Details for: FABP2

Gene ID: 2169

Symbol: FABP2

Ensembl ID: ENSG00000145384

Description: fatty acid binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.14
    Marker Score: 3006
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.07
    Marker Score: 14754
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.72
    Marker Score: 4193
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.66
    Marker Score: 770
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.14
    Marker Score: 6723.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.93
    Marker Score: 725
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.53
    Marker Score: 3633
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.49
    Marker Score: 783
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.43
    Marker Score: 347
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.25
    Marker Score: 1247
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.22
    Marker Score: 303
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7663
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 472
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1548
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.85
    Marker Score: 621
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 319
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11585
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.73
    Marker Score: 509
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1384
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.71
    Marker Score: 185
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2889
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.66
    Marker Score: 175
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1337
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.59
    Marker Score: 273
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.53
    Marker Score: 145
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.53
    Marker Score: 151
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.41
    Marker Score: 495
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.39
    Marker Score: 113
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.36
    Marker Score: 273
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.36
    Marker Score: 78
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.32
    Marker Score: 354
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 286
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.28
    Marker Score: 145
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 160
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 156
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.27
    Marker Score: 229
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.22
    Marker Score: 12459
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.19
    Marker Score: 373
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 287
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.16
    Marker Score: 35
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.14
    Marker Score: 246
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.14
    Marker Score: 154
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.12
    Marker Score: 82.5
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.11
    Marker Score: 104
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 224
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.11
    Marker Score: 81
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1
    Marker Score: 637
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 30.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 63
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 156
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31

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Other Information

## Summary The FABP2 gene encodes a protein that is expressed in various cells in the body, particularly in epithelial cells of the intestine and colon. It is involved in the metabolism of fatty acids and plays a role in maintaining intestinal health. ## Key characteristics * The protein is a member of the FABP family of fatty acid binding proteins. * It is expressed in high levels in the intestine and colon. * It is involved in the transport and metabolism of fatty acids, including long-chain fatty acids (LCFAs). * It is also involved in the regulation of intestinal inflammation. ## Pathways and functions * FABP2 is involved in the apical-cortical pathway of fatty acid metabolism. * It is also involved in the regulation of the intestinal epithelial barrier. * It plays a role in the absorption of LCFAs from the intestinal lumen. * It is involved in the regulation of intestinal inflammation. ## Clinical significance Mutations in the FABP2 gene have been linked to several human diseases, including Crohn's disease and ulcerative colitis. These diseases are characterized by inflammation and damage to the intestinal tract. FABP2 is a potential target for the treatment of these diseases. ## Conclusion FABP2 is a key protein involved in the metabolism of fatty acids in the intestine and colon. Its mutations have been linked to several human diseases, underscoring its importance for intestinal health.

Genular Protein ID: 881912928

Symbol: FABPI_HUMAN

Name: Fatty acid-binding protein, intestinal

UniProtKB Accession Codes:

P12104 Q2NKJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2824476

Title: The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships.

PubMed ID: 2824476

DOI: 10.1016/s0021-9258(18)47696-x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14563446

Title: Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility.

PubMed ID: 14563446

DOI: 10.1016/s0009-9120(03)00096-1

PubMed ID: 10070036

Title: Epidermal growth factor regulates fatty acid uptake and metabolism in Caco-2 cells.

PubMed ID: 10070036

DOI: 10.1152/ajpgi.1999.276.3.g606

PubMed ID: 14567680

Title: Consequences of single-site mutations in the intestinal fatty acid binding protein.

PubMed ID: 14567680

DOI: 10.1021/bi0301688

PubMed ID: 9204553

Title: Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.

PubMed ID: 9204553

DOI: 10.1023/a:1018666522787

PubMed ID: 12809489

Title: Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.

PubMed ID: 12809489

DOI: 10.1021/bi0273617

PubMed ID: 7883976

Title: An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

PubMed ID: 7883976

DOI: 10.1172/jci117778

PubMed ID: 12899384

Title: The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots.

PubMed ID: 12899384

Sequence Information:

  • Length: 132
  • Mass: 15237
  • Checksum: 7329BF8D81693DAE
  • Sequence:
    • MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV KESSTFRNIE 
VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG NELNTVREII GDELVQTYVY 
EGVEAKRIFK KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.