Details for: HBP1

Gene ID: 26959

Symbol: HBP1

Ensembl ID: ENSG00000105856

Description: HMG-box transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 342.4085
    Cell Significance Index: -53.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 211.8723
    Cell Significance Index: -53.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.2352
    Cell Significance Index: -57.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 111.1981
    Cell Significance Index: -45.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.8521
    Cell Significance Index: -53.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.5102
    Cell Significance Index: -45.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.0162
    Cell Significance Index: -54.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.0641
    Cell Significance Index: -51.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.3257
    Cell Significance Index: -56.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8869
    Cell Significance Index: -36.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2206
    Cell Significance Index: -20.1800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.4857
    Cell Significance Index: 47.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6144
    Cell Significance Index: 35.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.3123
    Cell Significance Index: 66.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1971
    Cell Significance Index: 357.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1009
    Cell Significance Index: 220.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0482
    Cell Significance Index: 49.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0432
    Cell Significance Index: 28.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9619
    Cell Significance Index: 57.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7524
    Cell Significance Index: 103.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6814
    Cell Significance Index: 122.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6385
    Cell Significance Index: 126.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6382
    Cell Significance Index: 282.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6347
    Cell Significance Index: 43.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6140
    Cell Significance Index: 220.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5810
    Cell Significance Index: 71.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5727
    Cell Significance Index: 56.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5709
    Cell Significance Index: 73.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5476
    Cell Significance Index: 30.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.5465
    Cell Significance Index: 8.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5282
    Cell Significance Index: 39.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5040
    Cell Significance Index: 23.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4925
    Cell Significance Index: 63.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4626
    Cell Significance Index: 252.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4430
    Cell Significance Index: 23.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4143
    Cell Significance Index: 31.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3387
    Cell Significance Index: 234.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2992
    Cell Significance Index: 56.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2632
    Cell Significance Index: 5.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2489
    Cell Significance Index: 12.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2395
    Cell Significance Index: 6.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2363
    Cell Significance Index: 10.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1799
    Cell Significance Index: 4.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1549
    Cell Significance Index: 291.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1530
    Cell Significance Index: 7.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1502
    Cell Significance Index: 95.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0977
    Cell Significance Index: 16.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0447
    Cell Significance Index: 68.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0346
    Cell Significance Index: 63.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0288
    Cell Significance Index: 2.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0248
    Cell Significance Index: 11.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0230
    Cell Significance Index: 31.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0143
    Cell Significance Index: 0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0044
    Cell Significance Index: 3.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0084
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0357
    Cell Significance Index: -26.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0371
    Cell Significance Index: -27.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0379
    Cell Significance Index: -1.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0501
    Cell Significance Index: -37.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0551
    Cell Significance Index: -34.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0635
    Cell Significance Index: -35.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0719
    Cell Significance Index: -2.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0746
    Cell Significance Index: -7.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0850
    Cell Significance Index: -1.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0871
    Cell Significance Index: -2.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1057
    Cell Significance Index: -12.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1474
    Cell Significance Index: -42.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1531
    Cell Significance Index: -22.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1570
    Cell Significance Index: -18.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1776
    Cell Significance Index: -37.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1972
    Cell Significance Index: -5.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2061
    Cell Significance Index: -3.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2219
    Cell Significance Index: -3.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2390
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2744
    Cell Significance Index: -31.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2798
    Cell Significance Index: -2.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2935
    Cell Significance Index: -12.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3035
    Cell Significance Index: -4.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3678
    Cell Significance Index: -23.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4192
    Cell Significance Index: -2.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4217
    Cell Significance Index: -43.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4298
    Cell Significance Index: -16.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4766
    Cell Significance Index: -10.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4836
    Cell Significance Index: -25.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5013
    Cell Significance Index: -8.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5128
    Cell Significance Index: -58.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5491
    Cell Significance Index: -43.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5633
    Cell Significance Index: -14.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6006
    Cell Significance Index: -7.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6423
    Cell Significance Index: -5.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6657
    Cell Significance Index: -21.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7057
    Cell Significance Index: -15.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7713
    Cell Significance Index: -10.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8469
    Cell Significance Index: -14.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8676
    Cell Significance Index: -21.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8922
    Cell Significance Index: -23.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9237
    Cell Significance Index: -56.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0493
    Cell Significance Index: -36.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0541
    Cell Significance Index: -34.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HBP1 gene is a member of the HMG-box family of transcription factors, which are known for their ability to regulate gene expression by binding to specific DNA sequences. The HBP1 protein has a distinctive HMG box domain, which is a highly conserved region of the protein that is responsible for its ability to bind to DNA. The HBP1 protein is also known to interact with other proteins, including RNA polymerase II, which is involved in the regulation of transcription. **Pathways and Functions:** The HBP1 gene is involved in several signaling pathways, including: 1. **Wnt signaling pathway:** The HBP1 protein is a component of the Wnt signaling pathway, which is a complex signaling cascade that regulates various cellular processes, including cell proliferation, differentiation, and survival. 2. **Regulation of cell cycle:** The HBP1 protein is involved in the regulation of the cell cycle, particularly in the G1 phase, where it helps to control the expression of genes involved in cell proliferation. 3. **Regulation of transcription by RNA polymerase II:** The HBP1 protein interacts with RNA polymerase II, which is the primary enzyme responsible for transcription in eukaryotic cells. The HBP1 protein helps to regulate the transcription of target genes by controlling the recruitment of RNA polymerase II to specific DNA sequences. 4. **Chromatin remodeling:** The HBP1 protein is also involved in chromatin remodeling, which is the process by which the structure of chromatin is altered to facilitate or inhibit gene expression. **Clinical Significance:** The HBP1 gene has been implicated in various diseases, including: 1. **Cancer:** The HBP1 protein has been shown to be overexpressed in several types of cancer, including breast, prostate, and colon cancer. The HBP1 protein is involved in the regulation of cell proliferation and survival, and its overexpression may contribute to tumorigenesis. 2. **Autoimmune diseases:** The HBP1 protein has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it is thought to play a role in the regulation of immune responses. 3. **Neurological disorders:** The HBP1 protein has been shown to be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in the regulation of gene expression and neuronal survival. In conclusion, the HBP1 gene is a critical regulator of gene expression and cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of the HBP1 gene in human health and disease.

