Details for: F3

Gene ID: 2152

Symbol: F3

Ensembl ID: ENSG00000117525

Description: coagulation factor III, tissue factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.1467
    Cell Significance Index: -35.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.2585
    Cell Significance Index: -30.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.8107
    Cell Significance Index: -30.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8595
    Cell Significance Index: -34.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.5743
    Cell Significance Index: 233.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1684
    Cell Significance Index: 42.3200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.2394
    Cell Significance Index: 10.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2018
    Cell Significance Index: 34.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1335
    Cell Significance Index: 7.6800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.0939
    Cell Significance Index: 6.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0503
    Cell Significance Index: 948.3800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.0398
    Cell Significance Index: 14.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0002
    Cell Significance Index: 28.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9647
    Cell Significance Index: 526.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9156
    Cell Significance Index: 90.5700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7668
    Cell Significance Index: 7.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7168
    Cell Significance Index: 15.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6497
    Cell Significance Index: 105.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6482
    Cell Significance Index: 29.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6353
    Cell Significance Index: 82.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6270
    Cell Significance Index: 68.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5605
    Cell Significance Index: 76.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4689
    Cell Significance Index: 28.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4305
    Cell Significance Index: 33.0400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.4177
    Cell Significance Index: 5.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3275
    Cell Significance Index: 22.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3203
    Cell Significance Index: 16.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3101
    Cell Significance Index: 23.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2872
    Cell Significance Index: 529.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2614
    Cell Significance Index: 33.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2061
    Cell Significance Index: 317.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1943
    Cell Significance Index: 23.9000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1861
    Cell Significance Index: 0.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1591
    Cell Significance Index: 11.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1368
    Cell Significance Index: 86.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1252
    Cell Significance Index: 94.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1154
    Cell Significance Index: 51.0100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.1129
    Cell Significance Index: 0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1101
    Cell Significance Index: 18.8000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1093
    Cell Significance Index: 0.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1071
    Cell Significance Index: 2.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0755
    Cell Significance Index: 1.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0713
    Cell Significance Index: 134.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0703
    Cell Significance Index: 12.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0421
    Cell Significance Index: 1.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0150
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0059
    Cell Significance Index: 1.1200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0026
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0168
    Cell Significance Index: -10.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0193
    Cell Significance Index: -0.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0224
    Cell Significance Index: -30.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0383
    Cell Significance Index: -7.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0456
    Cell Significance Index: -6.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0667
    Cell Significance Index: -7.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0677
    Cell Significance Index: -4.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0798
    Cell Significance Index: -28.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0905
    Cell Significance Index: -19.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1007
    Cell Significance Index: -20.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1134
    Cell Significance Index: -32.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1280
    Cell Significance Index: -3.2000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1282
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1390
    Cell Significance Index: -15.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1517
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1616
    Cell Significance Index: -18.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2097
    Cell Significance Index: -6.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2221
    Cell Significance Index: -22.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2427
    Cell Significance Index: -14.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2799
    Cell Significance Index: -33.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2883
    Cell Significance Index: -4.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3038
    Cell Significance Index: -17.0500
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.3285
    Cell Significance Index: -3.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3285
    Cell Significance Index: -34.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3518
    Cell Significance Index: -27.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3692
    Cell Significance Index: -19.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4162
    Cell Significance Index: -6.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4755
    Cell Significance Index: -30.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4795
    Cell Significance Index: -30.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4858
    Cell Significance Index: -8.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4903
    Cell Significance Index: -32.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5283
    Cell Significance Index: -18.5700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5622
    Cell Significance Index: -4.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5724
    Cell Significance Index: -8.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5784
    Cell Significance Index: -6.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5860
    Cell Significance Index: -21.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6077
    Cell Significance Index: -8.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6718
    Cell Significance Index: -18.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6772
    Cell Significance Index: -35.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7053
    Cell Significance Index: -19.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7110
    Cell Significance Index: -14.7500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7175
    Cell Significance Index: -9.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7193
    Cell Significance Index: -18.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7358
    Cell Significance Index: -25.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7536
    Cell Significance Index: -26.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7758
    Cell Significance Index: -34.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7785
    Cell Significance Index: -16.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8302
    Cell Significance Index: -12.5100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.8352
    Cell Significance Index: -6.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Coagulation Factor III:** F3 is a crucial component of the coagulation cascade, facilitating the formation of fibrin clots and promoting hemostasis. 2. **Tissue Factor:** F3 is also known as tissue factor, a transmembrane receptor that triggers the extrinsic pathway of blood coagulation upon binding to coagulation factor VIIa. 3. **Cell Surface Receptor:** F3 is a cell surface receptor, expressed on various cell types, including epithelial cells, immune cells, and astrocytes. 4. **Signaling Pathways:** F3 is involved in multiple signaling pathways, including those regulating angiogenesis, cell migration, endothelial cell proliferation, and gene expression. **Pathways and Functions:** 1. **Blood Coagulation:** F3 is essential for the activation of the coagulation cascade, leading to the formation of fibrin clots and hemostasis. 2. **Apoptotic Process:** F3 is involved in the regulation of apoptotic processes, including the activation of cysteine-type endopeptidase activity. 3. **Inflammatory Response:** F3 modulates the inflammatory response by regulating the production of cytokines, such as interleukin-8. 4. **Angiogenesis:** F3 promotes angiogenesis by activating signaling pathways that regulate endothelial cell proliferation and migration. 5. **Immune Regulation:** F3 is expressed on immune cells and regulates immune responses, including the activation of cytokine-mediated signaling pathways. **Clinical Significance:** 1. **Thrombotic Disorders:** Dysregulation of F3 has been implicated in various thrombotic disorders, including deep vein thrombosis and pulmonary embolism. 2. **Cancer:** F3 has been shown to promote angiogenesis and tumor growth, highlighting its potential role in cancer progression. 3. **Inflammatory Diseases:** F3's involvement in the regulation of inflammatory responses makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 4. **Neurological Disorders:** F3's expression in astrocytes and its role in regulating apoptosis and angiogenesis have implications for the treatment of neurological disorders, such as multiple sclerosis and stroke. In conclusion, F3, or coagulation factor III and tissue factor, is a multifaceted gene with far-reaching implications for our understanding of the immune system, coagulation cascade, and disease pathology. Further research is necessary to fully elucidate the complex roles of F3 in these processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2561779153

