Details for: F11
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.5239
Cell Significance Index: 25.6700 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 1.1549
Cell Significance Index: 0.5800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.9601
Cell Significance Index: 23.2600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5744
Cell Significance Index: 16.5500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5663
Cell Significance Index: 107.7800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5251
Cell Significance Index: 104.2100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4082
Cell Significance Index: 13.0800 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.3829
Cell Significance Index: 1.0100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3473
Cell Significance Index: 20.8500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.3096
Cell Significance Index: 9.1200 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.2651
Cell Significance Index: 2.0100 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.2509
Cell Significance Index: 0.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2109
Cell Significance Index: 4.5700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2061
Cell Significance Index: 22.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2038
Cell Significance Index: 183.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1887
Cell Significance Index: 18.6700 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.1624
Cell Significance Index: 0.9400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1244
Cell Significance Index: 8.6100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1078
Cell Significance Index: 17.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0850
Cell Significance Index: 12.3600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0772
Cell Significance Index: 1.1100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0684
Cell Significance Index: 1.0100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0651
Cell Significance Index: 11.1100 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0612
Cell Significance Index: 1.0300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0352
Cell Significance Index: 0.5300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0338
Cell Significance Index: 0.7200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0247
Cell Significance Index: 18.1400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0222
Cell Significance Index: 6.3800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0205
Cell Significance Index: 4.1200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0179
Cell Significance Index: 0.6300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0173
Cell Significance Index: 2.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0164
Cell Significance Index: 25.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0121
Cell Significance Index: 0.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0120
Cell Significance Index: 1.3800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0114
Cell Significance Index: 0.7200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0104
Cell Significance Index: 0.2600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0068
Cell Significance Index: 4.6800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0048
Cell Significance Index: 3.6200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0040
Cell Significance Index: 0.2500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0028
Cell Significance Index: 5.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0022
Cell Significance Index: 1.4000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0015
Cell Significance Index: 2.8700 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.0014
Cell Significance Index: 0.0200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0003
Cell Significance Index: 0.3700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0005
Cell Significance Index: -0.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0017
Cell Significance Index: -0.9800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0017
Cell Significance Index: -1.2800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0029
Cell Significance Index: -1.8000 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0032
Cell Significance Index: -1.7400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0033
Cell Significance Index: -1.5000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0038
Cell Significance Index: -0.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0049
Cell Significance Index: -0.3800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0061
Cell Significance Index: -0.4100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0065
Cell Significance Index: -0.2500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0071
Cell Significance Index: -1.4900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0099
Cell Significance Index: -1.7800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0121
Cell Significance Index: -0.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0126
Cell Significance Index: -1.7300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0148
Cell Significance Index: -1.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0160
Cell Significance Index: -1.6700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0172
Cell Significance Index: -1.7600 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0211
Cell Significance Index: -0.1900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0221
Cell Significance Index: -1.7500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0221
Cell Significance Index: -0.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0225
Cell Significance Index: -1.1700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0267
Cell Significance Index: -1.5000 - Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.0274
Cell Significance Index: -0.2700 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0274
Cell Significance Index: -0.4400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0280
Cell Significance Index: -1.7200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0280
Cell Significance Index: -0.7500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0326
Cell Significance Index: -1.5300 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0327
Cell Significance Index: -0.2500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0394
Cell Significance Index: -1.3800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0396
Cell Significance Index: -1.2600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0399
Cell Significance Index: -2.0100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0409
Cell Significance Index: -2.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0414
Cell Significance Index: -1.1600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0416
Cell Significance Index: -1.7100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0422
Cell Significance Index: -1.0900 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0443
Cell Significance Index: -1.0800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0455
Cell Significance Index: -1.4900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0463
Cell Significance Index: -1.0700 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0482
Cell Significance Index: -1.5300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0496
Cell Significance Index: -0.8500 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0498
Cell Significance Index: -0.6900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0499
Cell Significance Index: -1.8300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0501
Cell Significance Index: -0.7000 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0506
Cell Significance Index: -0.7200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0516
Cell Significance Index: -1.4800 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0527
Cell Significance Index: -0.6900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0555
Cell Significance Index: -0.9600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0558
Cell Significance Index: -1.0900 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0585
Cell Significance Index: -0.8900 - Cell Name: neuron (CL0000540)
Fold Change: -0.0591
Cell Significance Index: -0.5600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0603
Cell Significance Index: -1.0400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0616
Cell Significance Index: -0.9100 - Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.0629
Cell Significance Index: -0.5200 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0629
Cell Significance Index: -1.5700 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0643
Cell Significance Index: -0.8300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0646
Cell Significance Index: -1.0700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 999734601
Symbol: FA11_HUMAN
Name: Coagulation factor XI
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3636155
Title: Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein.
PubMed ID: 3636155
DOI: 10.1021/bi00357a018
PubMed ID: 2827746
PubMed ID: 9593722
Title: Molecular cloning of platelet factor XI, an alternative splicing product of the plasma factor XI gene.
PubMed ID: 9593722
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1998667
Title: Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains.
