Details for: EGFR

Gene ID: 1956

Symbol: EGFR

Ensembl ID: ENSG00000146648

Description: epidermal growth factor receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 137.1889
    Cell Significance Index: -64.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 57.9214
    Cell Significance Index: -55.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.4166
    Cell Significance Index: -42.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 15.6493
    Cell Significance Index: 417.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 13.7510
    Cell Significance Index: 93.1700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 13.1355
    Cell Significance Index: 116.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 7.0056
    Cell Significance Index: 136.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 6.8481
    Cell Significance Index: 191.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 6.0482
    Cell Significance Index: 82.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.0707
    Cell Significance Index: 68.5700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.5204
    Cell Significance Index: 44.3300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.5690
    Cell Significance Index: 15.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5012
    Cell Significance Index: 68.0800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.4618
    Cell Significance Index: 5.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.2316
    Cell Significance Index: 47.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0481
    Cell Significance Index: 734.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8803
    Cell Significance Index: 132.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8616
    Cell Significance Index: 369.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.8067
    Cell Significance Index: 91.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7580
    Cell Significance Index: 216.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6734
    Cell Significance Index: 93.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6083
    Cell Significance Index: 289.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4455
    Cell Significance Index: 63.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.4359
    Cell Significance Index: 2703.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3421
    Cell Significance Index: 593.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2006
    Cell Significance Index: 762.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1938
    Cell Significance Index: 1837.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1875
    Cell Significance Index: 193.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0529
    Cell Significance Index: 26.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8850
    Cell Significance Index: 25.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.8463
    Cell Significance Index: 1560.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7194
    Cell Significance Index: 27.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.7163
    Cell Significance Index: 973.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7090
    Cell Significance Index: 77.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7016
    Cell Significance Index: 42.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6184
    Cell Significance Index: 427.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5815
    Cell Significance Index: 8.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5708
    Cell Significance Index: 35.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5067
    Cell Significance Index: 69.5800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4157
    Cell Significance Index: 4.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2937
    Cell Significance Index: 160.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2685
    Cell Significance Index: 12.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2454
    Cell Significance Index: 7.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1515
    Cell Significance Index: 14.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1253
    Cell Significance Index: 5.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1067
    Cell Significance Index: 5.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0471
    Cell Significance Index: 1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0238
    Cell Significance Index: 0.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0202
    Cell Significance Index: 18.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0183
    Cell Significance Index: 3.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0071
    Cell Significance Index: -1.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0276
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0423
    Cell Significance Index: -31.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0626
    Cell Significance Index: -47.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0697
    Cell Significance Index: -51.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0728
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0745
    Cell Significance Index: -46.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0918
    Cell Significance Index: -41.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1031
    Cell Significance Index: -58.1300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1144
    Cell Significance Index: -1.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1430
    Cell Significance Index: -14.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1818
    Cell Significance Index: -4.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2233
    Cell Significance Index: -44.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2235
    Cell Significance Index: -64.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2238
    Cell Significance Index: -15.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2770
    Cell Significance Index: -31.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2799
    Cell Significance Index: -58.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2827
    Cell Significance Index: -32.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2835
    Cell Significance Index: -36.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3028
    Cell Significance Index: -15.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3376
    Cell Significance Index: -43.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3632
    Cell Significance Index: -5.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3876
    Cell Significance Index: -8.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4041
    Cell Significance Index: -42.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4764
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4866
    Cell Significance Index: -55.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5380
    Cell Significance Index: -17.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5509
    Cell Significance Index: -64.9700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.6027
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6134
    Cell Significance Index: -37.6100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6786
    Cell Significance Index: -9.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7885
    Cell Significance Index: -62.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8050
    Cell Significance Index: -61.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8074
    Cell Significance Index: -16.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8261
    Cell Significance Index: -61.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8633
    Cell Significance Index: -7.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9283
    Cell Significance Index: -16.0500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9624
    Cell Significance Index: -5.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9761
    Cell Significance Index: -21.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9824
    Cell Significance Index: -66.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0467
    Cell Significance Index: -54.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1192
    Cell Significance Index: -70.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1708
    Cell Significance Index: -61.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.4117
    Cell Significance Index: -44.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4727
    Cell Significance Index: -54.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4884
    Cell Significance Index: -24.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6250
    Cell Significance Index: -41.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.6918
    Cell Significance Index: -58.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.6963
    Cell Significance Index: -28.5300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.8209
    Cell Significance Index: -20.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** EGFR is a transmembrane receptor with an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. 2. **Ligand binding:** EGFR is activated by binding to its ligands, including epidermal growth factor (EGF), transforming growth factor-alpha (TGF-α), and heparin-binding EGF-like growth factor (HB-EGF). 3. **Tyrosine kinase activity:** EGFR has intrinsic tyrosine kinase activity, which allows it to phosphorylate and activate downstream signaling molecules. 4. **Dimerization:** EGFR can dimerize with other ErbB family members, including EGFR-related receptors (ERBB2, ERBB3, and ERBB4), to form heterodimers that activate downstream signaling pathways. **Pathways and Functions:** 1. **Signaling pathways:** EGFR activates various signaling pathways, including the PI3K/AKT, MAPK/ERK, and JAK/STAT pathways, which regulate cell growth, differentiation, and survival. 2. **Cell proliferation:** EGFR signaling promotes cell proliferation and survival by activating the PI3K/AKT pathway. 3. **Angiogenesis:** EGFR signaling also promotes angiogenesis, the formation of new blood vessels, by activating the PI3K/AKT pathway. 4. **Metastasis:** EGFR signaling can contribute to metastasis by promoting cell migration and invasion through the activation of the MAPK/ERK pathway. **Clinical Significance:** 1. **Cancer development:** EGFR overexpression or mutation is associated with various cancers, including non-small cell lung cancer (NSCLC), colon cancer, and breast cancer. 2. **Therapeutic targets:** EGFR inhibitors, such as cetuximab and erlotinib, are approved therapies for NSCLC and other cancers. 3. **Prognosis:** EGFR expression levels can serve as a prognostic marker for cancer patients, with high expression levels associated with poor prognosis. 4. **Combination therapies:** EGFR inhibitors can be used in combination with other therapies, such as chemotherapy and radiation, to improve treatment outcomes. In conclusion, EGFR is a key player in cellular signaling and cancer development. Its dysregulation has significant implications for cancer therapy and patient prognosis. Further research is needed to fully understand the mechanisms of EGFR signaling and to develop more effective therapies for cancer treatment.

