VENTX | ENSG00000151650 | NCBI 27287

Details for: VENTX

Gene ID: 27287

Symbol: VENTX

Ensembl ID: ENSG00000151650

Description: VENT homeobox

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Transcriptional regulation by ventx
(R-HSA-8853884)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Nucleoplasm
(GO:0005654)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Stem cell population maintenance
(GO:0019827)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 16.2011
Cell Significance Index: -2.5200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 10.0141
Cell Significance Index: -2.5400
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 2.2826
Cell Significance Index: 33.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 2.0520
Cell Significance Index: -2.5300
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.1135
Cell Significance Index: 13.1600
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.5417
Cell Significance Index: 6.7000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2478
Cell Significance Index: 4.5800
Cell Name: secondary lymphoid organ macrophage (CL0000867)
Fold Change: 0.1069
Cell Significance Index: 0.7900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0936
Cell Significance Index: 1.3400
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0733
Cell Significance Index: 1.0500
Cell Name: germ cell (CL0000586)
Fold Change: 0.0616
Cell Significance Index: 0.4700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0012
Cell Significance Index: -2.2400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0014
Cell Significance Index: -0.0600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0017
Cell Significance Index: -2.6300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0027
Cell Significance Index: -1.7300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0028
Cell Significance Index: -2.0600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0033
Cell Significance Index: -2.4700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0036
Cell Significance Index: -2.0300
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0042
Cell Significance Index: -2.2900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0045
Cell Significance Index: -0.8100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0045
Cell Significance Index: -2.0500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0049
Cell Significance Index: -1.7600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0068
Cell Significance Index: -1.9600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0089
Cell Significance Index: -0.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0094
Cell Significance Index: -1.9000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0101
Cell Significance Index: -1.0300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0105
Cell Significance Index: -2.0900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0113
Cell Significance Index: -1.6400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0118
Cell Significance Index: -2.4800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0127
Cell Significance Index: -2.1700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0138
Cell Significance Index: -0.6500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0145
Cell Significance Index: -1.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0149
Cell Significance Index: -2.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0162
Cell Significance Index: -1.8900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0166
Cell Significance Index: -0.2200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0183
Cell Significance Index: -0.4800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0186
Cell Significance Index: -2.1300
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0206
Cell Significance Index: -0.2700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0227
Cell Significance Index: -0.1900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0240
Cell Significance Index: -1.8400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0262
Cell Significance Index: -1.2300
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0270
Cell Significance Index: -0.4000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0270
Cell Significance Index: -1.7000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0307
Cell Significance Index: -0.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0310
Cell Significance Index: -2.0000
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0352
Cell Significance Index: -0.2900
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0365
Cell Significance Index: -0.6200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0368
Cell Significance Index: -2.2600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0402
Cell Significance Index: -1.4100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0410
Cell Significance Index: -2.7600
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0426
Cell Significance Index: -0.3600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0437
Cell Significance Index: -1.9800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0448
Cell Significance Index: -1.2200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0449
Cell Significance Index: -2.2700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0450
Cell Significance Index: -0.8800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0454
Cell Significance Index: -1.2700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0456
Cell Significance Index: -2.3700
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0465
Cell Significance Index: -0.7200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0517
Cell Significance Index: -1.2900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0566
Cell Significance Index: -1.3700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0599
Cell Significance Index: -2.6500
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0642
Cell Significance Index: -2.0300
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0678
Cell Significance Index: -1.3800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0681
Cell Significance Index: -2.5800
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0684
Cell Significance Index: -0.6500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0698
Cell Significance Index: -0.9800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0710
Cell Significance Index: -2.0900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0721
