Significance Index: -7.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0752
    Cell Significance Index: -1.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0818
    Cell Significance Index: -1.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0860
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1007
    Cell Significance Index: -21.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1067
    Cell Significance Index: -13.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1136
    Cell Significance Index: -16.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1207
    Cell Significance Index: -20.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1263
    Cell Significance Index: -16.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1327
    Cell Significance Index: -4.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1409
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1411
    Cell Significance Index: -16.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1563
    Cell Significance Index: -2.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1565
    Cell Significance Index: -18.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1720
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1722
    Cell Significance Index: -17.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1769
    Cell Significance Index: -2.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1966
    Cell Significance Index: -14.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1982
    Cell Significance Index: -9.3200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2124
    Cell Significance Index: -1.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2231
    Cell Significance Index: -11.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2341
    Cell Significance Index: -15.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2390
    Cell Significance Index: -9.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2394
    Cell Significance Index: -5.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2506
    Cell Significance Index: -10.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2562
    Cell Significance Index: -3.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2569
    Cell Significance Index: -15.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2680
    Cell Significance Index: -16.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2723
    Cell Significance Index: -15.2800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3081
    Cell Significance Index: -2.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3110
    Cell Significance Index: -14.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3122
    Cell Significance Index: -4.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3315
    Cell Significance Index: -8.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3459
    Cell Significance Index: -15.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3579
    Cell Significance Index: -18.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3691
    Cell Significance Index: -12.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3759
    Cell Significance Index: -8.0100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3867
    Cell Significance Index: -1.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3904
    Cell Significance Index: -20.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4003
    Cell Significance Index: -12.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4067
    Cell Significance Index: -15.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4215
    Cell Significance Index: -6.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4274
    Cell Significance Index: -15.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4307
    Cell Significance Index: -10.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4561
    Cell Significance Index: -12.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4647
    Cell Significance Index: -12.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4832
    Cell Significance Index: -15.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Composition:** ECM1 is a type of extracellular matrix protein that is rich in collagen and other structural components, contributing to the organization and stability of tissues. 2. **Cellular Expression:** ECM1 is expressed in various cell types, including epithelial cells, stromal cells, and fibroblasts, suggesting its involvement in tissue development and maintenance. 3. **Signal Transduction:** ECM1 interacts with multiple signaling molecules, including growth factors, cytokines, and transcription factors, to regulate cellular processes. 4. **Protein-Protein Interactions:** ECM1 forms complexes with other proteins, such as collagen, laminin, and integrins, to modulate its function and interactions. **Pathways and Functions:** 1. **Angiogenesis:** ECM1 promotes angiogenesis by interacting with vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), stimulating endothelial cell proliferation and migration. 2. **Chondrocyte Development:** ECM1 regulates chondrocyte differentiation and matrix synthesis, influencing the development of cartilage and bone tissue. 3. **Immune Regulation:** ECM1 modulates the immune response by interacting with immune cells, such as T cells and dendritic cells, and influencing cytokine production and signaling pathways. 4. **Tissue Development:** ECM1 plays a crucial role in tissue development, including embryonic development, wound healing, and organogenesis. **Clinical Significance:** 1. **Cancer Progression:** ECM1's role in angiogenesis and immune regulation makes it a potential target for cancer therapy, particularly in solid tumors. 2. **Inflammatory Diseases:** ECM1's involvement in inflammatory responses suggests its potential as a therapeutic target for diseases characterized by excessive inflammation, such as arthritis and atherosclerosis. 3. **Wound Healing:** ECM1's role in tissue development and repair makes it a promising candidate for the treatment of wound healing disorders. 4. **Autoimmune Diseases:** ECM1's interaction with immune cells and cytokines may influence the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, ECM1 is a multifaceted protein that plays a crucial role in various biological processes, including angiogenesis, chondrocyte development, and immune regulation. Its clinical significance is evident in its potential as a therapeutic target for cancer, inflammatory diseases, wound healing disorders, and autoimmune diseases. Further research is necessary to fully elucidate the mechanisms of ECM1's function and to explore its therapeutic potential.

Genular Protein ID: 3840153054

Symbol: ECM1_HUMAN

Name: Extracellular matrix protein 1

UniProtKB Accession Codes:

Q16610 A8K8S0 B4DW49 B4DY60 O43266 Q5T5G4 Q5T5G5 Q5T5G6 Q8IZ60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367673

Title: The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization.

PubMed ID: 9367673

DOI: 10.1006/geno.1997.4918

PubMed ID: 9501329

Title: Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21.

PubMed ID: 9501329

DOI: 10.1016/s0945-053x(97)90017-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11165938

Title: Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro.

PubMed ID: 11165938

DOI: 10.1016/s8756-3282(00)00428-2

PubMed ID: 11292659

Title: Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells.

PubMed ID: 11292659

DOI: 10.1096/fj.99-0934com

PubMed ID: 11929856

Title: Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).

PubMed ID: 11929856

DOI: 10.1093/hmg/11.7.833

PubMed ID: 12604605

Title: Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.

PubMed ID: 12604605

DOI: 10.1074/jbc.m210529200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16512877

Title: Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions.

PubMed ID: 16512877

DOI: 10.1111/j.0906-6705.2006.00409.x

PubMed ID: 19275936

Title: ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.

PubMed ID: 19275936

DOI: 10.1016/j.matbio.2009.02.003

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12603844

Title: Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation.

PubMed ID: 12603844

DOI: 10.1046/j.1523-1747.2003.12073.x

Sequence Information:

  • Length: 540
  • Mass: 60674
  • Checksum: EA575895CDE068BE
  • Sequence:
    • MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP LSRSLPMDHP 
DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK EVGPPLPQEA VPLQKELPSL 
QHPNEQKEGT PAPFGDQSHP EPESWNAAQH CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI 
CLPNRQHVVY GPWNLPQSSY SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA 
MSRFCEAEFS VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP 
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR QGNNHTCTWK 
AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA PYPNYDRDIL TIDIGRVTPN 
LMGHLCGNQR VLTKHKHIPG LIHNMTARCC DLPFPEQACC AEEEKLTFIN DLCGPRRNIW 
RDPALCCYLS PGDEQVNCFN INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.