Genular Protein ID: 2119381142

Symbol: HBP1_HUMAN

Name: HMG box-containing protein 1

UniProtKB Accession Codes:

O60381 B3KVB7 Q8TBM1 Q8TE93 Q96AJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10958660

Title: Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.

PubMed ID: 10958660

DOI: 10.1128/mcb.20.18.6627-6637.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10562551

Title: Human HMG box transcription factor HBP1: a role in hCD2 LCR function.

PubMed ID: 10562551

DOI: 10.1093/emboj/18.22.6396

PubMed ID: 11500377

Title: Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.

PubMed ID: 11500377

DOI: 10.1093/emboj/20.16.4500

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29911972

Title: The multi-subunit GID/CTLH E3 ligase promotes proliferation and targets the transcription factor Hbp1 for degradation.

PubMed ID: 29911972

DOI: 10.7554/elife.35528

Sequence Information:

  • Length: 514
  • Mass: 57645
  • Checksum: 2AFADC995F73A031
  • Sequence:
    • MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC DEHMELDDLP 
ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW LTELANIATS 
PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW KEETPVRHER 
ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA 
EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH 
PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV FDTFKSYDFT 
PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS NSLYAKAVKN 
HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD RWKKMKNEER 
RMYTLEAKAL AEEQKRLNPD CWKRKRTNSG SQQH

Genular Protein ID: 144659783

Symbol: B4DJ36_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJ36

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 524
  • Mass: 58723
  • Checksum: AA06D73CA8E22BD8
  • Sequence:
    • MATGLSEHHN MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC 
DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW 
LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW 
KEETPVRHER ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE 
WQDVEDFARA EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG 
LLTVECKLDH PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV 
FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS 
NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD 
RWKKMKNEER RMYTLEAKAL AEEQKRLNPD CWKRKRTNSG SQQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.