Genular Protein ID: 3861136894

Symbol: EGFR_HUMAN

Name: Proto-oncogene c-ErbB-1

UniProtKB Accession Codes:

P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 3 CORUM 1 CPTAC 23 CPTC 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 34 DrugCentral 1 EC 2 ELM 1 EMBL 25 EMDB 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 36 RefSeq 4 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6328312

Title: Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.

PubMed ID: 6328312

DOI: 10.1038/309418a0

PubMed ID: 7654368

Title: Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta.

PubMed ID: 7654368

DOI: 10.1002/mrd.1080410205

PubMed ID: 8918811

Title: A 1.8 kb alternative transcript from the human epidermal growth factor receptor gene encodes a truncated form of the receptor.

PubMed ID: 8918811

DOI: 10.1093/nar/24.20.4050

PubMed ID: 9103388

Title: Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer.

PubMed ID: 9103388

DOI: 10.1006/gyno.1996.4526

PubMed ID: 11161793

Title: Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms.

PubMed ID: 11161793

DOI: 10.1006/geno.2000.6341

PubMed ID: 6326261

Title: Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.

PubMed ID: 6326261

DOI: 10.1126/science.6326261

PubMed ID: 6330563

Title: Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.

PubMed ID: 6330563

DOI: 10.1038/309806a0

PubMed ID: 6093780

Title: Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells.

PubMed ID: 6093780

DOI: 10.1016/0006-291x(84)90926-4

PubMed ID: 3329716

Title: The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription.

PubMed ID: 3329716

PubMed ID: 1988448

Title: Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis.

PubMed ID: 1988448

DOI: 10.1016/s0021-9258(18)52359-0

PubMed ID: 2991899

Title: Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

PubMed ID: 2991899

DOI: 10.1073/pnas.82.15.4920

PubMed ID: 6324343

Title: Production of an epidermal growth factor receptor-related protein.

PubMed ID: 6324343

DOI: 10.1126/science.6324343

PubMed ID: 3138233

Title: Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.

PubMed ID: 3138233

DOI: 10.1016/s0021-9258(18)37684-1

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2985580

Title: Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase.

PubMed ID: 2985580

DOI: 10.1016/s0021-9258(18)89002-0

PubMed ID: 16543144

Title: Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain.

