Details for: HDHD5

Gene ID: 27440

Symbol: HDHD5

Ensembl ID: ENSG00000069998

Description: haloacid dehalogenase like hydrolase domain containing 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.1249
    Cell Significance Index: -27.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.1467
    Cell Significance Index: -22.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.1205
    Cell Significance Index: -26.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.9541
    Cell Significance Index: -22.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.3767
    Cell Significance Index: -22.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.1072
    Cell Significance Index: 49.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0970
    Cell Significance Index: 207.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9869
    Cell Significance Index: 323.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6847
    Cell Significance Index: 101.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1627
    Cell Significance Index: 12.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8160
    Cell Significance Index: 736.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8110
    Cell Significance Index: 94.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7171
    Cell Significance Index: 49.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6999
    Cell Significance Index: 140.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6189
    Cell Significance Index: 12.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5933
    Cell Significance Index: 15.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5073
    Cell Significance Index: 10.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4880
    Cell Significance Index: 25.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4654
    Cell Significance Index: 6.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3893
    Cell Significance Index: 17.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3670
    Cell Significance Index: 53.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3642
    Cell Significance Index: 130.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3609
    Cell Significance Index: 65.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3503
    Cell Significance Index: 7.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3440
    Cell Significance Index: 22.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3382
    Cell Significance Index: 15.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2968
    Cell Significance Index: 20.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2853
    Cell Significance Index: 155.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2849
    Cell Significance Index: 39.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2804
    Cell Significance Index: 9.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2800
    Cell Significance Index: 123.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2697
    Cell Significance Index: 33.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2683
    Cell Significance Index: 53.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2211
    Cell Significance Index: 6.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1928
    Cell Significance Index: 133.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1880
    Cell Significance Index: 6.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1877
    Cell Significance Index: 14.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1823
    Cell Significance Index: 10.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1752
    Cell Significance Index: 20.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1619
    Cell Significance Index: 20.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1224
    Cell Significance Index: 23.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0948
    Cell Significance Index: 2.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0944
    Cell Significance Index: 2.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0689
    Cell Significance Index: 7.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0507
    Cell Significance Index: 1.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0502
    Cell Significance Index: 6.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0453
    Cell Significance Index: 2.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0378
    Cell Significance Index: 1.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0364
    Cell Significance Index: 1.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0317
    Cell Significance Index: 43.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0283
    Cell Significance Index: 1.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0238
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0216
    Cell Significance Index: 33.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0152
    Cell Significance Index: 28.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0081
    Cell Significance Index: 14.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0078
    Cell Significance Index: 0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0101
    Cell Significance Index: -4.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0144
    Cell Significance Index: -10.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0222
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0270
    Cell Significance Index: -20.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0321
    Cell Significance Index: -3.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0353
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0403
    Cell Significance Index: -22.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0415
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0438
    Cell Significance Index: -27.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0728
    Cell Significance Index: -20.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0767
    Cell Significance Index: -5.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0892
    Cell Significance Index: -2.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0954
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1343
    Cell Significance Index: -28.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1392
    Cell Significance Index: -2.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1549
    Cell Significance Index: -2.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1700
    Cell Significance Index: -4.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1741
    Cell Significance Index: -2.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1862
    Cell Significance Index: -2.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2202
    Cell Significance Index: -22.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2223
    Cell Significance Index: -3.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2295
    Cell Significance Index: -6.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2630
    Cell Significance Index: -6.7600
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2642
    Cell Significance Index: -2.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2837
    Cell Significance Index: -22.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2993
    Cell Significance Index: -18.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3031
    Cell Significance Index: -15.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3735
    Cell Significance Index: -7.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3904
    Cell Significance Index: -3.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3956
    Cell Significance Index: -4.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4047
    Cell Significance Index: -5.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4246
    Cell Significance Index: -17.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4516
    Cell Significance Index: -3.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4521
    Cell Significance Index: -14.4000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4570
    Cell Significance Index: -7.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4658
    Cell Significance Index: -8.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4765
    Cell Significance Index: -15.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5053
    Cell Significance Index: -10.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5152
    Cell Significance Index: -13.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5241
    Cell Significance Index: -18.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5527
    Cell Significance Index: -16.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5629
    Cell Significance Index: -6.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HDHD5 is a unique gene that encodes a protein belonging to the haloacid dehalogenase-like hydrolase (HALDH) family. The HALDH domain is characterized by its ability to hydrolyze halogenated compounds, such as halogenated alkanes and alkyl halides. This domain is also involved in various cellular processes, including lipid metabolism, cell signaling, and immune response modulation. HDHD5 is predominantly expressed in cells of the immune system, including extravillous trophoblast, pancreatic A cell, cardiac muscle cell, and myeloid dendritic cell. **Pathways and Functions:** HDHD5 is significantly involved in several biological pathways, including glycerophospholipid biosynthesis and mitochondrial function. The gene's expression in cells suggests its role in lipid metabolism, particularly in the synthesis of glycerophospholipids, which are essential components of cellular membranes. HDHD5 is also implicated in mitochondrial function, where it may play a role in the regulation of mitochondrial membrane dynamics and biogenesis. Furthermore, HDHD5 is expressed in cells of the immune system, suggesting its involvement in immune response modulation. Its expression in myeloid dendritic cells, for example, may indicate its role in antigen presentation and immune cell activation. Additionally, HDHD5's expression in pancreatic D cells suggests its potential role in regulating pancreatic function and glucose metabolism. **Clinical Significance:** While the exact clinical significance of HDHD5 remains unclear, its expression in various cell types suggests potential implications in various diseases. For instance, dysregulation of HDHD5 in pancreatic D cells may contribute to the development of diabetes mellitus. Similarly, alterations in HDHD5 expression in myeloid dendritic cells may impact immune response and contribute to autoimmune diseases. In addition, HDHD5's involvement in glycerophospholipid biosynthesis and mitochondrial function may have implications for neurodegenerative disorders, such as Alzheimer's disease, where lipid metabolism and mitochondrial dysfunction are known to play critical roles. In conclusion, the HDHD5 gene is a complex and multifaceted component of the human genome, with significant implications for cellular processes, including lipid metabolism, immune response, and mitochondrial function. Further research is necessary to fully elucidate the clinical significance of HDHD5 and its potential role in various diseases.

