Details for: SMR3A

Gene ID: 26952

Symbol: SMR3A

Ensembl ID: ENSG00000109208

Description: submaxillary gland androgen regulated protein 3A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 10.8987
    Cell Significance Index: 78.4300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.4234
    Cell Significance Index: 8.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2389
    Cell Significance Index: 3.2600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2133
    Cell Significance Index: 2.5800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0753
    Cell Significance Index: 0.8100
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.0675
    Cell Significance Index: 0.5200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0405
    Cell Significance Index: 0.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0216
    Cell Significance Index: 0.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0067
    Cell Significance Index: 0.4300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0046
    Cell Significance Index: 0.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0035
    Cell Significance Index: 0.1300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0025
    Cell Significance Index: -0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0033
    Cell Significance Index: -0.1300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.0072
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0117
    Cell Significance Index: -3.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0171
    Cell Significance Index: -0.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0174
    Cell Significance Index: -3.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0271
    Cell Significance Index: -0.3700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0327
    Cell Significance Index: -0.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0348
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0388
    Cell Significance Index: -0.4200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0394
    Cell Significance Index: -0.3100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0403
    Cell Significance Index: -0.4200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0407
    Cell Significance Index: -0.4500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0413
    Cell Significance Index: -0.3700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0441
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0470
    Cell Significance Index: -1.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0479
    Cell Significance Index: -1.5200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0499
    Cell Significance Index: -0.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0560
    Cell Significance Index: -0.3000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0585
    Cell Significance Index: -0.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0654
    Cell Significance Index: -3.0700
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.0706
    Cell Significance Index: -0.6600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0709
    Cell Significance Index: -0.4700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0799
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0834
    Cell Significance Index: -0.8800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0875
    Cell Significance Index: -1.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0885
    Cell Significance Index: -0.9400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0943
    Cell Significance Index: -0.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1181
    Cell Significance Index: -3.7400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1212
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1216
    Cell Significance Index: -1.8000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1239
    Cell Significance Index: -1.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1270
    Cell Significance Index: -1.3200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1380
    Cell Significance Index: -1.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1413
    Cell Significance Index: -3.5300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1503
    Cell Significance Index: -1.7200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1513
    Cell Significance Index: -1.9800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1537
    Cell Significance Index: -1.9500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1556
    Cell Significance Index: -1.7900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1595
    Cell Significance Index: -1.4500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1605
    Cell Significance Index: -1.6400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1616
    Cell Significance Index: -2.0300
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1648
    Cell Significance Index: -1.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1680
    Cell Significance Index: -4.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1760
    Cell Significance Index: -2.9500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1862
    Cell Significance Index: -2.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1952
    Cell Significance Index: -1.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1970
    Cell Significance Index: -2.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1995
    Cell Significance Index: -3.3600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2081
    Cell Significance Index: -1.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2104
    Cell Significance Index: -2.9900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2257
    Cell Significance Index: -2.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2298
    Cell Significance Index: -2.9000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2341
    Cell Significance Index: -1.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2359
    Cell Significance Index: -3.6500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2414
    Cell Significance Index: -3.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2450
    Cell Significance Index: -3.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2463
    Cell Significance Index: -2.9100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2481
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2507
    Cell Significance Index: -2.9800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2510
    Cell Significance Index: -3.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2516
    Cell Significance Index: -2.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2518
    Cell Significance Index: -3.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2559
    Cell Significance Index: -3.1500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2601
    Cell Significance Index: -2.9500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2690
    Cell Significance Index: -3.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2703
    Cell Significance Index: -3.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2726
    Cell Significance Index: -2.9700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2742
    Cell Significance Index: -2.6000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2762
    Cell Significance Index: -2.9900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2797
    Cell Significance Index: -2.9700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2802
    Cell Significance Index: -3.2300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2827
    Cell Significance Index: -3.2900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2853
    Cell Significance Index: -3.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2866
    Cell Significance Index: -3.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2881
    Cell Significance Index: -3.7100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2901
    Cell Significance Index: -1.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2924
    Cell Significance Index: -3.4900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2948
    Cell Significance Index: -3.0100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.2959
    Cell Significance Index: -3.3800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2969
    Cell Significance Index: -3.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Alternative Splicing:** SMR3A undergoes alternative splicing, resulting in multiple isoforms that may contribute to its diverse functions. 2. **Androgen Regulation:** SMR3A is androgen-regulated, suggesting a potential role in male reproductive physiology and development. 3. **Endopeptidase Inhibitory Activity:** SMR3A possesses endopeptidase inhibitory activity, which may modulate the levels of various peptides and proteins in the extracellular environment. 4. **Protein Binding:** SMR3A interacts with multiple proteins, including extracellular region proteins, which may facilitate its functions in cell signaling and regulation. **Pathways and Functions:** 1. **Endopeptidase Inhibition:** SMR3A inhibits endopeptidases, enzymes that degrade peptides and proteins, thereby modulating the levels of various signaling molecules in the extracellular environment. 2. **Extracellular Region Regulation:** SMR3A regulates the extracellular region, influencing cell signaling, adhesion, and migration. 3. **Regulation of Sensory Perception of Pain:** SMR3A modulates the sensory perception of pain by interacting with pain-related proteins and signaling pathways. 4. **Cellular Homeostasis:** SMR3A maintains cellular homeostasis by regulating the levels of various peptides and proteins, which is essential for proper cellular function and tissue development. **Clinical Significance:** 1. **Cancer Research:** SMR3A has been implicated in cancer progression, suggesting its potential as a therapeutic target for cancer treatment. 2. **Neurological Disorders:** SMR3A's role in regulating sensory perception of pain and modulating pain-related signaling pathways makes it a potential therapeutic target for neurological disorders, such as chronic pain and neuropathic pain. 3. **Androgen-Related Disorders:** SMR3A's androgen-regulated expression and potential role in male reproductive physiology make it a potential therapeutic target for androgen-related disorders, such as hypogonadism and prostate cancer. 4. **Neurodevelopmental Disorders:** SMR3A's expression in oligodendrocyte precursor cells and forebrain radial glial cells suggests its potential role in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, SMR3A is a multifaceted gene with diverse functions in cellular homeostasis, endopeptidase inhibition, and sensory perception modulation. Its clinical significance is underscored by its potential role in cancer, neurological disorders, and androgen-related disorders. Further research is necessary to fully elucidate the mechanisms of SMR3A and its therapeutic potential.

Genular Protein ID: 2196645324

Symbol: SMR3A_HUMAN

Name: Submaxillary gland androgen-regulated protein 3A

UniProtKB Accession Codes:

Q99954

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9354371

Title: Nucleotide sequence of gene PBI encoding a protein homologous to salivary proline-rich protein P-B.

PubMed ID: 9354371

DOI: 10.1093/oxfordjournals.jbchem.a021689

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 134
  • Mass: 14048
  • Checksum: BF0192C0D09C4A63
  • Sequence:
    • MKSLTWILGL WALAACFTPG ESQRGPRGPY PPGPLAPPPP PCFPFGTGFV PPPHPPPYGP 
GRFPPPLSPP YGPGRIPPSP PPPYGPGRIQ SHSLPPPYGP GYPQPPSQPR PYPPGPPFFP 
VNSPTDPALP TPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.