PubMed ID: 16543144

DOI: 10.1016/j.molcel.2006.02.018

PubMed ID: 9556602

Title: Disulfide bond structure of human epidermal growth factor receptor.

PubMed ID: 9556602

DOI: 10.1074/jbc.273.18.11150

PubMed ID: 6325948

Title: ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA.

PubMed ID: 6325948

DOI: 10.1038/309270a0

PubMed ID: 3039909

Title: Receptors for epidermal growth factor and other polypeptide mitogens.

PubMed ID: 3039909

DOI: 10.1146/annurev.bi.56.070187.004313

PubMed ID: 2790960

Title: Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation.

PubMed ID: 2790960

DOI: 10.1016/0092-8674(89)90867-2

PubMed ID: 2543678

Title: All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

PubMed ID: 2543678

DOI: 10.1016/s0021-9258(18)81674-x

PubMed ID: 7679104

Title: Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells.

PubMed ID: 7679104

DOI: 10.1016/s0021-9258(18)53862-x

PubMed ID: 8650580

Title: Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.

PubMed ID: 8650580

DOI: 10.1126/science.272.5269.1797

PubMed ID: 9852145

Title: Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.

PubMed ID: 9852145

DOI: 10.1083/jcb.143.6.1471

PubMed ID: 10523301

Title: Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor.

PubMed ID: 10523301

DOI: 10.1093/emboj/18.20.5567

PubMed ID: 8144591

Title: Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction.

PubMed ID: 8144591

DOI: 10.1016/s0021-9258(17)36977-6

PubMed ID: 7657591

Title: Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.

PubMed ID: 7657591

DOI: 10.1074/jbc.270.35.20242

PubMed ID: 8962717

Title: Analysis of the glycosylation patterns of the extracellular domain of the epidermal growth factor receptor expressed in Chinese hamster ovary fibroblasts.

PubMed ID: 8962717

DOI: 10.3109/08977199609034572

PubMed ID: 9419975

Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

PubMed ID: 9419975

DOI: 10.1038/sj.onc.1201458

PubMed ID: 9488479

Title: Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.

PubMed ID: 9488479

DOI: 10.1128/mcb.18.3.1622

PubMed ID: 10228163

Title: Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.

PubMed ID: 10228163

DOI: 10.1093/emboj/18.9.2489

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10731668

Title: Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptor.

PubMed ID: 10731668

DOI: 10.1093/oxfordjournals.jbchem.a022585

PubMed ID: 11602604

Title: RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.

PubMed ID: 11602604

DOI: 10.1074/jbc.m108862200

PubMed ID: 12731890

Title: Characterization of glycosylation sites of the epidermal growth factor receptor.

PubMed ID: 12731890

DOI: 10.1021/bi027101p

PubMed ID: 12873986

Title: Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.

PubMed ID: 12873986

PubMed ID: 15282549

Title: LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.

PubMed ID: 15282549

DOI: 10.1038/sj.emboj.7600342

PubMed ID: 10805725

Title: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.

PubMed ID: 10805725

DOI: 10.1128/mcb.20.11.3817-3830.2000

PubMed ID: 11116146

Title: The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.

PubMed ID: 11116146

DOI: 10.1074/jbc.m008458200

PubMed ID: 11483589

Title: The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.

PubMed ID: 11483589

DOI: 10.1074/jbc.c100359200

PubMed ID: 15590694

Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

PubMed ID: 15590694

DOI: 10.1074/jbc.m408575200

PubMed ID: 15611079

Title: Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.

PubMed ID: 15611079

DOI: 10.1074/jbc.m413919200

PubMed ID: 16083266

Title: Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR).

PubMed ID: 16083266

DOI: 10.1021/pr050113n

PubMed ID: 16140940

Title: Functional implications of altered subcellular localization of PELP1 in breast cancer cells.

PubMed ID: 16140940

DOI: 10.1158/0008-5472.can-05-0614

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17115032

Title: Tyrosine phosphorylation controls PCNA function through protein stability.

PubMed ID: 17115032

DOI: 10.1038/ncb1501

PubMed ID: 16420529

Title: Syntaxin 9 is enriched in skin hair follicle epithelium and interacts with the epidermal growth factor receptor.

PubMed ID: 16420529

DOI: 10.1111/j.1600-0854.2005.00378.x

PubMed ID: 17909029

Title: The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.

PubMed ID: 17909029

DOI: 10.1158/0008-5472.can-07-1333

PubMed ID: 17671655

Title: Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.

