Details for: CNTN6

Gene ID: 27255

Symbol: CNTN6

Ensembl ID: ENSG00000134115

Description: contactin 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.5389
    Cell Significance Index: 94.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.6732
    Cell Significance Index: 35.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6966
    Cell Significance Index: 37.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.6795
    Cell Significance Index: 28.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1478
    Cell Significance Index: 30.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8191
    Cell Significance Index: 164.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8042
    Cell Significance Index: 556.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4960
    Cell Significance Index: 14.1600
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.4743
    Cell Significance Index: 5.4000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2205
    Cell Significance Index: 2.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1001
    Cell Significance Index: 184.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0839
    Cell Significance Index: 2.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0736
    Cell Significance Index: 26.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0356
    Cell Significance Index: 67.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0320
    Cell Significance Index: 49.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0286
    Cell Significance Index: 4.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0211
    Cell Significance Index: 28.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0133
    Cell Significance Index: 5.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0075
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0167
    Cell Significance Index: -7.5900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0184
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0197
    Cell Significance Index: -14.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0212
    Cell Significance Index: -16.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0271
    Cell Significance Index: -16.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0275
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0298
    Cell Significance Index: -0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0388
    Cell Significance Index: -0.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0407
    Cell Significance Index: -2.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0456
    Cell Significance Index: -13.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0475
    Cell Significance Index: -0.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0587
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0630
    Cell Significance Index: -10.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0762
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0802
    Cell Significance Index: -16.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0830
    Cell Significance Index: -5.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0877
    Cell Significance Index: -11.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0938
    Cell Significance Index: -4.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1017
    Cell Significance Index: -2.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1088
    Cell Significance Index: -13.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1207
    Cell Significance Index: -16.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1373
    Cell Significance Index: -16.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1373
    Cell Significance Index: -5.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1408
    Cell Significance Index: -16.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1461
    Cell Significance Index: -15.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1465
    Cell Significance Index: -14.9700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1469
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1503
    Cell Significance Index: -17.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1628
    Cell Significance Index: -4.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1665
    Cell Significance Index: -5.4500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1834
    Cell Significance Index: -2.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1846
    Cell Significance Index: -14.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1941
    Cell Significance Index: -10.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2003
    Cell Significance Index: -15.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2072
    Cell Significance Index: -5.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2167
    Cell Significance Index: -7.5900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2349
    Cell Significance Index: -2.7400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2350
    Cell Significance Index: -1.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2482
    Cell Significance Index: -15.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2520
    Cell Significance Index: -3.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2680
    Cell Significance Index: -2.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2700
    Cell Significance Index: -12.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2786
