Details for: GLUD2

Gene ID: 2747

Symbol: GLUD2

Ensembl ID: ENSG00000182890

Description: glutamate dehydrogenase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.94
    Marker Score: 1945
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 356
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.84
    Marker Score: 2440
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 367.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.74
    Marker Score: 2180
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.42
    Marker Score: 168
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.4
    Marker Score: 156
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.37
    Marker Score: 3096
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.28
    Marker Score: 278
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.26
    Marker Score: 1519.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.25
    Marker Score: 432
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.19
    Marker Score: 297
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.18
    Marker Score: 254
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.18
    Marker Score: 187
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 401
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.16
    Marker Score: 206.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.16
    Marker Score: 9625
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.16
    Marker Score: 100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.15
    Marker Score: 576
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 411
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.12
    Marker Score: 75
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.11
    Marker Score: 1127
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.11
    Marker Score: 711
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1
    Marker Score: 102
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.09
    Marker Score: 100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 554
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.09
    Marker Score: 866
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.09
    Marker Score: 134
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.08
    Marker Score: 693
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.08
    Marker Score: 102
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.07
    Marker Score: 103
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.07
    Marker Score: 163
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.06
    Marker Score: 183
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 15

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Other Information

**Key characteristics:** * GLUD2 is a multi-functional enzyme that can act as an enzyme in both the glutamate biosynthetic and catabolic processes. * It is involved in the regulation of synaptic plasticity and learning and memory. * It is a key regulator of intestinal epithelial cell proliferation and differentiation. * It is involved in the regulation of the immune response. **Pathways and functions:** * GLUD2 is involved in the following pathways: * Adp binding * Glutamate and glutamine metabolism * Glutamate biosynthetic process * Glutamate catabolic process * Glutamate dehydrogenase (nad+) activity * Glutamate dehydrogenase (nadp+) activity * Glutamate dehydrogenase [nad(p)+] activity * It is also involved in the regulation of mitochondrial biogenesis, mitochondrial matrix, and organelle biogenesis and maintenance. **Clinical significance:** * Mutations in GLUD2 have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. * GLUD2 inhibitors are being investigated as potential treatments for these disorders. **Additional information:** * GLUD2 is a highly conserved protein, with a similar sequence found in other species. * It is a very important protein in the central nervous system, and its dysfunction is associated with a number of neurological disorders.

Genular Protein ID: 3880818699

Symbol: DHE4_HUMAN

Name: Glutamate dehydrogenase 2, mitochondrial

UniProtKB Accession Codes:

P49448 B2R8G0 Q9UDQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8207021

Title: Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene.

PubMed ID: 8207021

DOI: 10.1016/s0021-9258(19)89484-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16023112

Title: Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.

PubMed ID: 16023112

DOI: 10.1016/j.febslet.2005.06.041

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22709669

Title: Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import.

PubMed ID: 22709669

DOI: 10.1016/j.neuint.2012.06.006

Sequence Information:

  • Length: 558
  • Mass: 61434
  • Checksum: F222B1B2CB74A6EA
  • Sequence:
    • MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR RHYSELVADR 
EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 
GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR 
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG 
FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 
NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLLSV QESLERKFGK 
HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 
NAIEKVFKVY SEAGVTFT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.