Details for: CSDC2

Gene ID: 27254

Symbol: CSDC2

Ensembl ID: ENSG00000172346

Description: cold shock domain containing C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.5110
    Cell Significance Index: 88.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3392
    Cell Significance Index: 179.5100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.5268
    Cell Significance Index: 8.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.1697
    Cell Significance Index: -2.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0369
    Cell Significance Index: 8.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5423
    Cell Significance Index: 14.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3863
    Cell Significance Index: 20.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3318
    Cell Significance Index: 4.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2860
    Cell Significance Index: 197.8300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2567
    Cell Significance Index: 3.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2467
    Cell Significance Index: 33.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2413
    Cell Significance Index: 6.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2000
    Cell Significance Index: 40.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1909
    Cell Significance Index: 68.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1669
    Cell Significance Index: 10.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1430
    Cell Significance Index: 1.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0706
    Cell Significance Index: 1.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0563
    Cell Significance Index: 1.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0474
    Cell Significance Index: 21.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0302
    Cell Significance Index: 46.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0109
    Cell Significance Index: 20.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0077
    Cell Significance Index: 14.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0064
    Cell Significance Index: 0.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0061
    Cell Significance Index: 2.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0048
    Cell Significance Index: 3.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0036
    Cell Significance Index: 0.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0035
    Cell Significance Index: 0.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0055
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0086
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0192
    Cell Significance Index: -14.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0212
    Cell Significance Index: -4.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0216
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0228
    Cell Significance Index: -14.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0234
    Cell Significance Index: -12.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0651
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0666
    Cell Significance Index: -14.0300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0679
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0797
    Cell Significance Index: -9.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0874
    Cell Significance Index: -1.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0908
    Cell Significance Index: -1.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0996
    Cell Significance Index: -12.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1096
    Cell Significance Index: -12.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1124
    Cell Significance Index: -13.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1162
    Cell Significance Index: -12.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1281
    Cell Significance Index: -13.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1305
    Cell Significance Index: -2.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1385
    Cell Significance Index: -2.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1400
    Cell Significance Index: -11.0900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1434
    Cell Significance Index: -1.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1467
    Cell Significance Index: -3.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1485
    Cell Significance Index: -6.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1521
    Cell Significance Index: -1.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1599
    Cell Significance Index: -10.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1738
    Cell Significance Index: -12.9500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1897
    Cell Significance Index: -1.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1945
    Cell Significance Index: -9.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2033
    Cell Significance Index: -2.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2060
    Cell Significance Index: -11.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2128
    Cell Significance Index: -4.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2182
    Cell Significance Index: -4.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2183
    Cell Significance Index: -11.3400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2471
    Cell Significance Index: -3.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2523
    Cell Significance Index: -11.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2539
    Cell Significance Index: -4.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2540
    Cell Significance Index: -8.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2578
    Cell Significance Index: -9.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2593
    Cell Significance Index: -7.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2643
    Cell Significance Index: -12.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2716
    Cell Significance Index: -5.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2772
    Cell Significance Index: -5.9900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2791
    Cell Significance Index: -3.9700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2800
    Cell Significance Index: -3.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2804
    Cell Significance Index: -9.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2862
    Cell Significance Index: -4.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2901
    Cell Significance Index: -13.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2990
    Cell Significance Index: -2.3100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3046
    Cell Significance Index: -1.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3081
    Cell Significance Index: -8.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3103
    Cell Significance Index: -3.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3111
    Cell Significance Index: -11.7800
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3177
    Cell Significance Index: -3.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3275
    Cell Significance Index: -11.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3292
    Cell Significance Index: -6.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3303
    Cell Significance Index: -8.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3352
    Cell Significance Index: -9.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3356
    Cell Significance Index: -12.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3361
    Cell Significance Index: -11.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3463
    Cell Significance Index: -10.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3502
    Cell Significance Index: -3.3200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3513
    Cell Significance Index: -2.3800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3661
    Cell Significance Index: -3.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3748
    Cell Significance Index: -6.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSDC2 is a gene that belongs to the cold shock domain-containing protein family. The protein it encodes, CSDC2_HUMAN, is a small, conserved protein that interacts with various RNAs and proteins, modulating their stability and activity. The gene is expressed in multiple cell types, including cardiac myocytes, dendritic cells, and Sertoli cells, suggesting its role in maintaining tissue-specific functions. The gene's expression is also observed in hematopoietic cells, such as granulocyte-monocyte progenitor cells, indicating its involvement in immune cell development. **Pathways and Functions:** CSDC2 is involved in several cellular pathways, including mRNA 3'-UTR binding, mRNA processing, and regulation of mRNA stability. The protein interacts with various RNAs, including microRNAs and long non-coding RNAs, influencing their expression and stability. CSDC2 also interacts with proteins involved in transcriptional regulation, such as transcription factors and RNA-binding proteins, modulating their activity and gene expression. These interactions suggest that CSDC2 plays a crucial role in regulating gene expression and maintaining cellular homeostasis. **Clinical Significance:** The clinical significance of CSDC2 is an area of active research. Given its expression in cardiac myocytes and dendritic cells, CSDC2 may play a role in cardiac function and immune system regulation. Alterations in CSDC2 expression have been implicated in various disease states, including cardiovascular disease and immune disorders. For example, studies have shown that CSDC2 is downregulated in patients with heart failure, suggesting its potential role in cardiac function. Additionally, CSDC2 may play a role in regulating immune responses, particularly in the context of autoimmune diseases. In conclusion, CSDC2 is a gene that encodes a protein involved in various cellular processes, including mRNA stability, regulation of gene expression, and protein binding. Its expression in multiple cell types highlights its diverse roles in maintaining cellular homeostasis. Further research is needed to fully elucidate the clinical significance of CSDC2 and its potential implications in disease states.

Genular Protein ID: 3913713870

Symbol: CSDC2_HUMAN

Name: Cold shock domain-containing protein C2

UniProtKB Accession Codes:

Q9Y534 Q8ND37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 153
  • Mass: 16786
  • Checksum: F0CB947289356E93
  • Sequence:
    • MTSESTSPPV VPPLHSPKSP VWPTFPFHRE GSRVWERGGV PPRDLPSPLP TKRTRTYSAT 
ARASAGPVFK GVCKQFSRSQ GHGFITPENG SEDIFVHVSD IEGEYVPVEG DEVTYKMCPI 
PPKNQKFQAV EVVLTQLAPH TPHETWSGQV VGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.