Details for: AMY2A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 285.4574
Cell Significance Index: 143.3600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 8.1474
Cell Significance Index: 1391.2200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 7.3598
Cell Significance Index: 840.1200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.4680
Cell Significance Index: 35.5600 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.4617
Cell Significance Index: 6.7300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.2761
Cell Significance Index: 31.6300 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.2462
Cell Significance Index: 3.1000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.1275
Cell Significance Index: 2.6600 - Cell Name: PP cell (CL0000696)
Fold Change: 0.0836
Cell Significance Index: 0.8500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0722
Cell Significance Index: 45.0800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0371
Cell Significance Index: 1.0600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0277
Cell Significance Index: 1.0500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0265
Cell Significance Index: 19.6100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0251
Cell Significance Index: 0.4900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0240
Cell Significance Index: 1.0600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0135
Cell Significance Index: 2.7100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0070
Cell Significance Index: 0.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0055
Cell Significance Index: 1.9600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.0032
Cell Significance Index: 1.7900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0020
Cell Significance Index: 0.5800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.0003
Cell Significance Index: 0.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0003
Cell Significance Index: -0.6100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0004
Cell Significance Index: -0.7700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0006
Cell Significance Index: -0.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0010
Cell Significance Index: -0.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0011
Cell Significance Index: -0.8500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0022
Cell Significance Index: -1.4000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0025
Cell Significance Index: -0.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0030
Cell Significance Index: -1.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0052
Cell Significance Index: -0.7100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0053
Cell Significance Index: -0.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0055
Cell Significance Index: -0.1800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0057
Cell Significance Index: -1.1300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0060
Cell Significance Index: -0.2800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0067
Cell Significance Index: -0.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0071
Cell Significance Index: -0.7300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0086
Cell Significance Index: -1.2500 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0128
Cell Significance Index: -0.1700 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0133
Cell Significance Index: -0.2600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0140
Cell Significance Index: -0.4900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0143
Cell Significance Index: -0.4200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0143
Cell Significance Index: -1.1000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0147
Cell Significance Index: -0.1600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0167
Cell Significance Index: -0.8700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0173
Cell Significance Index: -0.9700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0174
Cell Significance Index: -0.4400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0184
Cell Significance Index: -0.4600 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.0186
Cell Significance Index: -0.2000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0196
Cell Significance Index: -0.2800 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.0201
Cell Significance Index: -0.2200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0202
Cell Significance Index: -0.5400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0203
Cell Significance Index: -1.2500 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0225
Cell Significance Index: -0.3700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0226
Cell Significance Index: -0.4800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0236
Cell Significance Index: -0.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0236
Cell Significance Index: -1.1100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0236
Cell Significance Index: -0.6100 - Cell Name: neuron (CL0000540)
Fold Change: -0.0243
Cell Significance Index: -0.2300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0243
Cell Significance Index: -0.4800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0247
Cell Significance Index: -0.5000 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0255
Cell Significance Index: -0.3100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0255
Cell Significance Index: -0.4400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0270
Cell Significance Index: -0.7600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0276
Cell Significance Index: -0.7500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0286
Cell Significance Index: -1.4500 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0309
Cell Significance Index: -0.4100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0318
Cell Significance Index: -0.8500 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0321
Cell Significance Index: -0.4200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0359
Cell Significance Index: -0.4500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0364
Cell Significance Index: -0.7600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0373
Cell Significance Index: -0.4400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0379
Cell Significance Index: -0.7000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0382
Cell Significance Index: -0.6600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0383
Cell Significance Index: -0.6500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0387
Cell Significance Index: -1.1100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0392
Cell Significance Index: -0.9400 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.0417
Cell Significance Index: -0.3200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0422
Cell Significance Index: -0.8300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0422
Cell Significance Index: -0.6200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0427
Cell Significance Index: -0.7200 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0431
Cell Significance Index: -0.4700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0436
Cell Significance Index: -0.8700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0438
Cell Significance Index: -0.9600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0442
Cell Significance Index: -1.1100 - Cell Name: endocrine cell (CL0000163)
Fold Change: -0.0447
Cell Significance Index: -0.5400 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0452
Cell Significance Index: -0.4300 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.0455
Cell Significance Index: -0.6800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0455
Cell Significance Index: -1.6700 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0459
Cell Significance Index: -1.1700 - Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: -0.0475
Cell Significance Index: -0.4400 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0481
Cell Significance Index: -0.6100 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0492
Cell Significance Index: -0.6800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.0501
Cell Significance Index: -0.6500 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0502
Cell Significance Index: -0.6500 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0508
Cell Significance Index: -0.7100 - Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
Fold Change: -0.0514
Cell Significance Index: -0.6100 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.0515
Cell Significance Index: -0.5500 - Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0541
Cell Significance Index: -0.6100 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0549
Cell Significance Index: -0.8800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0552
Cell Significance Index: -1.2800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3521307398
Symbol: AMYP_HUMAN
Name: Pancreatic alpha-amylase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6610603
Title: Corrected sequences of cDNAs for human salivary and pancreatic alpha-amylases.
PubMed ID: 6610603
PubMed ID: 2450054
Title: Primary structure of human pancreatic alpha-amylase gene: its comparison with human salivary alpha-amylase gene.
PubMed ID: 2450054
PubMed ID: 6336237
Title: A complementary DNA sequence that predicts a human pancreatic amylase primary structure consistent with the electrophoretic mobility of the common isozyme, Amy2 A.
PubMed ID: 6336237
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3260028
Title: Human pancreatic amylase is encoded by two different genes.
PubMed ID: 3260028
PubMed ID: 2452973
Title: Concerted evolution of human amylase genes.
PubMed ID: 2452973
PubMed ID: 27066537
Title: Potent human alpha-amylase inhibition by the beta-defensin-like protein helianthamide.
PubMed ID: 27066537
PubMed ID: 8193143
Title: The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution.
PubMed ID: 8193143
DOI: 10.1021/bi00186a031
PubMed ID: 8528071
Title: The structure of human pancreatic alpha-amylase at 1.8-A resolution and comparisons with related enzymes.
PubMed ID: 8528071
PubMed ID: 10091666
Title: Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.
PubMed ID: 10091666
DOI: 10.1110/ps.8.3.635
PubMed ID: 10769135
Title: Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
PubMed ID: 10769135
DOI: 10.1021/bi9921182
PubMed ID: 11772019
Title: Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
PubMed ID: 11772019
DOI: 10.1021/bi0115636
PubMed ID: 11914097
Title: Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
PubMed ID: 11914097
DOI: 10.1021/bi011821z
Sequence Information:
- Length: 511
- Mass: 57707
- Checksum: A77B1A34EACB3C2A
- Sequence:
MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLTGL LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV IFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED PFIAIHAESK L
Genular Protein ID: 1595439742
Symbol: Q53F26_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8125298
Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
PubMed ID: 8125298
PubMed ID: 9373149
Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
PubMed ID: 9373149
Sequence Information:
- Length: 511
- Mass: 57721
- Checksum: 90336EBD8F5D654B
- Sequence:
MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLTGL LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTI IRKWNGEKMS YLKNWGEGWG FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV IFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED PFIAIHAESK L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.