PubMed ID: 17671655

DOI: 10.1172/jci31680

PubMed ID: 17182860

Title: Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.

PubMed ID: 17182860

DOI: 10.1091/mbc.e06-02-0142

PubMed ID: 17334392

Title: A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells.

PubMed ID: 17334392

DOI: 10.1038/sj.onc.1210341

PubMed ID: 18602463

Title: Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.

PubMed ID: 18602463

DOI: 10.1016/j.cellsig.2008.05.018

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19509291

Title: GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.

PubMed ID: 19509291

DOI: 10.1074/jbc.m109.021139

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19749156

Title: G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.

PubMed ID: 19749156

DOI: 10.1210/me.2009-0120

PubMed ID: 19718021

Title: ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.

PubMed ID: 19718021

DOI: 10.1038/nature08297

PubMed ID: 20674546

Title: COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.

PubMed ID: 20674546

DOI: 10.1016/j.bbrc.2010.07.096

PubMed ID: 20551055

Title: Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.

PubMed ID: 20551055

DOI: 10.1158/0008-5472.can-10-0408

PubMed ID: 20462955

Title: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.

PubMed ID: 20462955

DOI: 10.1091/mbc.e10-01-0028

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21487020

Title: Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.

PubMed ID: 21487020

DOI: 10.1074/jbc.m111.240796

PubMed ID: 21258366

Title: Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.

PubMed ID: 21258366

DOI: 10.1038/ncb2158

PubMed ID: 21516087

Title: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.

PubMed ID: 21516087

DOI: 10.1038/nm.2341

PubMed ID: 21518868

Title: FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.

PubMed ID: 21518868

DOI: 10.1073/pnas.1105369108

PubMed ID: 22298428

Title: The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane.

PubMed ID: 22298428

DOI: 10.1091/mbc.e11-09-0817

PubMed ID: 22179831

Title: Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.

PubMed ID: 22179831

DOI: 10.1038/onc.2011.587

PubMed ID: 23774213

Title: CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.

PubMed ID: 23774213

DOI: 10.1158/0008-5472.can-12-4441

PubMed ID: 23418353

Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.

PubMed ID: 23418353

DOI: 10.1242/jcs.116129

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25187647

Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

PubMed ID: 25187647

DOI: 10.1091/mbc.e14-05-0978

PubMed ID: 23589287

Title: Transforming growth factor-beta1 (TGF-beta1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts.

PubMed ID: 23589287

DOI: 10.1074/jbc.m113.451336

PubMed ID: 25311788

Title: EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.

PubMed ID: 25311788

DOI: 10.1186/1476-4598-13-233

PubMed ID: 23912460

Title: Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B.

PubMed ID: 23912460

DOI: 10.1038/onc.2013.293

PubMed ID: 25922362

Title: NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels.

PubMed ID: 25922362

DOI: 10.1093/glycob/cwv026

PubMed ID: 27153536

Title: Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.

PubMed ID: 27153536

DOI: 10.1016/j.molcel.2016.04.003

PubMed ID: 26988023

Title: Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

PubMed ID: 26988023

DOI: 10.1038/ncomms11030

PubMed ID: 28479384

Title: Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.

PubMed ID: 28479384

DOI: 10.1016/j.gene.2017.05.006

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 30352854

Title: TRAF4 binds to the juxtamembrane region of EGFR directly and promotes kinase activation.

PubMed ID: 30352854

DOI: 10.1073/pnas.1809599115

PubMed ID: 33996800

Title: ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation.

PubMed ID: 33996800

DOI: 10.3389/fcell.2021.642625

PubMed ID: 35538033

Title: CD82 palmitoylation site mutations at Cys5+Cys74 affect EGFR internalization and metabolism through recycling pathway.

PubMed ID: 35538033

DOI: 10.3724/abbs.2022011

PubMed ID: 12297049

Title: Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

PubMed ID: 12297049

DOI: 10.1016/s0092-8674(02)00940-6

PubMed ID: 12297050

Title: Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.

PubMed ID: 12297050

DOI: 10.1016/s0092-8674(02)00963-7

PubMed ID: 12620237

Title: EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

PubMed ID: 12620237

DOI: 10.1016/s1097-2765(03)00047-9

PubMed ID: 15374980

Title: A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.

PubMed ID: 15374980

DOI: 10.1158/0008-5472.can-04-1168

PubMed ID: 15837620

Title: Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.