Symbol: TF_HUMAN

Name: Tissue factor

UniProtKB Accession Codes:

P13726 D3DT47 Q6FHG2 Q86WH4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 50 PDBsum 50 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2823875

Title: Human tissue factor: cDNA sequence and chromosome localization of the gene.

PubMed ID: 2823875

DOI: 10.1021/bi00391a004

PubMed ID: 3297348

Title: Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade.

PubMed ID: 3297348

DOI: 10.1016/0092-8674(87)90669-6

PubMed ID: 3037536

Title: Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

PubMed ID: 3037536

DOI: 10.1073/pnas.84.15.5148

PubMed ID: 3424286

Title: Cloning and expression of human tissue factor cDNA.

PubMed ID: 3424286

DOI: 10.1016/0049-3848(87)90349-5

PubMed ID: 2719931

Title: Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade.

PubMed ID: 2719931

DOI: 10.1021/bi00430a050

PubMed ID: 12652293

Title: Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.

PubMed ID: 12652293

DOI: 10.1038/nm841

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3166978

Title: Human tissue factor contains thioester-linked palmitate and stearate on the cytoplasmic half-cystine.

PubMed ID: 3166978

DOI: 10.1021/bi00412a004

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 20634491

Title: Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII.

PubMed ID: 20634491

DOI: 10.3324/haematol.2010.023713

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 8086403

Title: Structure of the extracellular domain of human tissue factor: location of the factor VIIa binding site.

PubMed ID: 8086403

DOI: 10.1021/bi00202a003

PubMed ID: 8609606

Title: The crystal structure of the extracellular domain of human tissue factor refined to 1.7-A resolution.

PubMed ID: 8609606

DOI: 10.1006/jmbi.1996.0073

PubMed ID: 8598903

Title: The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.

PubMed ID: 8598903

DOI: 10.1038/380041a0

PubMed ID: 9925787

Title: Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant.

PubMed ID: 9925787

DOI: 10.1006/jmbi.1998.2452

Sequence Information:

  • Length: 295
  • Mass: 33068
  • Checksum: D3486C713ED8EAD0
  • Sequence:
    • METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK 
PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS 
AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG 
KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE 
CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.