Details for: AMY2A

Gene ID: 279

Symbol: AMY2A

Ensembl ID: ENSG00000243480

Description: amylase alpha 2A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.23
    Marker Score: 3514
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3179
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.48
    Marker Score: 5237
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2208
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7455
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2420
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 496
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1334
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 802
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8
    Marker Score: 834
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 503
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.58
    Marker Score: 363
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 515
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.51
    Marker Score: 114
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.44
    Marker Score: 309
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 355
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.34
    Marker Score: 550.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 288
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3
    Marker Score: 130
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 232
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.16
    Marker Score: 747
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 87.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 231
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.13
    Marker Score: 243
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.12
    Marker Score: 266
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.11
    Marker Score: 231
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.11
    Marker Score: 136.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.11
    Marker Score: 911
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.11
    Marker Score: 1651
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.08
    Marker Score: 262
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 126
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 752
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 225
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.06
    Marker Score: 123
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.05
    Marker Score: 86
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.05
    Marker Score: 436.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.04
    Marker Score: 116
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.04
    Marker Score: 26.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.04
    Marker Score: 146
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 14.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 183
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 1836
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 86
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 55
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.02
    Marker Score: 9

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Other Information

**Key characteristics:** - AMY2A is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a secreted protein that is found in the lumen of pancreatic acinar cells. - It is a member of the alpha-amylase family of enzymes. **Pathways and functions:** - AMY2A is involved in the alpha-amylase activity pathway, which is responsible for the hydrolysis of carbohydrates into simple sugars. - It also plays a role in the calcium ion binding pathway, which is involved in regulating various cellular processes. - AMY2A is involved in the carbohydrate catabolic process, which is responsible for breaking down complex carbohydrates into simpler molecules that can be absorbed by the body. - It is also involved in the chloride ion binding pathway, which is involved in maintaining the body's fluid and electrolyte balance. **Clinical significance:** - Mutations in the AMY2A gene have been linked to several human diseases, including pancreatitis, diabetes, and obesity. - These mutations can lead to the production of a defective protein that is unable to function properly, resulting in the symptoms of these diseases. - As such, AMY2A is a promising target for the development of new therapeutic strategies for these diseases.

Genular Protein ID: 3521307398

Symbol: AMYP_HUMAN

Name: Pancreatic alpha-amylase

UniProtKB Accession Codes:

P04746 B9EJG1 Q9UBH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 67 PDBsum 51 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SABIO-RK 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6610603

Title: Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases.

PubMed ID: 6610603

DOI: 10.1016/0378-1119(84)90265-8

PubMed ID: 2450054

Title: Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene.

PubMed ID: 2450054

DOI: 10.1016/0378-1119(87)90213-7

PubMed ID: 6336237

Title: A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A.

PubMed ID: 6336237

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3260028

Title: Human pancreatic amylase is encoded by two different genes.

PubMed ID: 3260028

DOI: 10.1093/nar/16.10.4724

PubMed ID: 2452973

Title: Concerted evolution of human amylase genes.

PubMed ID: 2452973

DOI: 10.1128/mcb.8.3.1197-1205.1988

PubMed ID: 27066537

Title: Potent human alpha-amylase inhibition by the beta-defensin-like protein helianthamide.

PubMed ID: 27066537

DOI: 10.1021/acscentsci.5b00399

PubMed ID: 8193143

Title: The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution.

PubMed ID: 8193143

DOI: 10.1021/bi00186a031

PubMed ID: 8528071

Title: The structure of human pancreatic alpha-amylase at 1.8-A resolution and comparisons with related enzymes.

PubMed ID: 8528071

DOI: 10.1002/pro.5560040908

PubMed ID: 10091666

Title: Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.

PubMed ID: 10091666

DOI: 10.1110/ps.8.3.635

PubMed ID: 10769135

Title: Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.

PubMed ID: 10769135

DOI: 10.1021/bi9921182

PubMed ID: 11772019

Title: Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.

PubMed ID: 11772019

DOI: 10.1021/bi0115636

PubMed ID: 11914097

Title: Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.

PubMed ID: 11914097

DOI: 10.1021/bi011821z

Sequence Information:

  • Length: 511
  • Mass: 57707
  • Checksum: A77B1A34EACB3C2A
  • Sequence:
    • MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP 
NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN 
AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLTGL 
LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG 
SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG 
FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP 
RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV IFRNVVDGQP 
FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS FSLTLQTGLP AGTYCDVISG DKINGNCTGI 
KIYVSDDGKA HFSISNSAED PFIAIHAESK L

Genular Protein ID: 1595439742

Symbol: Q53F26_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F26

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 2 SAM 1 SMART 4 SMR 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 511
  • Mass: 57721
  • Checksum: 90336EBD8F5D654B
  • Sequence:
    • MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP 
NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN 
AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLTGL 
LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG 
SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTI IRKWNGEKMS YLKNWGEGWG 
FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP 
RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV IFRNVVDGQP 
FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS FSLTLQTGLP AGTYCDVISG DKINGNCTGI 
KIYVSDDGKA HFSISNSAED PFIAIHAESK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.