Details for: AATF

Gene ID: 26574

Symbol: AATF

Ensembl ID: ENSG00000275700

Description: apoptosis antagonizing transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 93.9925
    Cell Significance Index: -38.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.7905
    Cell Significance Index: -41.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.7093
    Cell Significance Index: -34.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.5975
    Cell Significance Index: -39.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.7010
    Cell Significance Index: -35.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3481
    Cell Significance Index: -30.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.0348
    Cell Significance Index: -27.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1416
    Cell Significance Index: -15.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.8692
    Cell Significance Index: 19.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8417
    Cell Significance Index: 214.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2875
    Cell Significance Index: 255.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2240
    Cell Significance Index: 16.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1668
    Cell Significance Index: 31.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1071
    Cell Significance Index: 29.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0240
    Cell Significance Index: 205.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9950
    Cell Significance Index: 161.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8703
    Cell Significance Index: 56.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.7767
    Cell Significance Index: 79.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6895
    Cell Significance Index: 19.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5852
    Cell Significance Index: 40.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5463
    Cell Significance Index: 28.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5164
    Cell Significance Index: 93.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4736
    Cell Significance Index: 258.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4469
    Cell Significance Index: 25.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4460
    Cell Significance Index: 54.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4421
    Cell Significance Index: 9.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4421
    Cell Significance Index: 60.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4402
    Cell Significance Index: 51.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4243
    Cell Significance Index: 152.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3886
    Cell Significance Index: 17.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3858
    Cell Significance Index: 5.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3681
    Cell Significance Index: 17.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3668
    Cell Significance Index: 162.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3353
    Cell Significance Index: 231.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3136
    Cell Significance Index: 15.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3033
    Cell Significance Index: 273.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2929
    Cell Significance Index: 28.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2332
    Cell Significance Index: 6.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1919
    Cell Significance Index: 24.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1899
    Cell Significance Index: 8.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1854
    Cell Significance Index: 13.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1759
    Cell Significance Index: 6.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1749
    Cell Significance Index: 29.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1587
    Cell Significance Index: 7.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1079
    Cell Significance Index: 13.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0896
    Cell Significance Index: 0.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0624
    Cell Significance Index: 4.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0600
    Cell Significance Index: 4.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0446
    Cell Significance Index: 84.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0182
    Cell Significance Index: 33.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0171
    Cell Significance Index: 0.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0147
    Cell Significance Index: 22.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0135
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0125
    Cell Significance Index: 2.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0109
    Cell Significance Index: 4.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0102
    Cell Significance Index: 6.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0329
    Cell Significance Index: -24.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0337
    Cell Significance Index: -4.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0575
    Cell Significance Index: -32.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0720
    Cell Significance Index: -44.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1221
    Cell Significance Index: -3.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1303
    Cell Significance Index: -37.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1363
    Cell Significance Index: -3.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1395
    Cell Significance Index: -2.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1485
    Cell Significance Index: -9.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1535
    Cell Significance Index: -2.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1568
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1684
    Cell Significance Index: -19.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1735
    Cell Significance Index: -36.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2096
    Cell Significance Index: -4.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2529
    Cell Significance Index: -3.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2961
    Cell Significance Index: -5.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3055
    Cell Significance Index: -31.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3529
    Cell Significance Index: -9.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3772
    Cell Significance Index: -19.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3981
    Cell Significance Index: -20.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4352
    Cell Significance Index: -34.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4453
    Cell Significance Index: -8.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4794
    Cell Significance Index: -8.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5528
    Cell Significance Index: -11.5700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5978
    Cell Significance Index: -8.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6006
    Cell Significance Index: -20.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6015
    Cell Significance Index: -10.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6270
    Cell Significance Index: -19.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6317
    Cell Significance Index: -18.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6524
    Cell Significance Index: -21.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6540
    Cell Significance Index: -22.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6710
    Cell Significance Index: -41.1400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6879
    Cell Significance Index: -14.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7195
    Cell Significance Index: -15.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7209
    Cell Significance Index: -23.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7285
    Cell Significance Index: -16.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8208
    Cell Significance Index: -11.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8449
    Cell Significance Index: -14.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8753
    Cell Significance Index: -32.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8942
    Cell Significance Index: -19.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9022
    Cell Significance Index: -22.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AATF is a transcription factor that belongs to the leucine zipper domain family. Its protein structure consists of a leucine-rich repeat domain, a DNA-binding domain, and a transcriptional activation domain. AATF is highly expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, tracheal goblet cells, extravillous trophoblasts, and myeloid dendritic cells. **Pathways and Functions:** AATF regulates multiple cellular pathways, including: 1. **Apoptosis**: AATF acts as an anti-apoptotic factor, inhibiting the execution of programmed cell death. It interacts with pro-apoptotic proteins, such as BAX and BAK, to prevent their activation. 2. **Cell Adhesion**: AATF regulates cell adhesion by modulating the expression of adhesion molecules, such as N-CAM and ICAM-1. 3. **Transcriptional Control**: AATF regulates the expression of various genes involved in cellular differentiation, proliferation, and survival. It interacts with transcription factors, such as NF-κB and AP-1, to modulate their activity. 4. **DNA Damage Response**: AATF regulates the response to DNA damage by modulating the expression of genes involved in nucleotide synthesis and repair. 5. **Reactive Oxygen Species (ROS) Metabolism**: AATF regulates the production of ROS by modulating the expression of enzymes involved in ROS production and scavenging. **Clinical Significance:** Dysregulation of AATF has been implicated in various diseases, including: 1. **Cancer**: AATF is often downregulated in cancer cells, leading to increased apoptosis and reduced cell proliferation. 2. **Inflammatory Diseases**: AATF regulates the expression of genes involved in inflammation, and its dysregulation can contribute to the development of inflammatory diseases, such as rheumatoid arthritis. 3. **Neurodegenerative Diseases**: AATF regulates the expression of genes involved in neuronal survival and death, and its dysregulation can contribute to the development of neurodegenerative diseases, such as Alzheimer's disease. In conclusion, the AATF gene plays a critical role in regulating apoptosis, cell adhesion, and transcriptional control. Its dysregulation can contribute to various diseases, highlighting the importance of AATF in maintaining cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which AATF regulates cellular processes and to explore its therapeutic potential in disease prevention and treatment. **References:** * [Insert references to relevant studies on AATF gene function and regulation] **Note:** This article is a summary of the key characteristics, pathways, and functions of the AATF gene, as well as its clinical significance. It is intended to provide a comprehensive overview of the gene's role in regulating cellular processes and its potential implications in disease prevention and treatment.

