Details for: FMO4

Gene ID: 2329

Symbol: FMO4

Ensembl ID: ENSG00000076258

Description: flavin containing dimethylaniline monoxygenase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.2888
    Cell Significance Index: -7.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.3218
    Cell Significance Index: -6.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.1483
    Cell Significance Index: -5.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9045
    Cell Significance Index: -7.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4563
    Cell Significance Index: -6.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9177
    Cell Significance Index: -5.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8322
    Cell Significance Index: -7.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3346
    Cell Significance Index: 253.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0650
    Cell Significance Index: 17.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8136
    Cell Significance Index: 15.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7696
    Cell Significance Index: 22.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6799
    Cell Significance Index: 40.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5831
    Cell Significance Index: 526.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5447
    Cell Significance Index: 53.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5197
    Cell Significance Index: 56.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4549
    Cell Significance Index: 12.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4527
    Cell Significance Index: 7.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3813
    Cell Significance Index: 8.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3811
    Cell Significance Index: 19.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3484
    Cell Significance Index: 56.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3171
    Cell Significance Index: 2.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2981
    Cell Significance Index: 59.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2961
    Cell Significance Index: 20.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2590
    Cell Significance Index: 11.7400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2337
    Cell Significance Index: 0.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2138
    Cell Significance Index: 3.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2049
    Cell Significance Index: 3.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2046
    Cell Significance Index: 15.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1639
    Cell Significance Index: 3.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1508
    Cell Significance Index: 5.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1472
    Cell Significance Index: 1.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1386
    Cell Significance Index: 1.9900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1293
    Cell Significance Index: 0.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1217
    Cell Significance Index: 6.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1100
    Cell Significance Index: 2.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0602
    Cell Significance Index: 113.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0522
    Cell Significance Index: 1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0498
    Cell Significance Index: 91.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0420
    Cell Significance Index: 19.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0408
    Cell Significance Index: 7.3500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0400
    Cell Significance Index: 0.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0386
    Cell Significance Index: 1.0800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0366
    Cell Significance Index: 0.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0292
    Cell Significance Index: 3.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0278
    Cell Significance Index: 17.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0269
    Cell Significance Index: 41.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0225
    Cell Significance Index: 2.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0188
    Cell Significance Index: 1.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0160
    Cell Significance Index: 11.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0136
    Cell Significance Index: 1.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0133
    Cell Significance Index: 1.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0125
    Cell Significance Index: 5.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0062
    Cell Significance Index: 0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0051
    Cell Significance Index: 0.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0043
    Cell Significance Index: 3.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0042
    Cell Significance Index: -2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0045
    Cell Significance Index: -0.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0121
    Cell Significance Index: -7.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0139
    Cell Significance Index: -0.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0140
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0148
    Cell Significance Index: -2.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0156
    Cell Significance Index: -1.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0158
    Cell Significance Index: -5.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0165
    Cell Significance Index: -0.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0169
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0193
    Cell Significance Index: -2.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0289
    Cell Significance Index: -5.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0291
    Cell Significance Index: -0.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0300
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0351
    Cell Significance Index: -7.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0351
    Cell Significance Index: -3.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0358
    Cell Significance Index: -4.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0394
