Details for: EDN3

Gene ID: 1908

Symbol: EDN3

Ensembl ID: ENSG00000124205

Description: endothelin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.39
    Marker Score: 3268
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.37
    Marker Score: 18115
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.35
    Marker Score: 469
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2103
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.11
    Marker Score: 4607
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7307
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.09
    Marker Score: 565
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.09
    Marker Score: 600
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.05
    Marker Score: 3294
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251812
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.01
    Marker Score: 589
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.98
    Marker Score: 4687
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 484
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 778
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1595
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.78
    Marker Score: 1200
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.73
    Marker Score: 732
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.73
    Marker Score: 189
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2855
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.63
    Marker Score: 714
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.62
    Marker Score: 412
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.61
    Marker Score: 6907
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.61
    Marker Score: 367
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9551
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.61
    Marker Score: 151
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.59
    Marker Score: 238
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.56
    Marker Score: 130
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.55
    Marker Score: 584
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.53
    Marker Score: 151
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.52
    Marker Score: 317
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.47
    Marker Score: 545
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.47
    Marker Score: 245
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.45
    Marker Score: 730
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 182.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 229
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.38
    Marker Score: 153
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 176
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.37
    Marker Score: 89
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 358.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.34
    Marker Score: 166
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.33
    Marker Score: 144
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.29
    Marker Score: 250
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 324
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.28
    Marker Score: 200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.28
    Marker Score: 1039
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 122
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.26
    Marker Score: 602
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.26
    Marker Score: 2228
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.25
    Marker Score: 71
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.25
    Marker Score: 127
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 580
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 381
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.24
    Marker Score: 53
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 376
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 135
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.21
    Marker Score: 135
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.2
    Marker Score: 1587
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 103
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.19
    Marker Score: 47
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.19
    Marker Score: 182
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.18
    Marker Score: 187
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 153
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.17
    Marker Score: 178
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 62
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.15
    Marker Score: 55

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Other Information

**Key characteristics:** * EDN3 is a cell surface receptor for endothelin. * It is a member of the Class a/1 (rhodopsin-like receptors) of cell surface receptors. * It is expressed in high levels in blood vessel endothelial cells, enteric smooth muscle cells, and cardiac endothelial cells. * It is also expressed in low levels in epithelial cells of the lower respiratory tract and goblet cells. **Pathways and functions:** * EDN3 is a key regulator of blood pressure. It does this by binding to endothelin on the surface of blood vessels and promoting the formation of the endothelial cell adhesion molecule (ECAM) complex. The ECAM complex is a bridge between the endothelial cells and the smooth muscle cells that line the blood vessels. When the ECAM complex is formed, it allows the smooth muscle cells to contract and relax, which can affect blood pressure. * EDN3 also plays a role in maintaining blood vessel integrity. It does this by binding to endothelin and promoting the assembly of a complex called the endothelial cell adhesion molecule (ECAM) complex. The ECAM complex is a network of adhesion molecules that holds the endothelial cells together and prevents them from dislodging. * EDN3 also plays a role in regulating inflammation. It does this by binding to endothelin and promoting the migration of immune cells into the blood vessel. This migration can help to clear infection and inflammation, but it can also contribute to the development of atherosclerosis. **Clinical significance:** EDN3 is a promising target for the treatment of a variety of diseases. For example, EDN3 mutations have been linked to the development of hypertension, atherosclerosis, and heart failure. Targeting EDN3 with small molecules is a promising way to treat these diseases.

Genular Protein ID: 2634647396

Symbol: EDN3_HUMAN

Name: Endothelin-3

UniProtKB Accession Codes:

P14138 E1P5I5 Q03229 Q7Z6D2 Q9UGT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 33 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2509452

Title: cDNA cloning and chromosomal assignment of the gene encoding endothelin 3.

PubMed ID: 2509452

DOI: 10.1016/s0021-9258(19)84690-2

PubMed ID: 2178974

Title: One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta.

PubMed ID: 2178974

DOI: 10.1016/0014-5793(90)80583-5

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

PubMed ID: 1610811

Title: Solution structure of endothelin-3 determined using NMR spectroscopy.

PubMed ID: 1610811

DOI: 10.1021/bi00139a030

PubMed ID: 9359036

Title: Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.

PubMed ID: 9359036

PubMed ID: 8630503

Title: A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome).

PubMed ID: 8630503

DOI: 10.1038/ng0496-445

PubMed ID: 9359047

Title: Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease.

PubMed ID: 9359047

PubMed ID: 11303518

Title: A heterozygous endothelin 3 mutation in Waardenburg-Hirschsprung disease: is there a dosage effect of EDN3/EDNRB gene mutations on neurocristopathy phenotypes?

PubMed ID: 11303518

DOI: 10.1136/jmg.38.3.205

PubMed ID: 12189494

Title: SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism.

PubMed ID: 12189494

DOI: 10.1007/s00439-002-0765-8

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 238
  • Mass: 25454
  • Checksum: 7D7E90BC7DE37273
  • Sequence:
    • MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 
SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP

Genular Protein ID: 1409594597

Symbol: Q4FAT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4FAT2

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 192
  • Mass: 20594
  • Checksum: 8D744C578A40BED5
  • Sequence:
    • MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 
RLKSRTNKAS RL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.