Details for: FLI1

Gene ID: 2313

Symbol: FLI1

Ensembl ID: ENSG00000151702

Description: Fli-1 proto-oncogene, ETS transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.3719
    Cell Significance Index: -17.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.9345
    Cell Significance Index: -19.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.0976
    Cell Significance Index: -21.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.9667
    Cell Significance Index: -9.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4450
    Cell Significance Index: -17.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1631
    Cell Significance Index: -26.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.9360
    Cell Significance Index: 114.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1530
    Cell Significance Index: -21.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1813
    Cell Significance Index: -13.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6071
    Cell Significance Index: -18.1800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.8893
    Cell Significance Index: 7.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.1632
    Cell Significance Index: 112.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9200
    Cell Significance Index: 87.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.8835
    Cell Significance Index: 11.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5248
    Cell Significance Index: 33.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4635
    Cell Significance Index: 94.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3570
    Cell Significance Index: 258.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3453
    Cell Significance Index: 39.5100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.3126
    Cell Significance Index: 13.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9500
    Cell Significance Index: 93.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8490
    Cell Significance Index: 100.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7445
    Cell Significance Index: 13.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6604
    Cell Significance Index: 11.6700
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.6261
    Cell Significance Index: 3.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4105
    Cell Significance Index: 66.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3118
    Cell Significance Index: 8.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3055
    Cell Significance Index: 33.2300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2286
    Cell Significance Index: 1.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1377
    Cell Significance Index: 9.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0748
    Cell Significance Index: 1.4600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0068
    Cell Significance Index: 0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0058
    Cell Significance Index: 1.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0076
    Cell Significance Index: -14.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0082
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0149
    Cell Significance Index: -0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0159
    Cell Significance Index: -21.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0172
    Cell Significance Index: -0.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0175
    Cell Significance Index: -12.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0282
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0290
    Cell Significance Index: -21.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0296
    Cell Significance Index: -18.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0297
    Cell Significance Index: -16.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0313
    Cell Significance Index: -19.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0313
    Cell Significance Index: -11.2100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0332
    Cell Significance Index: -0.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0360
    Cell Significance Index: -20.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0461
    Cell Significance Index: -3.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0503
    Cell Significance Index: -14.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0618
    Cell Significance Index: -12.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0667
    Cell Significance Index: -12.0200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0689
    Cell Significance Index: -0.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0874
    Cell Significance Index: -11.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0948
    Cell Significance Index: -19.9800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0971
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0986
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1032
    Cell Significance Index: -17.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1036
    Cell Significance Index: -6.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1107
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1182
    Cell Significance Index: -17.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1220
    Cell Significance Index: -16.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1352
    Cell Significance Index: -16.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1532
    Cell Significance Index: -19.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1679
    Cell Significance Index: -17.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1716
    Cell Significance Index: -19.6600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2135
    Cell Significance Index: -2.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2571
    Cell Significance Index: -11.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2657
    Cell Significance Index: -19.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2757
    Cell Significance Index: -18.5400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2826
    Cell Significance Index: -4.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2879
    Cell Significance Index: -17.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2896
    Cell Significance Index: -13.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2959
    Cell Significance Index: -18.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3204
    Cell Significance Index: -4.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3404
    Cell Significance Index: -19.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3490
    Cell Significance Index: -5.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3629
    Cell Significance Index: -18.8500
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.3653
    Cell Significance Index: -3.9900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3680
    Cell Significance Index: -4.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3690
    Cell Significance Index: -11.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4076
    Cell Significance Index: -18.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4336
    Cell Significance Index: -6.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4341
    Cell Significance Index: -3.5400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4355
    Cell Significance Index: -6.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4463
    Cell Significance Index: -16.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4504
    Cell Significance Index: -21.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4941
    Cell Significance Index: -17.3100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.4973
    Cell Significance Index: -1.7300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5000
    Cell Significance Index: -4.0500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.5196
    Cell Significance Index: -5.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5341
    Cell Significance Index: -19.6100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5410
    Cell Significance Index: -2.9500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5413
    Cell Significance Index: -6.3700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5461
    Cell Significance Index: -7.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5473
    Cell Significance Index: -17.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FLI1 is a proto-oncogene that functions as a transcription factor, binding to specific DNA sequences and regulating the expression of target genes. Its structure consists of a DNA-binding domain and a transcription activation domain, which enable it to interact with other transcription factors and regulate gene expression. FLI1 is also known for its ability to form dimers with other ETS family members, such as EGR-1 and PEA3, to regulate gene expression. **Pathways and Functions** FLI1 is involved in various cellular pathways, including: 1. **Cell differentiation**: FLI1 regulates the expression of genes involved in the differentiation of hematopoietic cells, including megakaryocytes and B cells. 2. **Developmental biology**: FLI1 is involved in the regulation of gene expression during embryonic development, particularly in the formation of the vascular system. 3. **Chromatin regulation**: FLI1 interacts with chromatin-modifying enzymes to regulate gene expression and maintain chromatin structure. 4. **Transcriptional regulation**: FLI1 regulates the expression of target genes in response to DNA damage, cytokines, and other cellular signals. **Functions** FLI1 functions as a transcription factor to regulate gene expression, including: 1. **Positive regulation of transcription**: FLI1 activates the expression of target genes by binding to specific DNA sequences and recruiting other transcription factors. 2. **Negative regulation of transcription**: FLI1 can also repress gene expression by binding to specific DNA sequences and recruiting chromatin-modifying enzymes. 3. **DNA damage response**: FLI1 regulates the expression of genes involved in the response to DNA damage, including genes involved in DNA repair and cell cycle arrest. **Clinical Significance** FLI1 has been implicated in various human diseases, including: 1. **Leukemia**: FLI1 is involved in the pathogenesis of acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). 2. **Vascular disorders**: FLI1 is involved in the regulation of gene expression in endothelial cells, which is critical for vascular development and maintenance. 3. **Neurological disorders**: FLI1 is expressed in the brain and is involved in the regulation of gene expression in neural cells, which may be relevant to neurological disorders such as Alzheimer's disease. In conclusion, FLI1 is a critical transcription factor involved in various cellular processes, including cell differentiation, development, and regulation of gene expression. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the role of FLI1 in human health and disease.