    Cell Significance Index: -0.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0399
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0437
    Cell Significance Index: -3.4600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0437
    Cell Significance Index: -0.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0444
    Cell Significance Index: -0.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0474
    Cell Significance Index: -3.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0478
    Cell Significance Index: -0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0530
    Cell Significance Index: -2.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0597
    Cell Significance Index: -0.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0703
    Cell Significance Index: -1.0600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0823
    Cell Significance Index: -1.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0824
    Cell Significance Index: -4.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0874
    Cell Significance Index: -5.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0925
    Cell Significance Index: -2.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0958
    Cell Significance Index: -2.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0980
    Cell Significance Index: -6.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1132
    Cell Significance Index: -6.9600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1354
    Cell Significance Index: -1.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1356
    Cell Significance Index: -2.2800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1365
    Cell Significance Index: -0.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1381
    Cell Significance Index: -2.0700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1404
    Cell Significance Index: -1.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1427
    Cell Significance Index: -7.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1440
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FMO4 is a member of the flavin-containing monooxygenase (FMO) family, which is known for its role in metabolizing a wide range of compounds, including xenobiotics, endogenous substances, and drugs. FMO4 is specifically characterized by its ability to catalyze the N-oxidation of dimethylaniline, a process that has been linked to the regulation of various cellular processes. Notably, FMO4 is highly expressed in specific cell types, including retina horizontal cells, pulmonary interstitial fibroblasts, and intestinal epithelial cells, highlighting its potential role in tissue-specific functions. **Pathways and Functions:** FMO4 is implicated in several cellular pathways, including: 1. **Endoplasmic Reticulum Membrane:** FMO4 is localized to the endoplasmic reticulum membrane, where it is thought to play a role in the regulation of lipid metabolism and the transport of lipids across the membrane. 2. **Energy Homeostasis:** FMO4 has been linked to the regulation of energy metabolism, with potential implications for the management of metabolic disorders such as obesity and diabetes. 3. **Flavin Adenine Dinucleotide Binding:** FMO4 is a flavin-containing enzyme, which means it relies on the binding of flavin adenine dinucleotide (FAD) to catalyze its enzymatic activities. 4. **Hypotaurine Dehydrogenase Activity:** FMO4 has been shown to possess hypotaurine dehydrogenase activity, which is thought to play a role in the regulation of amino acid metabolism. **Clinical Significance:** FMO4 has been implicated in various diseases and disorders, including: 1. **Cancer:** FMO4 has been shown to be overexpressed in certain types of cancer, including lung and breast cancer, suggesting its potential role in tumorigenesis. 2. **Neurological Disorders:** FMO4 has been linked to neurological disorders such as Parkinson's disease and Alzheimer's disease, where it may play a role in the regulation of dopamine and acetylcholine metabolism. 3. **Metabolic Disorders:** FMO4 has been implicated in metabolic disorders such as obesity and diabetes, where it may play a role in the regulation of energy metabolism. In conclusion, FMO4 is a complex and multifaceted gene that plays a critical role in various cellular processes, including energy homeostasis, lipid metabolism, and xenobiotic catabolism. Further research is needed to fully elucidate the functions and clinical significance of FMO4, but its unique expression patterns and potential involvement in disease suggest that it is a gene worthy of further investigation. **Recommendations:** 1. Further studies are needed to fully elucidate the functions of FMO4 in different cell types and tissues. 2. The potential role of FMO4 in cancer, neurological disorders, and metabolic disorders should be further investigated. 3. The development of FMO4-targeted therapies may provide new avenues for the treatment of various diseases. By continuing to unravel the mysteries of FMO4, we may uncover new insights into the regulation of cellular processes and the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2153124878

Symbol: FMO4_HUMAN

Name: Dimethylaniline monooxygenase [N-oxide-forming] 4

UniProtKB Accession Codes:

P31512 Q53XR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1417778

Title: Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

PubMed ID: 1417778

DOI: 10.1042/bj2870261

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

PubMed ID: 28940097

Title: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 28940097

DOI: 10.1007/s00439-017-1843-2

PubMed ID: 29288388

Title: Correction to: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 29288388

DOI: 10.1007/s00439-017-1859-7

Sequence Information:

  • Length: 558
  • Mass: 63343
  • Checksum: 6981AE9180C07802
  • Sequence:
    • MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG MTRVYKSLVT 
NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL LKYIQFKTTV CSITKRPDFS 
ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE 
GFQGKRVLVI GLGNTGGDIA VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC 
SFIAQVLPSR FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT 
SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF LYKQVFPLNL 
ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP SQKLMMEATE KEQLIKRGVF 
KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD 
GARNAILTQW DRTLKPLKTR IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV 
RDKLQDRMSP YLVSLWRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.