Details for: EDN3

Gene ID: 1908

Symbol: EDN3

Ensembl ID: ENSG00000124205

Description: endothelin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.0213
    Cell Significance Index: -5.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.6246
    Cell Significance Index: -5.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.3713
    Cell Significance Index: 36.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0990
    Cell Significance Index: 67.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9038
    Cell Significance Index: 131.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4174
    Cell Significance Index: 460.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4115
    Cell Significance Index: -6.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0015
    Cell Significance Index: 29.9900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.6888
    Cell Significance Index: 9.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5563
    Cell Significance Index: 44.8400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.3708
    Cell Significance Index: 28.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2883
    Cell Significance Index: 77.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2708
    Cell Significance Index: 19.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2288
    Cell Significance Index: 25.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1027
    Cell Significance Index: 995.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0397
    Cell Significance Index: 169.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9858
    Cell Significance Index: 27.5500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.9507
    Cell Significance Index: 13.1900
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.9265
    Cell Significance Index: 6.3300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9145
    Cell Significance Index: 5.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9087
    Cell Significance Index: 98.8400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8410
    Cell Significance Index: 8.7800
  • Cell Name: myoblast (CL0000056)
    Fold Change: 0.5903
    Cell Significance Index: 5.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5688
    Cell Significance Index: 39.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3979
    Cell Significance Index: 248.4800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.3082
    Cell Significance Index: 2.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3059
    Cell Significance Index: 6.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2744
    Cell Significance Index: 12.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2386
    Cell Significance Index: 23.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1698
    Cell Significance Index: 5.4400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1338
    Cell Significance Index: 1.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1100
    Cell Significance Index: 0.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1084
    Cell Significance Index: 1.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1039
    Cell Significance Index: 12.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0948
    Cell Significance Index: 1.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0724
    Cell Significance Index: 1.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0639
    Cell Significance Index: 12.6900
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: 0.0582
    Cell Significance Index: 0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0566
    Cell Significance Index: 7.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0363
    Cell Significance Index: 4.1400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0203
    Cell Significance Index: 0.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0168
    Cell Significance Index: 0.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0148
    Cell Significance Index: 0.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.0143
    Cell Significance Index: 0.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0036
    Cell Significance Index: 2.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0013
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0010
    Cell Significance Index: 0.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0056
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0063
    Cell Significance Index: -0.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0077
    Cell Significance Index: -1.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0078
    Cell Significance Index: -4.2400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0085
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0098
    Cell Significance Index: -3.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0158
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0162
    Cell Significance Index: -1.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0188
    Cell Significance Index: -1.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0206
    Cell Significance Index: -0.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0217
    Cell Significance Index: -0.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0269
    Cell Significance Index: -1.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0276
    Cell Significance Index: -4.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0281
    Cell Significance Index: -5.0700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0304
    Cell Significance Index: -0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0384
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0407
    Cell Significance Index: -5.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0434
    Cell Significance Index: -1.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0527
    Cell Significance Index: -6.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0562
    Cell Significance Index: -3.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0573
    Cell Significance Index: -3.6100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0578
    Cell Significance Index: -0.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0613
    Cell Significance Index: -0.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0639
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0676
    Cell Significance Index: -1.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0696
    Cell Significance Index: -2.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0802
    Cell Significance Index: -2.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0824
    Cell Significance Index: -6.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0896
    Cell Significance Index: -5.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0907
    Cell Significance Index: -1.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0908
    Cell Significance Index: -5.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0965
    Cell Significance Index: -5.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0966
    Cell Significance Index: -5.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0992
    Cell Significance Index: -4.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0995
    Cell Significance Index: -2.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1029
    Cell Significance Index: -1.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1059
    Cell Significance Index: -3.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1120
    Cell Significance Index: -4.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1128
    Cell Significance Index: -3.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1158
    Cell Significance Index: -4.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1223
    Cell Significance Index: -2.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EDN3 exhibits several key characteristics that distinguish it from other endothelins: 1. **Vasoconstrictive properties**: EDN3 is a potent vasoconstrictor that induces vascular smooth muscle contraction, leading to increased blood pressure and reduced blood flow. 2. **Receptor specificity**: EDN3 binds to endothelin B receptors (ETBR), which are G-protein coupled receptors that activate a signaling cascade that regulates various cellular processes. 3. **Cellular expression**: EDN3 is expressed in a wide range of cell types, including endothelial cells, smooth muscle cells, immune cells, and neural crest cells. 4. **Signaling pathways**: EDN3 activates various signaling pathways, including G-protein coupled receptor signaling, MAP kinase signaling, and calcium ion homeostasis. **Pathways and Functions** EDN3 regulates various physiological and pathological processes through its interaction with endothelin B receptors: 1. **Vascular tone regulation**: EDN3 induces vasoconstriction, increasing blood pressure and reducing blood flow to specific tissues. 2. **Cell proliferation and differentiation**: EDN3 regulates cell proliferation and differentiation in various cell types, including endothelial cells, smooth muscle cells, and immune cells. 3. **Immune function**: EDN3 modulates immune responses, including neutrophil chemotaxis, leukocyte chemotaxis, and melanocyte differentiation. 4. **Neurological function**: EDN3 is involved in axon extension, axon guidance, and neural crest cell migration, highlighting its role in neuronal development and function. 5. **Cardiovascular function**: EDN3 regulates heart rate, cardiac endothelial cell function, and systemic arterial blood pressure. **Clinical Significance** Dysregulation of EDN3 has been implicated in various cardiovascular and immune disorders, including: 1. **Hypertension**: Increased EDN3 expression has been linked to hypertension, suggesting a potential therapeutic target for blood pressure regulation. 2. **Atherosclerosis**: EDN3 has been shown to contribute to atherosclerosis, a disease characterized by the buildup of plaque in arterial walls. 3. **Neurological disorders**: EDN3 has been implicated in neurological disorders, including stroke, multiple sclerosis, and neurodegenerative diseases. 4. **Cancer**: EDN3 has been shown to promote cancer progression, suggesting its potential as a therapeutic target in cancer therapy. In conclusion, EDN3 is a multifunctional peptide hormone that plays a critical role in maintaining vascular homeostasis, immune function, and neuronal development. Its dysregulation has been implicated in various cardiovascular and immune disorders, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2634647396

