Details for: GCKR

Gene ID: 2646

Symbol: GCKR

Ensembl ID: ENSG00000084734

Description: glucokinase regulator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.63
    Marker Score: 8766.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.51
    Marker Score: 9729.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.48
    Marker Score: 6384.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.35
    Marker Score: 1346
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.76
    Marker Score: 367
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 501
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2977
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.68
    Marker Score: 1401.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.65
    Marker Score: 701
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 470
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.43
    Marker Score: 811
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6197.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.38
    Marker Score: 588
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 807
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.34
    Marker Score: 128
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.29
    Marker Score: 90
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.28
    Marker Score: 587
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.28
    Marker Score: 562
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.27
    Marker Score: 891
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.27
    Marker Score: 105
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.27
    Marker Score: 268.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.25
    Marker Score: 1577
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 134
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 227
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 79
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.19
    Marker Score: 105
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 735
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 168
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.15
    Marker Score: 1576
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.13
    Marker Score: 1267
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1115
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.13
    Marker Score: 1232
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.12
    Marker Score: 4589.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.12
    Marker Score: 7578.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 125
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1
    Marker Score: 21.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1
    Marker Score: 407
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.09
    Marker Score: 1994
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.09
    Marker Score: 21.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.09
    Marker Score: 1728
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 77
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.08
    Marker Score: 116
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24

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Other Information

**Key characteristics:** - GCKR is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a serine/threonine kinase that is highly expressed in the liver and other tissues with high glucose metabolism. - GCKR is a key regulator of hepatic glucose metabolism, including the regulation of glycolysis, gluconeogenesis, and glycogenolysis. - It is a key regulator of the regulation of blood glucose levels by controlling the flux of glucose between the blood and the cells. **Pathways and functions:** - GCKR is a key regulator of glucose metabolism. - It plays a crucial role in maintaining glucose homeostasis by controlling the rate of glucose uptake, utilization, and secretion. - It is involved in the regulation of hepatic glucose metabolism, including the regulation of glycolysis, gluconeogenesis, and glycogenolysis. - It is also involved in the regulation of blood glucose levels by controlling the flux of glucose between the blood and the cells. - GCKR is a key regulator of the regulation of energy metabolism in response to changes in blood glucose levels. **Clinical significance:** - Mutations in the GCKR gene have been linked to the development of several human diseases, including non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and cancer. - Studies have shown that mutations in the GCKR gene can lead to the development of these diseases by impairing the regulation of glucose metabolism. - GCKR is a potential therapeutic target for the treatment of these diseases.

Genular Protein ID: 1145640165

Symbol: GCKR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14397 A1L4C2 B4DPQ2 Q53RY6 Q99522

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 18 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8589523

Title: Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.

PubMed ID: 8589523

DOI: 10.1007/bf00356171

PubMed ID: 9570959

Title: Organization of the human glucokinase regulator gene GCKR.

PubMed ID: 9570959

DOI: 10.1006/geno.1997.5195

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10456334

Title: Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

PubMed ID: 10456334

DOI: 10.1016/s0014-5793(99)00971-0

PubMed ID: 18556336

Title: The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.

PubMed ID: 18556336

DOI: 10.2337/db07-1807

PubMed ID: 19643913

Title: The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

PubMed ID: 19643913

DOI: 10.1093/hmg/ddp357

PubMed ID: 23733961

Title: Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase.

PubMed ID: 23733961

DOI: 10.1073/pnas.1300457110

PubMed ID: 23621087

Title: Crystal structure of glucokinase regulatory protein.

PubMed ID: 23621087

DOI: 10.1021/bi4000782

PubMed ID: 18678614

Title: Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations.

PubMed ID: 18678614

DOI: 10.2337/db08-0516

Sequence Information:

  • Length: 625
  • Mass: 68685
  • Checksum: DE750462AC603C80
  • Sequence:
    • MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI 
FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV 
GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ 
KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV 
RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ 
TIVEQVKEKT NHIQALAHST VGQTLPIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL 
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR 
AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
VRSALAGPGQ KRTADPLEIL EPDVQ

Genular Protein ID: 1294067980

Symbol: A0A0C4DFN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFN2

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 15 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 625
  • Mass: 68701
  • Checksum: C275186BEC6975DC
  • Sequence:
    • MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI 
FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS 
FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV 
GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ 
KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE 
RAHQVTYSQS PKIATLMKSV STSLEKKGHV YLVGWQTLGI IAIMDGVECI HTFGADFRDV 
RGFLIGDHSD MFNQKAELTN QGPQFTFSQE DFLTSILPSL TEIDTVVFIF TLDDNLTEVQ 
TIVEQVKEKT NHIQALAHST VGQTLLIPLK KLFPSIISIT WPLLFFEYEG NFIQKFQREL 
STKWVLNTVS TGAHVLLGKI LQNHMLDLRI SNSKLFWRAL AMLQRFSGQS KARCIESLLR 
AIHFPQPLSD DIRAAPISCH VQVAHEKEQV IPIALLSLLF RCSITEAQAH LAAAPSVCEA 
VRSALAGPGQ KRTADPLEIL EPDVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.