EREG | ENSG00000124882 | NCBI 2069

Details for: EREG

Gene ID: 2069

Symbol: EREG

Ensembl ID: ENSG00000124882

Description: epiregulin

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytokine-mediated signaling pathway
(GO:0019221)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female meiotic nuclear division
(GO:0007143)
Growth factor activity
(GO:0008083)
Keratinocyte differentiation
(GO:0030216)
Keratinocyte proliferation
(GO:0043616)
Luteinizing hormone signaling pathway
(GO:0042700)
Mrna transcription
(GO:0009299)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of smooth muscle cell differentiation
(GO:0051151)
Oocyte maturation
(GO:0001556)
Ovarian cumulus expansion
(GO:0001550)
Ovulation
(GO:0030728)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Primary follicle stage
(GO:0048160)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Response to peptide hormone
(GO:0043434)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Wound healing
(GO:0042060)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 66.6044
Cell Significance Index: -10.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.8568
Cell Significance Index: -10.9200
Cell Name: early promyelocyte (CL0002154)
Fold Change: 7.2568
Cell Significance Index: 46.3300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 5.8484
Cell Significance Index: 156.4400
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.2981
Cell Significance Index: 21.8800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.8839
Cell Significance Index: -11.3800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 2.3595
Cell Significance Index: 24.4300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.7195
Cell Significance Index: 25.7700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2839
Cell Significance Index: -2.8100
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.2738
Cell Significance Index: 14.4200
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.1179
Cell Significance Index: 6.8800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.0799
Cell Significance Index: 19.9600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8836
Cell Significance Index: 13.6700
Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.8225
Cell Significance Index: 14.1300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7876
Cell Significance Index: 35.7000
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 0.7303
Cell Significance Index: 5.2500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6525
Cell Significance Index: 48.6300
Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
Fold Change: 0.5915
Cell Significance Index: 5.6900
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.5911
Cell Significance Index: 8.4700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4271
Cell Significance Index: 42.2500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3215
Cell Significance Index: 290.2600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2238
Cell Significance Index: 36.4000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1811
Cell Significance Index: 19.7000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1154
Cell Significance Index: 6.9300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0980
Cell Significance Index: 2.8300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0760
Cell Significance Index: 14.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0700
Cell Significance Index: 4.8400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0637
Cell Significance Index: 1.3800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0220
Cell Significance Index: 0.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0071
Cell Significance Index: 0.2500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0031
Cell Significance Index: -2.1500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0054
Cell Significance Index: -0.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0058
Cell Significance Index: -10.8300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0059
Cell Significance Index: -4.5000
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0075
Cell Significance Index: -4.1200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0096
Cell Significance Index: -0.2000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0105
Cell Significance Index: -19.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0128
Cell Significance Index: -19.6500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0146
Cell Significance Index: -19.9000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0174
Cell Significance Index: -12.7400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0190
Cell Significance Index: -8.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0196
Cell Significance Index: -12.4300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0211
Cell Significance Index: -0.5900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0216
Cell Significance Index: -16.0000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0235
Cell Significance Index: -8.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0277
Cell Significance Index: -0.5900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0291
Cell Significance Index: -16.4100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0315
Cell Significance Index: -19.6900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0339
Cell Significance Index: -15.3700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0402
Cell Significance Index: -2.0300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0416
Cell Significance Index: -5.1200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0453
Cell Significance Index: -13.0300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0457
Cell Significance Index: -8.2300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0469
Cell Significance Index: -9.4100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0595
Cell Significance Index: -11.8000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0685
Cell Significance Index: -8.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0748
Cell Significance Index: -7.6400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0767
Cell Significance Index: -16.1500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0775
Cell Significance Index: -9.0300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0845
Cell Significance Index: -12.2800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0859
Cell Significance Index: -11.7900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0871
Cell Significance Index: -2.2400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0889
Cell Significance Index: -11.4900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0949
Cell Significance Index: -5.8200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0969
Cell Significance Index: -16.5400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0991
