Details for: GP9

Gene ID: 2815

Symbol: GP9

Ensembl ID: ENSG00000169704

Description: glycoprotein IX platelet

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.6084
    Cell Significance Index: -3.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.3007
    Cell Significance Index: -3.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 6.4057
    Cell Significance Index: -3.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5784
    Cell Significance Index: 74.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4981
    Cell Significance Index: -3.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.1832
    Cell Significance Index: 54.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.0196
    Cell Significance Index: 41.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9580
    Cell Significance Index: 120.0500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3667
    Cell Significance Index: 16.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2310
    Cell Significance Index: 26.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5514
    Cell Significance Index: 8.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5220
    Cell Significance Index: 99.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3219
    Cell Significance Index: 31.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2998
    Cell Significance Index: 270.6600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2378
    Cell Significance Index: 2.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2024
    Cell Significance Index: 4.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1816
    Cell Significance Index: 29.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1803
    Cell Significance Index: 19.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1136
    Cell Significance Index: 6.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1002
    Cell Significance Index: 1.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0978
    Cell Significance Index: 6.7700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0898
    Cell Significance Index: 1.1600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.0285
    Cell Significance Index: 0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0258
    Cell Significance Index: 14.5400
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.0209
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0068
    Cell Significance Index: 1.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0018
    Cell Significance Index: 1.3200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0007
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0079
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0083
    Cell Significance Index: -3.7600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0094
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0124
    Cell Significance Index: -2.1200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0125
    Cell Significance Index: -0.1500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0136
    Cell Significance Index: -0.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0137
    Cell Significance Index: -2.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0138
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0143
    Cell Significance Index: -0.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0148
    Cell Significance Index: -0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0160
    Cell Significance Index: -3.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0162
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0170
    Cell Significance Index: -0.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0178
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0212
    Cell Significance Index: -0.2400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0238
    Cell Significance Index: -0.2600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0257
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0258
    Cell Significance Index: -0.2800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0270
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0293
    Cell Significance Index: -3.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0300
    Cell Significance Index: -3.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0331
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0353
    Cell Significance Index: -0.4500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0358
    Cell Significance Index: -0.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0360
    Cell Significance Index: -2.3200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0378
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0384
    Cell Significance Index: -0.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0393
    Cell Significance Index: -0.5800
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0403
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0409
    Cell Significance Index: -1.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0462
    Cell Significance Index: -1.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0470
    Cell Significance Index: -3.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0492
    Cell Significance Index: -1.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0503
    Cell Significance Index: -3.3800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0521
    Cell Significance Index: -0.7400
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0528
    Cell Significance Index: -0.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0538
    Cell Significance Index: -2.8000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0545
    Cell Significance Index: -0.3800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0571
    Cell Significance Index: -0.3500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0585
    Cell Significance Index: -0.8500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0594
    Cell Significance Index: -0.4400
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0595
    Cell Significance Index: -0.6300
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.0664
    Cell Significance Index: -0.3600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0800
    Cell Significance Index: -0.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0828
    Cell Significance Index: -2.1100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0830
    Cell Significance Index: -1.2100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0831
    Cell Significance Index: -0.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0864
    Cell Significance Index: -2.8300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0874
    Cell Significance Index: -0.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0879
    Cell Significance Index: -1.2600
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0885
    Cell Significance Index: -1.0200
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1000
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1008
    Cell Significance Index: -2.0100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1029
    Cell Significance Index: -0.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1065
    Cell Significance Index: -2.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1068
    Cell Significance Index: -3.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1073
    Cell Significance Index: -1.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1084
    Cell Significance Index: -2.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1096
    Cell Significance Index: -1.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1110
    Cell Significance Index: -2.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1120
    Cell Significance Index: -2.0700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1132
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1151
    Cell Significance Index: -1.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1174
    Cell Significance Index: -3.0000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1174
    Cell Significance Index: -2.3100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1182
    Cell Significance Index: -1.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GP9 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is composed of two immunoglobulin-like domains and a transmembrane domain, which enables it to interact with other proteins and cell surfaces. GP9 is specifically localized to the platelet surface and is associated with the glycoprotein Ib-IX-V complex. The complex plays a crucial role in the binding of von Willebrand factor (vWF) to platelets, which is essential for platelet adhesion and activation. **Pathways and Functions:** GP9 is involved in several key pathways and functions, including: 1. **Blood Coagulation:** GP9 is essential for the intrinsic pathway of blood coagulation, which involves the activation of factor IX and the subsequent formation of fibrin clots. 2. **Cell Adhesion:** GP9 interacts with vWF and other proteins to regulate platelet adhesion to exposed collagen and other surfaces. 3. **Platelet Activation:** GP9 plays a crucial role in the activation of platelets, including the release of sequestered calcium ions into the cytosol. 4. **Signaling:** GP9 is involved in the regulation of platelet signaling pathways, including the activation of signaling molecules such as phospholipase C. 5. **Megakaryocyte Development:** GP9 is also expressed in megakaryocytes, the cells responsible for the production of platelets. **Clinical Significance:** Dysregulation of GP9 has been implicated in various clinical conditions, including: 1. **Hemophilia B:** Defects in GP9 can lead to hemophilia B, a bleeding disorder caused by the deficiency of factor IX. 2. **Defective Binding of vwf:** Abnormalities in the binding of vWF to GP9 can lead to platelet dysfunction and bleeding disorders. 3. **Defective F9 Activation:** Defects in GP9 can also lead to defective activation of factor IX, which is essential for the formation of fibrin clots. 4. **Platelet Aggregation Disorders:** Abnormalities in GP9 can lead to platelet aggregation disorders, including thrombocytopenia and thrombosis. In conclusion, GP9 is a critical component of the glycoprotein Ib-IX-V complex, which plays a pivotal role in the regulation of platelet adhesion, activation, and aggregation. Its dysregulation has been implicated in various clinical conditions, including hemophilia B, defective binding of vWF, and platelet aggregation disorders. Further research is needed to fully elucidate the role of GP9 in hemostasis and its clinical significance.

