Details for: FMO3

Gene ID: 2328

Symbol: FMO3

Ensembl ID: ENSG00000007933

Description: flavin containing dimethylaniline monoxygenase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.0703
    Cell Significance Index: 51.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6972
    Cell Significance Index: 45.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.0175
    Cell Significance Index: 48.8700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.8946
    Cell Significance Index: 2.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.7795
    Cell Significance Index: 47.7900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.4905
    Cell Significance Index: 5.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4797
    Cell Significance Index: 7.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4765
    Cell Significance Index: 94.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4755
    Cell Significance Index: 15.2300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3863
    Cell Significance Index: 1.4600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3377
    Cell Significance Index: 1.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2742
    Cell Significance Index: 5.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2678
    Cell Significance Index: 12.1400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2480
    Cell Significance Index: 1.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1966
    Cell Significance Index: 37.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1760
    Cell Significance Index: 5.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1684
    Cell Significance Index: 2.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1682
    Cell Significance Index: 8.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1204
    Cell Significance Index: 108.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1115
    Cell Significance Index: 11.0300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1008
    Cell Significance Index: 2.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0529
    Cell Significance Index: 0.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0512
    Cell Significance Index: 8.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0089
    Cell Significance Index: 0.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0082
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0029
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0131
    Cell Significance Index: -7.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0178
    Cell Significance Index: -3.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0184
    Cell Significance Index: -6.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0220
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0322
    Cell Significance Index: -3.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0362
    Cell Significance Index: -7.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0371
    Cell Significance Index: -5.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0408
    Cell Significance Index: -1.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0450
    Cell Significance Index: -3.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0467
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0471
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0484
    Cell Significance Index: -10.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0596
    Cell Significance Index: -7.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0608
    Cell Significance Index: -7.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0618
    Cell Significance Index: -8.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0663
    Cell Significance Index: -6.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0665
    Cell Significance Index: -6.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0712
    Cell Significance Index: -8.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0775
    Cell Significance Index: -4.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0919
    Cell Significance Index: -7.0600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1006
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1063
    Cell Significance Index: -7.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1098
    Cell Significance Index: -7.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1201
    Cell Significance Index: -7.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1264
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1265
    Cell Significance Index: -6.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1396
    Cell Significance Index: -6.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1444
    Cell Significance Index: -1.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1464
    Cell Significance Index: -6.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1514
    Cell Significance Index: -2.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1596
    Cell Significance Index: -4.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1611
    Cell Significance Index: -6.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1698
    Cell Significance Index: -9.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1715
    Cell Significance Index: -7.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1796
    Cell Significance Index: -5.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1798
    Cell Significance Index: -1.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1823
    Cell Significance Index: -9.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1881
    Cell Significance Index: -9.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1949
    Cell Significance Index: -4.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1956
    Cell Significance Index: -7.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1998
    Cell Significance Index: -7.0000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2030
    Cell Significance Index: -1.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2092
    Cell Significance Index: -4.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2129
    Cell Significance Index: -5.9500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2194
    Cell Significance Index: -4.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2269
    Cell Significance Index: -8.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2385
    Cell Significance Index: -7.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2407
    Cell Significance Index: -6.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2499
    Cell Significance Index: -7.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2607
    Cell Significance Index: -7.4400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2646
    Cell Significance Index: -2.6700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2667
    Cell Significance Index: -2.6100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2732
    Cell Significance Index: -6.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2818
    Cell Significance Index: -7.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2820
    Cell Significance Index: -7.5300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2863
    Cell Significance Index: -2.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2936
    Cell Significance Index: -7.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2959
    Cell Significance Index: -7.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3019
    Cell Significance Index: -7.7600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.3057
    Cell Significance Index: -2.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3098
    Cell Significance Index: -9.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** The FMO3 gene is a member of the FMO (flavin-containing monooxygenase) family of enzymes, which are involved in the oxidative metabolism of various compounds. The FMO3 enzyme is specifically involved in the oxidative deamination of aromatic amines, such as TMA, resulting in the formation of a N-oxide intermediate. This enzyme is highly specific and has a narrow substrate specificity, with TMA being its primary substrate. The FMO3 enzyme is also involved in the metabolism of other compounds, including hypotaurine, taurine, and certain biogenic amines. **Pathways and functions** The FMO3 enzyme is involved in several key metabolic pathways, including: 1. **Albendazole monooxygenase activity**: FMO3 is involved in the metabolism of albendazole, an antiparasitic medication. 2. **Biological oxidations**: FMO3 is involved in the oxidative metabolism of various compounds, including aromatic amines and biogenic amines. 3. **Defective fmo3 causes tmau**: Defects in the FMO3 gene have been linked to the accumulation of TMA, leading to a condition known as trimethylaminuria (TMAU). 4. **Taurine biosynthetic process**: FMO3 is involved in the metabolism of taurine, an amino acid involved in various cellular processes. 5. **Hypotaurine dehydrogenase activity**: FMO3 is involved in the metabolism of hypotaurine, a compound involved in various cellular processes. **Clinical significance** The FMO3 gene has significant clinical implications, particularly in the context of metabolic disorders. Defects in the FMO3 gene have been linked to: 1. **Trimethylaminuria (TMAU)**: A condition characterized by the accumulation of TMA, leading to a fishy breath odor. 2. **Metabolic disorders**: Defects in the FMO3 gene have been linked to various metabolic disorders, including those related to the metabolism of biogenic amines and other compounds. 3. **Albendazole toxicity**: FMO3 is involved in the metabolism of albendazole, an antiparasitic medication, and defects in the FMO3 gene may increase the risk of albendazole toxicity. 4. **Cancer**: FMO3 has been implicated in the metabolism of certain carcinogens, and defects in the FMO3 gene may increase the risk of certain types of cancer. In conclusion, the FMO3 gene plays a crucial role in the metabolism of various compounds in the human body, and defects in the FMO3 gene have significant clinical implications, particularly in the context of metabolic disorders. Further research is needed to fully understand the role of the FMO3 gene in human health and disease.

