Details for: SLC29A1

Gene ID: 2030

Symbol: SLC29A1

Ensembl ID: ENSG00000112759

Description: solute carrier family 29 member 1 (Augustine blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.3
    Marker Score: 2403
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.02
    Marker Score: 7920
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.53
    Marker Score: 1040
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168578
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.45
    Marker Score: 411
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.39
    Marker Score: 560
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1736.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.35
    Marker Score: 699
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.34
    Marker Score: 1006
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.33
    Marker Score: 323
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.33
    Marker Score: 29696
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.32
    Marker Score: 482
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.3
    Marker Score: 647
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.26
    Marker Score: 528
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19369
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.13
    Marker Score: 625
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.11
    Marker Score: 3949
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.1
    Marker Score: 589
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.08
    Marker Score: 441
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.06
    Marker Score: 846
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.01
    Marker Score: 277
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.01
    Marker Score: 249
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1
    Marker Score: 1477
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2033.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1
    Marker Score: 1541
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71756
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47980
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.97
    Marker Score: 407
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.97
    Marker Score: 35805
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.96
    Marker Score: 3923
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.94
    Marker Score: 227
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.94
    Marker Score: 219
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.93
    Marker Score: 213
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5175
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.9
    Marker Score: 2268
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.89
    Marker Score: 1476
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.88
    Marker Score: 3663
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1826
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.86
    Marker Score: 5467
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.85
    Marker Score: 477
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.85
    Marker Score: 414
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.84
    Marker Score: 2187
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.82
    Marker Score: 994
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.82
    Marker Score: 8428
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.81
    Marker Score: 49551
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.8
    Marker Score: 3336
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.79
    Marker Score: 265
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6764
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.78
    Marker Score: 477
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4645
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.77
    Marker Score: 221
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 25812
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.74
    Marker Score: 999
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.74
    Marker Score: 1678
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.74
    Marker Score: 664
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6980
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.73
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 233
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.72
    Marker Score: 726
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.71
    Marker Score: 465
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.71
    Marker Score: 6642
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.7
    Marker Score: 13829
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.69
    Marker Score: 253
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.69
    Marker Score: 849
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.69
    Marker Score: 401
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.68
    Marker Score: 236
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.67
    Marker Score: 1480
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.67
    Marker Score: 528
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.67
    Marker Score: 677
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.67
    Marker Score: 1129
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2792
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.66
    Marker Score: 166
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.66
    Marker Score: 930.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.66
    Marker Score: 249
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.65
    Marker Score: 1745
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 307
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.63
    Marker Score: 446.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.63
    Marker Score: 669
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.63
    Marker Score: 16052
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.62
    Marker Score: 390
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.62
    Marker Score: 393
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.62
    Marker Score: 204
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.62
    Marker Score: 152
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.61
    Marker Score: 2371
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.61
    Marker Score: 3711
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.61
    Marker Score: 575

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Other Information

**Key characteristics:** * SLC29A1 is a highly expressed gene in cells of the hematopoietic system, particularly in erythroid progenitor cells, placental villous trophoblast, proerythroblast, mural cell, preosteoblast, type A enteroendocrine cell, and primitive red blood cell. * It is also expressed in endothelial cells of the sinusoid. * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a multi-pass protein with a hydrophilic N-terminal domain and a hydrophobic C-terminal domain. **Pathways and functions:** * SLC29A1 is involved in the transport of various small molecules and ions across the plasma membrane, including nucleosides, nucleotides, amino acids, and small molecules. * It is essential for the maintenance of cellular homeostasis and for the transport of nutrients and waste products to and from cells. * It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in SLC29A1 have been linked to human immunodeficiency, autoimmune disorders, and other diseases. * Studies of SLC29A1 have implications for the development of new therapeutic strategies for these diseases. **Additional notes:** * SLC29A1 is a promising target for the treatment of autoimmune disorders, such as immunodeficiency. * It is a potential therapeutic for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * Further research is needed to elucidate the role of SLC29A1 in human health and disease.

Genular Protein ID: 92181643

Symbol: S29A1_HUMAN

Name: Equilibrative nucleoside transporter 1

UniProtKB Accession Codes:

Q99808 B3KQV7 B3KQY5 Q5T9W9 Q9UJY2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 19 DrugCentral 1 EMBL 10 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 12 Rhea 11 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8986748

Title: Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.

PubMed ID: 8986748

DOI: 10.1038/nm0197-89

PubMed ID: 10755314

Title: Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.

PubMed ID: 10755314

DOI: 10.1007/s002800050040

PubMed ID: 12384580

Title: Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity.

PubMed ID: 12384580

DOI: 10.1093/nar/gkf564

PubMed ID: 12527552

Title: Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.

PubMed ID: 12527552

DOI: 10.1152/ajprenal.00215.2002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10722669

Title: Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.

PubMed ID: 10722669

DOI: 10.1074/jbc.275.12.8375

PubMed ID: 11584005

Title: Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.

PubMed ID: 11584005

DOI: 10.1074/jbc.m107169200

PubMed ID: 11311901

Title: Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system.

PubMed ID: 11311901

DOI: 10.1016/s0028-3908(00)00207-0

PubMed ID: 14759222

Title: Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.

PubMed ID: 14759222

DOI: 10.1042/bj20031880

PubMed ID: 15037197

Title: Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.

PubMed ID: 15037197

DOI: 10.1016/j.bcp.2003.09.018

PubMed ID: 15501974

Title: The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.

PubMed ID: 15501974

DOI: 10.1158/1078-0432.ccr-04-0224

PubMed ID: 17379602

Title: Residues 334 and 338 in transmembrane segment 8 of human equilibrative nucleoside transporter 1 are important determinants of inhibitor sensitivity, protein folding, and catalytic turnover.

PubMed ID: 17379602

DOI: 10.1074/jbc.m701735200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21795683

Title: Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).

PubMed ID: 21795683

DOI: 10.1074/jbc.m111.236117

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 23639800

Title: Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.

PubMed ID: 23639800

DOI: 10.1124/jpet.113.203265

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26406980

Title: The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters.

PubMed ID: 26406980

DOI: 10.1371/journal.pone.0136779

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27995448

Title: Functional characterization of human equilibrative nucleoside transporter 1.

PubMed ID: 27995448

DOI: 10.1007/s13238-016-0350-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 35790189

Title: Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.

PubMed ID: 35790189

DOI: 10.1038/s41586-022-05041-0

Sequence Information:

  • Length: 456
  • Mass: 50219
  • Checksum: F18535A95DEBC95D
  • Sequence:
    • MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS LVTAELSKDA 
QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS FLHQRIPQSV RILGSLVAIL 
LVFLITAILV KVQLDALPFF VITMIKIVLI NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ 
GLAGFFASVA MICAIASGSE LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL 
EGPGEQETKL DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF 
TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV FMWPGKDSRW 
LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM AAFAFSNGYL ASLCMCFGPK 
KVKPAEAETA GAIMAFFLCL GLALGAVFSF LFRAIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.