Details for: GCKR
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.4197
Cell Significance Index: 40.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6404
Cell Significance Index: 127.0900 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.6282
Cell Significance Index: 4.1700 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.5669
Cell Significance Index: 2.1400 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.5641
Cell Significance Index: 3.3800 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.3829
Cell Significance Index: 2.2100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3129
Cell Significance Index: 8.3900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2733
Cell Significance Index: 5.9200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2695
Cell Significance Index: 3.8600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2297
Cell Significance Index: 3.3900 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.2176
Cell Significance Index: 2.7500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1215
Cell Significance Index: 3.0300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1157
Cell Significance Index: 80.0200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0643
Cell Significance Index: 12.8900 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0541
Cell Significance Index: 0.9100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0408
Cell Significance Index: 0.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0297
Cell Significance Index: 3.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0115
Cell Significance Index: 4.1100 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.0106
Cell Significance Index: 0.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0003
Cell Significance Index: 0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0004
Cell Significance Index: -0.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0013
Cell Significance Index: -2.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0014
Cell Significance Index: -2.5900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0026
Cell Significance Index: -0.4600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0029
Cell Significance Index: -1.8500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0029
Cell Significance Index: -3.9600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0050
Cell Significance Index: -0.5800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0053
Cell Significance Index: -3.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0056
Cell Significance Index: -3.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0070
Cell Significance Index: -2.0100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0076
Cell Significance Index: -4.3100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0080
Cell Significance Index: -3.6100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0096
Cell Significance Index: -0.2100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0107
Cell Significance Index: -0.0700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0109
Cell Significance Index: -1.2700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0119
Cell Significance Index: -1.6300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0122
Cell Significance Index: -0.3400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0135
Cell Significance Index: -1.9700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0171
Cell Significance Index: -2.1000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0201
Cell Significance Index: -4.2400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0236
Cell Significance Index: -0.1600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0282
Cell Significance Index: -3.6400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0286
Cell Significance Index: -2.9200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0316
Cell Significance Index: -0.9100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0347
Cell Significance Index: -0.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0350
Cell Significance Index: -3.6400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0369
Cell Significance Index: -2.8300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0412
Cell Significance Index: -2.5300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0416
Cell Significance Index: -2.1600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0420
Cell Significance Index: -3.1300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0425
Cell Significance Index: -1.0300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0449
Cell Significance Index: -2.8300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0452
Cell Significance Index: -3.0400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0453
Cell Significance Index: -1.9700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0480
Cell Significance Index: -2.2400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0516
Cell Significance Index: -1.2900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0572
Cell Significance Index: -0.6500 - Cell Name: neuron (CL0000540)
Fold Change: -0.0591
Cell Significance Index: -0.5600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0595
Cell Significance Index: -3.6500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0614
Cell Significance Index: -3.2000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0636
Cell Significance Index: -1.7300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0665
Cell Significance Index: -1.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0675
Cell Significance Index: -3.7900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0680
Cell Significance Index: -1.9400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0697
Cell Significance Index: -3.2800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0705
Cell Significance Index: -3.5600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0709
Cell Significance Index: -3.7200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0710
Cell Significance Index: -3.1400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0728
Cell Significance Index: -2.5500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0735
Cell Significance Index: -2.3400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0743
Cell Significance Index: -3.3700 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.0775
Cell Significance Index: -0.6700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0790
Cell Significance Index: -2.9900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0800
Cell Significance Index: -2.6200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0810
Cell Significance Index: -1.7200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0850
Cell Significance Index: -1.7800 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0866
Cell Significance Index: -1.2300 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0875
Cell Significance Index: -0.7900 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0913
Cell Significance Index: -3.3500 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0945
Cell Significance Index: -1.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0959
Cell Significance Index: -3.3700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0966
Cell Significance Index: -2.4100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0973
Cell Significance Index: -3.9900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0984
Cell Significance Index: -1.9200 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0992
Cell Significance Index: -1.7100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1017
Cell Significance Index: -2.0100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1083
Cell Significance Index: -3.1900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1113
Cell Significance Index: -3.1900 - Cell Name: chondrocyte (CL0000138)
Fold Change: -0.1163
Cell Significance Index: -1.3400 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.1216
Cell Significance Index: -0.9300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1264
Cell Significance Index: -2.7300 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.1280
Cell Significance Index: -1.8200 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.1295
Cell Significance Index: -1.7900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1315
Cell Significance Index: -2.6400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1333
Cell Significance Index: -3.5600 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1343
Cell Significance Index: -1.7900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1347
Cell Significance Index: -2.4900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1350
Cell Significance Index: -3.6100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1366
Cell Significance Index: -4.3200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1145640165
Symbol: GCKR_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8589523
Title: Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.
PubMed ID: 8589523
DOI: 10.1007/bf00356171
PubMed ID: 9570959
Title: Organization of the human glucokinase regulator gene GCKR.
PubMed ID: 9570959
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10456334
Title: Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.
PubMed ID: 10456334
PubMed ID: 18556336
Title: The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
PubMed ID: 18556336
DOI: 10.2337/db07-1807
PubMed ID: 19643913
Title: The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
PubMed ID: 19643913
DOI: 10.1093/hmg/ddp357
PubMed ID: 23733961
Title: Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase.
PubMed ID: 23733961
PubMed ID: 23621087
Title: Crystal structure of glucokinase regulatory protein.
PubMed ID: 23621087
DOI: 10.1021/bi4000782
PubMed ID: 18678614
Title: Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.
PubMed ID: 18678614
DOI: 10.2337/db08-0516
Sequence Information:
- Length: 625
- Mass: 68685
- Checksum: DE750462AC603C80
- Sequence:
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA VRSALAGPGQ KRTADPLEIL EPDVQ
Genular Protein ID: 1294067980
Symbol: A0A0C4DFN2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 625
- Mass: 68701
- Checksum: C275186BEC6975DC
- Sequence:
MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ TIVEQVKEKT NHIQALAHST VGQTLLIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA VRSALAGPGQ KRTADPLEIL EPDVQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.