PubMed ID: 15837620

DOI: 10.1016/j.ccr.2005.03.003

PubMed ID: 15840573

Title: A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor.

PubMed ID: 15840573

DOI: 10.1074/jbc.m502698200

PubMed ID: 17349580

Title: Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.

PubMed ID: 17349580

DOI: 10.1016/j.ccr.2006.12.017

PubMed ID: 18046415

Title: Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

PubMed ID: 18046415

DOI: 10.1038/nature05998

PubMed ID: 18227510

Title: The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.

PubMed ID: 18227510

DOI: 10.1073/pnas.0709662105

PubMed ID: 19563760

Title: Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.

PubMed ID: 19563760

DOI: 10.1016/j.cell.2009.04.025

Sequence Information:

  • Length: 1210
  • Mass: 134277
  • Checksum: D8A2A50B4EFB6ED2
  • Sequence:
    • MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN 
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV 
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN 
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV 
APQSSEFIGA

Genular Protein ID: 2071487100

Symbol: F2YGG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

F2YGG7

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 3 InterPro 15 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 4 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1167
  • Mass: 129365
  • Checksum: 1A345CEE26B795A0
  • Sequence:
    • MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 
VLSNYDANKT GLKELPMRNL QGQKCDPSCP NGSCWGAGEE NCQKLTKIIC AQQCSGRCRG 
KSPSDCCHNQ CAAGCTGPRE SDCLVCRKFR DEATCKDTCP PLMLYNPTTY QMDVNPEGKY 
SFGATCVKKC PRNYVVTDHG SCVRACGADS YEMEEDGVRK CKKCEGPCRK VCNGIGIGEF 
KDSLSINATN IKHFKNCTSI SGDLHILPVA FRGDSFTHTP PLDPQELDIL KTVKEITGFL 
LIQAWPENRT DLHAFENLEI IRGRTKQHGQ FSLAVVSLNI TSLGLRSLKE ISDGDVIISG 
NKNLCYANTI NWKKLFGTSG QKTKIISNRG ENSCKATGQV CHALCSPEGC WGPEPRDCVS 
CRNVSRGREC VDKCNLLEGE PREFVENSEC IQCHPECLPQ AMNITCTGRG PDNCIQCAHY 
IDGPHCVKTC PAGVMGENNT LVWKYADAGH VCHLCHPNCT YGCTGPGLEG CPTNGPKIPS 
IATGMVGALL LLLVVALGIG LFMRRRHIVR KRTLRRLLQE RELVEPLTPS GEAPNQALLR 
ILKETEFKKI KVLGSGAFGT VYKGLWIPEG EKVKIPVAIK ELREATSPKA NKEILDEAYV 
MASVDNPHVC RLLGICLTST VQLITQLMPF GCLLDYVREH KDNIGSQYLL NWCVQIAKGM 
NYLEDRRLVH RDLAARNVLV KTPQHVKITD FGLAKLLGAE EKEYHAEGGK VPIKWMALES 
ILHRIYTHQS DVWSYGVTVW ELMTFGSKPY DGIPASEISS ILEKGERLPQ PPICTIDVYM 
IMVKCWMIDA DSRPKFRELI IEFSKMARDP QRYLVIQGDE RMHLPSPTDS NFYRALMDEE 
DMDDVVDADE YLIPQQGFFS SPSTSRTPLL SSLSATSNNS TVACIDRNGL QSCPIKEDSF 
LQRYSSDPTG ALTEDSIDDT FLPVPEYINQ SVPKRPAGSV QNPVYHNQPL NPAPSRDPHY 
QDPHSTAVGN PEYLNTVQPT CVNSTFDSPA HWAQKGSHQI SLDNPDYQQD FFPKEAKPNG 
IFKGSTAENA EYLRVAPQSS EFIGAVP

