Details for: GLP1R

Gene ID: 2740

Symbol: GLP1R

Ensembl ID: ENSG00000112164

Description: glucagon like peptide 1 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.44
    Marker Score: 4119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.85
    Marker Score: 1053
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.29
    Marker Score: 679
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4822
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1
    Marker Score: 418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15261
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1838
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1576
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.68
    Marker Score: 1411
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.5
    Marker Score: 298.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2981
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 185
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.28
    Marker Score: 70
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 508
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.27
    Marker Score: 295
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 136
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.25
    Marker Score: 890
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.23
    Marker Score: 478
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.19
    Marker Score: 1021.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.19
    Marker Score: 132
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 183
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.18
    Marker Score: 428
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 128
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 187
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 79.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.09
    Marker Score: 306.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.08
    Marker Score: 608
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.08
    Marker Score: 1706
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.07
    Marker Score: 166
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.07
    Marker Score: 54
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.05
    Marker Score: 192
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.04
    Marker Score: 589
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.04
    Marker Score: 1471
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 14

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Other Information

**Key characteristics:** * The GLP1R is a single-pass transmembrane protein with a molecular weight of approximately 142 kDa. * It is a member of the class b/2 (secretin family receptors) of G protein-coupled receptors. * It is expressed in high levels in the pancreas, where it is primarily expressed in alpha cells. * It is also expressed in other tissues, including the liver, kidney, and adipose tissue. **Pathways and functions:** * The GLP1R signaling pathway is responsible for regulating insulin secretion by the beta cells of the pancreas. * When GLP1 binds to the GLP1R, it triggers the activation of the adenylate cyclase, which leads to the production of cyclic AMP (cAMP). * cAMP acts on the beta cells to inhibit the phosphorylation of a key regulatory protein, thereby promoting the opening of the ATP-gated channel in the cell membrane. * This allows glucose to enter the cell, which leads to the release of insulin into the bloodstream. **Clinical significance:** * Mutations in the GLP1R gene have been linked to type 2 diabetes. * In type 2 diabetes, the body's cells become less sensitive to GLP1, which leads to impaired insulin secretion. * This results in high blood sugar levels and eventually to the development of diabetes. **Conclusion:** The GLP1R is a key regulator of insulin secretion by the pancreas. Mutations in the GLP1R gene have been linked to type 2 diabetes, highlighting the importance of this receptor in maintaining blood sugar homeostasis.

Genular Protein ID: 2596835132

Symbol: GLP1R_HUMAN

Name: Glucagon-like peptide 1 receptor

UniProtKB Accession Codes:

P43220 Q2M229 Q99669

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 11 EMDB 29 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 63 PDBsum 46 PIR 2 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8405712

Title: Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.

PubMed ID: 8405712

DOI: 10.2337/diab.42.11.1678

PubMed ID: 8404634

Title: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor.

PubMed ID: 8404634

DOI: 10.1210/endo.133.4.8404634

PubMed ID: 8216285

Title: Cloning and functional expression of a human glucagon-like peptide-1 receptor.

PubMed ID: 8216285

DOI: 10.1006/bbrc.1993.2226

PubMed ID: 7517895

Title: Signal transduction of the GLP-1-receptor cloned from a human insulinoma.

PubMed ID: 7517895

DOI: 10.1016/0014-5793(94)00553-2

PubMed ID: 7843404

Title: Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences.

PubMed ID: 7843404

DOI: 10.1016/0014-5793(94)01430-9

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9213353

Title: Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.

PubMed ID: 9213353

DOI: 10.1016/s0196-9781(97)00001-6

PubMed ID: 20869417

Title: Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.

PubMed ID: 20869417

DOI: 10.1016/j.peptides.2010.09.015

PubMed ID: 21901419

Title: Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase.

PubMed ID: 21901419

DOI: 10.1007/s11033-011-1225-0

PubMed ID: 22412906

Title: Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

PubMed ID: 22412906

DOI: 10.1371/journal.pone.0032675

PubMed ID: 18287102

Title: Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

PubMed ID: 18287102

DOI: 10.1074/jbc.m708740200

PubMed ID: 19861722

Title: Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.

PubMed ID: 19861722

DOI: 10.1074/jbc.m109.033829

PubMed ID: 26308095

Title: Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.

PubMed ID: 26308095

DOI: 10.1021/acs.jmedchem.5b00726

PubMed ID: 27196125

Title: Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor.

PubMed ID: 27196125

DOI: 10.1038/srep26236

PubMed ID: 28514449

Title: Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

PubMed ID: 28514449

DOI: 10.1038/nature22378

Sequence Information:

  • Length: 463
  • Mass: 53026
  • Checksum: EE7C0EAE29931F5D
  • Sequence:
    • MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL 
FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW 
RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH 
LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN 
YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL 
GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW 
RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS

Genular Protein ID: 3670634888

Symbol: A0A142FHB8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A142FHB8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 6 Pfam 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 26936963

Title: Glucagon-like peptide-1 receptor activation attenuates platelet aggregation and thrombosis.

PubMed ID: 26936963

Sequence Information:

  • Length: 463
  • Mass: 53042
  • Checksum: 1C02BC0B2056CD23
  • Sequence:
    • MAGAPGLLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL 
FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW 
RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH 
LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN 
YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL 
GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW 
RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.