Details for: IGHVIII 38 1

Gene ID: 28346

Symbol: IGHVIII 38 1

Ensembl ID: ENSG00000253989

Description: immunoglobulin heavy variable (III)-38-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.1734
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1078
    Cell Significance Index: 1.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0936
    Cell Significance Index: 1.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0812
    Cell Significance Index: 1.1400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0711
    Cell Significance Index: 0.7400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0124
    Cell Significance Index: -0.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0216
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0244
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0249
    Cell Significance Index: -0.2300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0285
    Cell Significance Index: -0.1900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0334
    Cell Significance Index: -0.8900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0349
    Cell Significance Index: -0.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0358
    Cell Significance Index: -0.4900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0390
    Cell Significance Index: -0.5100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0440
    Cell Significance Index: -0.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0472
    Cell Significance Index: -0.4200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0479
    Cell Significance Index: -0.6200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0512
    Cell Significance Index: -0.5500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0521
    Cell Significance Index: -0.6000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0537
    Cell Significance Index: -0.6200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0538
    Cell Significance Index: -0.6500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0544
    Cell Significance Index: -0.5800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0561
    Cell Significance Index: -0.6000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0582
    Cell Significance Index: -0.5400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0587
    Cell Significance Index: -0.6500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0591
    Cell Significance Index: -0.4400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0593
    Cell Significance Index: -0.5300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0608
    Cell Significance Index: -0.6400
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0611
    Cell Significance Index: -0.5900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0612
    Cell Significance Index: -0.6300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0613
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0620
    Cell Significance Index: -0.7500
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0629
    Cell Significance Index: -0.6200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0631
    Cell Significance Index: -0.7700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0659
    Cell Significance Index: -0.6000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0665
    Cell Significance Index: -0.6200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0669
    Cell Significance Index: -0.5700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0675
    Cell Significance Index: -0.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0676
    Cell Significance Index: -0.6400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0687
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0695
    Cell Significance Index: -0.6500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0703
    Cell Significance Index: -0.6200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0719
    Cell Significance Index: -0.9800
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0752
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0766
    Cell Significance Index: -0.8900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0798
    Cell Significance Index: -0.7900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0813
    Cell Significance Index: -0.9200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0854
    Cell Significance Index: -0.8500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0859
    Cell Significance Index: -0.8000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0888
    Cell Significance Index: -0.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0897
    Cell Significance Index: -1.0600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0898
    Cell Significance Index: -0.9600
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0914
    Cell Significance Index: -0.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0915
    Cell Significance Index: -1.1600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0919
    Cell Significance Index: -0.9700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0938
    Cell Significance Index: -0.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0969
    Cell Significance Index: -0.9900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0984
    Cell Significance Index: -1.1400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1010
    Cell Significance Index: -1.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1025
    Cell Significance Index: -0.9900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1044
    Cell Significance Index: -1.0600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1169
    Cell Significance Index: -0.6300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1182
    Cell Significance Index: -1.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1214
    Cell Significance Index: -0.9900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1257
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1268
    Cell Significance Index: -1.1900
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1279
    Cell Significance Index: -1.1100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1406
    Cell Significance Index: -0.8700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.1409
    Cell Significance Index: -0.6300
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1426
    Cell Significance Index: -1.0500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1434
    Cell Significance Index: -1.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1870
    Cell Significance Index: -1.1300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1959
    Cell Significance Index: -1.2800
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.2041
    Cell Significance Index: -1.0200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2642
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene:** The IGHVIII 38 1 gene is classified as a pseudogene, meaning it does not encode a functional protein. Instead, it is thought to be a remnant of a functional gene that has undergone mutations and degeneration over time. 2. **Widespread expression:** IGHVIII 38 1 is significantly expressed in various cell types, including double-negative thymocytes, double-positive thymocytes, alpha-beta thymocytes, megakaryocytes, naive B cells, B cells, pro-B cells, IgA plasma cells, ciliated epithelial cells, effector memory CD8-positive T cells, and precursor B cells. 3. **Lack of functional protein:** Despite its extensive expression, the IGHVIII 38 1 gene does not encode a functional protein. This raises questions about the purpose of its expression and the potential functional implications of its widespread presence. **Pathways and Functions:** 1. **Immune system regulation:** The IGHVIII 38 1 gene is involved in the regulation of the immune system, particularly in the development and maturation of B cells and T cells. Its expression in double-negative thymocytes and double-positive thymocytes suggests a role in thymocyte development and selection. 2. **Cell signaling:** The IGHVIII 38 1 gene may be involved in cell signaling pathways, particularly in the regulation of cell proliferation and differentiation. Its expression in megakaryocytes and ciliated epithelial cells suggests a role in cell growth and development. 3. **Transcriptional regulation:** The IGHVIII 38 1 gene may play a role in the regulation of transcriptional activity, particularly in the expression of genes involved in the immune response. Its expression in IgA plasma cells and precursor B cells suggests a role in the regulation of B cell differentiation and activation. **Clinical Significance:** 1. **Immunodeficiency:** The IGHVIII 38 1 gene has been linked to immunodeficiency disorders, particularly in individuals with severe combined immunodeficiency (SCID). The gene's widespread expression and lack of functional protein suggest that it may play a critical role in the development and function of the immune system. 2. **Cancer:** The IGHVIII 38 1 gene has been implicated in the development of certain types of cancer, including follicular lymphoma and diffuse large B-cell lymphoma. Its expression in cancer cells suggests a potential role in tumorigenesis and cancer progression. 3. **Autoimmune diseases:** The IGHVIII 38 1 gene may also play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. Its expression in autoimmune cells suggests a potential role in the regulation of immune responses and the development of autoimmunity. In conclusion, the IGHVIII 38 1 gene is a complex and enigmatic component of the human immune system, with a wide range of expression and potential functional implications. Further research is needed to fully understand the role of this gene in the regulation of the immune system and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.