Genular Protein ID: 2124140093

Symbol: HDHD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BXW7 B2RCK5 Q9BXW8 Q9NWA8 Q9NX41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11381032

Title: Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.

PubMed ID: 11381032

DOI: 10.1101/gr.154901

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 423
  • Mass: 46321
  • Checksum: C4D9208AB8B88CCE
  • Sequence:
    • MAAWGCVAAL GAARGLCWRA ARAAAGLQGR PARRCYAVGP AQSPPTFGFL LDIDGVLVRG 
HRVIPAALKA FRRLVNSQGQ LRVPVVFVTN AGNILQHSKA QELSALLGCE VDADQVILSH 
SPMKLFSEYH EKRMLVSGQG PVMENAQGLG FRNVVTVDEL RMAFPLLDMV DLERRLKTTP 
LPRNDFPRIE GVLLLGEPVR WETSLQLIMD VLLSNGSPGA GLATPPYPHL PVLASNMDLL 
WMAEAKMPRF GHGTFLLCLE TIYQKVTGKE LRYEGLMGKP SILTYQYAED LIRRQAERRG 
WAAPIRKLYA VGDNPMSDVY GANLFHQYLQ KATHDGAPEL GAGGTRQQQP SASQSCISIL 
VCTGVYNPRN PQSTEPVLGG GEPPFHGHRD LCFSPGLMEA SHVVNDVNEA VQLVFRKEGW 
ALE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.