Details for: NDOR1

Gene ID: 27158

Symbol: NDOR1

Ensembl ID: ENSG00000188566

Description: NADPH dependent diflavin oxidoreductase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.1888
    Cell Significance Index: -7.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.9239
    Cell Significance Index: -7.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.9997
    Cell Significance Index: -6.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.8186
    Cell Significance Index: -6.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1559
    Cell Significance Index: -7.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8034
    Cell Significance Index: -7.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7134
    Cell Significance Index: -3.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4943
    Cell Significance Index: 48.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4207
    Cell Significance Index: 8.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3281
    Cell Significance Index: 296.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3238
    Cell Significance Index: 4.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2773
    Cell Significance Index: 7.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2758
    Cell Significance Index: 55.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2510
    Cell Significance Index: 40.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2211
    Cell Significance Index: 24.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1846
    Cell Significance Index: 4.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1551
    Cell Significance Index: 9.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1537
    Cell Significance Index: 30.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1263
    Cell Significance Index: 45.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1179
    Cell Significance Index: 9.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1067
    Cell Significance Index: 4.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1063
    Cell Significance Index: 2.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1062
    Cell Significance Index: 1.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0958
    Cell Significance Index: 6.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0929
    Cell Significance Index: 4.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0873
    Cell Significance Index: 16.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0856
    Cell Significance Index: 3.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0744
    Cell Significance Index: 1.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0674
    Cell Significance Index: 2.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0627
    Cell Significance Index: 7.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0624
    Cell Significance Index: 1.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0529
    Cell Significance Index: 36.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0453
    Cell Significance Index: 6.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0433
    Cell Significance Index: 7.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0367
    Cell Significance Index: 2.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0340
    Cell Significance Index: 1.7700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0327
    Cell Significance Index: 0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0317
    Cell Significance Index: 0.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0250
    Cell Significance Index: 1.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0161
    Cell Significance Index: 29.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0131
    Cell Significance Index: 0.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0115
    Cell Significance Index: 1.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0115
    Cell Significance Index: 17.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0095
    Cell Significance Index: 17.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0060
    Cell Significance Index: 8.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0037
    Cell Significance Index: 2.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0002
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0119
    Cell Significance Index: -1.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0122
    Cell Significance Index: -6.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0168
    Cell Significance Index: -1.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0174
    Cell Significance Index: -1.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0206
    Cell Significance Index: -2.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0216
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0218
    Cell Significance Index: -3.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0257
    Cell Significance Index: -0.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0259
    Cell Significance Index: -1.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0337
    Cell Significance Index: -4.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0381
    Cell Significance Index: -8.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0409
    Cell Significance Index: -4.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0464
    Cell Significance Index: -6.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0612
    Cell Significance Index: -6.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0666
    Cell Significance Index: -4.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0732
    Cell Significance Index: -3.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0768
    Cell Significance Index: -4.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0778
    Cell Significance Index: -2.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0793
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0905
    Cell Significance Index: -7.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0933
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0943
    Cell Significance Index: -2.6900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0952
    Cell Significance Index: -2.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0968
    Cell Significance Index: -3.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1092
    Cell Significance Index: -4.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1159
    Cell Significance Index: -3.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1178
    Cell Significance Index: -2.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1203
    Cell Significance Index: -1.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1216
    Cell Significance Index: -3.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1258
    Cell Significance Index: -4.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1296
    Cell Significance Index: -2.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1333
    Cell Significance Index: -4.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1345
    Cell Significance Index: -3.9500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1474
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1477
    Cell Significance Index: -4.0200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1535
    Cell Significance Index: -2.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1585
    Cell Significance Index: -2.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1663
    Cell Significance Index: -2.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1693
    Cell Significance Index: -2.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1714
    Cell Significance Index: -3.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1740
    Cell Significance Index: -4.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NDOR1 is a cytosolic enzyme that exhibits NADPH-dependent diflavin oxidoreductase activity, enabling it to facilitate electron transfer and reduce diflavin oxidized forms. Its ability to bind FAD, FMN, and NADPH further underscores its role as a versatile electron carrier. Notably, NDOR1 is also involved in iron-sulfur cluster assembly, a process critical for maintaining the structural integrity of various proteins and enzymes. **Pathways and Functions:** NDOR1 is implicated in several key cellular pathways, including: 1. **Electron Transfer Activity:** NDOR1 participates in electron transfer reactions, facilitating the movement of electrons between diflavin oxidized forms and NADPH or other electron donors. 2. **Iron-Sulfur Cluster Assembly:** NDOR1 plays a crucial role in the assembly of iron-sulfur clusters, which are essential for maintaining the structure and function of various proteins and enzymes. 3. **Metabolism:** NDOR1 is involved in metabolic processes, including energy production and redox homeostasis, by regulating the flow of electrons through the electron transport chain. 4. **Cytoskeleton Assembly:** NDOR1 has been shown to interact with intermediate filaments, suggesting a potential role in cytoskeleton assembly and maintenance. **Clinical Significance:** The dysregulation of NDOR1 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** Alterations in NDOR1 expression have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggesting a potential role in oxidative stress and redox homeostasis. 2. **Metabolic Disorders:** NDOR1 dysfunction has been implicated in metabolic disorders, including diabetes and obesity, highlighting its importance in energy metabolism and redox balance. 3. **Cancer:** NDOR1 has been shown to play a role in cancer progression, with altered expression levels observed in various cancer types, including colorectal and breast cancer. In conclusion, NDOR1 is a complex enzyme that plays a multifaceted role in various cellular processes. Further research is necessary to fully elucidate its mechanisms of action and to explore its therapeutic potential in diseases characterized by NDOR1 dysfunction.

