Details for: AFF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 80.7827
Cell Significance Index: -20.4900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 43.2731
Cell Significance Index: -17.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.4969
Cell Significance Index: -20.3400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.4747
Cell Significance Index: 97.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 3.3942
Cell Significance Index: 96.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 2.7928
Cell Significance Index: 47.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.8647
Cell Significance Index: 104.6400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.8323
Cell Significance Index: 58.6900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.6839
Cell Significance Index: 40.3900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.5591
Cell Significance Index: 95.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.3137
Cell Significance Index: 82.8000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1214
Cell Significance Index: 224.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0513
Cell Significance Index: 377.0700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.8312
Cell Significance Index: 10.3100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.6377
Cell Significance Index: 8.2700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6249
Cell Significance Index: 432.2000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4263
Cell Significance Index: 50.2700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3780
Cell Significance Index: 25.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2389
Cell Significance Index: 45.4600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1267
Cell Significance Index: 12.5300 - Cell Name: radial glial cell (CL0000681)
Fold Change: 0.1078
Cell Significance Index: 0.6400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0914
Cell Significance Index: 1.0900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0738
Cell Significance Index: 1.4600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0463
Cell Significance Index: 2.7800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0083
Cell Significance Index: 3.6800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0028
Cell Significance Index: -0.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0050
Cell Significance Index: -9.4500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0076
Cell Significance Index: -14.0100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0107
Cell Significance Index: -16.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0114
Cell Significance Index: -10.2800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0134
Cell Significance Index: -1.4600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0135
Cell Significance Index: -18.2900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0137
Cell Significance Index: -7.4900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0150
Cell Significance Index: -9.5200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0192
Cell Significance Index: -3.8200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0209
Cell Significance Index: -15.4800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0280
Cell Significance Index: -20.5500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0281
Cell Significance Index: -1.2200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0285
Cell Significance Index: -21.5900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0335
Cell Significance Index: -18.8800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0343
Cell Significance Index: -21.4100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0399
Cell Significance Index: -18.0900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0433
Cell Significance Index: -0.6200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0625
Cell Significance Index: -1.9900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0682
Cell Significance Index: -1.3700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0730
Cell Significance Index: -20.9900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0741
Cell Significance Index: -9.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0755
Cell Significance Index: -13.6100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0792
Cell Significance Index: -11.5100 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.0846
Cell Significance Index: -0.8700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0870
Cell Significance Index: -1.8800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0933
Cell Significance Index: -19.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0939
Cell Significance Index: -15.2700 - Cell Name: glioblast (CL0000030)
Fold Change: -0.1099
Cell Significance Index: -0.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1107
Cell Significance Index: -6.7900 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.1109
Cell Significance Index: -1.4000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1153
Cell Significance Index: -4.0500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1215
Cell Significance Index: -2.5200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1217
Cell Significance Index: -14.9600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1278
Cell Significance Index: -21.8300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1394
Cell Significance Index: -19.1400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1463
Cell Significance Index: -17.0500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1577
Cell Significance Index: -4.5500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1683
Cell Significance Index: -11.6400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1700
Cell Significance Index: -4.7500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1768
Cell Significance Index: -3.6900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1809
Cell Significance Index: -20.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1820
Cell Significance Index: -12.8700 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.1829
Cell Significance Index: -1.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1962
Cell Significance Index: -8.9000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1981
Cell Significance Index: -20.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1982
Cell Significance Index: -6.4900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2044
Cell Significance Index: -5.1100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2129
Cell Significance Index: -2.3200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2161
Cell Significance Index: -4.6200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2192
Cell Significance Index: -22.4000 - Cell Name: neuron (CL0000540)
Fold Change: -0.2331
Cell Significance Index: -2.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2553
Cell Significance Index: -19.5900 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.2649
Cell Significance Index: -2.5200 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.2726
Cell Significance Index: -3.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2726
Cell Significance Index: -5.9100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
Fold Change: -0.3005
Cell Significance Index: -3.1400 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3103
Cell Significance Index: -3.6200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3272
Cell Significance Index: -6.4400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3279
Cell Significance Index: -17.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3407
Cell Significance Index: -17.8900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3475
Cell Significance Index: -22.4200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3645
Cell Significance Index: -8.8300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3705
Cell Significance Index: -12.9800 - Cell Name: retinal cone cell (CL0000573)
Fold Change: -0.3869
Cell Significance Index: -4.8300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3987
Cell Significance Index: -18.5900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4094
Cell Significance Index: -8.5700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4307
Cell Significance Index: -11.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4440
Cell Significance Index: -19.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4465
Cell Significance Index: -20.9900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4528
Cell Significance Index: -11.6400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.4741
Cell Significance Index: -4.0300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4903
Cell Significance Index: -24.7800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5026
Cell Significance Index: -26.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5028
Cell Significance Index: -19.0400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2076862996
Symbol: AFF2_HUMAN
Name: Protein FMR-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8673085
Title: Identification of the gene FMR2, associated with FRAXE mental retardation.
