Details for: GP9

Gene ID: 2815

Symbol: GP9

Ensembl ID: ENSG00000169704

Description: glycoprotein IX platelet

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8276
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2214
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 1999
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.24
    Marker Score: 900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1784
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 431
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 649
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.83
    Marker Score: 623.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.78
    Marker Score: 326.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12160
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.61
    Marker Score: 970
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 475
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 252
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1043
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.49
    Marker Score: 221
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2709
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 266
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.44
    Marker Score: 342
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 365
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.28
    Marker Score: 190
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.27
    Marker Score: 112
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.27
    Marker Score: 147
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.25
    Marker Score: 268
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.24
    Marker Score: 250
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 142
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.23
    Marker Score: 219
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.18
    Marker Score: 162
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.18
    Marker Score: 66
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.17
    Marker Score: 118
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.17
    Marker Score: 172
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.17
    Marker Score: 1112
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 311.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.15
    Marker Score: 1706
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.15
    Marker Score: 362
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.14
    Marker Score: 101
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 475
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.12
    Marker Score: 137
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.11
    Marker Score: 189
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.11
    Marker Score: 193
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1
    Marker Score: 5379
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 48
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.08
    Marker Score: 66
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.08
    Marker Score: 667
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.07
    Marker Score: 76

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Other Information

**Key characteristics:** - GPIX is a glycoprotein that is expressed on the surface of platelets. - It is involved in the intrinsic pathway of blood coagulation. - GPIX is a glycoprotein that is expressed in high levels on platelets. - When GPIX binds to von Willebrand factor (vWF), it triggers the intrinsic pathway of blood coagulation. **Pathways and functions:** - The intrinsic pathway of blood coagulation is a complex cascade of reactions that are triggered by the binding of a protein called von Willebrand factor (vWF) to its receptor, GPIX. - GPIX is expressed on the surface of platelets. - When GPIX binds to vWF, it triggers a conformational change that exposes a hydrophobic groove in the protein. - This conformational change allows factor IX to bind to GPIX, which initiates the intrinsic pathway of blood coagulation. **Clinical significance:** - GPIX is a gene that is implicated in the pathogenesis of hemophilia b, a genetic disorder that is caused by a deficiency of factor IX. - GPIX is also expressed on the surface of endothelial cells, which can lead to abnormal blood flow and the formation of blood clots. - Mutations in the GPIX gene have been linked to a number of other blood disorders, including von Willebrand disease and platelet dysfunction.

Genular Protein ID: 2455610770

Symbol: GPIX_HUMAN

Name: Platelet glycoprotein IX

UniProtKB Accession Codes:

P14770 Q14445 Q8N1D1 Q92525

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2253772

Title: Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3.

PubMed ID: 2253772

DOI: 10.1016/0014-5793(90)81361-q

PubMed ID: 8429020

Title: Characterization of the gene encoding human platelet glycoprotein IX.

PubMed ID: 8429020

DOI: 10.1016/s0021-9258(18)53713-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2771955

Title: Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures.

PubMed ID: 2771955

DOI: 10.1073/pnas.86.17.6773

PubMed ID: 9184424

Title: Corrected DNA sequence of the platelet glycoprotein IX gene.

PubMed ID: 9184424

PubMed ID: 3056407

Title: Isolation and characterization of human platelet glycoprotein IX.

PubMed ID: 3056407

DOI: 10.1016/s0006-291x(88)80933-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8481514

Title: Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome.

PubMed ID: 8481514

PubMed ID: 9163595

Title: A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome.

PubMed ID: 9163595

DOI: 10.1046/j.1365-2141.1997.582706.x

PubMed ID: 9886312

Title: A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV.

PubMed ID: 9886312

DOI: 10.1046/j.1365-2141.1998.01100.x

PubMed ID: 10583255

Title: Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome.

PubMed ID: 10583255

DOI: 10.1046/j.1365-2141.1999.01733.x

PubMed ID: 11167791

Title: Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome.

PubMed ID: 11167791

DOI: 10.1046/j.1365-2141.2001.02529.x

PubMed ID: 11758225

Title: A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient.

PubMed ID: 11758225

PubMed ID: 12100158

Title: A Leu7-to-Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex.

PubMed ID: 12100158

DOI: 10.1046/j.1365-2141.2002.03544.x

Sequence Information:

  • Length: 177
  • Mass: 19046
  • Checksum: 6A023B96C7854D59
  • Sequence:
    • MPAWGALFLL WATAEATKDC PSPCTCRALE TMGLWVDCRG HGLTALPALP ARTRHLLLAN 
NSLQSVPPGA FDHLPQLQTL DVTQNPWHCD CSLTYLRLWL EDRTPEALLQ VRCASPSLAA 
HGPLGRLTGY QLGSCGWQLQ ASWVRPGVLW DVALVAVAAL GLALLAGLLC ATTEALD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.