PubMed ID: 1998667
DOI: 10.1021/bi00222a008
PubMed ID: 2844223
Title: Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.
PubMed ID: 2844223
DOI: 10.1021/bi00412a005
PubMed ID: 11412111
Title: Localization of a heparin binding site in the catalytic domain of factor XIa.
PubMed ID: 11412111
DOI: 10.1021/bi0027433
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 25092234
Title: Site-specific N-glycosylation analysis of human factor XI: Identification of a noncanonical NXC glycosite.
PubMed ID: 25092234
PubMed ID: 35460690
Title: Novel salivary antihemostatic activities of long-form D7 proteins from the malaria vector Anopheles gambiae facilitate hematophagy.
PubMed ID: 35460690
PubMed ID: 18510371
Title: Clavatadine A, a natural product with selective recognition and irreversible inhibition of factor XIa.
PubMed ID: 18510371
DOI: 10.1021/jm800314b
PubMed ID: 2813350
Title: Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations.
PubMed ID: 2813350
PubMed ID: 1547342
Title: Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency.
PubMed ID: 1547342
PubMed ID: 7888672
Title: Six point mutations that cause factor XI deficiency.
PubMed ID: 7888672
PubMed ID: 7669672
Title: Identification of two novel mutations in non-Jewish factor XI deficiency.
PubMed ID: 7669672
PubMed ID: 9401068
Title: Severe factor XI deficiency in an Arab family associated with a novel mutation in exon 11.
PubMed ID: 9401068
PubMed ID: 9787168
Title: Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting.
PubMed ID: 9787168
PubMed ID: 10027710
Title: Identification of a novel mutation in a non-Jewish factor XI deficient kindred.
PubMed ID: 10027710
PubMed ID: 10606881
Title: Heterozygous factor XI deficiency associated with three novel mutations.
PubMed ID: 10606881
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 11895778
Title: Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene.
PubMed ID: 11895778
PubMed ID: 15026311
Title: Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain.
PubMed ID: 15026311
PubMed ID: 15180874
Title: Severe factor XI deficiency caused by compound heterozygosity.
PubMed ID: 15180874
PubMed ID: 15953011
Title: Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion.
PubMed ID: 15953011
PubMed ID: 16607084
Title: Identification of five novel mutations in the factor XI gene (F11) of patients with factor XI deficiency.
PubMed ID: 16607084
PubMed ID: 18005151
Title: Seven novel point mutations in the F11 gene in Iranian FXI-deficient patients.
PubMed ID: 18005151
PubMed ID: 21668437
Title: Population-specific spectrum of the F11 mutations in Koreans: evidence for a founder effect.
PubMed ID: 21668437
PubMed ID: 21457405
Title: Three dominant-negative mutations in factor XI-deficient patients.
PubMed ID: 21457405
PubMed ID: 22016685
Title: A novel missense mutation Asp506Gly in exon 13 of the F11 gene in an asymptomatic Korean woman with mild factor XI deficiency.
PubMed ID: 22016685
PubMed ID: 22322133
Title: Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency.
PubMed ID: 22322133
PubMed ID: 21999818
Title: A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy.
PubMed ID: 21999818
PubMed ID: 22159456
Title: Revisiting the molecular epidemiology of factor XI deficiency: nine new mutations and an original large 4qTer deletion in western Brittany (France).
PubMed ID: 22159456
DOI: 10.1160/th11-06-0415
PubMed ID: 25158988
Title: Molecular basis and bleeding manifestations of factor XI deficiency in 11 Turkish families.
PubMed ID: 25158988
Sequence Information:
- Length: 625
- Mass: 70109
- Checksum: 147AFA94B7709E8F
- Sequence:
MIFLYQVVHF ILFTSVSGEC VTQLLKDTCF EGGDITTVFT PSAKYCQVVC TYHPRCLLFT FTAESPSEDP TRWFTCVLKD SVTETLPRVN RTAAISGYSF KQCSHQISAC NKDIYVDLDM KGINYNSSVA KSAQECQERC TDDVHCHFFT YATRQFPSLE HRNICLLKHT QTGTPTRITK LDKVVSGFSL KSCALSNLAC IRDIFPNTVF ADSNIDSVMA PDAFVCGRIC THHPGCLFFT FFSQEWPKES QRNLCLLKTS ESGLPSTRIK KSKALSGFSL QSCRHSIPVF CHSSFYHDTD FLGEELDIVA AKSHEACQKL CTNAVRCQFF TYTPAQASCN EGKGKCYLKL SSNGSPTKIL HGRGGISGYT LRLCKMDNEC TTKIKPRIVG GTASVRGEWP WQVTLHTTSP TQRHLCGGSI IGNQWILTAA HCFYGVESPK ILRVYSGILN QSEIKEDTSF FGVQEIIIHD QYKMAESGYD IALLKLETTV NYTDSQRPIC LPSKGDRNVI YTDCWVTGWG YRKLRDKIQN TLQKAKIPLV TNEECQKRYR GHKITHKMIC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCA QRERPGVYTN VVEYVDWILE KTQAV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.