Details for: CRCP

Gene ID: 27297

Symbol: CRCP

Ensembl ID: ENSG00000241258

Description: CGRP receptor component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.1405
    Cell Significance Index: -28.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.6207
    Cell Significance Index: -26.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.7456
    Cell Significance Index: -31.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9790
    Cell Significance Index: -29.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0603
    Cell Significance Index: -26.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5696
    Cell Significance Index: -29.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7069
    Cell Significance Index: -20.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3094
    Cell Significance Index: -11.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4043
    Cell Significance Index: 163.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3469
    Cell Significance Index: 80.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2591
    Cell Significance Index: 1136.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2079
    Cell Significance Index: 16.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0057
    Cell Significance Index: 201.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9068
    Cell Significance Index: 147.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8944
    Cell Significance Index: 40.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7798
    Cell Significance Index: 140.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6464
    Cell Significance Index: 231.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6459
    Cell Significance Index: 79.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5777
    Cell Significance Index: 30.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5600
    Cell Significance Index: 16.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5259
    Cell Significance Index: 14.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5148
    Cell Significance Index: 70.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5016
    Cell Significance Index: 144.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3856
    Cell Significance Index: 23.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3527
    Cell Significance Index: 27.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3445
    Cell Significance Index: 22.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3432
    Cell Significance Index: 33.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3279
    Cell Significance Index: 226.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3119
    Cell Significance Index: 14.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3091
    Cell Significance Index: 21.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3019
    Cell Significance Index: 164.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3016
    Cell Significance Index: 19.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2903
    Cell Significance Index: 128.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2409
    Cell Significance Index: 11.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2156
    Cell Significance Index: 15.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2076
    Cell Significance Index: 26.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1805
    Cell Significance Index: 10.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1618
    Cell Significance Index: 32.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1449
    Cell Significance Index: 3.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1410
    Cell Significance Index: 6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1056
    Cell Significance Index: 3.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0977
    Cell Significance Index: 3.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0970
    Cell Significance Index: 4.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0598
    Cell Significance Index: 7.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0034
    Cell Significance Index: -2.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0087
    Cell Significance Index: -1.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0088
    Cell Significance Index: -0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0121
    Cell Significance Index: -18.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0199
    Cell Significance Index: -27.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0218
    Cell Significance Index: -16.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0245
    Cell Significance Index: -15.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0286
    Cell Significance Index: -21.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0335
    Cell Significance Index: -2.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0411
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0500
    Cell Significance Index: -28.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0528
    Cell Significance Index: -23.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0539
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0603
    Cell Significance Index: -37.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0721
    Cell Significance Index: -12.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0787
    Cell Significance Index: -0.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0811
    Cell Significance Index: -8.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0826
    Cell Significance Index: -2.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0928
    Cell Significance Index: -1.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0980
    Cell Significance Index: -14.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1248
    Cell Significance Index: -3.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1364
    Cell Significance Index: -2.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1368
    Cell Significance Index: -3.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1591
    Cell Significance Index: -33.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1622
    Cell Significance Index: -18.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2521
    Cell Significance Index: -5.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2778
    Cell Significance Index: -22.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2807
    Cell Significance Index: -29.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2898
    Cell Significance Index: -10.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3217
    Cell Significance Index: -8.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3507
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3554
    Cell Significance Index: -23.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3761
    Cell Significance Index: -10.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4135
    Cell Significance Index: -5.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4335
    Cell Significance Index: -12.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4415
    Cell Significance Index: -11.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4681
    Cell Significance Index: -9.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4733
    Cell Significance Index: -29.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5187
    Cell Significance Index: -13.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5406
    Cell Significance Index: -11.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5558
    Cell Significance Index: -17.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5568
    Cell Significance Index: -9.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5621
    Cell Significance Index: -11.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5660
    Cell Significance Index: -18.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5679
    Cell Significance Index: -6.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5892
    Cell Significance Index: -12.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5914
    Cell Significance Index: -15.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6026
    Cell Significance Index: -21.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6308
    Cell Significance Index: -9.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6505
    Cell Significance Index: -13.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6609
    Cell Significance Index: -14.2800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6670
    Cell Significance Index: -4.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6859
    Cell Significance Index: -17.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** The CRCP gene encodes for a protein that acts as a receptor component for calcitonin gene-related peptide (CGRP), a neuropeptide involved in neurotransmission and immune responses. 2. **Cellular Localization:** CRCP is expressed in various cell types, including choroid plexus epithelial cells, neurons, and immune cells, such as CD14-low, CD16-positive monocytes. 3. **Signaling Pathways:** CRCP is involved in calcitonin gene-related peptide receptor activity, immune system, and neurotransmission pathways. **Pathways and Functions:** 1. **Calcitonin Gene-Related Peptide Receptor Activity:** CRCP is a key component of the calcitonin gene-related peptide receptor, which plays a crucial role in neurotransmission and immune responses. 2. **Immune System:** CRCP is involved in innate immune response and defense against pathogens, particularly virus. 3. **Neurotransmission:** CRCP is expressed in neurons and plays a role in neurotransmission, particularly in the regulation of glutamatergic neurotransmission. 4. **Gene Expression (Transcription):** CRCP is involved in the regulation of gene expression, particularly in the transcription of RNA polymerase III. 5. **DNA Polymerase III Complex:** CRCP is a subunit of the DNA polymerase III complex, which is responsible for DNA replication and transcription. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of CRCP has been implicated in various neurological disorders, including migraine, epilepsy, and multiple sclerosis. 2. **Inflammatory Conditions:** CRCP has been implicated in inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 3. **Cancer:** CRCP has been identified as a potential biomarker for cancer, particularly in the regulation of tumor growth and metastasis. 4. **Neuropathic Pain:** CRCP has been implicated in the regulation of neuropathic pain, particularly in the treatment of chronic pain syndromes. In conclusion, the CRCP gene plays a complex and multifaceted role in various physiological and pathological processes. Further research is needed to fully elucidate the functions and dysregulation of CRCP in human diseases.

Genular Protein ID: 2259289256

Symbol: RPC9_HUMAN

Name: DNA-directed RNA polymerase III subunit RPC9

UniProtKB Accession Codes:

O75575 A8MUZ4 A8MW23 B2R4H4 B4E198 Q3KRA3 Q5HYF1 Q8IXL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 11 EMDB 14 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10067875

Title: Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein.

PubMed ID: 10067875

DOI: 10.1210/endo.140.3.6541

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12391170

Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.

PubMed ID: 12391170

DOI: 10.1128/mcb.22.22.8044-8055.2002

PubMed ID: 12482973

Title: An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.

PubMed ID: 12482973

DOI: 10.1128/mcb.23.1.195-205.2003

PubMed ID: 19631370

Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

PubMed ID: 19631370

DOI: 10.1016/j.cell.2009.06.015

PubMed ID: 19609254

Title: RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

PubMed ID: 19609254

DOI: 10.1038/ni.1779

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

Sequence Information:

  • Length: 148
  • Mass: 16871
  • Checksum: 75943BA57A63AF3D
  • Sequence:
    • MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH 
QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV 
TSILPAEPEA EQKKNTNSNV AMDEEDPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.