Cell Significance Index: -2.3600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0722
Cell Significance Index: -2.3000
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0750
Cell Significance Index: -0.9100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0778
Cell Significance Index: -2.2300
Cell Name: macrophage (CL0000235)
Fold Change: -0.0784
Cell Significance Index: -0.8000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0799
Cell Significance Index: -2.1400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0801
Cell Significance Index: -2.9400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0809
Cell Significance Index: -2.1600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0821
Cell Significance Index: -1.3300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0844
Cell Significance Index: -2.1500
Cell Name: microglial cell (CL0000129)
Fold Change: -0.0859
Cell Significance Index: -1.0100
Cell Name: myelocyte (CL0002193)
Fold Change: -0.0866
Cell Significance Index: -0.9300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0875
Cell Significance Index: -2.5200
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0902
Cell Significance Index: -2.2500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0908
Cell Significance Index: -2.3200
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0933
Cell Significance Index: -1.3600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0974
Cell Significance Index: -2.7800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0975
Cell Significance Index: -1.3300
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0984
Cell Significance Index: -0.8900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0984
Cell Significance Index: -2.3600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0994
Cell Significance Index: -1.7000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1005
Cell Significance Index: -2.2000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1007
Cell Significance Index: -2.5200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1009
Cell Significance Index: -2.1800
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1045
Cell Significance Index: -2.1800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1074
Cell Significance Index: -2.2800
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1080
Cell Significance Index: -1.6400
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1082
Cell Significance Index: -1.4000
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1082
Cell Significance Index: -2.1300
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1085
Cell Significance Index: -1.7400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1143
Cell Significance Index: -2.3000
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1147
Cell Significance Index: -1.9300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1151
Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** The Ventx gene belongs to the homeobox family of transcription factors, which are essential for regulating developmental processes and cellular differentiation. VENTX is predominantly expressed in specific cell types, including goblet cells, granulocyte monocyte progenitor cells, early T lineage precursors, and cerebral cortex GABAergic interneurons. Its expression is also observed in absorptive cells, intestinal crypt stem cells, transit amplifying cells, and abnormal/necrotic cells, suggesting a broader role in maintaining tissue homeostasis. **Pathways and Functions:** The Ventx gene is involved in several signaling pathways, including: 1. **Cellular responses to stimuli**: VENTX regulates the expression of genes involved in immune responses, such as those related to inflammation and immune cell differentiation. 2. **Cellular responses to stress**: The gene is also involved in regulating cellular responses to stress, including DNA damage and senescence. 3. **Chromatin remodeling**: VENTX interacts with chromatin-remodeling complexes to regulate gene expression and maintain chromatin structure. 4. **Transcriptional regulation**: The gene acts as a transcriptional regulator, influencing the expression of target genes involved in various cellular processes. **Clinical Significance:** The Ventx gene's expression in specific cell types and its involvement in immune regulation and cellular homeostasis suggest potential implications in various diseases, including: 1. **Immunological disorders**: Dysregulation of VENTX expression may contribute to the development of immunological disorders, such as autoimmune diseases or cancer. 2. **Neurological disorders**: The gene's expression in cerebral cortex GABAergic interneurons and other neural cells may be involved in the pathogenesis of neurological disorders, such as neurodegenerative diseases or psychiatric disorders. 3. **Cancer**: Aberrant expression of VENTX in neoplastic cells may contribute to tumor development and progression. In conclusion, the Ventx gene plays a crucial role in regulating immune responses, cellular senescence, and gene expression. Further research is necessary to fully elucidate the mechanisms by which Ventx influences cellular homeostasis and to explore its potential implications in disease pathogenesis. **Recommendations for Future Research:** 1. Investigate the specific mechanisms by which Ventx regulates immune responses and cellular senescence. 2. Examine the role of Ventx in various disease models, including immunological disorders, neurological disorders, and cancer. 3. Explore the potential therapeutic applications of Ventx in disease treatment, including gene therapy or RNA-based interventions. By advancing our understanding of the Ventx gene's functions and implications, we can better elucidate the complex relationships between immune regulation, cellular homeostasis, and disease pathogenesis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein VENTX

Genular Protein ID: 982482317

Symbol: VENTX_HUMAN

Name: Homeobox protein VENTX

UniProtKB Accession Codes:

O95231 Q32MZ3

Database IDs:

Citations:

PubMed ID: 11549314

Title: Molecular cloning of a human Vent-like homeobox gene.

PubMed ID: 11549314

DOI: 10.1006/geno.2001.6574

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 258
Mass: 27552
Checksum: 6F611169122D8244
Sequence:

MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA 
VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE 
RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL 
QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA 
LSTGPRGLCA MPQTGDAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.