Cell Significance Index: -4.3100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1012
Cell Significance Index: -3.2400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1344
Cell Significance Index: -15.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1427
Cell Significance Index: -16.8300
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1428
Cell Significance Index: -1.3300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1468
Cell Significance Index: -2.2300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1550
Cell Significance Index: -10.9600
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1672
Cell Significance Index: -3.2700
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.1732
Cell Significance Index: -1.1500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1744
Cell Significance Index: -13.3800
Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1791
Cell Significance Index: -2.1100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1874
Cell Significance Index: -12.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2050
Cell Significance Index: -9.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2057
Cell Significance Index: -13.2700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2097
Cell Significance Index: -12.8900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2131
Cell Significance Index: -10.0200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2147
Cell Significance Index: -13.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2164
Cell Significance Index: -11.2400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2382
Cell Significance Index: -3.5900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2531
Cell Significance Index: -9.2900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2570
Cell Significance Index: -14.4200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2751
Cell Significance Index: -12.1700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2790
Cell Significance Index: -14.6500
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.2958
Cell Significance Index: -2.5000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2966
Cell Significance Index: -7.9200
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3211
Cell Significance Index: -12.1600
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3223
Cell Significance Index: -8.0500
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.3330
Cell Significance Index: -2.8800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3374
Cell Significance Index: -11.8200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3418
Cell Significance Index: -11.1900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: -0.3548
Cell Significance Index: 0.0900
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.3594
Cell Significance Index: -4.8500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3715
Cell Significance Index: -12.9100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3762
Cell Significance Index: -11.9800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3905
Cell Significance Index: -7.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structure and Function:** ERG is a secreted glycoprotein that belongs to the EGF family, which includes other growth factors such as EGF, TGF-α, and HB-EGF. Its structure consists of a single polypeptide chain with a hydrophobic N-terminus and a hydrophilic C-terminus. 2. **Cellular Expression:** ERG is widely expressed in various tissues, including the lung, liver, and pancreas, as well as in immune cells such as macrophages and T-cells. 3. **Receptor Binding:** ERG binds to EGFR and other receptor tyrosine kinases, triggering a cascade of signaling events that regulate cell proliferation, survival, and migration. **Pathways and Functions:** 1. **EGFR Signaling:** ERG interacts with EGFR to activate the PI3K/AKT pathway, which promotes cell survival, proliferation, and migration. 2. **MAPK/ERK Signaling:** ERG also activates the MAPK/ERK pathway, which regulates cell differentiation, proliferation, and survival. 3. **Wnt/β-catenin Signaling:** ERG modulates the Wnt/β-catenin pathway, which is involved in cell proliferation, differentiation, and cancer development. 4. **Apoptosis and Proliferation:** ERG regulates apoptosis and proliferation by modulating the expression of anti-apoptotic and pro-apoptotic proteins. **Clinical Significance:** 1. **Cancer:** ERG is often upregulated in various cancers, including lung, breast, and colon cancer, where it promotes tumor growth, metastasis, and resistance to therapy. 2. **Inflammation:** ERG is involved in the regulation of immune responses, including inflammation, which is a hallmark of various diseases, including cancer and autoimmune disorders. 3. **Neurological Disorders:** ERG has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cardiovascular Disease:** ERG is involved in the regulation of cardiovascular function, including blood pressure regulation and cardiovascular disease. In conclusion, ERG is a multifunctional growth factor that plays a critical role in various cellular processes, including cell signaling, proliferation, and survival. Its dysregulation has been implicated in various diseases, including cancer, inflammation, and neurological disorders. Further research is needed to fully understand the complex role of ERG in human health and disease. **References:** * [List of relevant studies and reviews on ERG and its role in various diseases]

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proepiregulin

Genular Protein ID: 890993416

Symbol: EREG_HUMAN

Name: Proepiregulin

UniProtKB Accession Codes:

O14944 B2RC66 Q6FH69

Database IDs:

Citations:

PubMed ID: 9337852

Title: Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family.

PubMed ID: 9337852

DOI: 10.1042/bj3260069

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9419975

Title: Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

PubMed ID: 9419975

DOI: 10.1038/sj.onc.1201458

PubMed ID: 14572630

Title: Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity.

PubMed ID: 14572630

DOI: 10.1016/s0014-5793(03)01005-6

PubMed ID: 24631357

Title: Epiregulin: roles in normal physiology and cancer.

PubMed ID: 24631357

DOI: 10.1016/j.semcdb.2014.03.005

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 169
Mass: 19044
Checksum: 17F3926ADFB2BDEE
Sequence:

MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV 
AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA 
LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EREG

Associated with

Cells (max top 100)

Other Information

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. PubMed ID: 9337852

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. PubMed ID: 9419975

Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity. PubMed ID: 14572630

Epiregulin: roles in normal physiology and cancer. PubMed ID: 24631357

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974