Symbol: EDN3_HUMAN

Name: Endothelin-3

UniProtKB Accession Codes:

P14138 E1P5I5 Q03229 Q7Z6D2 Q9UGT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 34 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2509452

Title: cDNA cloning and chromosomal assignment of the gene encoding endothelin 3.

PubMed ID: 2509452

DOI: 10.1016/s0021-9258(19)84690-2

PubMed ID: 2178974

Title: One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta.

PubMed ID: 2178974

DOI: 10.1016/0014-5793(90)80583-5

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

PubMed ID: 1610811

Title: Solution structure of endothelin-3 determined using NMR spectroscopy.

PubMed ID: 1610811

DOI: 10.1021/bi00139a030

PubMed ID: 9359036

Title: Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype.

PubMed ID: 9359036

PubMed ID: 8630503

Title: A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome).

PubMed ID: 8630503

DOI: 10.1038/ng0496-445

PubMed ID: 9359047

Title: Endothelin-3 gene mutations in isolated and syndromic Hirschsprung disease.

PubMed ID: 9359047

PubMed ID: 11303518

Title: A heterozygous endothelin 3 mutation in Waardenburg-Hirschsprung disease: is there a dosage effect of EDN3/EDNRB gene mutations on neurocristopathy phenotypes?

PubMed ID: 11303518

DOI: 10.1136/jmg.38.3.205

PubMed ID: 12189494

Title: SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism.

PubMed ID: 12189494

DOI: 10.1007/s00439-002-0765-8

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 238
  • Mass: 25454
  • Checksum: 7D7E90BC7DE37273
  • Sequence:
    • MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 
SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP

Genular Protein ID: 1409594597

Symbol: Q4FAT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4FAT2

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 192
  • Mass: 20594
  • Checksum: 8D744C578A40BED5
  • Sequence:
    • MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG 
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT 
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS 
RLKSRTNKAS RL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.