Gene F3 - ENSG00000117525 | NCBI Gene ID: 2152

Details for: F3

Gene ID: 2152

Symbol: F3

Ensembl ID: ENSG00000117525

Description: coagulation factor III, tissue factor

Associated with

Extrinsic pathway of fibrin clot formation
(R-HSA-140834)
Formation of fibrin clot (clotting cascade)
(R-HSA-140877)
Hemostasis
(R-HSA-109582)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Activation of blood coagulation via clotting cascade
(GO:0002543)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of plasma proteins involved in acute inflammatory response
(GO:0002541)
Blood coagulation
(GO:0007596)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Membrane
(GO:0016020)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010641)
Positive regulation of positive chemotaxis
(GO:0050927)
Positive regulation of tor signaling
(GO:0032008)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase complex
(GO:1905286)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3.51
Marker Score: 2348
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.43
Marker Score: 25552
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.8
Marker Score: 1841
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.47
Marker Score: 3325
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.45
Marker Score: 1669
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.38
Marker Score: 5814
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.34
Marker Score: 1156
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.3
Marker Score: 14984
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.26
Marker Score: 2381
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.23
Marker Score: 1756
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.21
Marker Score: 47249
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.19
Marker Score: 3041.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.03
Marker Score: 8741
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2
Marker Score: 9843.5
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.98
Marker Score: 2389
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.95
Marker Score: 564
Cell Name: fat cell (CL0000136)
Fold Change: 1.86
Marker Score: 1042
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.83
Marker Score: 669
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.82
Marker Score: 2201
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.8
Marker Score: 2900
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.77
Marker Score: 484
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.64
Marker Score: 735
Cell Name: malignant cell (CL0001064)
Fold Change: 1.47
Marker Score: 19731
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168361
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.43
Marker Score: 666
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.38
Marker Score: 1586
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.38
Marker Score: 15489
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.31
Marker Score: 859
Cell Name: astrocyte (CL0000127)
Fold Change: 1.29
Marker Score: 1121
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.26
Marker Score: 311
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.26
Marker Score: 1203
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.25
Marker Score: 1106
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.24
Marker Score: 615
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.2
Marker Score: 40722
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2
Marker Score: 41435.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.19
Marker Score: 18593
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.16
Marker Score: 369
Cell Name: keratocyte (CL0002363)
Fold Change: 1.13
Marker Score: 261
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.08
Marker Score: 918
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.06
Marker Score: 23771
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.06
Marker Score: 2773
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.06
Marker Score: 1129
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.05
Marker Score: 5528
Cell Name: secretory cell (CL0000151)
Fold Change: 1.04
Marker Score: 1893
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.03
Marker Score: 530
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.01
Marker Score: 358
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1
Marker Score: 3871
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71778
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48002
Cell Name: club cell (CL0000158)
Fold Change: 0.99
Marker Score: 1161
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.97
Marker Score: 554
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: acinar cell (CL0000622)
Fold Change: 0.96
Marker Score: 676
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.95
Marker Score: 273.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.94
Marker Score: 390
Cell Name: podocyte (CL0000653)
Fold Change: 0.93
Marker Score: 344
Cell Name: fibroblast (CL0000057)
Fold Change: 0.93
Marker Score: 897
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.92
Marker Score: 1502
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.91
Marker Score: 814
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.9
Marker Score: 437
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.9
Marker Score: 5737
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.88
Marker Score: 807
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5006
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5273
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.86
Marker Score: 1752
Cell Name: basal cell (CL0000646)
Fold Change: 0.85
Marker Score: 1093
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.83
Marker Score: 1875
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 630.5
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.82
Marker Score: 687
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.81
Marker Score: 1856
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.8
Marker Score: 6925
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: stromal cell (CL0000499)
Fold Change: 0.77
Marker Score: 897
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.76
Marker Score: 200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.75
Marker Score: 187
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.75
Marker Score: 1415.5
Cell Name: theca cell (CL0000503)
Fold Change: 0.75
Marker Score: 535
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 674
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 295
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.73
Marker Score: 187
Cell Name: ionocyte (CL0005006)
Fold Change: 0.72
Marker Score: 220
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.71
Marker Score: 2753
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.71
Marker Score: 692
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.69
Marker Score: 443
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.69
Marker Score: 421.5
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.69
Marker Score: 943
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2868.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.68
Marker Score: 2852
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.68
Marker Score: 199
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.68
Marker Score: 1045
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.68
Marker Score: 746
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.66
Marker Score: 148
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.64
Marker Score: 160

Hover over a box to see details here...