PubMed ID: 8673085
DOI: 10.1038/ng0596-105
PubMed ID: 8673086
Title: Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island.
PubMed ID: 8673086
DOI: 10.1038/ng0596-109
PubMed ID: 8824884
Title: A candidate gene for mild mental handicap at the FRAXE fragile site.
PubMed ID: 8824884
DOI: 10.1093/hmg/5.2.275
PubMed ID: 9299237
Title: Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators.
PubMed ID: 9299237
PubMed ID: 9467002
Title: Expression of the murine homologue of FMR2 in mouse brain and during development.
PubMed ID: 9467002
DOI: 10.1093/hmg/7.3.441
PubMed ID: 12777533
Title: Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.
PubMed ID: 12777533
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19136466
Title: FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure.
PubMed ID: 19136466
DOI: 10.1093/nar/gkn1058
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21739600
Title: Familial intellectual disability and autistic behavior caused by a small FMR2 gene deletion.
PubMed ID: 21739600
DOI: 10.1002/ajmg.a.34122
Sequence Information:
- Length: 1311
- Mass: 144771
- Checksum: B5310BC074F893CB
- Sequence:
MDLFDFFRDW DLEQQCHYEQ DRSALKKREW ERRNQEVQQE DDLFSSGFDL FGEPYKVAEY TNKGDALANR VQNTLGNYDE MKNLLTNHSN QNHLVGIPKN SVPQNPNNKN EPSFFPEQKN RIIPPHQDNT HPSAPMPPPS VVILNSTLIH SNRKSKPEWS RDSHNPSTVL ASQASGQPNK MQTLTQDQSQ AKLEDFFVYP AEQPQIGEVE ESNPSAKEDS NPNSSGEDAF KEIFQSNSPE ESEFAVQAPG SPLVASSLLA PSSGLSVQNF PPGLYCKTSM GQQKPTAYVR PMDGQDQAPD ISPTLKPSIE FENSFGNLSF GTLLDGKPSA ASSKTKLPKF TILQTSEVSL PSDPSCVEEI LREMTHSWPT PLTSMHTAGH SEQSTFSIPG QESQHLTPGF TLQKWNDPTT RASTKSVSFK SMLEDDLKLS SDEDDLEPVK TLTTQCTATE LYQAVEKAKP RNNPVNPPLA TPQPPPAVQA SGGSGSSSES ESSSESDSDT ESSTTDSESN EAPRVATPEP EPPSTNKWQL DKWLNKVTSQ NKSFICGQNE TPMETISLPP PIIQPMEVQM KVKTNASQVP AEPKERPLLS LIREKARPRP TQKIPETKAL KHKLSTTSET VSQRTIGKKQ PKKVEKNTST DEFTWPKPNI TSSTPKEKES VELHDPPRGR NKATAHKPAP RKEPRPNIPL APEKKKYRGP GKIVPKSREF IETDSSTSDS NTDQEETLQI KVLPPCIISG GNTAKSKEIC GASLTLSTLM SSSGSNNNLS ISNEEPTFSP IPVMQTEILS PLRDHENLKN LWVKIDLDLL SRVPGHSSLH AAPAKPDHKE TATKPKRQTA VTAVEKPAPK GKRKHKPIEV AEKIPEKKQR LEEATTICLL PPCISPAPPH KPPNTRENNS SRRANRRKEE KLFPPPLSPL PEDPPRRRNV SGNNGPFGQD KNIAMTGQIT STKPKRTEGK FCATFKGISV NEGDTPKKAS SATITVTNTA IATATVTATA IVTTTVTATA TATATTTTTT TTISTITSTI TTGLMDSSHL EMTSWAALPL LSSSSTNVRR PKLTFDDSVH NADYYMQEAK KLKHKADALF EKFGKAVNYA DAALSFTECG NAMERDPLEA KSPYTMYSET VELLRYAMRL KNFASPLASD GDKKLAVLCY RCLSLLYLRM FKLKKDHAMK YSRSLMEYFK QNASKVAQIP SPWVSNGKNT PSPVSLNNVS PINAMGNCNN GPVTIPQRIH HMAASHVNIT SNVLRGYEHW DMADKLTREN KEFFGDLDTL MGPLTQHSSM TNLVRYVRQG LCWLRIDAHL L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.