    Cell Significance Index: -14.5100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2808
    Cell Significance Index: -3.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2929
    Cell Significance Index: -3.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2939
    Cell Significance Index: -13.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3184
    Cell Significance Index: -6.8800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3207
    Cell Significance Index: -3.8400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3240
    Cell Significance Index: -1.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3321
    Cell Significance Index: -17.2500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3339
    Cell Significance Index: -4.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3346
    Cell Significance Index: -3.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3438
    Cell Significance Index: -10.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3464
    Cell Significance Index: -10.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3685
    Cell Significance Index: -7.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4092
    Cell Significance Index: -14.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4413
    Cell Significance Index: -7.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4473
    Cell Significance Index: -12.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4923
    Cell Significance Index: -14.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4958
    Cell Significance Index: -17.4200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5030
    Cell Significance Index: -5.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5095
    Cell Significance Index: -6.4300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.5121
    Cell Significance Index: -6.3700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5139
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5141
    Cell Significance Index: -10.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5336
    Cell Significance Index: -7.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5419
    Cell Significance Index: -13.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5448
    Cell Significance Index: -11.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5463
    Cell Significance Index: -15.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5524
    Cell Significance Index: -14.7500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5529
    Cell Significance Index: -7.3700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5681
    Cell Significance Index: -11.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5834
    Cell Significance Index: -16.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5933
    Cell Significance Index: -16.1500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.5967
    Cell Significance Index: -6.9700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5990
    Cell Significance Index: -14.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6033
    Cell Significance Index: -12.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CNTN6 is predominantly expressed in the central nervous system, with high levels found in retinal cone and rod cells, melanocytes, dopaminergic neurons, and macroglial cells. 2. **Molecular structure:** Contactin 6 consists of an extracellular domain with three immunoglobulin-like domains, a transmembrane domain, and an intracellular domain. 3. **Function:** CNTN6 mediates homophilic cell adhesion, modulating cell-cell interactions and influencing axon guidance, synaptic organization, and neuronal development. 4. **Interactions:** CNTN6 interacts with other adhesion molecules, such as L1cam, Chl1, and Notch receptors, to regulate cell-cell adhesion and signaling pathways. **Pathways and Functions:** 1. **Axon guidance:** CNTN6 plays a crucial role in guiding axons during neural development, influencing the formation of neural circuits and the establishment of proper neuronal connections. 2. **Cell-cell adhesion:** CNTN6 mediates homophilic cell adhesion, regulating the interaction between neurons and glial cells, and influencing the organization of neural tissue. 3. **Synaptic organization:** CNTN6 is involved in the formation of synapses, modulating the interaction between neurons and regulating the release of neurotransmitters. 4. **Notch signaling pathway:** CNTN6 positively regulates the Notch signaling pathway, which is essential for cell fate determination, differentiation, and proliferation. **Clinical Significance:** Dysregulation of CNTN6 has been implicated in several neurological disorders, including: 1. **Neurodevelopmental disorders:** CNTN6 mutations have been associated with conditions such as autism spectrum disorder, schizophrenia, and intellectual disability. 2. **Neurodegenerative disorders:** CNTN6 dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** CNTN6 has been implicated in the development and progression of certain types of cancer, including glioblastoma and breast cancer. In conclusion, contactin 6 is a critical component in neural development and function, influencing axon guidance, cell-cell adhesion, and the regulation of the Notch signaling pathway. Its dysregulation has significant implications for the development and progression of neurological disorders, highlighting the importance of further research into the mechanisms of CNTN6 and its role in human disease.