Genular Protein ID: 1984828743

Symbol: FMO3_HUMAN

Name: Dimethylaniline monooxygenase [N-oxide-forming] 3

UniProtKB Accession Codes:

P31513 B2R816 Q14854 Q8N5N5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 40 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 18 EC 4 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 10 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1542660

Title: Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.

PubMed ID: 1542660

DOI: 10.1073/pnas.89.5.1685

PubMed ID: 8654418

Title: Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04.

PubMed ID: 8654418

DOI: 10.1111/j.1432-1033.1996.00683.x

PubMed ID: 9417913

Title: Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA.

PubMed ID: 9417913

DOI: 10.1006/geno.1997.5031

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9224773

Title: Baculovirus-mediated expression and purification of human FMO3: catalytic, immunochemical, and structural characterization.

PubMed ID: 9224773

PubMed ID: 9776311

Title: Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3.

PubMed ID: 9776311

DOI: 10.1016/s0006-2952(98)00218-4

PubMed ID: 9536088

Title: Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.

PubMed ID: 9536088

DOI: 10.1093/hmg/7.5.839

PubMed ID: 10759686

Title: Relative contribution of cytochromes P-450 and flavin-containing monooxygenases to the metabolism of albendazole by human liver microsomes.

PubMed ID: 10759686

DOI: 10.1046/j.1365-2125.2000.00170.x

PubMed ID: 17531949

Title: Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.

PubMed ID: 17531949

DOI: 10.1016/j.abb.2007.04.014

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29981269

Title: Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.

PubMed ID: 29981269

DOI: 10.1111/jth.14234

PubMed ID: 30381441

Title: Nicotine-N'-oxidation by flavin monooxygenase enzymes.

PubMed ID: 30381441

DOI: 10.1158/1055-9965.epi-18-0669

PubMed ID: 32156684

Title: Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.

PubMed ID: 32156684

DOI: 10.1124/dmd.119.089995

PubMed ID: 10338091

Title: Two novel mutations of the FMO3 gene in a proband with trimethylaminuria.

PubMed ID: 10338091

DOI: 10.1002/(sici)1098-1004(1999)13:5<376::aid-humu5>3.0.co;2-a

PubMed ID: 10479479

Title: Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort.

PubMed ID: 10479479

DOI: 10.1006/mgme.1999.2885

PubMed ID: 11191884

Title: Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome.

PubMed ID: 11191884

DOI: 10.1097/00008571-200012000-00005

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

PubMed ID: 15618753

Title: Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese.