Genular Protein ID: 3873200891

Symbol: FLI1_HUMAN

Name: Friend leukemia integration 1 transcription factor

UniProtKB Accession Codes:

Q01543 B2R8H2 B4DFV4 B4DTC6 G3V183 Q14319 Q92480 Q9UE07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1522903

Title: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.

PubMed ID: 1522903

DOI: 10.1038/359162a0

PubMed ID: 1445800

Title: The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors.

PubMed ID: 1445800

PubMed ID: 1394211

Title: Structure and expression of human Fli-1 gene.

PubMed ID: 1394211

PubMed ID: 8439553

Title: Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma.

PubMed ID: 8439553

DOI: 10.1016/0167-4781(93)90283-j

PubMed ID: 1765382

Title: The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24.

PubMed ID: 1765382

DOI: 10.1016/0888-7543(91)90124-w

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9751743

Title: Chromosome translocation based on illegitimate recombination in human tumors.

PubMed ID: 9751743

DOI: 10.1073/pnas.95.20.11786

PubMed ID: 7542907

Title: Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma.

PubMed ID: 7542907

DOI: 10.1002/gcc.2870130209

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24100448

Title: Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects.

PubMed ID: 24100448

DOI: 10.1182/blood-2013-06-506873

PubMed ID: 26316623

Title: Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1.

PubMed ID: 26316623

DOI: 10.1182/blood-2015-06-650887

PubMed ID: 28255014

Title: Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

PubMed ID: 28255014

DOI: 10.3324/haematol.2016.153577

PubMed ID: 7773776

Title: Solution structure of the ets domain of Fli-1 when bound to DNA.

PubMed ID: 7773776

DOI: 10.1038/nsb1294-871

Sequence Information:

  • Length: 452
  • Mass: 50982
  • Checksum: 9C2AAEEAF683F3FA
  • Sequence:
    • MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ 
PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM NYNSYMDEKN GPPPPNMTTN 
ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS LMEIDTSFFQ NMDGKELCKM NKEDFLRATT 
LYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK 
SPPLGGAQTI SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF 
DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF VPPHPSSMPV TSSSFFGAAS 
QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS YY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.