Details for: FLI1

Gene ID: 2313

Symbol: FLI1

Ensembl ID: ENSG00000151702

Description: Fli-1 proto-oncogene, ETS transcription factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.83
    Marker Score: 1690
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.74
    Marker Score: 1361.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.34
    Marker Score: 847
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.21
    Marker Score: 3217
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.07
    Marker Score: 2485
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.06
    Marker Score: 2428
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.9
    Marker Score: 1074
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.89
    Marker Score: 3633.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.75
    Marker Score: 1022
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.73
    Marker Score: 1627
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.69
    Marker Score: 1699
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.66
    Marker Score: 14560
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.65
    Marker Score: 7075
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.61
    Marker Score: 4002
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.55
    Marker Score: 4224
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.55
    Marker Score: 3101
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.55
    Marker Score: 1125
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.49
    Marker Score: 1600
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167533
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.45
    Marker Score: 1444
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.44
    Marker Score: 2799
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.44
    Marker Score: 1040
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.43
    Marker Score: 1348
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.43
    Marker Score: 4503.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.42
    Marker Score: 3473
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.42
    Marker Score: 79227
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.41
    Marker Score: 443
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.41
    Marker Score: 14306
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.41
    Marker Score: 74556
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 442
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.33
    Marker Score: 3378
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.3
    Marker Score: 636
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.3
    Marker Score: 1172
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.28
    Marker Score: 1127.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.28
    Marker Score: 8206
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.26
    Marker Score: 347
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.24
    Marker Score: 746
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.21
    Marker Score: 2105
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.21
    Marker Score: 1298
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.2
    Marker Score: 1450
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.2
    Marker Score: 518
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.18
    Marker Score: 1057
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.18
    Marker Score: 1179
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.17
    Marker Score: 860
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.16
    Marker Score: 1709
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.16
    Marker Score: 1679
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.16
    Marker Score: 267
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.16
    Marker Score: 278
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.14
    Marker Score: 1164
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.13
    Marker Score: 3350
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4726
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.12
    Marker Score: 2040.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.12
    Marker Score: 1000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.11
    Marker Score: 837
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.09
    Marker Score: 331
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.09
    Marker Score: 231
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.08
    Marker Score: 885
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.08
    Marker Score: 664
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.08
    Marker Score: 2254
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.07
    Marker Score: 375
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.07
    Marker Score: 2578
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.07
    Marker Score: 778
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.07
    Marker Score: 587
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.06
    Marker Score: 2969
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.06
    Marker Score: 520
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.04
    Marker Score: 1850
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.03
    Marker Score: 261
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.03
    Marker Score: 10159
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.01
    Marker Score: 2788
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1
    Marker Score: 864
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1
    Marker Score: 321
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71702
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47926
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.99
    Marker Score: 240
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 405
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.97
    Marker Score: 568
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.97
    Marker Score: 484
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.97
    Marker Score: 658.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.96
    Marker Score: 244
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.95
    Marker Score: 2774
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2403
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.95
    Marker Score: 293
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.93
    Marker Score: 618
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14522
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.92
    Marker Score: 3775
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.92
    Marker Score: 1225
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.91
    Marker Score: 567
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 417
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2715
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5121
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.9
    Marker Score: 443
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.89
    Marker Score: 1529
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.89
    Marker Score: 857.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.88
    Marker Score: 10260
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5243

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - FLI1 is a member of the ETS family of transcription factors, which are involved in a variety of cellular processes, including blood cell development, tissue differentiation, and immune responses. - It is a key regulator of hematopoiesis, the process of blood and bone marrow development. - FLI1 is expressed in a variety of cell types in the developing embryo and fetus, including endothelial cells, macrophages, microglia, vascular endothelial cells, pre-B cells, and class switched memory B cells. - It is a key regulator of the development of the cerebral cortex, central nervous system, and blood-forming organs. - FLI1 is also involved in the regulation of inflammation and immune responses. **Pathways and functions:** - FLI1 is a key regulator of blood cell development. It is expressed in high levels in endothelial cells, which are responsible for the formation of blood vessels. FLI1 helps to regulate the development and function of endothelial cells by promoting the expression of vascular endothelial growth factor (VEGF), which is essential for blood vessel formation. - FLI1 is also involved in the regulation of hematopoiesis. It is expressed in high levels in hematopoietic stem cells and early-differentiated blood cells. FLI1 helps to regulate the differentiation of hematopoietic stem cells into various blood cell types. - FLI1 is also involved in the regulation of inflammation and immune responses. It is expressed in immune cells, such as macrophages and dendritic cells, and it helps to regulate their activation and function. **Clinical significance:** - Mutations in the FLI1 gene have been linked to a number of human diseases, including leukemia, lymphoma, and autoimmune disorders. - FLI1 is a promising target for cancer therapy. Inhibition of FLI1 has been shown to be effective in blocking the growth of cancer cells and inducing their death.

Genular Protein ID: 3873200891

Symbol: FLI1_HUMAN

Name: Friend leukemia integration 1 transcription factor

UniProtKB Accession Codes:

Q01543 B2R8H2 B4DFV4 B4DTC6 G3V183 Q14319 Q92480 Q9UE07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1522903

Title: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.

PubMed ID: 1522903

DOI: 10.1038/359162a0

PubMed ID: 1445800

Title: The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors.

PubMed ID: 1445800

PubMed ID: 1394211

Title: Structure and expression of human Fli-1 gene.

PubMed ID: 1394211

PubMed ID: 8439553

Title: Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma.

PubMed ID: 8439553

DOI: 10.1016/0167-4781(93)90283-j

PubMed ID: 1765382

Title: The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24.

PubMed ID: 1765382

DOI: 10.1016/0888-7543(91)90124-w

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9751743

Title: Chromosome translocation based on illegitimate recombination in human tumors.

PubMed ID: 9751743

DOI: 10.1073/pnas.95.20.11786

PubMed ID: 7542907

Title: Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma.

PubMed ID: 7542907

DOI: 10.1002/gcc.2870130209

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24100448

Title: Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects.

PubMed ID: 24100448

DOI: 10.1182/blood-2013-06-506873

PubMed ID: 26316623

Title: Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1.

PubMed ID: 26316623

DOI: 10.1182/blood-2015-06-650887

PubMed ID: 28255014

Title: Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

PubMed ID: 28255014

DOI: 10.3324/haematol.2016.153577

PubMed ID: 7773776

Title: Solution structure of the ets domain of Fli-1 when bound to DNA.

PubMed ID: 7773776

DOI: 10.1038/nsb1294-871

Sequence Information:

  • Length: 452
  • Mass: 50982
  • Checksum: 9C2AAEEAF683F3FA
  • Sequence:
    • MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWINQ 
PVRVNVKREY DHMNGSRESP VDCSVSKCSK LVGGGESNPM NYNSYMDEKN GPPPPNMTTN 
ERRVIVPADP TLWTQEHVRQ WLEWAIKEYS LMEIDTSFFQ NMDGKELCKM NKEDFLRATT 
LYNTEVLLSH LSYLRESSLL AYNTTSHTDQ SSRLSVKEDP SYDSVRRGAW GNNMNSGLNK 
SPPLGGAQTI SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI 
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF 
DFHGIAQALQ PHPTESSMYK YPSDISYMPS YHAHQQKVNF VPPHPSSMPV TSSSFFGAAS 
QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS YY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.