Genular Protein ID: 1872450192

Symbol: B7Z2I3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2I3

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 3 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 Rhea 3 SAM 2 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 1157
  • Mass: 128653
  • Checksum: F46F912139C1FEC1
  • Sequence:
    • MFNNCEVVLG NLEITYVQRN YDLSFLKTIQ EVAGYVLIAL NTVERIPLEN LQIIRGNMYY 
ENSYALAVLS NYDANKTGLK ELPMRNLQEI LHGAVRFSNN PALCNVESIQ WRDIVSSDFL 
SNMSMDFQNH LGSCQKCDPS CPNGSCWGAG EENCQKLTKI ICAQQCSGRC RGKSPSDCCH 
NQCAAGCTGP RESDCLVCRK FRDEATCKDT CPPLMLYNPT TYQMDVNPEG KYSFGATCVK 
KCPRNYVVTD HGSCVRACGA DSYEMEEDGV RKCKKCEGPC RKVCNGIGIG EFKDSLSINA 
TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD ILKTVKEITG FLLIQAWPEN 
RTDLHAFENL EIIRGRTKQH GQFSLAVVSL NITSLGLRSL KEISDGDVII SGNKNLCYAN 
TINWKKLFGT SGQKTKIISN RGENSCKATG QVCHALCSPE GCWGPEPRDC VSCRNVSRGR 
ECVDKCNLLE GEPREFVENS ECIQCHPECL PQAMNITCTG RGPDNCIQCA HYIDGPHCVK 
TCPAGVMGEN NTLVWKYADA GHVCHLCHPN CTYGCTGPGL EGCPTNGPKI PSIATGMVGA 
LLLLLVVALG IGLFMRRRHI VRKRTLRRLL QERELVEPLT PSGEAPSQAL LRILKETEFK 
KIKVLGSGAF GTVYKGLWIP EGEKVKIPVA IKELREATSP KANKEILDEA YVMASVDNPH 
VCRLLGICLT STVQLITQLM PFGCLLDYVR EHKDNIGSQY LLNWCVQIAK GMNYLEDRRL 
VHRDLAARNV LVKTPQHVKI TDFGLAKLLG AEEKEYHAEG GKVPIKWMAL ESILHRIYTH 
QSDVWSYGVT VWELMTFGSK PYDGIPASEI SSILEKGERL PQPPICTIDV YMIMVKCWMI 
DADSRPKFRE LIIEFSKMAR DPQRYLVIQG DERMHLPSPT DSNFYRALMD EEDMDDVVDA 
DEYLIPQQGF FSSPSTSRTP LLSSLSATSN NSTVACIDRN GLQSCPIKED SFLQRYSSDP 
TGALTEDSID DTFLPVPEYI NQSVPKRPAG SVQNPVYHNQ PLNPAPSRDP HYQDPHSTAV 
GNPEYLNTVQ PTCVNSTFDS PAHWAQKGSH QISLDNPDYQ QDFFPKEAKP NGIFKGSTAE 
NAEYLRVAPQ SSEFIGA

Genular Protein ID: 131586833

Symbol: Q504U8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q504U8

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 2 GO 9 Gene3D 3 GeneTree 1 HGNC 1 InterPro 15 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 4 Rhea 3 SAM 3 SMART 2 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1091
  • Mass: 120692
  • Checksum: 25B062C735D62AD1
  • Sequence:
    • MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 
VLSNYDANKT GLKELPMRNL QGQKCDPSCP NGSCWGAGEE NCQKLTKIIC AQQCSGRCRG 
KSPSDCCHNQ CAAGCTGPRE SDCLVCRKFR DEATCKDTCP PLMLYNPTTY QMDVNPEGKY 
SFGATCVKKC PRNYVVTDHG SCVRACGADS YEMEEDGVRK CKKCEGPCRK VCNGIGIGEF 
KDSLSINATN IKHFKNCTSI SGDLHILPVA FRGDSFTHTP PLDPQELDIL KTVKEITGFL 
LIQAWPENRT DLHAFENLEI IRGRTKQHGQ FSLAVVSLNI TSLGLRSLKE ISDGDVIISG 
NKNLCYANTI NWKKLFGTSG QKTKIISNRG ENSCKATGQV CHALCSPEGC WGPEPRDCVS 
CRNVSRGREC VDKCNLLEGE PREFVENSEC IQCHPECLPQ AMNITCTGRG PDNCIQCAHY 
IDGPHCVKTC PAGVMGENNT LVWKYADAGH VCHLCHPNCT YGCTGPGLEG CPTNGPKIPS 
IATGMVGALL LLLVVALGIG LFMRRRHIVR KRTLRRLLQE RELVEPLTPS GEAPNQALLR 
ILKETEFKKI KVLGSGAFGT VYKGLWIPEG EKVKIPVAIK ELREATSPKA NKEILDEAYV 
MASVDNPHVC RLLGICLTST VQLITQLMPF GCLLDYVREH KDNIGSQYLL NWCVQIAKGM 
NYLEDRRLVH RDLAARNVLV KTPQHVKITD FGLAKLLGAE EKEYHAEGGK VPIKWMALES 
ILHRIYTHQS DVWSYGVTVW ELMTFGSKPY DGIPASEISS ILEKGERLPQ PPICTIDVYM 
IMVKCWMIDA DSRPKFRELI IEFSKMARDP QRYLVIQGDE RMHLPSPTDS NFYRALMDEE 
DMDDVVDADE YLIPQQGFFS SPSTSRTPLL SSLSATSNNS TVACIDRNGL QSCPIKEDSF 
LQRYSSDPTG ALTEDSIDDT FLPVPGEWLV WKQSCSSTSS THSAAASLQC PSQVLPPASP 
EGETVADLQT Q