**Key characteristics:** - F3 is a glycoprotein composed of three extracellular domains: F3a, F3b, and F3c. - F3a is responsible for binding to fibrinogen and initiating the coagulation cascade. - F3b and F3c are involved in the regulation of blood flow and inflammation. **Pathways and functions:** - F3 is activated by thrombin, a proteolytic enzyme that is generated during inflammation. - Once activated, F3 binds to fibrinogen, which is a protein found in blood plasma. - This binding initiates the coagulation cascade, which leads to the formation of a blood clot. **Clinical significance:** - Mutations in the F3 gene have been linked to several blood disorders, including hemophilia A and von Willebrand disease. - F3 inhibitors are used in the treatment of hemophilia A. - F3 is also involved in the regulation of inflammation. - Dysregulation of F3 has been linked to several inflammatory diseases, including rheumatoid arthritis and atherosclerosis. **Additional information:** - F3 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. - It is expressed in high levels in the liver, heart, and lungs. - F3 is a key regulator of hemostasis and inflammation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tissue factor

Genular Protein ID: 2561779153

Symbol: TF_HUMAN

Name: Tissue factor

UniProtKB Accession Codes:

P13726 D3DT47 Q6FHG2 Q86WH4

Database IDs:

Citations:

PubMed ID: 2823875

Title: Human tissue factor: cDNA sequence and chromosome localization of the gene.

PubMed ID: 2823875

DOI: 10.1021/bi00391a004

PubMed ID: 3297348

Title: Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade.

PubMed ID: 3297348

DOI: 10.1016/0092-8674(87)90669-6

PubMed ID: 3037536

Title: Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

PubMed ID: 3037536

DOI: 10.1073/pnas.84.15.5148

PubMed ID: 3424286

Title: Cloning and expression of human tissue factor cDNA.

PubMed ID: 3424286

DOI: 10.1016/0049-3848(87)90349-5

PubMed ID: 2719931

Title: Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.

PubMed ID: 2719931

DOI: 10.1021/bi00430a050

PubMed ID: 12652293

Title: Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.

PubMed ID: 12652293

DOI: 10.1038/nm841

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3166978

Title: Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.

PubMed ID: 3166978

DOI: 10.1021/bi00412a004

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 20634491

Title: Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.

PubMed ID: 20634491

DOI: 10.3324/haematol.2010.023713

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8086403

Title: Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site.

PubMed ID: 8086403

DOI: 10.1021/bi00202a003

PubMed ID: 8609606

Title: The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution.

PubMed ID: 8609606

DOI: 10.1006/jmbi.1996.0073

PubMed ID: 8598903

Title: The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.

PubMed ID: 8598903

DOI: 10.1038/380041a0

PubMed ID: 9925787

Title: Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.

PubMed ID: 9925787

DOI: 10.1006/jmbi.1998.2452

Sequence Information:

Length: 295
Mass: 33068
Checksum: D3486C713ED8EAD0
Sequence:

METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK 
PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS 
AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG 
KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE 
CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: F3

Associated with

Cells (max top 100)

Other Information

Human tissue factor: cDNA sequence and chromosome localization of the gene. PubMed ID: 2823875

Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. PubMed ID: 3297348

Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. PubMed ID: 3037536

Cloning and expression of human tissue factor cDNA. PubMed ID: 3424286

Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. PubMed ID: 2719931

Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. PubMed ID: 12652293

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine. PubMed ID: 3166978

Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. PubMed ID: 19168442

Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII. PubMed ID: 20634491

Initial characterization of the human central proteome. PubMed ID: 21269460

Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site. PubMed ID: 8086403

The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution. PubMed ID: 8609606

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. PubMed ID: 8598903

Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant. PubMed ID: 9925787