Genular Protein ID: 1191028805

Symbol: AATF_HUMAN

Name: Protein AATF

UniProtKB Accession Codes:

Q9NY61 A6NCJ6 B3KQ26 Q9P0A4 Q9UNX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11027528

Title: Identification of novel transcription factor-like gene from human intestinal cells.

PubMed ID: 11027528

DOI: 10.1006/bbrc.2000.3480

PubMed ID: 10783144

Title: Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.

PubMed ID: 10783144

DOI: 10.1096/fasebj.14.7.904

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12450794

Title: Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.

PubMed ID: 12450794

DOI: 10.1016/s1535-6108(02)00182-4

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12847090

Title: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.

PubMed ID: 12847090

DOI: 10.1074/jbc.m306694200

PubMed ID: 14697667

Title: Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.

PubMed ID: 14697667

DOI: 10.1016/j.mcn.2003.08.002

PubMed ID: 14627703

Title: AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.

PubMed ID: 14627703

DOI: 10.1074/jbc.m309811200

PubMed ID: 15207272

Title: AATF protects neural cells against oxidative damage induced by amyloid beta-peptide.

PubMed ID: 15207272

DOI: 10.1016/j.nbd.2004.02.003

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 560
  • Mass: 63133
  • Checksum: EC493EF3B4C3A199
  • Sequence:
    • MAGPQPLALQ LEQLLNPRPS EADPEADPEE ATAARVIDRF DEGEDGEGDF LVVGSIRKLA 
SASLLDTDKR YCGKTTSRKA WNEDHWEQTL PGSSDEEISD EEGSGDEDSE GLGLEEYDED 
DLGAAEEQEC GDHRESKKSR SHSAKTPGFS VQSISDFEKF TKGMDDLGSS EEEEDEESGM 
EEGDDAEDSQ GESEEDRAGD RNSEDDGVVM TFSSVKVSEE VEKGRAVKNQ IALWDQLLEG 
RIKLQKALLT TNQLPQPDVF PLFKDKGGPE FSSALKNSHK ALKALLRSLV GLQEELLFQY 
PDTRYLVDGT KPNAGSEEIS SEDDELVEEK KQQRRRVPAK RKLEMEDYPS FMAKRFADFT 
VYRNRTLQKW HDKTKLASGK LGKGFGAFER SILTQIDHIL MDKERLLRRT QTKRSVYRVL 
GKPEPAAQPV PESLPGEPEI LPQAPANAHL KDLDEEIFDD DDFYHQLLRE LIERKTSSLD 
PNDQVAMGRQ WLAIQKLRSK IHKKVDRKAS KGRKLRFHVL SKLLSFMAPI DHTTMNDDAR 
TELYRSLFGQ LHPPDEGHGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.