Genular Protein ID: 3148094502

Symbol: E7BSV0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7BSV0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 10 Gene3D 3 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1136
  • Mass: 125801
  • Checksum: 77E46C2B5E691E9F
  • Sequence:
    • MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV 
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA 
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF 
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK 
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF 
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL 
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN 
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM 
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV 
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS 
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI 
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA 
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY 
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK 
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ 
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED 
SIDDTFLPVP GEWLVWKQSC SSTSSTHSAA ASLQCPSQVL PPASPEGETV ADLQTQ

Genular Protein ID: 3352131491

Symbol: C9JYS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JYS6

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 15 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 2 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1157
  • Mass: 128680
  • Checksum: 679F912139C1FB3A
  • Sequence:
    • MFNNCEVVLG NLEITYVQRN YDLSFLKTIQ EVAGYVLIAL NTVERIPLEN LQIIRGNMYY 
ENSYALAVLS NYDANKTGLK ELPMRNLQEI LHGAVRFSNN PALCNVESIQ WRDIVSSDFL 
SNMSMDFQNH LGSCQKCDPS CPNGSCWGAG EENCQKLTKI ICAQQCSGRC RGKSPSDCCH 
NQCAAGCTGP RESDCLVCRK FRDEATCKDT CPPLMLYNPT TYQMDVNPEG KYSFGATCVK 
KCPRNYVVTD HGSCVRACGA DSYEMEEDGV RKCKKCEGPC RKVCNGIGIG EFKDSLSINA 
TNIKHFKNCT SISGDLHILP VAFRGDSFTH TPPLDPQELD ILKTVKEITG FLLIQAWPEN 
RTDLHAFENL EIIRGRTKQH GQFSLAVVSL NITSLGLRSL KEISDGDVII SGNKNLCYAN 
TINWKKLFGT SGQKTKIISN RGENSCKATG QVCHALCSPE GCWGPEPRDC VSCRNVSRGR 
ECVDKCNLLE GEPREFVENS ECIQCHPECL PQAMNITCTG RGPDNCIQCA HYIDGPHCVK 
TCPAGVMGEN NTLVWKYADA GHVCHLCHPN CTYGCTGPGL EGCPTNGPKI PSIATGMVGA 
LLLLLVVALG IGLFMRRRHI VRKRTLRRLL QERELVEPLT PSGEAPNQAL LRILKETEFK 
KIKVLGSGAF GTVYKGLWIP EGEKVKIPVA IKELREATSP KANKEILDEA YVMASVDNPH 
VCRLLGICLT STVQLITQLM PFGCLLDYVR EHKDNIGSQY LLNWCVQIAK GMNYLEDRRL 
VHRDLAARNV LVKTPQHVKI TDFGLAKLLG AEEKEYHAEG GKVPIKWMAL ESILHRIYTH 
QSDVWSYGVT VWELMTFGSK PYDGIPASEI SSILEKGERL PQPPICTIDV YMIMVKCWMI 
DADSRPKFRE LIIEFSKMAR DPQRYLVIQG DERMHLPSPT DSNFYRALMD EEDMDDVVDA 
DEYLIPQQGF FSSPSTSRTP LLSSLSATSN NSTVACIDRN GLQSCPIKED SFLQRYSSDP 
TGALTEDSID DTFLPVPEYI NQSVPKRPAG SVQNPVYHNQ PLNPAPSRDP HYQDPHSTAV 
GNPEYLNTVQ PTCVNSTFDS PAHWAQKGSH QISLDNPDYQ QDFFPKEAKP NGIFKGSTAE 
NAEYLRVAPQ SSEFIGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.