Genular Protein ID: 3424474907

Symbol: NDOR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UHB4 D3YTG6 D3YTH9 Q5VSG4 Q86US9 Q96BC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 19 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10625700

Title: Cloning and characterization of a novel human dual flavin reductase.

PubMed ID: 10625700

DOI: 10.1074/jbc.275.2.1471

PubMed ID: 12871939

Title: Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.

PubMed ID: 12871939

DOI: 10.1074/jbc.m306355200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12871938

Title: Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1.

PubMed ID: 12871938

DOI: 10.1074/jbc.m306282200

PubMed ID: 12631275

Title: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.

PubMed ID: 12631275

DOI: 10.1046/j.1432-1033.2003.03474.x

PubMed ID: 16140270

Title: Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.

PubMed ID: 16140270

DOI: 10.1016/j.bbrc.2005.08.129

PubMed ID: 20802492

Title: Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis.

PubMed ID: 20802492

DOI: 10.1038/nchembio.432

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28648056

Title: Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.

PubMed ID: 28648056

DOI: 10.1021/jacs.7b05003

PubMed ID: 23596212

Title: Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis.

PubMed ID: 23596212

DOI: 10.1073/pnas.1302378110

PubMed ID: 15900210

Title: Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1.

PubMed ID: 15900210

DOI: 10.1097/01213011-200506000-00002

Sequence Information:

  • Length: 597
  • Mass: 66763
  • Checksum: 0D1340D7280A4D8F
  • Sequence:
    • MPSPQLLVLF GSQTGTAQDV SERLGREARR RRLGCRVQAL DSYPVVNLIN EPLVIFVCAT 
TGQGDPPDNM KNFWRFIFRK NLPSTALCQM DFAVLGLGDS SYAKFNFVAK KLHRRLLQLG 
GSALLPVCLG DDQHELGPDA AVDPWLRDLW DRVLGLYPPP PGLTEIPPGV PLPSKFTLLF 
LQEAPSTGSE GQRVAHPGSQ EPPSESKPFL APMISNQRVT GPSHFQDVRL IEFDILGSGI 
SFAAGDVVLI QPSNSAAHVQ RFCQVLGLDP DQLFMLQPRE PDVSSPTRLP QPCSMRHLVS 
HYLDIASVPR RSFFELLACL SLHELEREKL LEFSSAQGQE ELFEYCNRPR RTILEVLCDF 
PHTAAAIPPD YLLDLIPVIR PRAFSIASSL LTHPSRLQIL VAVVQFQTRL KEPRRGLCSS 
WLASLDPGQG PVRVPLWVRP GSLAFPETPD TPVIMVGPGT GVAPFRAAIQ ERVAQGQTGN 
FLFFGCRWRD QDFYWEAEWQ ELEKRDCLTL IPAFSREQEQ KVYVQHRLRE LGSLVWELLD 
RQGAYFYLAG NAKSMPADVS EALMSIFQEE GGLCSPDAAA YLARLQQTRR FQTETWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.