Details for: PRSS33

Gene ID: 260429

Symbol: PRSS33

Ensembl ID: ENSG00000103355

Description: serine protease 33

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.9089
    Cell Significance Index: 10.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6436
    Cell Significance Index: 14.8700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.2247
    Cell Significance Index: 2.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1323
    Cell Significance Index: 15.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0400
    Cell Significance Index: 21.8500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0127
    Cell Significance Index: 0.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0078
    Cell Significance Index: 5.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0033
    Cell Significance Index: -6.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0299
    Cell Significance Index: -5.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0354
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0354
    Cell Significance Index: -6.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0405
    Cell Significance Index: -8.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0438
    Cell Significance Index: -6.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0451
    Cell Significance Index: -6.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0470
    Cell Significance Index: -5.7800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0472
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0668
    Cell Significance Index: -6.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0706
    Cell Significance Index: -9.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1007
    Cell Significance Index: -2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1057
    Cell Significance Index: -4.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1062
    Cell Significance Index: -7.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1108
    Cell Significance Index: -2.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1117
    Cell Significance Index: -5.8200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1167
    Cell Significance Index: -1.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1241
    Cell Significance Index: -7.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1290
    Cell Significance Index: -7.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1358
    Cell Significance Index: -10.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1460
    Cell Significance Index: -8.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1562
    Cell Significance Index: -8.2000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1758
    Cell Significance Index: -2.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1811
    Cell Significance Index: -8.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1868
    Cell Significance Index: -6.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1949
    Cell Significance Index: -4.8600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1973
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2125
    Cell Significance Index: -2.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2152
    Cell Significance Index: -6.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2228
    Cell Significance Index: -8.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2253
    Cell Significance Index: -7.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2311
    Cell Significance Index: -8.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2473
    Cell Significance Index: -8.1000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2498
    Cell Significance Index: -2.3900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2504
    Cell Significance Index: -2.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2538
    Cell Significance Index: -8.1300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2839
    Cell Significance Index: -2.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2889
    Cell Significance Index: -7.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2912
    Cell Significance Index: -4.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3001
    Cell Significance Index: -7.8900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.3003
    Cell Significance Index: -3.2300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.3047
    Cell Significance Index: -2.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3084
    Cell Significance Index: -8.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3085
    Cell Significance Index: -14.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3189
    Cell Significance Index: -6.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3192
    Cell Significance Index: -16.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3350
    Cell Significance Index: -7.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3423
    Cell Significance Index: -8.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3530
    Cell Significance Index: -7.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3542
    Cell Significance Index: -8.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3555
    Cell Significance Index: -7.0300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.3612
    Cell Significance Index: -2.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3628
    Cell Significance Index: -7.1400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3660
    Cell Significance Index: -4.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3675
    Cell Significance Index: -7.9400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3679
    Cell Significance Index: -2.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3711
    Cell Significance Index: -7.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3845
    Cell Significance Index: -8.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3847
    Cell Significance Index: -7.1100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3861
    Cell Significance Index: -4.8900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3879
    Cell Significance Index: -8.1000
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.3880
    Cell Significance Index: -2.4200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3918
    Cell Significance Index: -2.4000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3923
    Cell Significance Index: -3.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4044
    Cell Significance Index: -10.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4081
    Cell Significance Index: -7.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4084
    Cell Significance Index: -9.8000
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.4188
    Cell Significance Index: -2.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4207
    Cell Significance Index: -7.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4229
    Cell Significance Index: -6.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4266
    Cell Significance Index: -5.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4343
    Cell Significance Index: -7.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4406
    Cell Significance Index: -7.2600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4406
    Cell Significance Index: -13.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4519
    Cell Significance Index: -7.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4743
    Cell Significance Index: -8.0600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4845
    Cell Significance Index: -6.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4870
    Cell Significance Index: -5.7500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.4874
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4896
    Cell Significance Index: -5.8200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5024
    Cell Significance Index: -6.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5031
    Cell Significance Index: -7.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5060
    Cell Significance Index: -7.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5092
    Cell Significance Index: -7.1200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.5115
    Cell Significance Index: -5.7900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.5176
    Cell Significance Index: -7.2700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.5211
    Cell Significance Index: -7.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5234
    Cell Significance Index: -5.9900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5247
    Cell Significance Index: -6.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5366
    Cell Significance Index: -7.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease activity**: PRSS33 is a serine protease, which means it catalyzes the hydrolysis of peptide bonds using serine as a nucleophile. 2. **Widespread expression**: PRSS33 is expressed in various cell types, including microglial cells, endothelial cells, dendritic cells, and stem cells, indicating its involvement in different cellular processes. 3. **Cellular localization**: PRSS33 is primarily found in the cytoplasm and extracellular space, suggesting its role in proteolytic processes and cell signaling. 4. **Signaling pathways**: PRSS33 is involved in protein kinase C (PKC) signaling, proteolysis, and serine-type endopeptidase activity, highlighting its potential role in regulating cellular responses to environmental cues. **Pathways and Functions:** 1. **Protein Kinase C (PKC) signaling**: PRSS33 is involved in PKC signaling, which regulates various cellular processes, including cell growth, differentiation, and survival. PKC signaling pathways are crucial for maintaining immune system function and tissue homeostasis. 2. **Proteolysis**: PRSS33 is a serine protease that catalyzes the hydrolysis of peptide bonds, which is essential for protein processing and degradation. This process is critical for regulating protein function and cellular homeostasis. 3. **Serine-type endopeptidase activity**: PRSS33 exhibits serine-type endopeptidase activity, which is involved in the cleavage of peptide bonds in proteins. This process is essential for regulating protein function and cellular signaling. **Clinical Significance:** PRSS33 has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: PRSS33 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is involved in protein processing and degradation. 2. **Immune system disorders**: PRSS33 plays a crucial role in maintaining immune system function, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: PRSS33 has been found to be overexpressed in various types of cancer, including colon cancer, where it is involved in promoting tumor growth and metastasis. In conclusion, PRSS33 is a serine protease with widespread immunological and cellular significance. Its involvement in protein kinase C signaling, proteolysis, and serine-type endopeptidase activity highlights its potential role in regulating cellular responses to environmental cues. Further research is needed to fully elucidate the functions and clinical significance of PRSS33, but its importance in maintaining tissue homeostasis and immune system function is clear.

Genular Protein ID: 1566279194

Symbol: PRS33_HUMAN

Name: Serine protease 33

UniProtKB Accession Codes:

Q8NF86 A6NNQ3 Q8N171

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12795636

Title: A novel serine protease predominately expressed in macrophages.

PubMed ID: 12795636

DOI: 10.1042/bj20030242

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 280
  • Mass: 29787
  • Checksum: FCE00004DB1CFBF1
  • Sequence:
    • MRGVSCLQVL LLLVLGAAGT QGRKSAACGQ PRMSSRIVGG RDGRDGEWPW QASIQHRGAH 
VCGGSLIAPQ WVLTAAHCFP RRALPAEYRV RLGALRLGST SPRTLSVPVR RVLLPPDYSE 
DGARGDLALL QLRRPVPLSA RVQPVCLPVP GARPPPGTPC RVTGWGSLRP GVPLPEWRPL 
QGVRVPLLDS RTCDGLYHVG ADVPQAERIV LPGSLCAGYP QGHKDACQGD SGGPLTCLQS 
GSWVLVGVVS WGKGCALPNR PGVYTSVATY SPWIQARVSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.