Genular Protein ID: 765727893

Symbol: CNTN6_HUMAN

Name: Contactin-6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9486763

Title: cDNA cloning and chromosomal localization of neural adhesion molecule, NB-3 in human.

PubMed ID: 9486763

DOI: 10.1002/(sici)1097-4547(19980201)51:3<275::aid-jnr1>3.0.co;2-d

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20133774

Title: The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.

PubMed ID: 20133774

DOI: 10.1073/pnas.0911235107

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 1028
  • Mass: 113956
  • Checksum: 8B5A2ED2F29936A6
  • Sequence:
  • MRLLWKLVIL LPLINSSAGD GLLSRPIFTQ EPHDVIFPLD LSKSEVILNC AANGYPSPHY 
    RWKQNGTDID FTMSYHYRLD GGSLAINSPH TDQDIGMYQC LATNLLGTIL SRKAKLQFAY 
    IEDFETKTRS TVSVREGQGV VLLCGPPPHF GDLSYAWTFN DNPLYVQEDN RRFVSQETGN 
    LYIAKVEPSD VGNYTCFITN KEAQRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA 
    KDSSVKLECF ALGNPVPDIS WRRLDGSPLP GKVKYSKSQA ILEIPNFQQE DEGFYECIAS 
    NLRGRNLAKG QLIFYAPPEW EQKIQNTHLS IYDNLLWECK ASGKPNPWYT WLKNGERLNP 
    EERIQIENGT LIITMLNVSD SGVYQCAAEN KYQIIYANAE LRVLASAPDF SKSPVKKKSF 
    VQVGGDIVIG CKPNAFPRAA ISWKRGTETL RQSKRIFLLE DGSLKIYNIT RSDAGSYTCI 
    ATNQFGTAKN TGSLIVKERT VITVPPSKMD VTVGESIVLP CQVSHDPSIE VVFVWFFNGD 
    VIDLKKGVAH FERIGGESVG DLMIRNIQLH HSGKYLCTVQ TTLESLSAVA DIIVRGPPGP 
    PEDVQVEDIS STTSQLSWRA GPDNNSPIQI FTIQTRTPFS VGWQAVATVP EILNGKTYNA 
    TVVGLSPWVE YEFRVVAGNS IGIGEPSEPS ELLRTKASVP VVAPVNIHGG GGSRSELVIT 
    WESIPEELQN GEGFGYIIMF RPVGSTTWSK EKVSSVESSR FVYRNESIIP LSPFEVKVGV 
    YNNEGEGSLS TVTIVYSGED EPQLAPRGTS LQSFSASEME VSWNAIAWNR NTGRVLGYEV 
    LYWTDDSKES MIGKIRVSGN VTTKNITGLK ANTIYFASVR AYNTAGTGPS SPPVNVTTKK 
    SPPSQPPANI AWKLTNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT HILETNNTSA 
    ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSR GIQFLEPSTH FLSIVIVIFH 
    CFAIQPLI

Genular Protein ID: 3421567288

Symbol: B4DGV0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 956
  • Mass: 105838
  • Checksum: 80C91CC157236FBC
  • Sequence:
  • MSYHYRLDGG SLAINSPHTD QDIGMYQCLA TNLLGTILSR KAKLQFAYIE DFETKTRSTV 
    SVREGQGVVL LCGPPPHFGD LSYAWTFNDN PLYVQEDNRR FVSQETGNLY IAKVEPSDVG 
    NYTCFITNKE AQRSVQGPPT PLVQRTDGVM GEYEPKIEVR FPETIQAAKD SSVKLECFAL 
    GNPVPDISWR RLDGSPLPGK VKYSKSQAIL EIPNFQQEDE GFYECIASNL RGRNLAKGQL 
    IFYAPPEWEQ KIQNTHLSIY DNLLWECKAS GKPNPWYTWL KNGERLNPEE RIQIENGTLI 
    ITMLNVSDSG VYQCAAENKY QIIYANAELR VLASAPDFSK SPVKKKSFVQ VGGDIVIGCK 
    PNAFPRAAIS WKRGTETLRQ SKRIFLLEDG SLKIYNITRS DAGSYTCIAT NQFGTAKNTG 
    SLIVKERTVI TVPPSKMDVT VGESIVLPCQ VSHDPSIEVV FVWFFNGDVI DLKKGVAHFE 
    RIGGESVGDL MIRNIQLHHS GKYLCTVQTT LESLSAVADI IVRGPPGPPE DVQVEDISST 
    TSQLSWRAGP DNNSPIQIFT IQTRTPFSVG WQAVATVPEI LNGKTYNATV VGLSPWVEYE 
    FRVVAGNSIG IGEPSEPSEL LRTKASVPVV APVNIHGGGG SRSELVITWE SIPEELQNGE 
    GFGYIIMFRP VGSTTWSKEK VSSVESSRFV YRNESIIPLS PFEVKVGVYN DEGEGSLSTV 
    TIVYSGEDEP QLAPRGTSLQ SFSASEMEVS WNAIAWNRNT GRVLGYEVLY WTDDSKESMI 
    GKIRVSGNVT TKNITGLKAN TIYFASVRAY NTAGTGPSSP PVNVTTKKSP PSQPPANIAW 
    KLTNSKLCLN WEHVKTMENE SEVLGYKILY RQNRQSKTHI LETNNTSAEL LVPFEEDYLI 
    EIRTVSDGGD GSSSEEIRIP KMSSLSSRGI QFLEPSTHFL SIVIVIFHCF AIQPLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.