Details for: FABP2

Gene ID: 2169

Symbol: FABP2

Ensembl ID: ENSG00000145384

Description: fatty acid binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor cell (CL0011115)
    Fold Change: 23.5704
    Cell Significance Index: 178.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.5725
    Cell Significance Index: -6.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 9.7910
    Cell Significance Index: -6.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 8.4670
    Cell Significance Index: 243.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8043
    Cell Significance Index: -12.8700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.1877
    Cell Significance Index: 42.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3819
    Cell Significance Index: 153.2900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 3.2110
    Cell Significance Index: 34.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.1614
    Cell Significance Index: 47.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.0874
    Cell Significance Index: 2787.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.8898
    Cell Significance Index: 314.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.7107
    Cell Significance Index: 60.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6047
    Cell Significance Index: 34.1800
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.3065
    Cell Significance Index: 3.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1891
    Cell Significance Index: 226.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1420
    Cell Significance Index: 185.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0029
    Cell Significance Index: 60.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.9600
    Cell Significance Index: 16.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9224
    Cell Significance Index: 24.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6984
    Cell Significance Index: 22.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6088
    Cell Significance Index: 60.2200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.5392
    Cell Significance Index: 3.7600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0355
    Cell Significance Index: 0.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0188
    Cell Significance Index: 0.2000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0151
    Cell Significance Index: 0.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0021
    Cell Significance Index: -3.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0065
    Cell Significance Index: -1.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0085
    Cell Significance Index: -4.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0700
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0113
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0253
    Cell Significance Index: -1.1000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0277
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0286
    Cell Significance Index: -5.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0371
    Cell Significance Index: -5.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0409
    Cell Significance Index: -11.7600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0416
    Cell Significance Index: -0.5700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0485
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0523
    Cell Significance Index: -5.9900
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0562
    Cell Significance Index: -0.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0626
    Cell Significance Index: -3.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0761
    Cell Significance Index: -2.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0779
    Cell Significance Index: -5.9800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0779
    Cell Significance Index: -1.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0821
    Cell Significance Index: -10.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0824
    Cell Significance Index: -5.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0842
    Cell Significance Index: -5.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0856
    Cell Significance Index: -6.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0987
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1024
    Cell Significance Index: -5.3200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1028
    Cell Significance Index: -0.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1143
    Cell Significance Index: -11.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1293
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1335
    Cell Significance Index: -7.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1434
    Cell Significance Index: -1.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1492
    Cell Significance Index: -5.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1503
    Cell Significance Index: -2.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1504
    Cell Significance Index: -4.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1505
    Cell Significance Index: -4.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1616
    Cell Significance Index: -5.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1766
    Cell Significance Index: -4.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1787
    Cell Significance Index: -5.8500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1817
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1834
    Cell Significance Index: -2.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1840
    Cell Significance Index: -5.8600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1892
    Cell Significance Index: -2.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1893
    Cell Significance Index: -1.5900
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1904
    Cell Significance Index: -1.3400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1913
    Cell Significance Index: -3.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1935
    Cell Significance Index: -4.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1942
    Cell Significance Index: -2.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1983
    Cell Significance Index: -5.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1991
    Cell Significance Index: -4.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1996
    Cell Significance Index: -3.6900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2008
    Cell Significance Index: -2.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2046
    Cell Significance Index: -13.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2094
    Cell Significance Index: -5.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2108
    Cell Significance Index: -5.3700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.2115
    Cell Significance Index: -1.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2182
    Cell Significance Index: -8.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2253
    Cell Significance Index: -3.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2293
    Cell Significance Index: -5.5000
  • Cell Name: parietal cell (CL0000162)
    Fold Change: -0.2315
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2339
    Cell Significance Index: -5.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2369
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** FABP2 is predominantly expressed in the small intestine, where it is found in enterocytes, goblet cells, and intestinal crypt stem cells. This expression pattern suggests a critical role in intestinal lipid absorption and metabolism. 2. **Fatty Acid Binding:** FABP2 binds to long-chain fatty acids, facilitating their transport into cells, storage, and subsequent metabolism. The protein has a high affinity for palmitate, a common fatty acid found in dietary fats. 3. **Structural Features:** FABP2 consists of two alpha-helices and a short beta-sheet, which enables it to bind to fatty acids through a hydrophobic interaction. The protein also contains a conserved N-terminal domain, which is essential for its function. 4. **Regulation:** FABP2 expression is regulated by various factors, including hormones, growth factors, and transcription factors. For example, insulin and glucagon stimulate FABP2 expression in enterocytes, promoting glucose and lipid metabolism. **Pathways and Functions:** 1. **Fatty Acid Metabolism:** FABP2 plays a key role in the uptake and processing of long-chain fatty acids, which are essential for energy production, lipid synthesis, and storage. 2. **Intestinal Lipid Absorption:** FABP2 facilitates the absorption of dietary fats in the small intestine, allowing for the uptake of fatty acids and their subsequent metabolism. 3. **Long-chain Fatty Acid Transport:** FABP2 binds to long-chain fatty acids, enabling their transport into cells, where they can be stored or metabolized. 4. **Triglyceride Metabolism:** FABP2 is involved in the regulation of triglyceride synthesis and degradation in enterocytes, which is essential for maintaining energy homeostasis. **Clinical Significance:** 1. **Metabolic Disorders:** FABP2 has been implicated in various metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. Alterations in FABP2 expression or function may contribute to the development of these conditions. 2. **Inflammatory Diseases:** FABP2 has been shown to play a role in inflammatory processes, including atherosclerosis and inflammatory bowel disease. Abnormal FABP2 expression or function may contribute to the development of these conditions. 3. **Cancer:** FABP2 has been identified as a potential biomarker for cancer, particularly in colorectal cancer. Abnormal FABP2 expression or function may contribute to cancer progression and metastasis. 4. **Nutritional Interventions:** FABP2 may serve as a target for nutritional interventions aimed at promoting healthy lipid metabolism and reducing the risk of metabolic disorders. In conclusion, FABP2 is a crucial protein involved in fatty acid metabolism and intestinal lipid absorption. Its dysregulation has been implicated in various metabolic and inflammatory disorders, highlighting the importance of understanding its mechanisms and functions in maintaining overall health.

Genular Protein ID: 881912928

Symbol: FABPI_HUMAN

Name: Fatty acid-binding protein, intestinal

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2824476

Title: The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.

PubMed ID: 2824476

DOI: 10.1016/s0021-9258(18)47696-x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14563446

Title: Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility.

PubMed ID: 14563446

DOI: 10.1016/s0009-9120(03)00096-1

PubMed ID: 10070036

Title: Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells.

PubMed ID: 10070036

DOI: 10.1152/ajpgi.1999.276.3.g606

PubMed ID: 14567680

Title: Consequences of single-site mutations in the intestinal fatty acid binding protein.

PubMed ID: 14567680

DOI: 10.1021/bi0301688

PubMed ID: 9204553

Title: Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.

PubMed ID: 9204553

DOI: 10.1023/a:1018666522787

PubMed ID: 12809489

Title: Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.

PubMed ID: 12809489

DOI: 10.1021/bi0273617

PubMed ID: 7883976

Title: An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

PubMed ID: 7883976

DOI: 10.1172/jci117778

PubMed ID: 12899384

Title: The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots.

PubMed ID: 12899384

Sequence Information:

  • Length: 132
  • Mass: 15237
  • Checksum: 7329BF8D81693DAE
  • Sequence:
  • MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV KESSTFRNIE 
    VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG NELNTVREII GDELVQTYVY 
    EGVEAKRIFK KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.