Genular Protein ID: 2455610770

Symbol: GPIX_HUMAN

Name: Platelet glycoprotein IX

UniProtKB Accession Codes:

P14770 Q14445 Q8N1D1 Q92525

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2253772

Title: Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3.

PubMed ID: 2253772

DOI: 10.1016/0014-5793(90)81361-q

PubMed ID: 8429020

Title: Characterization of the gene encoding human platelet glycoprotein IX.

PubMed ID: 8429020

DOI: 10.1016/s0021-9258(18)53713-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2771955

Title: Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures.

PubMed ID: 2771955

DOI: 10.1073/pnas.86.17.6773

PubMed ID: 9184424

Title: Corrected DNA sequence of the platelet glycoprotein IX gene.

PubMed ID: 9184424

PubMed ID: 3056407

Title: Isolation and characterization of human platelet glycoprotein IX.

PubMed ID: 3056407

DOI: 10.1016/s0006-291x(88)80933-1

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8481514

Title: Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome.

PubMed ID: 8481514

PubMed ID: 9163595

Title: A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome.

PubMed ID: 9163595

DOI: 10.1046/j.1365-2141.1997.582706.x

PubMed ID: 9886312

Title: A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV.

PubMed ID: 9886312

DOI: 10.1046/j.1365-2141.1998.01100.x

PubMed ID: 10583255

Title: Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome.

PubMed ID: 10583255

DOI: 10.1046/j.1365-2141.1999.01733.x

PubMed ID: 11167791

Title: Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome.

PubMed ID: 11167791

DOI: 10.1046/j.1365-2141.2001.02529.x

PubMed ID: 11758225

Title: A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient.

PubMed ID: 11758225

PubMed ID: 12100158

Title: A Leu7-to-Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex.

PubMed ID: 12100158

DOI: 10.1046/j.1365-2141.2002.03544.x

Sequence Information:

  • Length: 177
  • Mass: 19046
  • Checksum: 6A023B96C7854D59
  • Sequence:
    • MPAWGALFLL WATAEATKDC PSPCTCRALE TMGLWVDCRG HGLTALPALP ARTRHLLLAN 
NSLQSVPPGA FDHLPQLQTL DVTQNPWHCD CSLTYLRLWL EDRTPEALLQ VRCASPSLAA 
HGPLGRLTGY QLGSCGWQLQ ASWVRPGVLW DVALVAVAAL GLALLAGLLC ATTEALD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.