PubMed ID: 15618753

DOI: 10.2133/dmpk.18.333

PubMed ID: 12893987

Title: Deleterious mutations in the flavin-containing monooxygenase 3 (FMO3) gene causing trimethylaminuria.

PubMed ID: 12893987

DOI: 10.1097/00008571-200308000-00007

PubMed ID: 17050781

Title: Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants.

PubMed ID: 17050781

DOI: 10.1124/jpet.106.112268

Sequence Information:

  • Length: 532
  • Mass: 60033
  • Checksum: 729E41D53EFC4110
  • Sequence:
    • MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFS 
NSSKEMMCFP DFPFPDDFPN FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA 
TTGQWDVTTE RDGKKESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG 
VFNGKRVLVV GLGNSGCDIA TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG 
TFLKNNLPTA ISDWLYVKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK 
PNVKEFTETS AIFEDGTIFE GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL 
LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF 
GKSETIQTDY IVYMDELSSF IGAKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGQWP 
GARNAILTQW DRSLKPMQTR VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT

Genular Protein ID: 119068729

Symbol: B7Z543_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z543

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 34 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 10 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 512
  • Mass: 58225
  • Checksum: 94B369600E10FB78
  • Sequence:
    • MPASTRSQKR QGMDSLLEPL KMNMDHAEEG RASIYKSVFS NSSKEMMCFP DFPFPDDFPN 
FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA TTGQWDVTTE RDGKKESAVF 
DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPV VFNGKRVLVV GLGNSGCDIA 
TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG TFLKNNLPTA ISDWLYVKQM 
NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK PNVKEFTETS AIFEDGTIFE 
GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL LEKSTIAVIG FVQSLGAAIP 
TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF GKSETIQTDY IVYMDELSSF 
IGAKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGQWP GARNAILTQW DRSLKPMQTR 
VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT

Genular Protein ID: 802182654

Symbol: Q53FW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FW5

Database IDs:

ARBA 23 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 34 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 5 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 4 Rhea 10 SAM 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 532
  • Mass: 59951
  • Checksum: DE8EA19CFFBAE9A4
  • Sequence:
    • MGKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFS 
NSSKEMMCFP DFPFPDDFPN FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA 
TTGQWDVTTE RDGKKESAVF DAVMVCSGHH VYPNLPKKSF PGLNHFKGKC FHSSDYKEPG 
VFNGKRVLVV GLGNSGCDIA TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG 
TFLKNNLPTA ISDWLYVKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK 
PNVKEFTGTS AIFEDGTIFE GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL 
LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF 
GKSETIQTDY IVYMDELSSF IGAKPNIPWL FLTDPKLAME VYFGPYSPYQ FRLVGPGQWP 
GARNAILTQW DRSLKPMQTR VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT

Genular Protein ID: 795688789

Symbol: B7Z3M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3M2

Database IDs:

ARBA 17 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 34 DNASU 1 DisGeNET 1 EC 4 EMBL 2 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 10 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 469
  • Mass: 52551
  • Checksum: B6C324C3CB47F72A
  • Sequence:
    • MGKKVAIIGA GVSGLASIRS CLEEGLEPTF FEKSNDIGGL WKFSTFVSSV NKHPDFATTG 
QWDVTTERDG KKESAVFDAV MVCSGHHVYP NLPKKSFPGL NHFKGKCFHS RDYKEPGVFN 
GKRVLVVGLG NSGCDIATEL SRTAEQVMIS SRSGSWVMSR VWDNGYPWDM LLVTRFGTFL 
KNNLPTAISD WLYVKQMNAR FKHENYGLMP LNGVLRKEPV FNDELPASIL CGIVSVKPNV 
KEFTGTSAIF EDGTIFEGID CVIFATGYSF AYPFLDESII KSRNNEIILF KGVFPPLLEK 
STIAVIGFVQ SLGAAIPTVD LQSRWAAQVI KGTCTLPSME DMMNDINEKM EKKRKWFGKS 
ETIQTDYIVY MDELSSFIGA KPNIPWLFLT DPKLAMEVYF GPCSPYQFRL VGPGQWPGAR 
NAILTQWDRS LKPMQTRVVG RLQKPCFFFH WLKLFAIPIL LIAVFLVLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.