Details for: FMO4

Gene ID: 2329

Symbol: FMO4

Ensembl ID: ENSG00000076258

Description: flavin containing dimethylaniline monoxygenase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.82
    Marker Score: 2708
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.24
    Marker Score: 992
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2060.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2236
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.92
    Marker Score: 3282
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.92
    Marker Score: 5929
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5180
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13645
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.83
    Marker Score: 1824
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.82
    Marker Score: 3554
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.78
    Marker Score: 1054
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 677
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 289.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.72
    Marker Score: 3855
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4183
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.66
    Marker Score: 2775.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.63
    Marker Score: 482
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 287
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 636
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.57
    Marker Score: 1528
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.56
    Marker Score: 4740
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.54
    Marker Score: 1035
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.52
    Marker Score: 547
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 526
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 433
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 149
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.45
    Marker Score: 542
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.39
    Marker Score: 1378
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.38
    Marker Score: 143
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.37
    Marker Score: 118
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.37
    Marker Score: 255
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 161
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.35
    Marker Score: 494
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.34
    Marker Score: 808
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.33
    Marker Score: 116
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.33
    Marker Score: 415
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.33
    Marker Score: 2475
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.33
    Marker Score: 185
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 173
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.31
    Marker Score: 334
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.31
    Marker Score: 294
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.3
    Marker Score: 767
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3
    Marker Score: 324
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.29
    Marker Score: 338
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 253
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.29
    Marker Score: 6116
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.29
    Marker Score: 816
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.28
    Marker Score: 385
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 72
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.27
    Marker Score: 320
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 109
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 335
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.27
    Marker Score: 91
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.27
    Marker Score: 155
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 96
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.26
    Marker Score: 229
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 67
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.25
    Marker Score: 419
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.25
    Marker Score: 169
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.25
    Marker Score: 816
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.25
    Marker Score: 103
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.25
    Marker Score: 317
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.24
    Marker Score: 135
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.24
    Marker Score: 834
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 240
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.24
    Marker Score: 5276
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.23
    Marker Score: 54
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.23
    Marker Score: 47
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.23
    Marker Score: 1982
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.22
    Marker Score: 87
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 423
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.22
    Marker Score: 3573
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.22
    Marker Score: 145
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.22
    Marker Score: 219

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FMO4 is a protein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed in the endoplasmic reticulum membrane. * FMO4 is a bifunctional enzyme that can act as a flavin monooxygenase or a flavin adenine dinucleotide binding protein. **Pathways and functions:** * FMO4 is involved in the endoplasmic reticulum membrane, where it is involved in the production of reactive oxygen species and the metabolism of fatty acids. * It also regulates the production of nitric oxide, which is a molecule that is involved in the regulation of inflammation and cell growth. * FMO4 is also involved in the regulation of energy homeostasis, and it helps to maintain the levels of reactive oxygen species in the body within a narrow range. **Clinical significance:** Mutations in the FMO4 gene have been linked to a number of human diseases, including retinal dystrophy, pulmonary fibrosis, and liver disease. These diseases are caused by mutations in genes that are involved in the metabolism of flavin, and FMO4 is one of the key enzymes involved in this metabolism. By understanding the role of FMO4 in these diseases, scientists may be able to develop new treatments for these conditions.

Genular Protein ID: 2153124878

Symbol: FMO4_HUMAN

Name: Dimethylaniline monooxygenase [N-oxide-forming] 4

UniProtKB Accession Codes:

P31512 Q53XR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1417778

Title: Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

PubMed ID: 1417778

DOI: 10.1042/bj2870261

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12527699

Title: Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

PubMed ID: 12527699

DOI: 10.1124/dmd.31.2.187

PubMed ID: 28940097

Title: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 28940097

DOI: 10.1007/s00439-017-1843-2

PubMed ID: 29288388

Title: Correction to: Expanding the genetic heterogeneity of intellectual disability.

PubMed ID: 29288388

DOI: 10.1007/s00439-017-1859-7

Sequence Information:

  • Length: 558
  • Mass: 63343
  • Checksum: 6981AE9180C07802
  • Sequence:
    • MAKKVAVIGA GVSGLSSIKC CVDEDLEPTC FERSDDIGGL WKFTESSKDG MTRVYKSLVT 
NVCKEMSCYS DFPFHEDYPN FMNHEKFWDY LQEFAEHFDL LKYIQFKTTV CSITKRPDFS 
ETGQWDVVTE TEGKQNRAVF DAVMVCTGHF LNPHLPLEAF PGIHKFKGQI LHSQEYKIPE 
GFQGKRVLVI GLGNTGGDIA VELSRTAAQV LLSTRTGTWV LGRSSDWGYP YNMMVTRRCC 
SFIAQVLPSR FLNWIQERKL NKRFNHEDYG LSITKGKKAK FIVNDELPNC ILCGAITMKT 
SVIEFTETSA VFEDGTVEEN IDVVIFTTGY TFSFPFFEEP LKSLCTKKIF LYKQVFPLNL 
ERATLAIIGL IGLKGSILSG TELQARWVTR VFKGLCKIPP SQKLMMEATE KEQLIKRGVF 
KDTSKDKFDY IAYMDDIAAC IGTKPSIPLL FLKDPRLAWE VFFGPCTPYQ YRLMGPGKWD 
GARNAILTQW DRTLKPLKTR IVPDSSKPAS MSHYLKAWGA PVLLASLLLI CKSSLFLKLV 
RDKLQDRMSP YLVSLWRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.