EGFR | ENSG00000146648 | NCBI 1956

Details for: EGFR

Gene ID: 1956

Symbol: EGFR

Ensembl ID: ENSG00000146648

Description: epidermal growth factor receptor

Associated with

Axon guidance
(R-HSA-422475)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Egfr transactivation by gastrin
(R-HSA-2179392)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Infectious disease
(R-HSA-5663205)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
L1cam interactions
(R-HSA-373760)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Plcg1 events in erbb2 signaling
(R-HSA-1251932)
Ptk6 promotes hif1a stabilization
(R-HSA-8857538)
Raf/map kinase cascade
(R-HSA-5673001)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by gpcr
(R-HSA-372790)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by notch
(R-HSA-157118)
Signaling by notch3
(R-HSA-9012852)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Signal transduction by l1
(R-HSA-445144)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-HSA-8866910)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-HSA-8864260)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Calmodulin binding
(GO:0005516)
Chromatin binding
(GO:0003682)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
Epidermal growth factor receptor activity
(GO:0005006)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Kinase binding
(GO:0019900)
Map kinase kinase kinase activity
(GO:0004709)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase activator activity
(GO:0030296)
Protein tyrosine kinase activity
(GO:0004713)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.79
Cell Significance Index: 2
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.73
Cell Significance Index: 2
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.28
Cell Significance Index: 1
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1
Cell Significance Index: 1
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal cell (CL0000646)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Structure:** EGFR is a transmembrane receptor with an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. 2. **Ligand binding:** EGFR is activated by binding to its ligands, including epidermal growth factor (EGF), transforming growth factor-alpha (TGF-α), and heparin-binding EGF-like growth factor (HB-EGF). 3. **Tyrosine kinase activity:** EGFR has intrinsic tyrosine kinase activity, which allows it to phosphorylate and activate downstream signaling molecules. 4. **Dimerization:** EGFR can dimerize with other ErbB family members, including EGFR-related receptors (ERBB2, ERBB3, and ERBB4), to form heterodimers that activate downstream signaling pathways. **Pathways and Functions:** 1. **Signaling pathways:** EGFR activates various signaling pathways, including the PI3K/AKT, MAPK/ERK, and JAK/STAT pathways, which regulate cell growth, differentiation, and survival. 2. **Cell proliferation:** EGFR signaling promotes cell proliferation and survival by activating the PI3K/AKT pathway. 3. **Angiogenesis:** EGFR signaling also promotes angiogenesis, the formation of new blood vessels, by activating the PI3K/AKT pathway. 4. **Metastasis:** EGFR signaling can contribute to metastasis by promoting cell migration and invasion through the activation of the MAPK/ERK pathway. **Clinical Significance:** 1. **Cancer development:** EGFR overexpression or mutation is associated with various cancers, including non-small cell lung cancer (NSCLC), colon cancer, and breast cancer. 2. **Therapeutic targets:** EGFR inhibitors, such as cetuximab and erlotinib, are approved therapies for NSCLC and other cancers. 3. **Prognosis:** EGFR expression levels can serve as a prognostic marker for cancer patients, with high expression levels associated with poor prognosis. 4. **Combination therapies:** EGFR inhibitors can be used in combination with other therapies, such as chemotherapy and radiation, to improve treatment outcomes. In conclusion, EGFR is a key player in cellular signaling and cancer development. Its dysregulation has significant implications for cancer therapy and patient prognosis. Further research is needed to fully understand the mechanisms of EGFR signaling and to develop more effective therapies for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.