Gene EREG - ENSG00000124882 | NCBI Gene ID: 2069

Details for: EREG

Gene ID: 2069

Symbol: EREG

Ensembl ID: ENSG00000124882

Description: epiregulin

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytokine-mediated signaling pathway
(GO:0019221)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female meiotic nuclear division
(GO:0007143)
Growth factor activity
(GO:0008083)
Keratinocyte differentiation
(GO:0030216)
Keratinocyte proliferation
(GO:0043616)
Luteinizing hormone signaling pathway
(GO:0042700)
Mrna transcription
(GO:0009299)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of smooth muscle cell differentiation
(GO:0051151)
Oocyte maturation
(GO:0001556)
Ovarian cumulus expansion
(GO:0001550)
Ovulation
(GO:0030728)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Primary follicle stage
(GO:0048160)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Response to peptide hormone
(GO:0043434)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Wound healing
(GO:0042060)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.14
Marker Score: 13019.5
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 1.69
Marker Score: 2425
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.53
Marker Score: 1750
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.3
Marker Score: 5388.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.27
Marker Score: 1133.5
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.23
Marker Score: 393
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.19
Marker Score: 862
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.14
Marker Score: 63886.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.13
Marker Score: 1128
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.01
Marker Score: 1905
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.99
Marker Score: 2020
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.99
Marker Score: 744.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.98
Marker Score: 998
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 458
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1518
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.93
Marker Score: 232
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5174
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9
Marker Score: 14096
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.9
Marker Score: 2329
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 614
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 316
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.78
Marker Score: 272
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3229
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 664
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.71
Marker Score: 296
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.68
Marker Score: 407
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.67
Marker Score: 453
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.65
Marker Score: 1576
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.65
Marker Score: 539
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.63
Marker Score: 1007
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.61
Marker Score: 5261
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.57
Marker Score: 4462
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.56
Marker Score: 14415
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.56
Marker Score: 2166.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 446
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.54
Marker Score: 142
Cell Name: erythroblast (CL0000765)
Fold Change: 0.54
Marker Score: 334
Cell Name: monocyte (CL0000576)
Fold Change: 0.53
Marker Score: 690
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.53
Marker Score: 1024
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.53
Marker Score: 151
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.49
Marker Score: 258
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.47
Marker Score: 980
Cell Name: macrophage (CL0000235)
Fold Change: 0.46
Marker Score: 511
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.44
Marker Score: 1095
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.43
Marker Score: 119
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.41
Marker Score: 280
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.4
Marker Score: 439
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.4
Marker Score: 165
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.39
Marker Score: 396
Cell Name: malignant cell (CL0001064)
Fold Change: 0.39
Marker Score: 5291
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.38
Marker Score: 130
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.36
Marker Score: 247
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.36
Marker Score: 290
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.36
Marker Score: 1128
Cell Name: basal cell (CL0000646)
Fold Change: 0.34
Marker Score: 441
Cell Name: club cell (CL0000158)
Fold Change: 0.34
Marker Score: 397
Cell Name: neutrophil (CL0000775)
Fold Change: 0.33
Marker Score: 200
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.33
Marker Score: 186
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.32
Marker Score: 905
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.3
Marker Score: 206
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.3
Marker Score: 229
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.29
Marker Score: 92
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.29
Marker Score: 65
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.29
Marker Score: 136
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.28
Marker Score: 293
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.28
Marker Score: 166
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.27
Marker Score: 74
Cell Name: mast cell (CL0000097)
Fold Change: 0.27
Marker Score: 154
Cell Name: B cell (CL0000236)
Fold Change: 0.26
Marker Score: 252
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.26
Marker Score: 273
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.26
Marker Score: 108
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.26
Marker Score: 77
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.25
Marker Score: 241
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.25
Marker Score: 397
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.25
Marker Score: 1295
Cell Name: enterocyte (CL0000584)
Fold Change: 0.24
Marker Score: 1173
Cell Name: phagocyte (CL0000234)
Fold Change: 0.24
Marker Score: 81
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.24
Marker Score: 64
Cell Name: leukocyte (CL0000738)
Fold Change: 0.24
Marker Score: 137
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.24
Marker Score: 112
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.24
Marker Score: 81
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.23
Marker Score: 75
Cell Name: promonocyte (CL0000559)
Fold Change: 0.23
Marker Score: 149.5
Cell Name: T cell (CL0000084)
Fold Change: 0.23
Marker Score: 395
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.22
Marker Score: 48
Cell Name: stem cell (CL0000034)
Fold Change: 0.22
Marker Score: 524
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.21
Marker Score: 42

Hover over a box to see details here...

**Key characteristics:** * EREG is a glycoprotein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including macrophages, lung cells, and cancer cells. * EREG binds to various growth factor receptors, including EGFR, ERBB2, and ERBB4. * Upon binding to these receptors, EREG triggers downstream signaling pathways that promote cell growth, survival, and migration. * It is also involved in the regulation of cell cycle progression, apoptosis, and angiogenesis. **Pathways and functions:** * EREG signaling through EGFR is critical for the growth and survival of cancer cells. * It promotes cell cycle progression, inhibits apoptosis, and facilitates cell migration. * It also plays a role in the regulation of angiogenesis and tumor growth. * Blockade of EREG signaling with antibodies or small molecules can inhibit cancer cell growth and metastasis. **Clinical significance:** * Mutations in the EREG gene have been linked to the development of several human cancers, including lung cancer, breast cancer, and colon cancer. * Targeting EREG signaling has emerged as a promising therapeutic approach for cancer treatment. * Several drugs, such as erlotinib (Tarceva), are currently used in clinical practice to inhibit EREG signaling in cancer. **Additional points:** * EREG is a highly conserved protein with a similar sequence in mammals. * It is a promising target for cancer immunotherapy due to its role in promoting cancer growth and metastasis. * Further research is needed to develop more effective and selective EREG inhibitors for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proepiregulin

Genular Protein ID: 890993416

Symbol: EREG_HUMAN

Name: Proepiregulin

UniProtKB Accession Codes:

O14944 B2RC66 Q6FH69

Database IDs:

Citations:

PubMed ID: 9337852

Title: Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family.

PubMed ID: 9337852

DOI: 10.1042/bj3260069

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9419975

Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

PubMed ID: 9419975

DOI: 10.1038/sj.onc.1201458

PubMed ID: 14572630

Title: Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity.

PubMed ID: 14572630

DOI: 10.1016/s0014-5793(03)01005-6

PubMed ID: 24631357

Title: Epiregulin: roles in normal physiology and cancer.

PubMed ID: 24631357

DOI: 10.1016/j.semcdb.2014.03.005

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 169
Mass: 19044
Checksum: 17F3926ADFB2BDEE
Sequence:

MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV 
AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA 
LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EREG

Associated with

Cells (max top 100)

Other Information

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. PubMed ID: 9337852

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. PubMed ID: 9419975

Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity. PubMed ID: 14572630

Epiregulin: roles in normal physiology and cancer. PubMed ID: 24631357

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974